LOCUS       NM_032805               2716 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens zinc finger and SCAN domain containing 10 (ZSCAN10),
            transcript variant 1, mRNA.
ACCESSION   NM_032805
VERSION     NM_032805.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Laugwitz,L., Cheng,F., Collins,S.C., Hustinx,A., Navarro,N.,
            Welsch,S., Cox,H., Hsieh,T.C., Vijayananth,A., Buchert,R.,
            Bender,B., Efthymiou,S., Murphy,D., Zafar,F., Rana,N.,
            Grasshoff,U., Falb,R.J., Grimmel,M., Seibt,A., Zheng,W., Ghaedi,H.,
            Thirion,M., Couette,S., Azizimalamiri,R., Sadeghian,S.,
            Galehdari,H., Zamani,M., Zeighami,J., Sedaghat,A., Ramshe,S.M.,
            Zare,A., Alipoor,B., Klee,D., Sturm,M., Ossowski,S., Houlden,H.,
            Riess,O., Wieczorek,D., Gavin,R., Maroofian,R., Krawitz,P.,
            Yalcin,B., Distelmaier,F. and Haack,T.B.
  TITLE     ZSCAN10 deficiency causes a neurodevelopmental disorder with
            characteristic oto-facial malformations
  JOURNAL   Brain 147 (7), 2471-2482 (2024)
   PUBMED   38386308
  REMARK    GeneRIF: ZSCAN10 deficiency causes a neurodevelopmental disorder
            with characteristic oto-facial malformations.
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Skamagki,M., Correia,C., Yeung,P., Baslan,T., Beck,S., Zhang,C.,
            Ross,C.A., Dang,L., Liu,Z., Giunta,S., Chang,T.P., Wang,J.,
            Ananthanarayanan,A., Bohndorf,M., Bosbach,B., Adjaye,J.,
            Funabiki,H., Kim,J., Lowe,S., Collins,J.J., Lu,C.W., Li,H., Zhao,R.
            and Kim,K.
  TITLE     ZSCAN10 expression corrects the genomic instability of iPSCs from
            aged donors
  JOURNAL   Nat Cell Biol 19 (9), 1037-1048 (2017)
   PUBMED   28846095
  REMARK    GeneRIF: The pluripotency factor ZSCAN10 is poorly expressed in
            A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4,
            SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes
            ROS-glutathione homeostasis and the DNA damage response, and
            recovers genomic stability.
            Erratum:[Nat Cell Biol. 2019 Apr;21(4):531-532. doi:
            10.1038/s41556-018-0269-y.. PMID: 30643186]
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Sugito,K., Kawashima,H., Uekusa,S., Yoshizawa,S., Hoshi,R.,
            Furuya,T., Kaneda,H., Hosoda,T., Masuko,T., Ohashi,K., Ikeda,T.,
            Koshinaga,T., Fujiwara,K., Igarashi,J., Ghosh,S., Held,W.A. and
            Nagase,H.
  TITLE     Identification of aberrant methylation regions in neuroblastoma by
            screening of tissue-specific differentially methylated regions
  JOURNAL   Pediatr Blood Cancer 60 (3), 383-389 (2013)
   PUBMED   22911660
  REMARK    GeneRIF: We demonstrated that SLC16A5 and ZNF206 displayed altered
            methylation patterns in the neuroblastoma genome
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Kawashima,H., Sugito,K., Yoshizawa,S., Uekusa,S., Furuya,T.,
            Ikeda,T., Koshinaga,T., Shinojima,Y., Hasegawa,R., Mishra,R.,
            Igarashi,J., Kimura,M., Wang,X., Fujiwara,K., Gosh,S. and Nagase,H.
  TITLE     DNA hypomethylation at the ZNF206-exon 5 CpG island associated with
            neuronal differentiation in mice and development of neuroblastoma
            in humans
  JOURNAL   Int J Oncol 40 (1), 31-39 (2012)
   PUBMED   22011711
  REMARK    GeneRIF: Data indicates that changes in DNA methylation levels at
            the Zfp206-exon 5 might be one of the important factors during
            neuronal development in mice and the hypomethylation of the
            homologous region induced ZNF206 expression in humans.
REFERENCE   6  (bases 1 to 2716)
  AUTHORS   Bernot,A., Heilig,R., Clepet,C., Smaoui,N., Da Silva,C.,
            Petit,J.L., Devaud,C., Chiannilkulchai,N., Fizames,C., Samson,D.,
            Cruaud,C., Caloustian,C., Gyapay,G., Delpech,M. and Weissenbach,J.
  TITLE     A transcriptional Map of the FMF region
  JOURNAL   Genomics 50 (2), 147-160 (1998)
   PUBMED   9653642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX781288.1, AC108134.3, AK027455.1, BC114452.1 and CN366927.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032805.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968189, SAMEA1968968
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000576985.6/ ENSP00000458879.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               CX781288.1         24-222
            200-200             AC108134.3         104434-104434       c
            201-249             CX781288.1         224-272
            250-1125            AK027455.1         1-876
            1126-2252           BC114452.1         588-1714
            2253-2716           CN366927.1         1-464
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2716
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /note="zinc finger and SCAN domain containing 10"
                     /db_xref="GeneID:84891"
                     /db_xref="HGNC:HGNC:12997"
                     /db_xref="MIM:618365"
     exon            1..105
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /inference="alignment:Splign:2.1.0"
     exon            106..568
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2515
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and SCAN domain-containing protein 10; zinc finger
                     protein 206"
                     /codon_start=1
                     /product="zinc finger and SCAN domain-containing protein
                     10 isoform 1"
                     /protein_id="NP_116194.2"
                     /db_xref="CCDS:CCDS10493.2"
                     /db_xref="GeneID:84891"
                     /db_xref="HGNC:HGNC:12997"
                     /db_xref="MIM:618365"
                     /translation="MLGESVPAAVEQEQLGEVKLEEEEAVSPEDPRRPESRLRPEVAH
                     QLFRCFQYQEDMGPRASLSRLRELCGHWLRPALHTKKQILELLVLEQFLSVLPPHLLG
                     RLQGQPLRDGEEVVLLLEGIHREPSHAGPLDFSCNAGKSCPRADVTLEEKGCASQVPS
                     HSPKKELPAEEPSVLGPSDEPPRPQPRAAQPAEPGQWRLPPSSKQPLSPGPQKTFQAL
                     QESSPQGPSPWPEESSRDQELAAVLECLTFEDVPENKAWPAHPLGFGSRTPDKEEFKQ
                     EEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEILEVKV
                     AEGVPEPNPELQFICADCGVSFPQLSRLKAHQLRSHPAGRSFLCLCCGKSFGRSSILK
                     LHMRTHTDERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRGFQRRASLVQH
                     LLAHAQDQKPPCAPESKAEAPPLTDVLCSHCGQSFQRRSSLKRHLRIHARDKDRRSSE
                     GSGSRRRDSDRRPFVCSDCGKAFRRSEHLVAHRRVHTGERPFSCQACGRSFTQSSQLV
                     SHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQTQDLARH
                     QRSHTGEKPCRCSECGEGFSQSAHLARHQRIHTGEKPHACDTCGHRFRNSSNLARHRR
                     SHTGERPYSCQTCGRSFRRNAHLRRHLATHAEPGQEQAEPPQECVECGKSFSRSCNLL
                     RHLLVHTGARPYSCTQCGRSFSRNSHLLRHLRTHARETLY"
     exon            569..836
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /inference="alignment:Splign:2.1.0"
     exon            837..901
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /inference="alignment:Splign:2.1.0"
     exon            902..959
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2716
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2695..2700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /note="hexamer: AGTAAA"
     polyA_site      2716
                     /gene="ZSCAN10"
                     /gene_synonym="OFNS; ZFP206; ZNF206"
                     /note="major polyA site"
ORIGIN      
        1 ccattttccc agagcccttc cccaggctgg cggaggctgg ctttggccct ggagtcctca
       61 gaaaaccccc cagcatctct gcctgtgtag tggggactcc gagtggtgtg ggaggagagg
      121 agagagaccc aagagcgggg ctggcgttag ggaggcatcc ccgcagtgaa ggatgcttgg
      181 agaatcagtc ccagctgccg tggagcagga gcagctgggg gaagtcaagc tggaggagga
      241 ggaggctgtc agcccagagg accccaggcg accagagtcc aggctgaggc ccgaggtggc
      301 tcaccagctg ttcagatgct tccagtatca ggaggacatg gggccacggg cgtccctgag
      361 ccggctccgg gagctctgcg gccactggct gcggccggct ctgcacacca agaaacagat
      421 cctggagctg ctggtgctgg agcagttcct gagtgtgctg cctccgcacc tcctgggccg
      481 cctgcagggg cagccgctca gggatgggga ggaggtggtg ctgctgctcg agggcatcca
      541 ccgggagccc agccacgcgg ggccgctgga ttttagttgt aatgctggca agagttgtcc
      601 ccgtgcagac gtcaccttgg aggaaaaggg gtgtgcttcc caggtcccca gccacagccc
      661 caagaaggaa ttgcctgcgg aagagccttc agtgctgggc ccatcggatg agcctccccg
      721 accccagcca agggctgccc agcctgctga gccgggacag tggaggcttc ccccaagttc
      781 aaagcagccg ctgagcccgg ggccccagaa gacattccag gccctgcaag aaagcagtcc
      841 ccagggcccc tcaccatggc cagaggagag ttcccgagat caggagctgg cggctgtgct
      901 ggagtgcctg acctttgagg atgtgccaga gaataaggcg tggcctgcac accccctggg
      961 attcggaagc agaaccccag acaaggagga atttaaacaa gaagagccca aaggggctgc
     1021 ctggcccact cccatcttag cagagtccca ggcagatagt cctggggtgc cgggagagcc
     1081 ttgcgcccag tcgctcggac ggggcgctgc ggctagcggc cctggtgaag atgggtccct
     1141 tcttggcagc agtgaaattt tggaggtcaa agtggctgag ggcgtccccg agcccaatcc
     1201 ggagttgcag ttcatctgcg cggactgcgg ggtgagcttc ccgcagctgt ctcgcctgaa
     1261 ggcgcaccag ctgcgctcgc acccggctgg gcgctccttc ctgtgccttt gctgcgggaa
     1321 gagcttcggc cgcagctcca ttctcaagct gcacatgcgc actcacacgg acgagcggcc
     1381 gcacgcctgc cacctgtgcg gccaccgctt ccgccagagc tcgcacctga gcaagcacct
     1441 gctgacccac tcctccgaac ccgccttcct gtgcgcagag tgcggccgcg gcttccagcg
     1501 ccgcgccagc cttgtgcagc acctgctggc gcacgcccag gaccagaagc cgccctgcgc
     1561 tcctgagagt aaggccgaag cgccgccact gaccgatgtc ctgtgctccc actgcggcca
     1621 gagcttccag cgccgctcca gcctcaagcg ccacctgcgg atccacgcca gggacaagga
     1681 ccgccggtcc tccgaaggct ccggcagccg ccgccgggac tccgaccgga ggcccttcgt
     1741 gtgcagcgac tgcggcaagg ccttccggcg cagcgagcac ctggtggccc accggagggt
     1801 gcacacgggc gagcggccct tctcctgcca ggcttgcggc cgcagcttca cgcagagctc
     1861 gcagctggtc agccaccaac gggtgcacac gggcgagaag ccctacgcct gtccgcagtg
     1921 cgggaagcgc tttgtgcgcc gggccagcct tgcccgccac ctgctgaccc acggtggccc
     1981 tcggccccac cactgcaccc agtgcgggaa gagtttcggc cagacccagg atctggcccg
     2041 ccaccagcgc agccacacgg gcgagaagcc ctgccgctgc agcgagtgcg gtgagggctt
     2101 cagccagagc gcccacctgg cgcgccacca gcgcatccac acaggggaga agccccacgc
     2161 ctgcgacacc tgcggccacc gtttccgcaa tagctccaac ctggcccgcc atcgccgcag
     2221 ccacacgggc gagcggccct acagctgtca gacgtgcggt cgcagcttcc ggcgcaacgc
     2281 gcatctgcgg cggcacctgg ctacccatgc ggagcccggg caggagcagg ccgagccccc
     2341 gcaggagtgc gtggagtgcg ggaagagctt cagccgcagc tgcaatctgc tgcgacacct
     2401 gctggtgcac acgggcgcca ggccctactc ctgcacgcag tgtggccgca gcttcagccg
     2461 caactcccac ctgctgcgcc acctgcgcac ccacgcccgc gagacgctgt actagcttgg
     2521 cccgccttcc gccagccgcg ccctgcgcca cctacccggg gtcctccaca gcggaggcct
     2581 gcaggaatgt cccttcccac cacaccccac ttccctctcc ttccactttc acagctgtcc
     2641 ttccctggcc gaggcattgc tttctggcct cagctatgta attaaaacgc ccgaagtaaa
     2701 atggccttct ccaaaa
//
