LOCUS       NM_032268               4626 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc and ring finger 1 (ZNRF1), mRNA.
ACCESSION   NM_032268 NM_032851
VERSION     NM_032268.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4626)
  AUTHORS   Nicolson,S., Manning,J.A., Lim,Y., Jiang,X., Kolze,E., Dayan,S.,
            Umargamwala,R., Xu,T., Sandow,J.J., Webb,A.I., Kumar,S. and
            Denton,D.
  TITLE     The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS
            complex and regulates autophagy
  JOURNAL   Commun Biol 7 (1), 183 (2024)
   PUBMED   38360932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4626)
  AUTHORS   Lin,Y.S., Chang,Y.C., Chao,T.L., Tsai,Y.M., Jhuang,S.J., Ho,Y.H.,
            Lai,T.Y., Liu,Y.L., Chen,C.Y., Tsai,C.Y., Hsueh,Y.P., Chang,S.Y.,
            Chuang,T.H., Lee,C.Y. and Hsu,L.C.
  TITLE     The Src-ZNRF1 axis controls TLR3 trafficking and interferon
            responses to limit lung barrier damage
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37158982
REFERENCE   3  (bases 1 to 4626)
  AUTHORS   Lu,J., Fu,L.M., Cao,Y., Fang,Y., Cao,J.Z., Pan,Y.H., Cen,J.J.,
            Liang,Y.P., Chen,Z.H., Wei,J.H., Huang,Y., Mumin,M.A., Xu,Q.H.,
            Wang,Y.H., Zhu,J.Q., Liang,H., Wang,Z., Deng,Q., Chen,W., Jin,X.H.,
            Liu,Z.P. and Luo,J.H.
  TITLE     LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT
            through ZNRF1-mediated ubiquitin proteosome pathway
  JOURNAL   Oncogene 42 (19), 1543-1557 (2023)
   PUBMED   36966254
  REMARK    GeneRIF: LZTFL1 inhibits kidney tumor cell growth by destabilizing
            AKT through ZNRF1-mediated ubiquitin proteosome pathway.
REFERENCE   4  (bases 1 to 4626)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4626)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4626)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   7  (bases 1 to 4626)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 4626)
  AUTHORS   Araki,T. and Milbrandt,J.
  TITLE     ZNRF proteins constitute a family of presynaptic E3 ubiquitin
            ligases
  JOURNAL   J Neurosci 23 (28), 9385-9394 (2003)
   PUBMED   14561866
  REMARK    GeneRIF: data suggest that ZNRF proteins play a role in the
            establishment and maintenance of neuronal transmission and
            plasticity via their ubiquitin ligase activity
REFERENCE   9  (bases 1 to 4626)
  AUTHORS   Araki,T., Nagarajan,R. and Milbrandt,J.
  TITLE     Identification of genes induced in peripheral nerve after injury.
            Expression profiling and novel gene discovery
  JOURNAL   J Biol Chem 276 (36), 34131-34141 (2001)
   PUBMED   11427537
REFERENCE   10 (bases 1 to 4626)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092383.4, AF378524.1 and
            AC099508.3.
            
            On May 17, 2019 this sequence version replaced NM_032268.4.
            
            Summary: This gene encodes an E3 ubiquitin-protein ligase that
            plays a role in neural-cell differentiation. Overexpression of this
            gene causes neurite-like elongation. The encoded protein contains
            both a zinc finger and a RING finger motif and is localized in the
            endosome/lysosome compartment, indicating that it may be involved
            in ubiquitin-mediated protein modification, and in synaptic
            vessicle membranes in neurons. [provided by RefSeq, Feb 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378524.1, SRR1660803.161893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335325.9/ ENSP00000335091.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               AC092383.4         83366-83864         c
            500-2057            AF378524.1         179-1736
            2058-4626           AC099508.3         100907-103475
FEATURES             Location/Qualifiers
     source          1..4626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..4626
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /note="zinc and ring finger 1"
                     /db_xref="GeneID:84937"
                     /db_xref="HGNC:HGNC:18452"
                     /db_xref="MIM:612060"
     exon            1..1072
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /inference="alignment:Splign:2.1.0"
     CDS             649..1332
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /EC_number="2.3.2.27"
                     /note="nerve injury gene 283; zinc and ring finger protein
                     1; zinc/RING finger protein 1; nerve injury-induced gene
                     283 protein; zinc and ring finger 1, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase ZNRF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNRF1"
                     /protein_id="NP_115644.1"
                     /db_xref="CCDS:CCDS10912.1"
                     /db_xref="GeneID:84937"
                     /db_xref="HGNC:HGNC:18452"
                     /db_xref="MIM:612060"
                     /translation="MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAM
                     GLRSRSVSSVAGMGMDPSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNG
                     YQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMH
                     FIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVN
                     RSCPEHPAD"
     exon            1073..1168
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1274
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1364
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..4626
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /note="hexamer: ATTAAA"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /note="hexamer: AATAAA"
     polyA_site      2341
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /note="major polyA site"
     polyA_site      2365
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
     regulatory      4321..4326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
                     /note="hexamer: AATAAA"
     polyA_site      4345
                     /gene="ZNRF1"
                     /gene_synonym="NIN283"
ORIGIN      
        1 attgtctcca cggcggcgag gagcgccggc gagcgcagcc cgggaccgag cggggcggcg
       61 cggctggcgg ggccggcggc ggctgaagcg agagcgcgac gcgacgcgac cgcggcttcc
      121 cgagctgcgc ctggccgccc agcgccgcgg cccgcccgag gcctggaggg gtccgggccg
      181 ccgtccatgg tcgcggcgtc ctgaggcggg ggacgcgccc ggcgcccccg gccctcctcc
      241 gcctcctccc gcggggcggg cggcctcctc cggcgcctcc ccgcgcccgc ccgccgctcg
      301 ccgccgcctc cctccctcct tccctgcggc tcccccggct ttcggagccc gggggcggcc
      361 tgtggcgcgc ggagcccgcg ccggactgcg cctctttgga ccttgagggg aaacatgcgt
      421 ttgccttgga tcgtttgaaa ttctgagttt gggatccccg cccgcccgcc tgcctcttcc
      481 gccccgcggg ttttttcctt ttttcctttt gctttttttc cttttctccc tccgggtctc
      541 ctttttgact ccctccccct ttatgctcgc ccagccctcc ccctgctgct gagaagtggg
      601 ggagggtctc ggcctccagg ttcccgcccc accggggccc gggcgagcat ggggggcaag
      661 cagagcacgg cggcccgctc ccggggcccc ttcccggggg tctccaccga tgacagcgcc
      721 gtgccgccgc cgggaggggc gccccatttc gggcactacc ggacgggcgg cggggccatg
      781 gggctgcgca gccgctcggt cagctcggtg gcaggcatgg gcatggaccc cagcacggcc
      841 gggggggtgc cctttggcct ctacaccccc gcctcccggg gcaccggcga ctccgagagg
      901 gcgcccggcg gcggagggtc tgcgtccgac tccacctatg cccatggcaa tggttaccag
      961 gagacgggcg gcggtcacca tagagacggg atgctgtacc tgggctcccg agcctcgctg
     1021 gcggatgctc tacctctgca catcgcaccc aggtggttca gctcgcatag tggtttcaag
     1081 tgccccattt gctccaagtc tgtggcttct gacgagatgg aaatgcactt tataatgtgt
     1141 ttgagcaaac ctcgcctctc ctacaacgat gatgtgctga ctaaagacgc gggtgagtgt
     1201 gtgatctgcc tggaggagct gctgcagggg gacacgatag ccaggctgcc ctgcctgtgc
     1261 atctatcaca aaagctgcat agactcgtgg tttgaagtga acagatcttg tccggaacac
     1321 cctgcggact gacctgcggg cttgcttgct gactcctctc aaagggacag agcgcccctg
     1381 ctccagggag gaggctcacc ggaccctggg gcagagctga gcttgggaca ccagcgggaa
     1441 cagggcaccc cttctgcact gacttccaga tcatggttct cccttcctcc ctgaggacac
     1501 caaattggat gagagcaagt ttgagagaag aatgaatcaa ctgctatcct tcccctcacc
     1561 cctcagccca ggagggaaag ggcattttct ttttcatctt tgaaaggcat tgtgggtctg
     1621 tctttaaagt gtttacaaaa aaaaattata taaaaaaaaa gtctagtgtc gactggtgtt
     1681 ttccctcgtg atgtttacag cttgctgttt gctgcccagc cataacccac tcagtgacag
     1741 acgaacacag ctaaggcctc gctgccagcc ttctgacggc gggcgagcac acggtctctt
     1801 cccctgcccc aactggccct ctccaccacc aacttctcta ctttgggttt gtttggtttt
     1861 ttccctctat ttttctggct ggttttttgc tcttttctcc ccttgagacc ctaatatctt
     1921 gacttcattg ccaaaaaaca acccattgag aactttcttc ctactgatcc catctctttt
     1981 cccttctttc ctcctggttc cggtcagttc agaggattta acaatcacaa gtgtcctgca
     2041 aaaatgcctg aacattattc ttaggccctc gtggattttt tttttcagaa aacttaaaca
     2101 aaaaaagact tactaagaaa tatgtacagc tacccctgtt ttcaggcact atgtttgaga
     2161 acattttagc cattgatgtt cacacgtggc atcagcccat gcaagatagg tttctgtatt
     2221 tatatattaa aatacaaaaa aaaacttata aaatgtttaa aaaaatgttc aaagcttggg
     2281 agaaaagctt tcttcattag tcaaggtgtt ttgatatggt attaaaatgt ctaataaaag
     2341 atggcactgc gtgattttat tttaatgaag tgttatacaa tcaagaaatg ggggcaaggg
     2401 cctgcccccc actccctcac ctacctcctt agcattcctt caggctgcta ctcggggctc
     2461 caggtgtgtg aattggtcct cagatagtca ggcctgggtg gagggagtgg caagtcaggc
     2521 gtgcctccta caagcttcct aacctcttaa gcatcatgga accagtcagc cctctgtgga
     2581 gtcattgtgc tggacctctg aaaagatctg caggggccaa gatgttgcag ccaccggagg
     2641 ctgcaaggat gtgggttctt ccaggtgtgg gcccagcccc cctccttcca gcctttgctc
     2701 cccatcccac gttccactcg ccctgcctgt tgttcagttt gcgtctcagt gctgactcac
     2761 gggcatgctt cattgaggcc caggaagagg ccctggtttg gggctgtgcc agctcagagc
     2821 ccttgaacca gaaccaactg ctcaggctca caaaagttgg caaaatgcgg gctgggcagg
     2881 cagctcgggg cagggagcag cagtgcaggc ctggcctgtg tccccgtgcc cagcgggctc
     2941 ccggagcagc attccagagc ctcctgcaga gccagcgaag gaaagctcta gagggagacg
     3001 actccaccgc ctctctgctc tgacccttct caggcccgcc tgatgtgctg gaccatcccc
     3061 ctgctgccac ggcccctggc tccgcagtca ccctccatca gatgcttcca gaagcaccta
     3121 ctctgtgcaa gggcattcac aacaggccag tgggcaaacg tgagccaggg ccagcggaga
     3181 aacactaaag aagactcggt ggttcagagc ctgggtctca gcgcgggacc cgtctggggt
     3241 gaagaccttg gggctgttgt gagtcggtgg caggaacgtg ggctctagac tgtgcattca
     3301 ggctctccta cttggcagaa tgatcttggg gaaacgactt catctgaact tcagatattt
     3361 cacatgtgaa gcggggacaa aaccatgcag ctcagaggtc cctgtggggg ctgggggagc
     3421 tgccctgcag gtcttggcac atgcacagca ggctccccat agctttgtca ccacaaaggg
     3481 cactgttcta ttcacagcac ctcctgcttc tgcctggcaa ctgtgtctcc ctgtgctata
     3541 tttaattcca ccagcaaagc tggcgaggca gggcccagcc ctgaaggaga tctccttgcc
     3601 tgacccctgg acctggaaat ggaggcttca tgtgcccgcc ttggcggctt aagcctgctg
     3661 ctttggcagt gccatgggtg agccgagcag ctgtgaggtg ggtggggcag ggctgtagcc
     3721 cacgccgggt gctattccag gctctagggg ctggtgctca tccccacccc cagcgacttc
     3781 cgtcctacct ggcatgctgc agccctctgc cggctgtggt gtcctctgaa tttggaccca
     3841 ggttgcctgc tcttgttgtg ggggtgggat tggggctgtc tgtgtttccc aggtggagct
     3901 catgtttgtg atcctctatc tggacagctc tccagaatcc tgtgttgccc ctgttctgcc
     3961 tttctgggat gggagagaag gtgagggagc cggcgagcag gttctaccct ctctgctaag
     4021 ggcctagcac actttgatga ggttcctgga cgtgagaccc tcacaaagac caaccattcc
     4081 tctaatagcc atttaacggt actgcagttc atgggaaaat gtcctcattc ttaggagata
     4141 gatgctggat tatataggtg aatgccttca agaaatgtgt aatttaattc caaatagttc
     4201 cccccaaaat acacaaagca aataaggcca aaatgttcat tgttgaatct gcagtggctg
     4261 gtatttcagt gaacagtgta cttgttcttt caacttttct gtatgtttgg aatttttctt
     4321 aataaaagat tgtgggaaat ggtcatttgc tgagcgcctc ctagttgcca ggcactggag
     4381 ggcgcatcaa agaagagtcc tacccaggag ggagagcgca gctgctgcag gattctcgcc
     4441 tggaagagtg ggtggctggc tggctggctg gaaggggagg ggcgagaggg ctgtctcggt
     4501 gatgagcaca cgcgtgctgg ggtggtttgg ggagagggct gagatttgtc accagtgagc
     4561 ccttggcacg gtctctgctc cccaccaggg cagcacggga cagaaacgtc acggaggagt
     4621 agcctc
//
