LOCUS       NM_006396                769 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens zinc ribbon domain containing 2 (ZNRD2), transcript
            variant 1, mRNA.
ACCESSION   NM_006396
VERSION     NM_006396.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 769)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 769)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 769)
  AUTHORS   Perdreau-Dahl,H., Progida,C., Barfeld,S.J., Guldsten,H., Thiede,B.,
            Arntzen,M., Bakke,O., Mills,I.G., Krauss,S. and Morth,J.P.
  TITLE     Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase
            binding partner in cancer cells
  JOURNAL   Commun Biol 3 (1), 123 (2020)
   PUBMED   32170109
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 769)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 769)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 769)
  AUTHORS   Ananthanarayanan,V., Deaton,R.J., Amatya,A., Macias,V., Luther,E.,
            Kajdacsy-Balla,A. and Gann,P.H.
  TITLE     Subcellular localization of p27 and prostate cancer recurrence:
            automated digital microscopy analysis of tissue microarrays
  JOURNAL   Hum Pathol 42 (6), 873-881 (2011)
   PUBMED   21292307
  REMARK    GeneRIF: Our method identified a strong relationship between p27
            expression and prostate cancer recurrence.
REFERENCE   7  (bases 1 to 769)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   8  (bases 1 to 769)
  AUTHORS   Shen,A., Wang,Y., Zhao,Y., Zou,L., Sun,L. and Cheng,C.
  TITLE     Expression of CRM1 in human gliomas and its significance in p27
            expression and clinical prognosis
  JOURNAL   Neurosurgery 65 (1), 153-9 (2009)
   PUBMED   19574837
  REMARK    GeneRIF: The current results showed that p27 expression were
            associated with glioma grade.
REFERENCE   9  (bases 1 to 769)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 769)
  AUTHORS   Muro,Y., Yamada,T., Himeno,M. and Sugimoto,K.
  TITLE     cDNA cloning of a novel autoantigen targeted by a minor subset of
            anti-centromere antibodies
  JOURNAL   Clin Exp Immunol 111 (2), 372-376 (1998)
   PUBMED   9486406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC014791.2 and DR759640.1.
            
            On May 17, 2019 this sequence version replaced NM_006396.2.
            
            Summary: This antigen is recognized by a subset of anti-centromere
            antibodies from patients with scleroderma and/or Sjogren's
            syndrome. Subcellular localization has not yet been established.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF568149.1, SRR7410570.488352.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309328.8/ ENSP00000312318.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-649               BC014791.2         5-653
            650-769             DR759640.1         728-847
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..769
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /note="zinc ribbon domain containing 2"
                     /db_xref="GeneID:10534"
                     /db_xref="HGNC:HGNC:11328"
                     /db_xref="MIM:606044"
     exon            1..34
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..615
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Sjogren's syndrome/scleroderma autoantigen 1; centromeric
                     autoantigen (27kD); sjoegren syndrome/scleroderma
                     autoantigen 1; autoantigen p27; Sjogren
                     syndrome/scleroderma autoantigen 1; zinc ribbon
                     domain-containing protein 2; protein ZNRD2; protein zinc
                     ribbon domain type 2"
                     /codon_start=1
                     /product="protein ZNRD2 isoform 1"
                     /protein_id="NP_006387.1"
                     /db_xref="CCDS:CCDS8104.1"
                     /db_xref="GeneID:10534"
                     /db_xref="HGNC:HGNC:11328"
                     /db_xref="MIM:606044"
                     /translation="MALNGAEVDDFSWEPPTEAETKVLQARRERQDRISRLMGDYLLR
                     GYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQAREHQLA
                     SASELPLGSRPAPQPPVPRPEHCEGAAAGLKAAQGPPAPAVPPNTDVMACTQTALLQK
                     LTWASAELGSSTSLETSIQLCGLIRACAEALRSLQQLQH"
     exon            35..186
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..271
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..769
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      649
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
                     /note="major polyA site"
     polyA_site      661
                     /gene="ZNRD2"
                     /gene_synonym="p27; SSSCA1"
ORIGIN      
        1 ggtgacaacg gcaacatggc cctgaacgga gctgaagtcg acgacttctc ctgggagccc
       61 ccgactgagg cggagacgaa ggtgctgcag gcgcgacggg agcggcaaga tcgcatctcc
      121 cggctcatgg gcgactatct gctgcgcggt taccgcatgc tgggcgagac gtgtgcggac
      181 tgcgggacga tcctcctcca agacaaacag cggaaaatct actgcgtggc ttgtcaggaa
      241 ctcgactcag acgtggataa agataatccc gctctgaatg cccaggctgc cctctcccaa
      301 gctcgggagc accagctggc ctcagcctca gagctccccc tgggctctcg acctgcgccc
      361 cagcccccag tacctcgtcc ggagcactgt gagggagctg cagcaggact caaggcagcc
      421 caggggccac ctgctcctgc tgtgcctcca aatacagatg tcatggcctg cacacagaca
      481 gccctcttgc agaagctgac ctgggcctct gctgaactgg gctctagcac ctccctggag
      541 actagcatcc agctgtgtgg ccttatccgc gcatgtgcgg aggccctgcg cagcctgcag
      601 cagctacagc actaagagaa gcccctgaga aaaaccctct agaaaaacag ctgttcctct
      661 gtgtggtttg tttttttcct ggttccaagt gtgcatgcca gccccagctc cactcacctt
      721 tttccagctt ttggcctctt cacctctcca ctctgctctc cttgacgcc
//
