LOCUS       NM_017580               5695 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger RANBP2-type containing 1 (ZRANB1), mRNA.
ACCESSION   NM_017580
VERSION     NM_017580.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5695)
  AUTHORS   Frank,D., Bergamasco,M., Mlodzianoski,M.J., Kueh,A., Tsui,E.,
            Hall,C., Kastrappis,G., Voss,A.K., McLean,C., Faux,M., Rogers,K.L.,
            Tran,B., Vincan,E., Komander,D., Dewson,G. and Tran,H.
  TITLE     Trabid patient mutations impede the axonal trafficking of
            adenomatous polyposis coli to disrupt neurite growth
  JOURNAL   Elife 12, 90796 (2023)
   PUBMED   38099646
  REMARK    GeneRIF: Trabid patient mutations impede the axonal trafficking of
            adenomatous polyposis coli to disrupt neurite growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5695)
  AUTHORS   Huang,S., Zhang,Q., Zhao,M., Wang,X., Zhang,Y., Gan,B. and Zhang,P.
  TITLE     The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and
            regulates ferroptotic resistance
  JOURNAL   J Cell Biol 222 (11) (2023)
   PUBMED   37831441
  REMARK    GeneRIF: The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for
            SLC7A11 and regulates ferroptotic resistance.
REFERENCE   3  (bases 1 to 5695)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   4  (bases 1 to 5695)
  AUTHORS   Chen,Y. and Zhang,X.
  TITLE     TRABID targets DDB2 for deubiquitination to promote proliferation
            of hepatocellular carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 625, 23-30 (2022)
   PUBMED   35944360
  REMARK    GeneRIF: TRABID targets DDB2 for deubiquitination to promote
            proliferation of hepatocellular carcinoma cells.
REFERENCE   5  (bases 1 to 5695)
  AUTHORS   Miao,D., Wang,Y., Jia,Y., Tong,J., Jiang,S. and Liu,L.
  TITLE     ZRANB1 enhances stem-cell-like features and accelerates tumor
            progression by regulating Sox9-mediated USP22/Wnt/beta-catenin
            pathway in colorectal cancer
  JOURNAL   Cell Signal 90, 110200 (2022)
   PUBMED   34798260
  REMARK    GeneRIF: ZRANB1 enhances stem-cell-like features and accelerates
            tumor progression by regulating Sox9-mediated
            USP22/Wnt/beta-catenin pathway in colorectal cancer.
REFERENCE   6  (bases 1 to 5695)
  AUTHORS   Licchesi,J.D., Mieszczanek,J., Mevissen,T.E., Rutherford,T.J.,
            Akutsu,M., Virdee,S., El Oualid,F., Chin,J.W., Ovaa,H., Bienz,M.
            and Komander,D.
  TITLE     An ankyrin-repeat ubiquitin-binding domain determines TRABID's
            specificity for atypical ubiquitin chains
  JOURNAL   Nat Struct Mol Biol 19 (1), 62-71 (2011)
   PUBMED   22157957
  REMARK    GeneRIF: Data show that the ankyrin-repeat ubiquitin-binding domain
            is crucial for TRABID efficiency and linkage specificity.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5695)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5695)
  AUTHORS   Komander,D., Reyes-Turcu,F., Licchesi,J.D., Odenwaelder,P.,
            Wilkinson,K.D. and Barford,D.
  TITLE     Molecular discrimination of structurally equivalent Lys 63-linked
            and linear polyubiquitin chains
  JOURNAL   EMBO Rep 10 (5), 466-473 (2009)
   PUBMED   19373254
REFERENCE   9  (bases 1 to 5695)
  AUTHORS   Tran,H., Hamada,F., Schwarz-Romond,T. and Bienz,M.
  TITLE     Trabid, a new positive regulator of Wnt-induced transcription with
            preference for binding and cleaving K63-linked ubiquitin chains
  JOURNAL   Genes Dev 22 (4), 528-542 (2008)
   PUBMED   18281465
REFERENCE   10 (bases 1 to 5695)
  AUTHORS   Evans,P.C., Taylor,E.R., Coadwell,J., Heyninck,K., Beyaert,R. and
            Kilshaw,P.J.
  TITLE     Isolation and characterization of two novel A20-like proteins
  JOURNAL   Biochem J 357 (Pt 3), 617-623 (2001)
   PUBMED   11463333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ252060.1, AL832925.1 and AL731571.3.
            
            On May 17, 2019 this sequence version replaced NM_017580.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ252060.1, SRR1803616.99761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359653.4/ ENSP00000352676.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1490              AJ252060.1         36-1525
            1491-2934           AL832925.1         671-2114
            2935-4942           AL731571.3         10008-12015
            4943-5695           AL731571.3         12016-12768
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..5695
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="zinc finger RANBP2-type containing 1"
                     /db_xref="GeneID:54764"
                     /db_xref="HGNC:HGNC:18224"
                     /db_xref="MIM:611749"
     exon            1..1185
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2498
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /EC_number="3.4.19.12"
                     /note="TRAF-binding protein domain; hTrabid; zinc finger
                     Ran-binding domain-containing protein 1; TRAF-binding
                     domain-containing protein; zinc finger, RAN-binding domain
                     containing 1"
                     /codon_start=1
                     /product="ubiquitin thioesterase ZRANB1"
                     /protein_id="NP_060050.2"
                     /db_xref="CCDS:CCDS7642.1"
                     /db_xref="GeneID:54764"
                     /db_xref="HGNC:HGNC:18224"
                     /db_xref="MIM:611749"
                     /translation="MSERGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKS
                     GSSDVGRDWDPSSTEGGSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAI
                     RCTQCLSQRRTRSPTESPQSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSVCTY
                     ENWAKAKRCVVCDHPRPNNIEAIELAETEEASSIINEQDRARWRGSCSSGNSQRRSPP
                     ATKRDSEVKMDFQRIELAGAVGSKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEG
                     DLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQDMLAILLTE
                     VSQQAAKCIPAMVCPELTEQIRREIAASLHQRKGDFACYFLTDLVTFTLPADIEDLPP
                     TVQEKLFDEVLDRDVQKELEEESPIINWSLELATRLDSRLYALWNRTAGDCLLDSVLQ
                     ATWGIYDKDSVLRKALHDSLHDCSHWFYTRWKDWESWYSQSFGLHFSLREEQWQEDWA
                     FILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLL
                     WEQSFCWKSPIALGYTRGHFSALVAMENDGYGNRGAGANLNTDDDVTITFLPLVDSER
                     KLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEK
                     WLDRYRQIRPCTSLSDGEEDEDDEDE"
     exon            1186..1373
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1527
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1599
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1798
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1919
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2049
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2279
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..5695
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3944..3949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="hexamer: ACTAAA"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="hexamer: AATAGA"
     polyA_site      3965
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="major polyA site"
     polyA_site      3970
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="major polyA site"
     regulatory      4915..4920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="hexamer: ATTAAA"
     polyA_site      4938
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
     regulatory      5540..5545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="hexamer: ATTAAA"
     polyA_site      5565
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
     regulatory      5670..5675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
                     /note="hexamer: ATTAAA"
     polyA_site      5695
                     /gene="ZRANB1"
                     /gene_synonym="TRABID"
ORIGIN      
        1 gtgatggcct ccctgaaatt aaacatttct attagtggct tcccgttaat ctcatccttc
       61 ttagatcaaa cctcgttata tctcctgcct atctcttttg cattccaaag ttcagtttta
      121 ttaaatccca gggtctaaga ttttttcttt gagaatttat ctccagtgtt tctatggaaa
      181 ttaaaaaaga aaattaggat aattcaatgt cgaaatgttg catgcatctt ttgagaaatt
      241 tatattttgt aggttgaagg acttgctttt tgggcagcgt atttttggag gtggaatgta
      301 gttattttaa taaccatgtc ctaattattt atagcttcct gcctgacaca gctcacttca
      361 agaagtgcac aatgtcagaa cgtggaatta agtgggcttg tgaatattgt acgtatgaaa
      421 actggccatc tgcaatcaag tgtactatgt gtcgtgccca aagacctagt ggaacaatta
      481 ttacagaaga tccatttaaa agtggttcaa gtgatgttgg tagagattgg gatccttcca
      541 gcaccgaagg aggaagtagt cctttgatat gtccagactc tagtgcaaga ccaagggtga
      601 aatcttcgta tagcatggaa aatgcaaata agtggtcatg ccacatgtgt acatatttga
      661 actggccaag agcaatcaga tgtacccagt gcttatccca acgtaggacc aggagtccta
      721 cagaatctcc tcagtcctca ggatctggct caagaccagt tgctttttct gttgatcctt
      781 gtgaggaata caatgataga aataaactga acactaggac acagcactgg acttgctctg
      841 tttgcacata tgaaaactgg gccaaggcta aaagatgtgt tgtttgtgat catcccagac
      901 ctaataacat tgaagcaata gaattggcag agactgaaga ggcttcttca ataataaatg
      961 agcaagacag agctcgatgg aggggaagtt gcagtagtgg taatagccaa aggagatcac
     1021 ctcctgctac gaagcgggac tctgaagtga aaatggattt tcagaggatt gaattggctg
     1081 gtgctgtggg aagcaaggag gaacttgaag tagactttaa aaaactaaag caaattaaaa
     1141 acaggatgaa aaagactgat tggctcttcc tcaatgcttg tgtgggggtt gtagaaggtg
     1201 atttagctgc catagaagca tacaagtcat caggaggaga cattgcacgt cagctcaccg
     1261 cagatgaagt acgcttgctg aatcgtcctt ctgcctttga tgttggctat actcttgtac
     1321 acttggctat acgttttcag aggcaggata tgctagcaat attgcttaca gaggtgtctc
     1381 aacaagcagc aaagtgtatt ccagcaatgg tgtgtcctga actgacagaa caaatccgga
     1441 gagagatagc tgcctctctt catcagagaa agggggattt tgcttgctat tttctgactg
     1501 accttgtaac atttacattg ccagcagata ttgaagattt gcccccaaca gtccaagaaa
     1561 aattatttga tgaggtgctt gatagagacg ttcaaaaaga attagaagaa gaatctccaa
     1621 ttattaactg gtccttggaa ttggctacac gtttggacag tcgactgtat gcactttgga
     1681 accggactgc aggagactgc ctacttgatt cagttctaca agctacctgg ggcatctatg
     1741 acaaggactc agtgcttcgg aaagccctgc atgacagcct gcatgactgt tcacattggt
     1801 tttacacacg ctggaaagat tgggaatcat ggtattctca gagctttggt ttacattttt
     1861 ccttgagaga agaacagtgg caagaagact gggcatttat actctctctt gctagtcagc
     1921 ctggagcaag cttggagcag acgcacattt ttgtactggc acatattctt agacgaccaa
     1981 ttatagttta tggagtaaaa tattacaaga gtttccgggg agaaacttta ggatatactc
     2041 ggtttcaagg tgtttatctg cctttgttgt gggaacagag tttttgttgg aaaagtccga
     2101 ttgctctggg ttatacgagg ggccacttct ctgctttggt tgccatggaa aatgatggct
     2161 atggcaaccg aggtgctggt gctaatctca ataccgatga tgatgtcacc atcacatttt
     2221 tgcctctggt tgacagtgaa aggaagctac tccatgtgca cttcctttct gctcaggagc
     2281 taggtaatga ggaacagcaa gaaaaactgc tcagggagtg gctggactgc tgtgtgacgg
     2341 aggggggagt tctggttgcc atgcagaaga gttctcggcg gcgaaatcac cccctggtca
     2401 ctcagatggt agaaaaatgg cttgaccgct accgacagat ccggccgtgt acatccctgt
     2461 ctgatggaga ggaagatgag gatgatgaag atgaatgaaa aaaaaaatca aacagcagaa
     2521 gaccaaggca tcagatctgt aatgacccta aagttagtgt ggtgctccaa gcagagtcga
     2581 catcatggaa tgaaccaaat ctggcaggat ctgctcgggg aagtgttttc ctggaccaca
     2641 cacaccttat ggagataatg cctctgctgc gtgaggagac agagaacttt agttggacta
     2701 cagtttgtaa aaaaaactaa ttttattaag acagaacttt ttttccttcc aaattgtaaa
     2761 tctgtctata aatgtaacgc atgtggttgt gtaagacatt gtttaatagg aaaagttgta
     2821 ccagcatctt catattattg agaaaatttt ttccagcatg ggcacttaga aaaagcacat
     2881 ggcaaatggc tctttgttcc tttcagatat tatttcagta gaacctggca ttctactttc
     2941 accttaaaag atccatctaa gtctcagatc tggaaacgtt ttgtaccgat tatccacagc
     3001 aaaacaaaaa taagctttta ttttattaat aatttcgttc ctcttgtgcc caatcaaatc
     3061 ttttaggaac aaactgcaag aaaagctaag aatgttttag agtgaactaa atacagacat
     3121 tgcttacttg ttttgaagag ggttttggtt ttggttattg tgtctttaag ttttctgata
     3181 tgcccccttt caatatttag atatttattt gttgggaaga ataccttaaa atgagggttc
     3241 ttattccaga ttctgggcag tggtctgtga gtagtttttt tcctggatga aaagggagca
     3301 agcccacttg tcactaaatg aattgtgtga aatgtgctca cttggactcc atcaacaatg
     3361 tgctgctccc agattgccat gccagagggt cttcggattc ttccttctat cacctctgct
     3421 ctaagcaaat cttgttagaa gggcatgcct ttgcttaggc agattgggaa taccaattca
     3481 ctacagaata aagattttaa aaatgcaata aggtggcaaa tgcattgtat gaagaatttc
     3541 tcagtgttta gtctgagaat ttttgcatgt tggttaattg tggccattct ttaatttaaa
     3601 gttaaaacta taatcttagg tagaaaaact tttttataag aagtattatt tgaccacttc
     3661 aggtatacat tcaatactgg gtaaaaattt cagacctatc tcaggaacac agaaatattt
     3721 ggtgtcctga taagcacttt ctagactatt gatgtggcca ggaatttgga aagacgacac
     3781 acgcacgcgc gcgcgcgcac acacacacac acacacacac acacacacag ttttttcctt
     3841 ccctgtgatg aaaaaggctg tgaaaacctt aaagtatttg cttgcttctt gttttgttta
     3901 gttgataatg aaatgtgtac aacctcaaat ttgctgccag aatactaaaa atagaaaaat
     3961 acccacaaaa ctgtcatgtc tttagttctt tccccccgaa aactcagtaa aaaggtgttc
     4021 ccaggatgaa aagatcattt tttgctgcat gctaaatctt gcaggaaaaa tgatttttta
     4081 gtacgattct gtagaaatga atctttgata taatgtaaat gctgctgttt gtttcaagtg
     4141 gtgaatgtgt tgttaaaaat tggctgtttg ctttcatttt ggccaataag taatcaagtt
     4201 tgtagaaaat gttagcattc tgactactta gcatctgtag taatttctct atgtataggg
     4261 ataatttttt agtgggcaga gatcctgttc tagttgcctg ttaagcaaaa tctgccctcc
     4321 caattgaaaa agccaaagag aattgttaga gggaaaagca tgtagccatt gcagtctgca
     4381 ttgcagccag cgttgtccag agtacacgct cagcacttag cttctactgt gtgttgtggt
     4441 ctggtgagtg ttgtttcccc tgagcgctct attatttatt tatttattat caatcagtga
     4501 ccctgaccac atagtgtgat aggtgcagca ttcttccctg tgggaaagaa ttaaagatgg
     4561 ttccatttcc taggctacag acaggaatgg ggctctaaat ggttttcata gactggctgt
     4621 taaaggccaa aaattttggt aaatcaatgc tatattatgc tcttgaacta ttaaaacagc
     4681 cataattatt gtcccaagat agaatatagt cctttttcaa agatgattat acgtggctag
     4741 gtgacagaca ttaatgactg actctggaga gtaagtcata cctgcactct gtggacttga
     4801 tggttctttt tctagagcaa acagagcgtg gcattttgtt ttgacttgtt cttccttggg
     4861 gtcaaattta tatatatata tataaatttt tgtttgggcg accaagatct aataattaaa
     4921 acccaggtgg accatggatt cagacctgcc tttttatgtt tttgactctt aggttcatcg
     4981 tgtcccagac ttcttcacat attcgtgaag gtaagatatt ctgtgtgcgc ttggcctcct
     5041 tttcacgcat atttcattgc ctctttgatg agtggttacg aagacgttaa actacctttt
     5101 tgttccctgg ggtaataggt cagtaactat gagcgccgtc tctctccatg tgagcttgtg
     5161 ttaatagaca cttttatggt agagttggga tggggccacc accttaaaat gagtgagcag
     5221 acaaggccag gcaagccaaa ggctttaaga caccatgatt ttcttgtttt gttttaattg
     5281 ggaagggaag tataaggaag agctcagagg gagtttcata cctggaattg ttggacttaa
     5341 ttgacacttg caaatacttt tagtataaag gtttaattct atttaaaaag aagatccatt
     5401 aaatcaagct cttaactcat gggactattt gcaacacttc tttgtaaata tcattttgtt
     5461 tgttaggtta ttggcaaaac agtttcaagg ttcacttccc tcccttgaac caggtccagg
     5521 tcattttgct ttggggtaga ttaaagtcag aactctaaaa gttgagcaac tttgtttttt
     5581 tttgaattga tttagcacta acccaccatt gcatcttaag gatggcatga cgtgataatg
     5641 atggacttgt gtgaggtttt gatttttcaa ttaaactttt tgttatcaca ggtaa
//
