LOCUS       NP_003895                459 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein ZPR1 isoform 1 [Homo sapiens].
ACCESSION   NP_003895
VERSION     NP_003895.1
DBSOURCE    REFSEQ: accession NM_003904.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Ellakwa,D.E., Amr,K.S., Zaki,M.E., Refeat,M. and Banksle,H.M.
  TITLE     Zinc finger 259 gene polymorphisms in Egyptian patients with
            metabolic syndrome and its association with dyslipidemia
  JOURNAL   Ir J Med Sci 193 (5), 2313-2323 (2024)
   PUBMED   38985417
  REMARK    GeneRIF: Zinc finger 259 gene polymorphisms in Egyptian patients
            with metabolic syndrome and its association with dyslipidemia.
REFERENCE   2  (residues 1 to 459)
  AUTHORS   Masjoudi,S., Sedaghati-Khayat,B., Givi,N.J., Bonab,L.N.H., Azizi,F.
            and Daneshpour,M.S.
  TITLE     Kernel machine SNP set analysis finds the association of BUD13,
            ZPR1, and APOA5 variants with metabolic syndrome in Tehran
            Cardio-metabolic Genetics Study
  JOURNAL   Sci Rep 11 (1), 10305 (2021)
   PUBMED   33986338
  REMARK    GeneRIF: Kernel machine SNP set analysis finds the association of
            BUD13, ZPR1, and APOA5 variants with metabolic syndrome in Tehran
            Cardio-metabolic Genetics Study.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 459)
  AUTHORS   Esteve-Luque,V., Padro-Miquel,A., Fanlo-Maresma,M., Corbella,E.,
            Corbella,X., Pinto,X. and Candas-Estebanez,B.
  TITLE     Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD
            Severity in Patients with Hypertriglyceridemia
  JOURNAL   Nutrients 13 (2), 552 (2021)
   PUBMED   33567543
  REMARK    GeneRIF: Implication between Genetic Variants from APOA5 and ZPR1
            and NAFLD Severity in Patients with Hypertriglyceridemia.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 459)
  AUTHORS   Paquette,M., Fantino,M., Bernard,S. and Baass,A.
  TITLE     The ZPR1 genotype predicts myocardial infarction in patients with
            familial hypercholesterolemia
  JOURNAL   J Clin Lipidol 14 (5), 660-666 (2020)
   PUBMED   32807694
  REMARK    GeneRIF: The ZPR1 genotype predicts myocardial infarction in
            patients with familial hypercholesterolemia.
REFERENCE   5  (residues 1 to 459)
  AUTHORS   Kannan,A., Jiang,X., He,L., Ahmad,S. and Gangwani,L.
  TITLE     ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and
            rescues spinal muscular atrophy
  JOURNAL   Brain 143 (1), 69-93 (2020)
   PUBMED   31828288
  REMARK    GeneRIF: ZPR1 prevents R-loop accumulation, upregulates SMN2
            expression and rescues spinal muscular atrophy.
            Erratum:[Brain. 2020 Mar 1;143(3):e24. doi: 10.1093/brain/awaa007.
            PMID: 32333675]
REFERENCE   6  (residues 1 to 459)
  AUTHORS   Gangwani,L., Mikrut,M., Theroux,S., Sharma,M. and Davis,R.J.
  TITLE     Spinal muscular atrophy disrupts the interaction of ZPR1 with the
            SMN protein
  JOURNAL   Nat Cell Biol 3 (4), 376-383 (2001)
   PUBMED   11283611
REFERENCE   7  (residues 1 to 459)
  AUTHORS   Moores,S.L., Selfors,L.M., Fredericks,J., Breit,T., Fujikawa,K.,
            Alt,F.W., Brugge,J.S. and Swat,W.
  TITLE     Vav family proteins couple to diverse cell surface receptors
  JOURNAL   Mol Cell Biol 20 (17), 6364-6373 (2000)
   PUBMED   10938113
REFERENCE   8  (residues 1 to 459)
  AUTHORS   Gangwani,L., Mikrut,M., Galcheva-Gargova,Z. and Davis,R.J.
  TITLE     Interaction of ZPR1 with translation elongation factor-1alpha in
            proliferating cells
  JOURNAL   J Cell Biol 143 (6), 1471-1484 (1998)
   PUBMED   9852145
REFERENCE   9  (residues 1 to 459)
  AUTHORS   Galcheva-Gargova,Z., Gangwani,L., Konstantinov,K.N., Mikrut,M.,
            Theroux,S.J., Enoch,T. and Davis,R.J.
  TITLE     The cytoplasmic zinc finger protein ZPR1 accumulates in the
            nucleolus of proliferating cells
  JOURNAL   Mol Biol Cell 9 (10), 2963-2971 (1998)
   PUBMED   9763455
REFERENCE   10 (residues 1 to 459)
  AUTHORS   Galcheva-Gargova,Z., Konstantinov,K.N., Wu,I.H., Klier,F.G.,
            Barrett,T. and Davis,R.J.
  TITLE     Binding of zinc finger protein ZPR1 to the epidermal growth factor
            receptor
  JOURNAL   Science 272 (5269), 1797-1802 (1996)
   PUBMED   8650580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017349.2, CD365951.1 and
            AP006216.1.
            
            Summary: The protein encoded by this gene is found in the cytoplasm
            of quiescent cells but translocates to the nucleolus in
            proliferating cells. The encoded protein interacts with survival
            motor neuron protein (SMN1) to enhance pre-mRNA splicing and to
            induce neuronal differentiation and axonal growth. Defects in this
            gene or the SMN1 gene can cause spinal muscular atrophy. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017349.2, SRR1660807.259745.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227322.8/ ENSP00000227322.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     Protein         1..459
                     /product="zinc finger protein ZPR1 isoform 1"
                     /note="zinc finger protein ZPR1; zinc finger protein 259"
                     /calculated_mol_wt=50794
     Region          1..32
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75312.1)"
     Region          49..206
                     /region_name="zf-ZPR1"
                     /note="ZPR1 zinc-finger domain; pfam03367"
                     /db_xref="CDD:427263"
     Region          257..416
                     /region_name="Zpr1"
                     /note="Duplicated domain in the epidermal growth factor-
                     and elongation factor-1alpha-binding protein Zpr1. Also
                     present in archaeal proteins; smart00709"
                     /db_xref="CDD:128949"
     Region          439..459
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75312.1)"
     CDS             1..459
                     /gene="ZPR1"
                     /gene_synonym="GKAF; ZNF259"
                     /coded_by="NM_003904.5:34..1413"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS8375.1"
                     /db_xref="GeneID:8882"
                     /db_xref="HGNC:HGNC:13051"
                     /db_xref="MIM:603901"
ORIGIN      
        1 maasgavepg ppgaavapsp apapppapdh lfrpisaede eqqpteiesl cmncycngmt
       61 rllltkipff reiivssfsc ehcgwnntei qsagriqdqg vrytlsvral edmnrevvkt
      121 dsaatripel dfeipafsqk galttvegli traisgleqd qparrankda taeridefiv
      181 klkelkqvas pftliiddps gnsfvenpha pqkddalvit hynrtrqqee mlglqeeapa
      241 ekpeeedlrn evlqfstncp ecnapaqtnm klvqiphfke viimatncen cghrtnevks
      301 ggaveplgtr itlhitdasd mtrdllkset csveipelef elgmavlggk fttlegllkd
      361 irelvtknpf tlgdssnpgq terlqefsqk mdqiiegnmk ahfimddpag nsylqnvyap
      421 eddpemkver ykrtfdqnee lglndmkteg yeaglapqr
//
