LOCUS       NM_025231               1279 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 16 (ZSCAN16),
            transcript variant 1, mRNA.
ACCESSION   NM_025231
VERSION     NM_025231.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Li,X., Shang,D., Shen,H., Song,J., Hao,G. and Tian,Y.
  TITLE     ZSCAN16 promotes proliferation, migration and invasion of bladder
            cancer via regulating NF-kB, AKT, mTOR, P38 and other genes
  JOURNAL   Biomed Pharmacother 126, 110066 (2020)
   PUBMED   32172065
  REMARK    GeneRIF: ZSCAN16 promotes proliferation, migration and invasion of
            bladder cancer via regulating NF-kB, AKT, mTOR, P38 and other
            genes.
            Erratum:[Biomed Pharmacother. 2020 Oct;130:110858. doi:
            10.1016/j.biopha.2020.110858.. PMID: 33054976]
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Gu,X., Zheng,M., Fei,X., Yang,Z., Li,F., Ji,C., Xie,Y. and Mao,Y.
  TITLE     ZNF435, a novel human SCAN-containing zinc finger protein, inhibits
            AP-1-mediated transcriptional activation
  JOURNAL   Mol Cells 23 (3), 316-322 (2007)
   PUBMED   17646705
  REMARK    GeneRIF: ZNF435 proved to be a transcription repressor as its
            overexpression in AD293 cells inhibited the transcriptional
            activities of AP-1.
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK025844.1 and CA306342.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025231.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025844.1, SRR1163655.384671.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340487.5/ ENSP00000366527.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1276              AK025844.1         1-1276
            1277-1279           CA306342.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1279
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /note="zinc finger and SCAN domain containing 16"
                     /db_xref="GeneID:80345"
                     /db_xref="HGNC:HGNC:20813"
                     /db_xref="MIM:618544"
     exon            1..69
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /inference="alignment:Splign:2.1.0"
     exon            70..487
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1147
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 392; zinc finger protein 435; zinc finger
                     and SCAN domain-containing protein 16"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     16 isoform a"
                     /protein_id="NP_079507.1"
                     /db_xref="CCDS:CCDS4644.1"
                     /db_xref="GeneID:80345"
                     /db_xref="HGNC:HGNC:20813"
                     /db_xref="MIM:618544"
                     /translation="MTTALEPEDQKGLLIIKAEDHYWGQDSSSQKCSPHRRELYRQHF
                     RKLCYQDAPGPREALTQLWELCRQWLRPECHTKEQILDLLVLEQFLSILPKDLQAWVR
                     AHHPETGEEAVTVLEDLERELDEPGKQVPGNSERRDILMDKLAPLGRPYESLTVQLHP
                     KKTQLEQEAGKPQRNGDKTRTKNEELFQKEDMPKDKEFLGEINDRLNKDTPQHPKSKD
                     IIENEGRSEWQQRERRRYKCDECGKSFSHSSDLSKHRRTHTGEKPYKCDECGKAFIQR
                     SHLIGHHRVHTGVKPYKCKECGKDFSGRTGLIQHQRIHTGEKPYECDECGRPFRVSSA
                     LIRHQRIHTANKLY"
     exon            488..626
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /inference="alignment:Splign:2.1.0"
     exon            627..1279
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /note="hexamer: ATTAAA"
     polyA_site      1279
                     /gene="ZSCAN16"
                     /gene_synonym="dJ265C24.3; ZNF392; ZNF435"
                     /note="major polyA site"
ORIGIN      
        1 gagtctagtc tttgttcggg gctgtccaaa ggacgctagc tgttgcacct gttcctccct
       61 gcgcgtaaga tagaggataa atctcctggc aaagcccaga atgaccacag ccctggaacc
      121 tgaggaccaa aaaggacttc tgataattaa ggcagaggac cattactggg gacaggattc
      181 cagctcacaa aagtgcagtc ctcacaggag ggaactctat agacaacact tcaggaagct
      241 ctgctatcag gatgcacctg gaccccgtga agctcttacc cagctgtggg agctctgccg
      301 tcagtggctg aggccagaat gccacaccaa ggagcagatt ttagacctgc tggtgctaga
      361 acagttcctg agcattcttc ctaaagacct gcaagcatgg gtgcgtgcac accatccaga
      421 gactggagag gaggcagtga cggtactgga ggatctggag agagagcttg atgaacctgg
      481 aaagcaggtc ccaggcaatt cagaaagacg ggacatactc atggacaagt tggccccctt
      541 gggaaggcca tatgaatcac tgactgtcca gctccatccc aaaaagaccc agctggagca
      601 ggaagctggg aaaccacaaa ggaatggtga taaaactagg actaagaatg aagagttgtt
      661 ccagaaggaa gatatgccca aagacaagga attccttggg gagataaatg acagactgaa
      721 caaagatact cctcagcatc ctaagtccaa agatattatt gaaaatgagg gcagatcaga
      781 atggcaacag agggaaagaa gacgatataa atgtgatgaa tgtgggaaaa gtttcagtca
      841 tagctcagac cttagtaaac acaggagaac tcacacggga gagaagccct ataaatgtga
      901 tgagtgtgga aaagccttca ttcagcgctc acatctcatt ggacatcata gagtacacac
      961 gggagtaaaa ccctataaat gtaaagaatg tgggaaagac ttcagtgggc gcacaggtct
     1021 tattcagcat cagagaatcc acacaggtga aaaaccctat gaatgtgatg agtgtggaag
     1081 gcctttccga gtaagttcag ctcttattag acatcaaaga attcataccg caaataaact
     1141 ctactaatat agcagtaata tcaaaagttc tttggacact caggcctaac tagttatcaa
     1201 agaatctatt ttagaaacct tgagtttcct caatgtggtc aaagcttcag tcatcattaa
     1261 acttctctgg accaaagaa
//
