LOCUS       NM_181877               3756 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 2 (ZSCAN2),
            transcript variant 1, mRNA.
ACCESSION   NM_181877
VERSION     NM_181877.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3756)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   2  (bases 1 to 3756)
  AUTHORS   Nicolas,E., Poitelon,Y., Chouery,E., Salem,N., Levy,N.,
            Megarbane,A. and Delague,V.
  TITLE     CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar
            ataxia, is caused by a mutant zinc-finger protein, ZNF592
  JOURNAL   Eur J Hum Genet 18 (10), 1107-1113 (2010)
   PUBMED   20531441
REFERENCE   3  (bases 1 to 3756)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 3756)
  AUTHORS   Denny,P. and Ashworth,A.
  TITLE     A zinc finger protein-encoding gene expressed in the post-meiotic
            phase of spermatogenesis
  JOURNAL   Gene 106 (2), 221-227 (1991)
   PUBMED   1937051
  REMARK    GeneRIF: PMID:1937051 pertains to studies in mouse.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC048382.7, BC041620.1,
            AY262259.1, AK128624.1, CK003500.1 and BU733585.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_181877.3.
            
            Summary: The protein encoded by this gene contains several copies
            of zinc finger motif, which is commonly found in transcriptional
            regulatory proteins. Studies in mice show that this gene is
            expressed during embryonic development, and specifically in the
            testis in adult mice, suggesting that it may play a role in
            regulating genes in germ cells. Alternative splicing of this gene
            results in several transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.154141.1,
                                           SRR1803615.73229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546148.6/ ENSP00000445451.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC048382.7         109767-109775
            10-641              BC041620.1         1-632
            642-2427            AY262259.1         598-2383
            2428-2932           AK128624.1         2428-2932
            2933-3212           CK003500.1         109-388
            3213-3752           AK128624.1         3213-3752
            3753-3756           BU733585.1         19-22               c
FEATURES             Location/Qualifiers
     source          1..3756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..3756
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /note="zinc finger and SCAN domain containing 2"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
     exon            1..127
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /inference="alignment:Splign:2.1.0"
     exon            128..641
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2080
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zfp-29; zinc finger protein 29 homolog; zinc finger
                     protein 854"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_870992.2"
                     /db_xref="CCDS:CCDS10329.2"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
                     /translation="MMAADIPRVTTPLSSLVQVPQEEDRQEEEVTTMILEDDSWVQEA
                     VLQEDGPESEPFPQSAGKGGPQEEVTRGPQGALGRLRELCRRWLRPEVHTKEQMLTML
                     PKEIQAWLQEHRPESSEEAAALVEDLTQTLQDSDFEIQSENGENCNQDMFENESRKIF
                     SEMPEGESAQHSDGESDFERDAGIQRLQGHSPGEDHGEVVSQDREVGQLIGLQGTYLG
                     EKPYECPQCGKTFSRKSHLITHERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEK
                     PYKCRDCGKSFSRSANLITHQRIHTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPY
                     SCPECGKSFGNRSSLNTHQGIHTGEKPYECKECGESFSYNSNLIRHQRIHTGEKPYKC
                     TDCGQRFSQSSALITHRRTHTGEKPYQCSECGKSFSRSSNLATHRRTHMVEKPYKCGV
                     CGKSFSQSSSLIAHQGMHTGEKPYECLTCGESFSWSSNLLKHQRIHTGEKPYKCSECG
                     KCFSQRSQLVVHQRTHTGEKPYKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKG
                     FSWNSVLIIHQRIHTGEKPYKCPECGKGFSNSSNFITHQRTHMKEKLY"
     exon            642..3756
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3735..3740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /note="hexamer: AATAAA"
     polyA_site      3756
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /note="major polyA site"
ORIGIN      
        1 ctctcccgtc cattgttctc ggtgccccac gggcttgagc cggggtgaat ctggaggggc
       61 cgggccgagc ccgggggcgc tttcgcacgc gaagcaaccg ctagagcagg acctggtctc
      121 ccgagagcgg gactacttgt tgatatttga ggagggaagt gtcttacctg agagcctggc
      181 tggagaagac tgaggtccaa ggcttgaagc ctaagtgatt gccccaggac tgtggatgat
      241 ggctgcagac atcccgagag tgaccactcc gctgagctcc ttggtccagg tgcctcaaga
      301 ggaagataga caggaggagg aggtcaccac catgatcctg gaggatgact cctgggtgca
      361 agaagctgtg ctgcaggagg atggccctga gtctgagccc tttccccaga gtgctggcaa
      421 gggcggcccc caggaggagg tgaccagggg accacagggt gcactcggcc gcctccgaga
      481 gctctgccgg cgctggctga gaccagaggt acacaccaag gagcagatgt taaccatgct
      541 gccaaaggaa attcaggctt ggctgcaaga gcatcggcct gaaagcagtg aggaggcagc
      601 ggccctggtg gaagacttga cccagaccct tcaggacagt gattttgaga tacagagtga
      661 aaatggggag aactgtaatc aagacatgtt tgagaatgaa tcacgtaaga tattctcgga
      721 aatgcctgaa ggtgaaagtg ctcagcactc cgatggggaa agtgactttg agagagatgc
      781 tggcatccag aggctccagg gacacagccc aggtgaggac cacggggagg tggtttctca
      841 ggacagggaa gttggccagc tcataggcct gcagggcacc tacctagggg agaagcccta
      901 cgaatgtccc cagtgtggga agaccttcag ccggaaatcc cacctcatca cacacgagag
      961 gacccacaca ggagagaaat actacaaatg tgatgaatgt ggaaaaagct ttagtgatgg
     1021 ttcaaatttt agtagacacc aaaccactca caccggggag aagccctaca aatgcagaga
     1081 ctgtgggaag agctttagcc ggagtgccaa cctcataacc caccagagga tccacacggg
     1141 ggaaaagccc ttccagtgtg ccgagtgtgg caagagcttc agcaggagtc ccaacctcat
     1201 tgcacatcag cgcacccaca caggagagaa accctactcg tgccccgagt gtggaaagag
     1261 ctttggcaac cgatccagcc ttaacacgca tcaggggatc cacactggag aaaagcccta
     1321 cgaatgtaaa gaatgcggcg aaagctttag ttacaactcc aatctaatca gacaccagag
     1381 aatccacaca ggagagaaac cctacaaatg taccgactgt gggcagaggt tcagccagag
     1441 ttcagccctc atcacccacc ggagaaccca cacaggagag aaaccctacc agtgcagcga
     1501 gtgtgggaaa agcttcagcc gcagctctaa cctggccaca caccggagaa cccacatggt
     1561 ggagaagccc tataagtgtg gggtgtgtgg gaagagcttc agccagagct ccagtctgat
     1621 tgcacaccag ggcatgcaca caggggagaa accctacgag tgcctgacat gtggggagag
     1681 cttcagctgg agctccaacc tcctcaagca ccagaggatc cacacgggag agaaacccta
     1741 caaatgcagc gagtgtggga aatgcttcag ccagcgctcc cagctcgtag tgcaccagcg
     1801 gacccacacg ggcgagaagc cctacaaatg cctcatgtgc ggcaagagct tcagccgggg
     1861 ctccattctg gtcatgcacc agagagccca tttgggagac aagccctaca ggtgccctga
     1921 gtgtgggaaa ggctttagct ggaactcagt cctcattata catcagcgaa tccacactgg
     1981 ggagaagccc tacaaatgcc ccgagtgtgg caaaggcttc agcaacagct ctaactttat
     2041 cacacatcag agaactcaca tgaaagagaa actttattga agtggcaaag agtgaaagtg
     2101 agggactggc ctggagtggg agttgccaca ctgccccaac agtgattccc tttcaaagag
     2161 ctgtgcttcc taaacattct ggggggtttt gccagagtct tccccttgct catcctcatt
     2221 tccaggacac tgtcatttta gtggtctgag tcaagtcccg tatacattca agaacagggc
     2281 ataggcgtgg aaggtctgga aagttgggtc tttttccctt acattgggtg acttgattgg
     2341 ccccctctca tgattcctct gtgcctcagt ttcctctttg gtaaaatggg gggaaatgtt
     2401 tctccatgtg gaatggaaga cagcatggcc cacaacgtgg gccgagtcct cagagaaata
     2461 ctggaaatca ttggtgtggt tctggttgtt ttgttgtttt gctgccacgt tgttgggcta
     2521 aggtgccttc accccaagct gttagtgttc cagggcaccc caagctgtca gttagaatct
     2581 gctcttctgg ctttggtgtc ttgggctttg atttcaggtc aagatggagg ggcttctcca
     2641 gttctgagtc acccacgtga aggtaaagac cctttctatt tccagaaagt gtcaggagca
     2701 cagaaacttg aggaagtaca gcctggagcc agtgtcccag tgtcctttcc attggtaaga
     2761 gttggacagg gccttcagga aaggggtaaa ccgaggacat ttcagtgctt gcttttgtct
     2821 ctgcctactg tcctgtggta gatcagctac caggggaaca catttgttct cgtggggttt
     2881 tgtcctggag agtgtagtga agtccgagag ccctagctgc caacccatgg tggatggtaa
     2941 cttctgtctc atcaagagta aaacagtcct gcacacagca gggtgggttt gtgcctttgg
     3001 cccaacaggt acatagcccc ataatttctg aattattcta tgcacttgtt tccctcttct
     3061 tttatttttt atttgatata tgccgagcta gaatcctgtc gggtagcttt tgtatactaa
     3121 gaacattatt attattatta tttttgagac ggagtctcac tctgtcaccc aggctggagt
     3181 gcagtggtgc catctcagct cactgcaagc tccgcctccc gggttcacgc cattctcctg
     3241 cctcagcctc ccgagtagct gggactacag gtgcccacca ccacacccag ctaatttctt
     3301 tttttgtatt tttagtagag acggggtttc accgcgttag ccaggatggt ttcgatctcc
     3361 tgtcctcgtg atctgcccgc cttggcctcc cgaagtgctg ggattacagg cgtgagccag
     3421 cgcacccggc caagaacatt atttttaaag aagtgttaac tttgaggaca tatctgttcc
     3481 ctggagatat ttgggcttga atcaggagtt tgtcctacag gtgtcgccct tgatctcagg
     3541 atgctaccag ggctttgttc tcgggatcct cgcacctgga gagtgaagac gggcatgacg
     3601 gcaggtgaag gggtttgctg tgaaggaaga ggagataagg catttccagg aaatgggaaa
     3661 ctgcctcctc ctacacatgg ggcctgtgct cagaatgggc ttagttctta taggatggat
     3721 gctcagtatt ccttaataaa gtagagttcc attctt
//
