LOCUS       NM_001110354            1303 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zona pellucida glycoprotein 3 (ZP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001110354 XM_001130779
VERSION     NM_001110354.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1303)
  AUTHORS   Sun,L., Tong,K., Liu,W., Tian,Y., Liu,D., Huang,G. and Li,J.
  TITLE     Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle
            syndrome and abnormal zona pellucida
  JOURNAL   Reprod Biomed Online 46 (5), 847-855 (2023)
   PUBMED   36931917
  REMARK    GeneRIF: Novel variants in ZP1, ZP2 and ZP3 associated with empty
            follicle syndrome and abnormal zona pellucida.
REFERENCE   2  (bases 1 to 1303)
  AUTHORS   Li,W., Li,Q., Xu,X., Wang,C., Hu,K. and Xu,J.
  TITLE     Novel mutations in TUBB8 and ZP3 cause human oocyte maturation
            arrest and female infertility
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 279, 132-139 (2022)
   PUBMED   36335766
  REMARK    GeneRIF: Novel mutations in TUBB8 and ZP3 cause human oocyte
            maturation arrest and female infertility.
REFERENCE   3  (bases 1 to 1303)
  AUTHORS   Jia,W., Xi,Q., Zhu,L., Luo,Y., Li,Z., Hou,M., Zhang,D., Yang,X.,
            Hu,J., Jin,L. and Zhang,X.
  TITLE     Novel mutations in ZP2 and ZP3 cause female infertility in three
            patients
  JOURNAL   J Assist Reprod Genet 39 (5), 1205-1215 (2022)
   PUBMED   35366744
  REMARK    GeneRIF: Novel mutations in ZP2 and ZP3 cause female infertility in
            three patients.
REFERENCE   4  (bases 1 to 1303)
  AUTHORS   Zhang,Z., Guo,Q., Jia,L., Zhou,C., He,S., Fang,C., Zhang,M.,
            Sun,P., Zeng,Z., Wang,M., Wang,D. and Liang,X.
  TITLE     A novel gene mutation in ZP3 loop region identified in patients
            with empty follicle syndrome
  JOURNAL   Hum Mutat 43 (2), 180-188 (2022)
   PUBMED   34816529
  REMARK    GeneRIF: A novel gene mutation in ZP3 loop region identified in
            patients with empty follicle syndrome.
REFERENCE   5  (bases 1 to 1303)
  AUTHORS   Pulawska,K., Ponikwicka-Tyszko,D., Lebiedzinska,W., Guo,P.,
            Bernaczyk,P., Pilaszewicz-Puza,A., Li,X., Chrusciel,M., Lupu,O.,
            Leskinen,S., Makela,J.A., Toppari,J., Wolczynski,S., Coelingh
            Bennink,H.J.T., Huhtaniemi,I. and Rahman,N.A.
  TITLE     Novel expression of zona pellucida 3 protein in normal testis;
            potential functional implications
  JOURNAL   Mol Cell Endocrinol 539, 111502 (2022)
   PUBMED   34736966
  REMARK    GeneRIF: Novel expression of zona pellucida 3 protein in normal
            testis; potential functional implications.
REFERENCE   6  (bases 1 to 1303)
  AUTHORS   Kipersztok,S., Osawa,G.A., Liang,L.F., Modi,W.S. and Dean,J.
  TITLE     POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121
            homologue
  JOURNAL   Genomics 25 (2), 354-359 (1995)
   PUBMED   7789967
REFERENCE   7  (bases 1 to 1303)
  AUTHORS   Miller,D.J., Gong,X. and Shur,B.D.
  TITLE     Sperm require beta-N-acetylglucosaminidase to penetrate through the
            egg zona pellucida
  JOURNAL   Development 118 (4), 1279-1289 (1993)
   PUBMED   8269854
REFERENCE   8  (bases 1 to 1303)
  AUTHORS   van Duin,M., Polman,J.E., Suikerbuijk,R.F., Geurts-van Kessel,A.H.
            and Olijve,W.
  TITLE     The human gene for the zona pellucida glycoprotein ZP3 and a second
            polymorphic locus are located on chromosome 7
  JOURNAL   Cytogenet Cell Genet 63 (2), 111-113 (1993)
   PUBMED   8467708
REFERENCE   9  (bases 1 to 1303)
  AUTHORS   van Duin,M., Polman,J.E., Verkoelen,C.C., Bunschoten,H.,
            Meyerink,J.H., Olijve,W. and Aitken,R.J.
  TITLE     Cloning and characterization of the human sperm receptor ligand
            ZP3: evidence for a second polymorphic allele with a different
            frequency in the Caucasian and Japanese populations
  JOURNAL   Genomics 14 (4), 1064-1070 (1992)
   PUBMED   1478648
REFERENCE   10 (bases 1 to 1303)
  AUTHORS   Chamberlin,M.E. and Dean,J.
  TITLE     Human homolog of the mouse sperm receptor
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6014-6018 (1990)
   PUBMED   2385582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005522.2, M60504.1,
            DB328313.1 and BC113949.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001110354.1.
            
            Summary: The zona pellucida is an extracellular matrix that
            surrounds the oocyte and early embryo. It is composed primarily of
            three or four glycoproteins with various functions during
            fertilization and preimplantation development. The protein encoded
            by this gene is a structural component of the zona pellucida and
            functions in primary binding and induction of the sperm acrosome
            reaction. The nascent protein contains a N-terminal signal peptide
            sequence, a conserved ZP domain, a C-terminal consensus furin
            cleavage site, and a transmembrane domain. It is hypothesized that
            furin cleavage results in release of the mature protein from the
            plasma membrane for subsequent incorporation into the zona
            pellucida matrix. However, the requirement for furin cleavage in
            this process remains controversial based on mouse studies. A
            variation in the last exon of this gene has previously served as
            the basis for an additional ZP3 locus; however, sequence and
            literature review reveals that there is only one full-length ZP3
            locus in the human genome. Another locus encoding a bipartite
            transcript designated POMZP3 contains a duplication of the last
            four exons of ZP3, including the above described variation, and
            maps closely to this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60504.1, SRR14038194.3340216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394857.8/ ENSP00000378326.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC005522.2         76228-76232         c
            6-957               M60504.1           1-952
            958-1296            DB328313.1         1-339               c
            1297-1303           BC113949.1         1442-1448
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1303
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /note="zona pellucida glycoprotein 3"
                     /db_xref="GeneID:7784"
                     /db_xref="HGNC:HGNC:13189"
                     /db_xref="MIM:182889"
     exon            1..327
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1290
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; zona pellucida protein C; zona pellucida
                     sperm-binding protein 3; zona pellucida glycoprotein 3B;
                     ZP3A/ZP3B; sperm receptor; zona pellucida glycoprotein
                     ZP3"
                     /codon_start=1
                     /product="zona pellucida sperm-binding protein 3 isoform 1
                     precursor"
                     /protein_id="NP_001103824.1"
                     /db_xref="CCDS:CCDS47618.1"
                     /db_xref="GeneID:7784"
                     /db_xref="HGNC:HGNC:13189"
                     /db_xref="MIM:182889"
                     /translation="MELSYRLFICLLLWGSTELCYPQPLWLLQGGASHPETSVQPVLV
                     ECQEATLMVMVSKDLFGTGKLIRAADLTLGPEACEPLVSMDTEDVVRFEVGLHECGNS
                     MQVTDDALVYSTFLLHDPRPVGNLSIVRTNRAEIPIECRYPRQGNVSSQAILPTWLPF
                     RTTVFSEEKLTFSLRLMEENWNAEKRSPTFHLGDAAHLQAEIHTGSHVPLRLFVDHCV
                     ATPTPDQNASPYHTIVDFHGCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRN
                     MIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSR
                     RQPHVMSQWSRSASRNRRHVTEEADVTVGPLIFLDRRGDHEVEQWALPSDTSVVLLGV
                     GLAVVVSLTLTAVILVLTRRCRTASHPVSASE"
     exon            328..446
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     exon            447..550
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     exon            551..728
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     exon            729..846
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     exon            847..938
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1075
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1303
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /note="hexamer: AATAAA"
     polyA_site      1303
                     /gene="ZP3"
                     /gene_synonym="OOMD3; OZEMA3; Zp-3; ZP3A; ZP3B; ZPC"
                     /note="major polyA site"
ORIGIN      
        1 tgctctgcag gtaccatgga gctgagctat aggctcttca tctgcctcct gctctggggt
       61 agtactgagc tgtgctaccc ccaacccctc tggctcttgc agggtggagc cagccatcct
      121 gagacgtccg tacagcccgt actggtggag tgtcaggagg ccactctgat ggtcatggtc
      181 agcaaagacc tttttggcac cgggaagctc atcagggctg ctgacctcac cttgggccca
      241 gaggcctgtg agcctctggt ctccatggac acagaagatg tggtcaggtt tgaggttgga
      301 ctccacgagt gtggcaacag catgcaggta actgacgatg ccctggtgta cagcaccttc
      361 ctgctccatg acccccgccc cgtgggaaac ctgtccatcg tgaggactaa ccgcgcagag
      421 attcccatcg agtgccgcta ccccaggcag ggcaatgtga gcagccaggc catcctgccc
      481 acctggttgc ccttcaggac cacggtgttc tcagaggaga agctgacttt ctctctgcgt
      541 ctgatggagg agaactggaa cgctgagaag aggtccccca ccttccacct gggagatgca
      601 gcccacctcc aggcagaaat ccacactggc agccacgtgc cactgcggtt gtttgtggac
      661 cactgcgtgg ccacaccgac accagaccag aatgcctccc cttatcacac catcgtggac
      721 ttccatggct gtcttgtcga cggtctcact gatgcctctt ctgcattcaa agttcctcga
      781 cccgggccag atacactcca gttcacagtg gatgtcttcc actttgctaa tgactccaga
      841 aacatgatat acatcacctg ccacctgaag gtcaccctag ctgagcagga cccagatgaa
      901 ctcaacaagg cctgttcctt cagcaagcct tccaacagct ggttcccagt ggaaggctcg
      961 gctgacatct gtcaatgctg taacaaaggt gactgtggca ctccaagcca ttccaggagg
     1021 cagcctcatg tcatgagcca gtggtccagg tctgcttccc gtaaccgcag gcatgtgaca
     1081 gaagaagcag atgtcaccgt ggggccactg atcttcctgg acaggagggg tgaccatgaa
     1141 gtagagcagt gggctttgcc ttctgacacc tcagtggtgc tgctgggcgt aggcctggct
     1201 gtggtggtgt ccctgactct gactgctgtt atcctggttc tcaccaggag gtgtcgcact
     1261 gcctcccacc ctgtgtctgc ttccgaataa aagaagaaag caa
//
