LOCUS       NM_181710               1440 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.
ACCESSION   NM_181710
VERSION     NM_181710.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1440)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1440)
  AUTHORS   Bist,P., Cheong,W.S., Ng,A., Dikshit,N., Kim,B.H., Pulloor,N.K.,
            Khameneh,H.J., Hedl,M., Shenoy,A.R., Balamuralidhar,V.,
            Malik,N.B.A., Hong,M., Neutzner,A., Chin,K.C., Kobayashi,K.S.,
            Bertoletti,A., Mortellaro,A., Abraham,C., MacMicking,J.D.,
            Xavier,R.J. and Sukumaran,B.
  TITLE     E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and
            induces tolerance to MDP
  JOURNAL   Nat Commun 8, 15865 (2017)
   PUBMED   28656966
  REMARK    GeneRIF: ZNRF4 is a negative regulator of NOD2 and NF-kappaB. ZNRF4
            promotes K48-linked ubiquitination of RIP2.ZNRF4 role in the
            protective host immunity.
            Erratum:[Nat Commun. 2017 Aug 18;8:16141. doi:
            10.1038/ncomms16141.. PMID: 28820178]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1440)
  AUTHORS   Neutzner,A., Neutzner,M., Benischke,A.S., Ryu,S.W., Frank,S.,
            Youle,R.J. and Karbowski,M.
  TITLE     A systematic search for endoplasmic reticulum (ER)
            membrane-associated RING finger proteins identifies Nixin/ZNRF4 as
            a regulator of calnexin stability and ER homeostasis
  JOURNAL   J Biol Chem 286 (10), 8633-8643 (2011)
   PUBMED   21205830
  REMARK    GeneRIF: Nixin/ZNRF4 to be central for the regulation of calnexin
            turnover.
REFERENCE   4  (bases 1 to 1440)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   5  (bases 1 to 1440)
  AUTHORS   Fujii,T., Tamura,K., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Yomogida,K., Tanaka,H., Nishimune,Y., Nojima,H. and Abiko,Y.
  TITLE     Sperizin is a murine RING zinc-finger protein specifically
            expressed in Haploid germ cells
  JOURNAL   Genomics 57 (1), 94-101 (1999)
   PUBMED   10191088
  REMARK    GeneRIF: Characterization and study of mouse homolog.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005764.1.
            
            On May 17, 2019 this sequence version replaced NM_181710.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC017592.2, AK292251.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222033.6/ ENSP00000222033.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1440              AC005764.1         12625-14064
FEATURES             Location/Qualifiers
     source          1..1440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1440
                     /gene="ZNRF4"
                     /gene_synonym="RNF204; SPERIZIN; spzn; Ssrzf1"
                     /note="zinc and ring finger 4"
                     /db_xref="GeneID:148066"
                     /db_xref="HGNC:HGNC:17726"
                     /db_xref="MIM:612063"
     exon            1..1440
                     /gene="ZNRF4"
                     /gene_synonym="RNF204; SPERIZIN; spzn; Ssrzf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1365
                     /gene="ZNRF4"
                     /gene_synonym="RNF204; SPERIZIN; spzn; Ssrzf1"
                     /EC_number="2.3.2.27"
                     /note="zinc/RING finger protein 4; RING finger protein
                     204; nixin; E3 ubiquitin-protein ligase ZNRF4; RING-type
                     E3 ubiquitin transferase ZNRF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNRF4 precursor"
                     /protein_id="NP_859061.3"
                     /db_xref="CCDS:CCDS42475.1"
                     /db_xref="GeneID:148066"
                     /db_xref="HGNC:HGNC:17726"
                     /db_xref="MIM:612063"
                     /translation="MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGR
                     PRRCPKASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRA
                     VLEDNSSSVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGAIVL
                     IRRYDCTFDLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAA
                     SQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLW
                     LWAQACCSHRRPVKTSTCQKAQVRTFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCK
                     CIDPWFSQAPRRSCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRS
                     RRLELLGRASPHCHCSTTSLEAEYTTVSSAPPEAPGQ"
     regulatory      1418..1423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNRF4"
                     /gene_synonym="RNF204; SPERIZIN; spzn; Ssrzf1"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="ZNRF4"
                     /gene_synonym="RNF204; SPERIZIN; spzn; Ssrzf1"
                     /note="major polyA site"
ORIGIN      
        1 ctggtctcca tgtcatctgc cagaaaggcc acctgcgcca gcacctcctg agaccggcct
       61 tcaaagacac gacgcatgcc gctctgccgt ccggagcact taatgcctag agccagcagg
      121 gtcccagtgg ccgcgtcact gcctctgagc cacgcggtca ttccaactca actgccctcg
      181 cgtcctggcc acaggccccc tgggagaccc cggagatgcc caaaggcctc atgcctgccg
      241 cctccagtgg gacctagcag cacacagaca gcgaagcggg tgaccatggg gtggccacgg
      301 ccgggccgag ccctcgtggc agtcaaagcc ttgctggtct tgtcgctgct ccaggtgccc
      361 gcgcaggcag tggtacgggc cgtgctggaa gacaactcga gctcggtgga ctttgcggat
      421 ctgccggcgc tgttcggcgt ccccctggcc cccgagggca tacggggcta cctgatggag
      481 gtcaagccag ccaacgcgtg ccatcccatc gaggccccgc gactgggcaa ccgctctctg
      541 ggcgccatcg tgctgatccg ccgctacgac tgcaccttcg acctcaaggt gctgaacgcc
      601 cagcgcgccg gcttcgaggc ggccatcgtg cacaacgtcc actccgacga cctcgtgagc
      661 atgacccacg tctacgagga cttgaggggc cagatcgcca tcccctcagt gttcgtgagc
      721 gaggccgcct cgcaggacct gcgggtcatc ctgggctgca acaagtcggc ccacgcgctg
      781 ctcctgcccg acgacccacc gtgccacgac ctgggctgtc accccgtgct gaccgtgtcc
      841 tgggtgctgg gctgtaccct ggccctggtc gtatcagcct tctttgtcct gaaccacctg
      901 tggctctggg cccaggcctg ctgcagccac agacggccgg tgaagacgtc tacctgccag
      961 aaggcccagg tccgcacctt cacgtggcac aacgacctgt gtgccatctg cctggatgag
     1021 tatgaggagg gcgaccaact caagatcctg ccctgctccc acacctacca ctgcaaatgc
     1081 attgacccct ggttctccca agccccccgg cgctcctgcc ccgtgtgcaa acagtcggtg
     1141 gccgccacag aagacagctt tgactccacc acctacagct tcagggacga ggacccctcc
     1201 ctaccgggcc accggccccc catctgggcc attcaagtcc agctacgctc ccggaggctg
     1261 gagctgctgg gccgcgccag tccccactgc cactgcagca ccacgtccct ggaggcagag
     1321 tataccactg tctcctcagc ccctcctgag gcccctggtc agtaaagatc tagggcaggg
     1381 aggggggtgc aatgaggaat gtttctggtc tgaaaagaat aaagtgggtt tgaaagcgga
//
