LOCUS       NM_001145543            2539 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 18 (ZSCAN18),
            transcript variant 4, mRNA.
ACCESSION   NM_001145543
VERSION     NM_001145543.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Wang,Y., Luo,Y., Fu,S., He,L., Pan,G., Fan,D., Wen,Q. and Fan,Y.
  TITLE     Zinc finger and SCAN domain-containing protein 18 is a potential
            DNA methylation-modified tumor suppressor and biomarker in breast
            cancer
  JOURNAL   Front Endocrinol (Lausanne) 14, 1095604 (2023)
   PUBMED   37223020
  REMARK    GeneRIF: Zinc finger and SCAN domain-containing protein 18 is a
            potential DNA methylation-modified tumor suppressor and biomarker
            in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Li,B., Ren,B., Ma,G., Cai,F., Wang,P., Zeng,Y., Liu,Y., Zhang,L.,
            Yang,Y., Liang,H., Zhang,R. and Deng,J.
  TITLE     Inactivation of ZSCAN18 by promoter hypermethylation drives the
            proliferation via attenuating TP53INP2-mediated autophagy in
            gastric cancer cells
  JOURNAL   Clin Epigenetics 15 (1), 10 (2023)
   PUBMED   36650573
  REMARK    GeneRIF: Inactivation of ZSCAN18 by promoter hypermethylation
            drives the proliferation via attenuating TP53INP2-mediated
            autophagy in gastric cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Qi,L., Zhou,L., Lu,M., Yuan,K., Li,Z., Wu,G., Huang,X., Shen,Y.,
            Zhao,M., Fu,W., Chu,B., Wang,G., Ren,F., Ma,D. and Chen,J.
  TITLE     Development of a highly specific HER2 monoclonal antibody for
            immunohistochemistry using protein microarray chips
  JOURNAL   Biochem Biophys Res Commun 484 (2), 248-254 (2017)
   PUBMED   28111342
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Vedeld,H.M., Andresen,K., Eilertsen,I.A., Nesbakken,A., Seruca,R.,
            Gladhaug,I.P., Thiis-Evensen,E., Rognum,T.O., Boberg,K.M. and
            Lind,G.E.
  TITLE     The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are
            frequently methylated across gastrointestinal cancers
  JOURNAL   Int J Cancer 136 (4), 844-853 (2015)
   PUBMED   24948044
  REMARK    GeneRIF: A high negative correlation between promoter DNA
            methylation and gene expression was observed for CDO1, ZNF331 and
            ZSCAN18 in gastrointestinal tumors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY280799.1 and BC006205.2.
            
            On Feb 27, 2020 this sequence version replaced NM_001145543.1.
            
            Transcript Variant: This variant (4) uses a different segment for
            its 5' UTR and lacks a coding region segment, which results in the
            use of a downstream start codon, compared to variant 1. Variants 3
            and 4 encode the same protein (isoform 3), which is shorter when it
            is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY280799.1, AK022957.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000601144.6/ ENSP00000468934.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1312              AY280799.1         26-1337
            1313-2539           BC006205.2         827-2053
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2539
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /note="zinc finger and SCAN domain containing 18"
                     /db_xref="GeneID:65982"
                     /db_xref="HGNC:HGNC:21037"
     exon            1..58
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     exon            59..580
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1710
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /note="isoform 3 is encoded by transcript variant 4; zinc
                     finger protein 447; zinc finger and SCAN domain-containing
                     protein 18"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     18 isoform 3"
                     /protein_id="NP_001139015.1"
                     /db_xref="CCDS:CCDS12971.1"
                     /db_xref="GeneID:65982"
                     /db_xref="HGNC:HGNC:21037"
                     /translation="MLPLEKAFASPRSSPAPPDLPTPGSAAGVQQEEPETIPERTPAD
                     LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILP
                     DKVRPWVVAQYPESCKKAASLVEGLADVLEEPGMLLGSPAGSSSILSDGVYERHMDPL
                     LLPGELASPSQALGAGEIPAPSETPWLSPDPLFLEQRRVREAKTEEDGPANTEQKLKS
                     FPEDPQHLGEWGHLDPAEENLKSYRKLLLWGYQLSQPDAASRLDTEELRLVERDPQGS
                     SLPEGGRRQESAGCACEEAAPAGVLPELPTEAPPGDALADPPSGTTEEEEEQPGKAPD
                     PQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSLEGVSSSGDSA
                     GLEAGQGPGADEPGLSRGKPYACGECGEAFAWLSHLMEHHSSHGGRKRYACQGCWKTF
                     HFSLALAEHQKTHEKEKSYALGGARGPQPSTREAQAGARAGGPPESVEGEAPPAPPEA
                     QR"
     exon            581..730
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     exon            731..819
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     exon            820..922
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1015
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..2539
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /note="hexamer: AATAAA"
     polyA_site      2539
                     /gene="ZSCAN18"
                     /gene_synonym="ZNF447"
                     /note="major polyA site"
ORIGIN      
        1 gccatcgcgc actggggctc cgggcggctg ggaccggcct ggggtagctg cgcagcaggt
       61 ctgtgggttc tggcaccacc tgagcccact gggcatctgg tcatccctgg cacctctcct
      121 ttggagccac cttgtccctg gctagacagt cacattttcc agtgccgttt tggaaagatg
      181 ttgcctttgg agaaggcgtt tgcctccccc aggagctccc cagccccgcc ggatctgccc
      241 acgccggggt cagcagccgg agtccagcag gaagaacccg agaccatccc tgagaggacc
      301 cctgctgacc tggagttctc ccgcctgcgt ttccgggaat ttgtctacca ggaggctgcc
      361 gggccccacc agaccctggc ccggctgcat gagctgtgcc gccagtggct gatgcctgag
      421 gcgcgctcca aggagcagat gctggagctg ctggtgctgg agcagttcct gggcatcctg
      481 cctgataagg tccggccctg ggtggtggca cagtaccctg agagctgcaa gaaggcagcc
      541 tccctggtgg agggcctcgc tgatgtcctg gaagagccag ggatgctgct gggctcccct
      601 gcgggctcat cctcaattct tagcgatgga gtgtacgaga ggcacatgga ccctctgctg
      661 ctaccaggcg agctcgcgag ccccagccag gcccttggag ctggggagat cccggcacct
      721 tctgagacac cctggctttc tccggacccc ctgtttctgg aacagaggag ggtcagagaa
      781 gcaaagaccg aagaggacgg ccctgccaac accgagcaga agctgaagtc ctttccagag
      841 gaccctcagc acctggggga gtggggccac ctggaccctg ccgaggagaa cctgaagagc
      901 taccggaagc tgctcctgtg ggggtatcag ctttcccagc ctgacgctgc ctccaggctg
      961 gacactgagg aactccggtt ggtggaaaga gatccacaag gaagcagcct cccagaaggc
     1021 gggaggcggc aggagagcgc tgggtgcgcc tgcgaggagg ccgcccccgc gggggtgctg
     1081 cctgagctgc ctacggaggc gccccctggg gacgcccttg ccgatccccc gtcgggcacc
     1141 actgaggagg aggaagagca gcctgggaag gccccggacc cgcaggaccc ccaggacgcg
     1201 gagtccgact ctgccaccgg atcgcagagg cagtccgtca tccagcagcc tgccccggac
     1261 aggggcacgg cgaaactggg aaccaagagg ccgcaccccg aggatgggga cgggcagagc
     1321 ctcgagggcg tctctagctc cggcgacagc gcagggctgg aggccgggca gggccctggg
     1381 gctgacgagc cgggcttgtc ccgcgggaag ccctatgcct gcggcgagtg cggggaggcc
     1441 ttcgcgtggc tctcgcacct gatggagcac cacagcagcc atggcggccg gaagcgctac
     1501 gcctgtcagg gctgctggaa gaccttccac ttcagcctgg ccctagccga gcaccagaag
     1561 acccacgaga aggagaaaag ctacgcgctg gggggcgccc ggggccccca accgtccacc
     1621 cgcgaagccc aggcgggggc tagggcgggc ggtcccccag agagcgtgga gggcgaggct
     1681 ccccccgcac ccccagaggc gcagaggtga gccgctgtgc tgtcccgttc cggaggggcc
     1741 gctttgccgg ccgtgaatcc cagacgaggc attgggcctt tccacgcccc tgggtggcgg
     1801 cttcctgtgg tgtttgtgga cgtcctctgc ctgtgccctg aatccgctcc tgaggctaag
     1861 cgctcccaac gagaagggtc cacgggaagc cctcacctct gtaaacacac cctgggccag
     1921 cgctcgcatc cgaggggagc cgccggatgt ggaagaagac tcggctttcc tgcagccatt
     1981 tagtgccgcc ccatgctagg ttatttgaca ttgtgcagtg tagagttgcc ttaaagtgcg
     2041 tgatctgcca gtgctttctt caagtcaccc ttgccccgat tcctcctgtt tgcgctcccc
     2101 agggttgctc aagtggaaat tttgtcagct gtttagcctt ttcgtacttg gcgtgatgtc
     2161 aacttcactt ctaatctgca aaagcagaag ctgtttccta gtttacctcg cgtgtgttta
     2221 cctatatgga gtagctcgca gagatcacag aaatgcttgc agcctaaggc agggttttca
     2281 gaccgtgggt cccagcccat ttagtaaaat gggaaatcaa ttagcaagtg gtcaccagca
     2341 ttacacagca atgaagcaga ataaagtagg ccagaatgca tcatgtagta aaggcaaata
     2401 ctgttttgtg aaacttttca cccatacatc taaatgtgag aactggttgc aatgtaagac
     2461 atttcttgct gggaagttgt gagcaaaata agttgaaaac actaataaag atctgtctgt
     2521 ctgagcaaag gagactaaa
//
