LOCUS       NM_032143               6712 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens zinc finger RANBP2-type containing 3 (ZRANB3),
            transcript variant 1, mRNA.
ACCESSION   NM_032143
VERSION     NM_032143.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6712)
  AUTHORS   Moore,C.E., Yalcindag,S.E., Czeladko,H., Ravindranathan,R.,
            Wijesekara Hanthi,Y., Levy,J.C., Sannino,V., Schindler,D.,
            Ciccia,A., Costanzo,V. and Elia,A.E.H.
  TITLE     RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of
            stalled replication forks
  JOURNAL   J Cell Biol 222 (5) (2023)
   PUBMED   37036693
  REMARK    GeneRIF: RFWD3 promotes ZRANB3 recruitment to regulate the
            remodeling of stalled replication forks.
REFERENCE   2  (bases 1 to 6712)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 6712)
  AUTHORS   Joseph,S.A., Taglialatela,A., Leuzzi,G., Huang,J.W.,
            Cuella-Martin,R. and Ciccia,A.
  TITLE     Time for remodeling: SNF2-family DNA translocases in replication
            fork metabolism and human disease
  JOURNAL   DNA Repair (Amst) 95, 102943 (2020)
   PUBMED   32971328
  REMARK    GeneRIF: Time for remodeling: SNF2-family DNA translocases in
            replication fork metabolism and human disease.
            Review article
REFERENCE   4  (bases 1 to 6712)
  AUTHORS   Adeyemo,A.A., Zaghloul,N.A., Chen,G., Doumatey,A.P., Leitch,C.C.,
            Hostelley,T.L., Nesmith,J.E., Zhou,J., Bentley,A.R., Shriner,D.,
            Fasanmade,O., Okafor,G., Eghan,B. Jr., Agyenim-Boateng,K.,
            Chandrasekharappa,S., Adeleye,J., Balogun,W., Owusu,S., Amoah,A.,
            Acheampong,J., Johnson,T., Oli,J., Adebamowo,C., Collins,F.,
            Dunston,G. and Rotimi,C.N.
  CONSRTM   South Africa Zulu Type 2 Diabetes Case-Control Study
  TITLE     ZRANB3 is an African-specific type 2 diabetes locus associated with
            beta-cell mass and insulin response
  JOURNAL   Nat Commun 10 (1), 3195 (2019)
   PUBMED   31324766
  REMARK    GeneRIF: ZRANB3 is an African-specific type 2 diabetes locus
            associated with beta-cell mass and insulin response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6712)
  AUTHORS   Fu,Y., Long,M.J.C., Wisitpitthaya,S., Inayat,H., Pierpont,T.M.,
            Elsaid,I.M., Bloom,J.C., Ortega,J., Weiss,R.S. and Aye,Y.
  TITLE     Nuclear RNR-alpha antagonizes cell proliferation by directly
            inhibiting ZRANB3
  JOURNAL   Nat Chem Biol 14 (10), 943-954 (2018)
   PUBMED   30150681
  REMARK    GeneRIF: Nuclear RNR-alpha antagonizes cell proliferation by
            directly inhibiting ZRANB3
REFERENCE   6  (bases 1 to 6712)
  AUTHORS   Badu-Nkansah,A., Mason,A.C., Eichman,B.F. and Cortez,D.
  TITLE     Identification of a Substrate Recognition Domain in the Replication
            Stress Response Protein Zinc Finger Ran-binding Domain-containing
            Protein 3 (ZRANB3)
  JOURNAL   J Biol Chem 291 (15), 8251-8257 (2016)
   PUBMED   26884333
  REMARK    GeneRIF: Here is described a substrate recognition domain within
            ZRANB3 that is needed for it to recognize forked DNA structures,
            hydrolyze ATP, catalyze fork remodeling, and act as a
            structure-specific endonuclease.
REFERENCE   7  (bases 1 to 6712)
  AUTHORS   Yuan,J., Ghosal,G. and Chen,J.
  TITLE     The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA
            and participates in cellular response to replication stress
  JOURNAL   Mol Cell 47 (3), 410-421 (2012)
   PUBMED   22705370
  REMARK    GeneRIF: AH2 is recruited to stalled replication forks and that
            cells depleted of AH2 are hypersensitive to replication stresses.
REFERENCE   8  (bases 1 to 6712)
  AUTHORS   Ciccia,A., Nimonkar,A.V., Hu,Y., Hajdu,I., Achar,Y.J., Izhar,L.,
            Petit,S.A., Adamson,B., Yoon,J.C., Kowalczykowski,S.C.,
            Livingston,D.M., Haracska,L. and Elledge,S.J.
  TITLE     Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain
            genomic integrity after replication stress
  JOURNAL   Mol Cell 47 (3), 396-409 (2012)
   PUBMED   22704558
  REMARK    GeneRIF: ZRANB3 translocase, a SNF2 family member related to the
            SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated
            PCNA to promote fork restart following replication arrest.
REFERENCE   9  (bases 1 to 6712)
  AUTHORS   Weston,R., Peeters,H. and Ahel,D.
  TITLE     ZRANB3 is a structure-specific ATP-dependent endonuclease involved
            in replication stress response
  JOURNAL   Genes Dev 26 (14), 1558-1572 (2012)
   PUBMED   22759634
  REMARK    GeneRIF: a role for ZRANB3 in the replication stress response and
            suggest new insights into how DNA repair is coordinated with DNA
            replication to maintain genome stability.
REFERENCE   10 (bases 1 to 6712)
  AUTHORS   Yusufzai,T. and Kadonaga,J.T.
  TITLE     Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 20970-20973 (2010)
   PUBMED   21078962
  REMARK    GeneRIF: structural and functional differences between AH2 and HARP
            suggest that different annealing helicases have distinct functions
            in the cell.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089429.1, AC017031.10 and AI670931.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032143.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.226493.1,
                                           SRR1803613.283075.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264159.11/ ENSP00000264159.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3680              BC089429.1         19-3698
            3681-6285           AC017031.10        32114-34718         c
            6286-6712           AI670931.1         11-437              c
FEATURES             Location/Qualifiers
     source          1..6712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.3"
     gene            1..6712
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="zinc finger RANBP2-type containing 3"
                     /db_xref="GeneID:84083"
                     /db_xref="HGNC:HGNC:25249"
                     /db_xref="MIM:615655"
     exon            1..92
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..260
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..3339
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger Ran-binding domain-containing protein 3; annealing
                     helicase 2; DNA annealing helicase and endonuclease
                     ZRANB3; zinc finger, RAN-binding domain containing 3"
                     /codon_start=1
                     /product="DNA annealing helicase and endonuclease ZRANB3
                     isoform 1"
                     /protein_id="NP_115519.2"
                     /db_xref="CCDS:CCDS46419.1"
                     /db_xref="GeneID:84083"
                     /db_xref="HGNC:HGNC:25249"
                     /db_xref="MIM:615655"
                     /translation="MPRVHNIKKSLTPHISCVTNESDNLLDFLPDRLRAKLLPFQKDG
                     IIFALKRNGRCMVADEMGLGKTIQAIGITYFYKEEWPLLIVVPSSLRYPWTEEIEKWI
                     PELSPEEINVIQNKTDVRRMSTSKVTVLGYGLLTADAKTLIDALNNQNFKVVIVDESH
                     YMKSRNATRSRILLPIVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAK
                     RYCNAHIRYFGKRPQWDCRGASNLNELHQLLSDIMIRRLKTEVLTQLPPKVRQRIPFD
                     LPSAAAKELNTSFEEWEKIMRTPNSGAMETVMGLITRMFKQTAIAKAGAVKDYIKMML
                     QNDSLKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTRV
                     AILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGT
                     LDTLMWGMLNRKAQVTGSTLNGRKEKIQAEEGDKEKWDFLQFAEAWTPNDSSEELRKE
                     ALFTHFEKEKQHDIRSFFVPQPKKRQLMTSCDESKRFREENTVVSSDPTKTAARDIID
                     YESDVEPETKRLKLAASEDHCSPSEETPSQSKQIRTPLVESVQEAKAQLTTPAFPVEG
                     WQCSLCTYINNSELPYCEMCETPQGSAVMQIDSLNHIQDKNEKDDSQKDTSKKVQTIS
                     DCEKQALAQSEPGQLADSKEETPKIEKEDGLTSQPGNEQWKSSDTLPVYDTLMFCASR
                     NTDRIHIYTKDGKQMSCNFIPLDIKLDLWEDLPASFQLKQYRSLILRFVREWSSLTAM
                     KQRIIRKSGQLFCSPILALEEITKQQTKQNCTKRYITKEDVAVASMDKVKNVGGHVRL
                     ITKESRPRDPFTKKLLEDGACVPFLNPYTVQADLTVKPSTSKGYLQAVDNEGNPLCLR
                     CQQPTCQTKQACKANSWDSRFCSLKCQEEFWIRSNNSYLRAKVFETEHGVCQLCNVNA
                     QELFLRLRDAPKSQRKNLLYATWTSKLPLEQLNEMIRNPGEGHFWQVDHIKPVYGGGG
                     QCSLDNLQTLCTVCHKERTARQAKERSQVRRQSLASKHGSDITRFLVKK"
     exon            261..279
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..458
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..690
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..776
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..948
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1065
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1185
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1305
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1485
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1638
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..2053
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2257
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2349
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2451
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2594
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2705
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..3108
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3240
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..6712
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3989..3994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="hexamer: ATTAAA"
     regulatory      4005..4010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="hexamer: CATAAA"
     polyA_site      4018
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="major polyA site"
     polyA_site      4028
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
     regulatory      4460..4465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="hexamer: ATTAAA"
     polyA_site      4480
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
     regulatory      6691..6696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
                     /note="hexamer: AATACA"
     polyA_site      6712
                     /gene="ZRANB3"
                     /gene_synonym="4933425L19Rik; AH2"
ORIGIN      
        1 ggacagccat tttgcccact tgtaaaagag ctaccttttc ccacgagttg gagcctgagg
       61 tgcggagttt cgtgagtttt tactgactcg aggatcatca tgcctagggt tcataacata
      121 aaaaagtctc ttacacctca catttcttgt gtgacaaatg aatctgataa tctgctggat
      181 tttttgcctg acagactaag agcaaagcta cttccattcc agaaagatgg catcattttt
      241 gccctcaaaa gaaatggcag gtgtatggtg gctgatgaaa tgggtctagg aaagacaatc
      301 caggcaattg gaattactta cttctataaa gaggaatggc ctctgttaat agtggtccct
      361 tcgtctctga ggtacccttg gacagaagaa attgaaaaat ggatcccaga gctaagtcca
      421 gaagaaatca atgttattca gaataaaact gatgttagga gaatgtcgac cagtaaagtg
      481 acagttctgg gttatggtct cttaaccgca gatgcaaaga ctttgataga tgcactgaat
      541 aatcagaact tcaaagtagt tatagtggat gaatcacact acatgaaatc cagaaatgca
      601 actcgcagca ggattttatt gccaatagta cagaaagcca gacgagccat tcttcttaca
      661 ggaacaccag ctttaggaag gcctgaagag ctttttatgc agattgaagc tctctttcca
      721 caaaaatttg gaagatggac cgactatgca aaaagatact gtaatgcaca catcagatat
      781 tttggtaaaa gacctcagtg ggattgtaga ggggcatcaa atcttaatga acttcaccag
      841 ctattaagtg acataatgat tagaagatta aagactgaag ttttaaccca gctaccccct
      901 aaagtcagac agcgtattcc atttgatctt ccatcagcag ctgccaagga attgaatacc
      961 agctttgaag agtgggaaaa aataatgaga actccaaatt caggtgccat ggagacagtc
     1021 atggggttga taactcgcat gtttaaacaa actgctattg ccaaggcagg tgctgtaaag
     1081 gattatatta agatgatgct tcagaatgat tcgcttaaat ttctggtttt tgctcaccat
     1141 ttaagcatgc tccaagcttg cacagaagca gtcatcgaaa ataagactcg ttacattagg
     1201 atagatggaa gtgtttcatc ttcagaaaga atacatctgg ttaatcagtt tcaaaaggat
     1261 cctgacactc gcgtggctat cctaagcatt caggctgctg gccagggatt aacatttact
     1321 gcagcaagtc atgttgtatt tgctgagttg tactgggacc ctggacatat aaaacaagca
     1381 gaagaccgag ctcacagaat tggccagtgc agttctgtga atattcacta ccttattgca
     1441 aatggaaccc tagacaccct tatgtgggga atgttgaatc gcaaggctca agttacaggg
     1501 agcacactga acggtaggaa agaaaaaatt caggctgagg aaggtgataa ggaaaaatgg
     1561 gatttcctgc agtttgctga agcttggact ccaaatgaca gttctgaaga gttaaggaag
     1621 gaagctttgt tcactcactt cgaaaaagaa aaacagcatg atattcgatc attttttgta
     1681 ccacaaccta aaaaaagaca gttgatgacc tcctgtgacg aatcaaagag attccgggag
     1741 gaaaatactg tagtgtcatc agaccctaca aaaacagctg caagagatat catcgattat
     1801 gaaagtgatg ttgaacctga aacgaaaaga ttgaaattgg ctgcctcgga agaccactgc
     1861 agtccgtcgg aagagacacc atcccagtcc aagcaaatcc gaactccact cgtggaaagt
     1921 gtacaggagg ccaaggccca gttaaccacc ccagcctttc ctgtagaggg ctggcaatgt
     1981 agtctctgca cctatatcaa taattcagag ttaccttatt gtgaaatgtg tgagactcct
     2041 caaggcagtg ctgttatgca aatagatagc ctcaaccata tccaggataa aaacgagaag
     2101 gatgattctc agaaagacac ctccaaaaag gttcaaacta tctcagactg tgaaaaacaa
     2161 gcccttgcac agtcagaacc tggccagttg gctgacagca aggaagaaac accaaaaatt
     2221 gagaaagaag acggacttac atcccagcca ggtaatgaac agtggaagag ttcagacact
     2281 ttgccagtgt atgacacctt aatgttctgt gcaagtagga atactgaccg gattcacatc
     2341 tatactaagg atggaaaaca gatgagctgt aatttcattc ctctggatat aaaattagac
     2401 ctttgggaag atttaccagc aagctttcag ctgaaacaat atcgctcact gattttgaga
     2461 tttgttcgag aatggagtag tctaactgcc atgaagcaaa ggataatcag gaaaagtgga
     2521 cagctattct gtagcccaat tcttgctttg gaagagatca caaagcaaca aaccaaacaa
     2581 aattgcacca aaagatacat aaccaaagaa gatgttgccg tagcctcaat ggacaaagtg
     2641 aagaatgttg ggggccatgt ccgtctgatc acaaaggagt ccaggccacg ggatcctttc
     2701 acaaaaaaac ttcttgaaga tggagcctgt gtcccatttc taaatccata cacagtccag
     2761 gcagatctca ctgtgaagcc ctctacatcc aaaggctatt tgcaagctgt ggataatgaa
     2821 ggaaatccac tttgccttcg ctgtcagcaa cccacttgcc agactaagca agcatgtaaa
     2881 gcgaactctt gggattcacg gttttgctct ctgaaatgtc aggaagagtt ttggattcga
     2941 tctaataaca gttacctgag agccaaagta tttgaaactg aacatggtgt gtgtcagctc
     3001 tgtaatgtga acgcacaaga actcttttta cgtctgagag atgcccctaa aagtcagagg
     3061 aagaatcttc tgtatgctac ctggacttca aagctcccat tagaacagct aaatgaaatg
     3121 ataagaaacc caggggaagg acatttctgg caggtggatc acatcaagcc agtgtatggg
     3181 ggaggaggac agtgttccct ggacaacctg cagactctct gcacagtctg tcacaaagag
     3241 agaactgcca gacaagctaa ggaaagaagc caggtgagaa gacaatctct agcatcaaag
     3301 catggatcag acatcacacg atttttggta aagaagtaaa gtagaaaaat atatgaatga
     3361 atgacaaatg gtttacatgt ggaagacttt aatacagaag ttttccatgt ttgtttaata
     3421 tatcgagagt aaaaattttc agaacaaaaa tcaagaattc aaattctctt ctactaatta
     3481 cttttagtat taaatacatt ttgaaagtac ttaacagaaa ctaagataca atactgaata
     3541 tttctgtggt ctttttgatt tgattcagac tcgcaattat gtttcagcaa tgttttgtaa
     3601 agctctttac ccctaatatg cctaatcact gtattgtgca tagattgtgt ttaaaaaatg
     3661 tactctcaat tacctaaaaa tgcttctgga ttagtattgt tctggactgt cataggtatg
     3721 agtggaacat tgcaaaacct tatgggaaat ttcagacgca aatcattatt tgggaattct
     3781 gggccaagca tgaccagcct gcttaggatt caagagagac tgtccactaa atacctccag
     3841 aatgagctag gggcacacat tttgggtgtt gcttttcttg ctttatttct tagctagtca
     3901 tctttatcaa aaatatcctt ttcaaaatga ggtacctatg gtgtttgtgg acaatttggg
     3961 ggttctgtgt aaagtaattg ttaaaactat taaataactg aaaacataaa atgtaaaatg
     4021 ccacttaagc ttgatttttt agatcttttt ttaaaaaatg aataaaacta ggcttactgt
     4081 tggctgggcg cggtggctca cgcatgtaat cccagcactt tgggaggcca aagcgggtgg
     4141 atcatgaggt caggagatag atcgagacca tcctggctaa tacggtgaaa ccccatctct
     4201 actaaaaata caaaaaatta gccgggcatg gtgttgtgca cgtgtaatct cagatactcg
     4261 ggaggctgag gcaggagaat tgcttgaacc cgggaagcag aggttgcagt gagccgagat
     4321 cacgccattg aactccagcc tgggcgacag agcgagactc cgtctcaaac aaacaaacaa
     4381 acaaaaaaaa aaactaagcg tactatcaaa atacactttg tcttctggtt ctcattttct
     4441 gtttttaaaa ccctgtgtta ttaaaggtat gtttctggta cttattttaa aaagagtgat
     4501 gatgacaaaa cactttataa taaggcataa tcagatggtt atatgcattt aaatatacaa
     4561 taataacatt aaaatgtaat tgacataaaa taagagtgac gatgaaacaa acccagggcc
     4621 tagtcctgca atatgtcaga atcatgaggg caaagagtca gaactataca aaatacagga
     4681 ccgaggaaga attacattcc caaaagggag ctgtttgtaa atactattag gacatatacc
     4741 tctttagttt gagcattttc ccacgttaat taatagctag tgttttacaa cataaaggac
     4801 ttgtttttag aaagattata caatcaaaga ttatacaacc acagttgttc ctcagtttct
     4861 atttcattgt atgagatcaa gtcatgttgg ttattttata aatgaagttg ggctttcttt
     4921 ggcctccttt ctgcttagtt ggtcaggtgc tctttgcagt tttctgcctc atttccaagg
     4981 taacctagga tttgtcacgg ttgagagcca agaagcaggc acgctgcctt tcctccagca
     5041 tggggttttg caagcgaggt ctaagtaggt caaatttgag gggaacttgc tcttcagatc
     5101 acactaaggt gataattcta aggagaaagt tctcagatgt aagaactgtg tgatggtttg
     5161 aggtgaaaca atccatgaag ataggctcag tctataccag gtttcagaat tctgactaat
     5221 taaaaatgcc gtaaggagca ttgagcattt gctgtacagg acactgactg gcccgtcccc
     5281 atcccttcct gacatgtctc agagctttgt gtcctgcctt cccctaattt ggtctgcatt
     5341 acttgtgggg cacattgaga tgaagggttc tgagacagaa aataaagata gagattgatc
     5401 taataaccga gaccgaaagg gcatcttgag gactgttctt tcctcctcac aatctgaaac
     5461 agaagctccc cactatgtat tgcaaatggg aggttatgac agagggacac agaaagtgtc
     5521 agagcaagtg gcagatcctg agtgcagaag gaagtgcaga tgccccagga agaagacagc
     5581 tgctgccact caggagatgg agatggagtg aaaacacagg tgggtacaat gagtgtaaaa
     5641 ggataggcct ggctctgaaa agactcagag aagctgcaag atacagttta ggctaagaaa
     5701 acaacaacaa aaaagggctc tggccaggta tgatggcact tgcttgtagt cctagctaca
     5761 caggaggctg aggtaggagg gtcacttaag cccaggggtt catgaccagc ctgggtaaca
     5821 cagcaaggcc ccatctcaaa aaagaaaaaa ggctctgggt ccagggaaca gagctgggaa
     5881 gtggtaggtg acgaaggaac tcgcttacga tagggaacca tatgaaaata tgcctgtggg
     5941 taggggtagg gtggggagga cttccggagc atggtgggct cacacactca aaccttgcac
     6001 agccagcatc aggctggcct gccttcctgt tcccgtcact gggtgacatt gatcccagac
     6061 acattctgat gactagtaaa gttgctttta gtagccccag agccaggagg aataattcat
     6121 atggaatttt taaagacgcc cactcttggc gttaattaca gcccaacgta catttcttgg
     6181 ggagattttc ctgtgacaag tgaataccct ctacattttc ttaactggat gggaaaagga
     6241 ttttatgccc atacatcttg ctaataaacc aaatcccttc ttcagattct tgagtgaaac
     6301 atttaaaatg tagtttcttt agaaataaaa gtatgaggca ttttaaatta tatgacagac
     6361 aaaaaagtca atgctcttga gctctttaca gtaaataggt tgtgtttact cataggatac
     6421 agaatcatgg atatcaaaca tcaaaaataa attataaaaa taatgtctca ttttctgttg
     6481 catattatta gcctgtctct cattccacca tttgttcttt tgaactggaa aattgtgggc
     6541 tcctagtcac tgcactaatc tatctgaata tccaactacc agaaagggtt tatcccatct
     6601 caagtttgtc agttgcttta tatcgttaag ggtgtttttg ccaccctggt tgtgttcata
     6661 attaccattg agaaatgtca ctgttattaa aatacattct gtgttccaac ta
//
