LOCUS       NM_203350               2816 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens zinc finger RANBP2-type containing 2 (ZRANB2),
            transcript variant 1, mRNA.
ACCESSION   NM_203350
VERSION     NM_203350.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Tanaka,I., Chakraborty,A., Saulnier,O., Benoit-Pilven,C.,
            Vacher,S., Labiod,D., Lam,E.W.F., Bieche,I., Delattre,O.,
            Pouzoulet,F., Auboeuf,D., Vagner,S. and Dutertre,M.
  TITLE     ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are
            involved in breast cancer cell resistance to doxorubicin
  JOURNAL   Nucleic Acids Res 48 (5), 2676-2693 (2020)
   PUBMED   31943118
  REMARK    GeneRIF: These data identify Aletrnative splicing programs
            controlled by ZRANB2 and SYF2 and converging on ECT2, that
            participate to breast cancer cell resistance to doxorubicin.
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Loughlin,F.E., Lee,M., Guss,J.M. and Mackay,J.P.
  TITLE     Crystallization of a ZRANB2-RNA complex
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 64 (Pt 12),
            1175-1177 (2008)
   PUBMED   19052380
  REMARK    GeneRIF: Crystallization of a ZRANB2-RNA complex
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Li,J., Hawkins,I.C., Harvey,C.D., Jennings,J.L., Link,A.J. and
            Patton,J.G.
  TITLE     Regulation of alternative splicing by SRrp86 and its interacting
            proteins
  JOURNAL   Mol Cell Biol 23 (21), 7437-7447 (2003)
   PUBMED   14559993
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Plambeck,C.A., Kwan,A.H., Adams,D.J., Westman,B.J., van der
            Weyden,L., Medcalf,R.L., Morris,B.J. and Mackay,J.P.
  TITLE     The structure of the zinc finger domain from human splicing factor
            ZNF265 fold
  JOURNAL   J Biol Chem 278 (25), 22805-22811 (2003)
   PUBMED   12657633
  REMARK    GeneRIF: sites responsible for MRNA binding have been
            characterized.
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Adams,D.J., van der Weyden,L., Mayeda,A., Stamm,S., Morris,B.J. and
            Rasko,J.E.
  TITLE     ZNF265--a novel spliceosomal protein able to induce alternative
            splicing
  JOURNAL   J Cell Biol 154 (1), 25-32 (2001)
   PUBMED   11448987
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Adams,D.J., van der Weyden,L., Kovacic,A., Lovicu,F.J.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Ioannou,P.A. and
            Morris,B.J.
  TITLE     Chromosome localization and characterization of the mouse and human
            zinc finger protein 265 gene
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 68-73 (2000)
   PUBMED   10773668
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Nakano,M., Yoshiura,K., Oikawa,M., Miyoshi,O., Yamada,K., Kondo,S.,
            Miwa,N., Soeda,E., Jinno,Y., Fujii,T. and Niikawa,N.
  TITLE     Identification, characterization and mapping of the human ZIS
            (zinc-finger, splicing) gene
  JOURNAL   Gene 225 (1-2), 59-65 (1998)
   PUBMED   9931435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA523601.1, AF065391.1, BC033648.1, AL512443.7 and BU677906.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203350.2.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF065391.1, SRR1660809.249280.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370920.8/ ENSP00000359958.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA523601.1         255-260
            7-810               AF065391.1         1-804
            811-1955            BC033648.1         811-1955
            1956-2774           AL512443.7         8450-9268           c
            2775-2816           BU677906.1         18-59               c
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2816
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /note="zinc finger RANBP2-type containing 2"
                     /db_xref="GeneID:9406"
                     /db_xref="HGNC:HGNC:13058"
                     /db_xref="MIM:604347"
     exon            1..96
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1033
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zinc-finger, splicing; zinc finger protein 265; zinc
                     finger Ran-binding domain-containing protein 2; zinc
                     finger, RAN-binding domain containing 2"
                     /codon_start=1
                     /product="zinc finger Ran-binding domain-containing
                     protein 2 isoform 1"
                     /protein_id="NP_976225.1"
                     /db_xref="CCDS:CCDS659.1"
                     /db_xref="GeneID:9406"
                     /db_xref="HGNC:HGNC:13058"
                     /db_xref="MIM:604347"
                     /translation="MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKM
                     MKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGY
                     GGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDE
                     DEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSS
                     SPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSS
                     SSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK"
     exon            97..149
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            150..258
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            259..341
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            342..418
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            419..553
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            554..723
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            724..810
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            811..969
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2816
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2749..2754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /note="hexamer: AATAAA"
     polyA_site      2770
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /note="major polyA site"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /note="hexamer: AATAAA"
     polyA_site      2816
                     /gene="ZRANB2"
                     /gene_synonym="ZIS; ZIS1; ZIS2; ZNF265"
                     /note="major polyA site"
ORIGIN      
        1 gaagacatag ctgcgggtgg ctgtgctggt ggcgttcaag atgtcgacca agaatttccg
       61 agtcagtgac ggggactgga tttgccctga caaaaaatgt ggaaatgtaa actttgctag
      121 aagaaccagc tgtaatcgat gtggtcggga gaaaacaact gaggccaaga tgatgaaagc
      181 tgggggcact gaaataggaa agacacttgc agaaaagagc cgaggcctat ttagtgctaa
      241 tgactggcaa tgtaaaactt gcagcaatgt gaattgggcc agaagatcag agtgtaatat
      301 gtgtaatact ccaaagtatg ctaaattaga agaaagaaca ggatatggtg gtggttttaa
      361 tgaaagagaa aatgttgaat atatagaaag agaagaatct gatggtgaat atgatgagtt
      421 tggacgtaaa aagaaaaaat acagagggaa agcagttggt cctgcatcta tattaaagga
      481 agttgaagat aaagaatcag agggagaaga agaggatgag gatgaagatc tttctaaata
      541 taagttagat gaggatgagg atgaagatga cgctgatctc tcaaaatata atcttgatgc
      601 cagtgaagaa gaagatagta ataaaaagaa atctaataga cgaagtcgct caaagtctcg
      661 atcttcacat tcacgatctt catcacgctc atcctccccc tcaagttcaa ggtctaggtc
      721 caggtcccgt tcaagaagtt cttccagttc gcagtcaaga tctcgttcca gttccagaga
      781 acgttcgaga tctcgtgggt cgaaatcaag atccagctcc aggtcccaca ggggctcttc
      841 ttccccacga aaaagatctt attcaagttc atcatcttct cctgagagga acagaaagag
      901 aagtcgttct agatcttctt catctggtga tcgcaaaaaa agacgaacaa gatcacggtc
      961 acccgaaaga cgccacaggt catcatctgg atcatcccat tctggttccc gttcaagttc
     1021 aaaaaagaaa taatgtatta aaatttacat cttaaaaaaa tccagtacag tgcatgaagc
     1081 atatttttaa agaagttggt gtcttacttg gtcagaagtg ctaaatctgc tagtagaggt
     1141 gcatgccttt cattgctttt caaaacaata cagctgtgtt tatttgtgaa gttaaaagta
     1201 aatagcattt taagccataa tgtcccaaaa tagatgttct gtcattcatt atttacaacc
     1261 atttgcttca tttaaaacca tttcagctat aacaaagtac tttgcttcct aatttaaacc
     1321 catttttgtc atttccaaat acatcctgtc cattggctaa gacaggatta cctaggcttg
     1381 cctgaacttt gggcatggaa gaaagactgg aaactagttg gaaacaacat acttatggaa
     1441 aagaaagtca gcctttttat gctgttaaca gatgtcagag tgattctcac caaaaaaagt
     1501 taaactatgt tgtaagcagc caactgtaaa tgtctatttt gaaattccct atgctaaggg
     1561 tgccttagaa tcattgtgtc tcttttatcc agctttactt ttttgctcca catttaatgc
     1621 aaaagaatct tgtgatgtct acaaggagag aagtgggata tattttcctt tctgacacat
     1681 aatttggggc aaaaaagaaa gtcttaagag tttatctttt ctctgctgat acggttgctt
     1741 gataaagaca tctcaaaatg tttaccaatg ttttaagaag ctttgtgtga tattcttcca
     1801 aatgtagtta ccaaatataa tatggtagaa aaggctaaat catacttaat gagcaaattg
     1861 aagtaagctt ttaaagtata tttctctttt ggtgaaaggc caatggagac attgtgaatt
     1921 taagtgaaca tttgcctcaa gatgttaact ataaacacac tgcatacaat tttcttctga
     1981 ataacaaatg aatgcttatt gctgcatgat gtaagcaaaa gtcattattt ttcctattca
     2041 tttgaaataa gttatggctt aaaatgcttt tggagtttat ttctcaaaat taaaatctgg
     2101 tcacatgagc tttagtttgt tttctggttt aaaaaataaa aaggtttctc ttaacagtat
     2161 ttccagtgac aatgcaaggt aagtatatca aaggaaatca acagttgtgc ttgggggctt
     2221 tttgttatgg gatattgatt tcttgttttt tttccgtaac attgtctgct gcaatttaaa
     2281 taaaaattac gacattttaa gatatttcat agacaaacca aacaaaaata tatgttttta
     2341 ctttaaagtg aatgtttttc tcttcagctg atctaaaaat gaaagcaaga tatcttatgt
     2401 agaaatattt tgataatatt tttacagtga gctttcccat gtttttatgt cttaagtttc
     2461 tttgctgcgt ttatgtaggt tgcacaagaa cttttactca cttgtaattg tgcctcagac
     2521 tttttgaaag tctaccttct aaattgcccc gacgatctag attctacatg ttaccattgg
     2581 tttattcttg tgctttctgt atttaaaact ttggctgtac taagcaaatg caaggttata
     2641 atttagctaa tagtagttta cagacaattc tgatgattat gatttcattt ggtttaacta
     2701 agctgtacta gttcatttca taaggaaatg atactgtaga caaatgtaaa taaagcctgt
     2761 gagtcaagca tcaagtggtg tttgttagaa ataaactaga gatttttaaa ctctga
//
