LOCUS       NM_017953               6203 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger HIT-type containing 6 (ZNHIT6), transcript
            variant 1, mRNA.
ACCESSION   NM_017953
VERSION     NM_017953.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6203)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6203)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   3  (bases 1 to 6203)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 6203)
  AUTHORS   McKeegan,K.S., Debieux,C.M., Boulon,S., Bertrand,E. and
            Watkins,N.J.
  TITLE     A dynamic scaffold of pre-snoRNP factors facilitates human box C/D
            snoRNP assembly
  JOURNAL   Mol Cell Biol 27 (19), 6782-6793 (2007)
   PUBMED   17636026
REFERENCE   5  (bases 1 to 6203)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   6  (bases 1 to 6203)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB169943.1, BC026236.1, AC092807.2 and BQ777734.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017953.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.192173.1,
                                           SRR1803617.46555.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370574.4/ ENSP00000359606.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB169943.1         1-13
            14-1571             BC026236.1         1-1558
            1572-5959           AC092807.2         155345-159732       c
            5960-6197           BQ777734.1         223-460
            6198-6203           AC092807.2         155101-155106       c
FEATURES             Location/Qualifiers
     source          1..6203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..6203
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="zinc finger HIT-type containing 6"
                     /db_xref="GeneID:54680"
                     /db_xref="HGNC:HGNC:26089"
                     /db_xref="MIM:620473"
     exon            1..805
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1562
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="isoform 1 is encoded by transcript variant 1; box
                     C/D snoRNA essential 1 homolog; zinc finger, HIT type 6;
                     box C/D snoRNA protein 1; zinc finger HIT
                     domain-containing protein 6; serologically defined breast
                     cancer antigen NY-BR-75"
                     /codon_start=1
                     /product="box C/D snoRNA protein 1 isoform 1"
                     /protein_id="NP_060423.3"
                     /db_xref="CCDS:CCDS707.1"
                     /db_xref="GeneID:54680"
                     /db_xref="HGNC:HGNC:26089"
                     /db_xref="MIM:620473"
                     /translation="MEFAAENEGKSGGGLHSVAEGVRLSPEPGREGVRDLAGAEEFGG
                     GEEGTGLTGIKEIGDGEEGSGQRPEEIPMDLTVVKQEIIDWPGTEGRLAGQWVEQEVE
                     DRPEVKDENAGVLEVKQETDSSLVVKEAKVGEPEVKEEKVKEEVMDWSEVKEEKDNLE
                     IKQEEKFVGQCIKEELMHGECVKEEKDFLKKEIVDDTKVKEEPPINHPVGCKRKLAMS
                     RCETCGTEEAKYRCPRCMRYSCSLPCVKKHKAELTCNGVRDKTAYISIQQFTEMNLLS
                     DYRFLEDVARTADHISRDAFLKRPISNKYMYFMKNRARRQGINLKLLPNGFTKRKENS
                     TFFDKKKQQFCWHVKLQFPQSQAEYIEKRVPDDKTINEILKPYIDPEKSDPVIRQRLK
                     AYIRSQTGVQILMKIEYMQQNLVRYYELDPYKSLLDNLRNKVIIEYPTLHVVLKGSNN
                     DMKVLHQVKSESTKNVGNEN"
     exon            806..871
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            872..978
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1064
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1168
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1237
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1318
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1396
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1521
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..6203
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="hexamer: AGTAAA"
     polyA_site      2812
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="major polyA site"
     regulatory      2892..2897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="hexamer: AATAAG"
     polyA_site      2911
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
     regulatory      4755..4760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="hexamer: AATAAA"
     polyA_site      4774
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
     regulatory      5013..5018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="hexamer: AATAAA"
     polyA_site      5035
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
     regulatory      6039..6044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="hexamer: ATTAAA"
     polyA_site      6072
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
     regulatory      6179..6184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
                     /note="hexamer: AATAAA"
     polyA_site      6203
                     /gene="ZNHIT6"
                     /gene_synonym="BCD1; C1orf181; NY-BR-75"
ORIGIN      
        1 agtcgcgtca agcaggctat tccgggtttg tggctgcttg gctccacacg tgggccgccg
       61 taggtattcc gaccggtaat tcctcctatt ggtgtgcagc agccacattg aaggatagag
      121 tggcagcaga ggccaaggat cgtgagttga tggagtttgc tgctgaaaat gaagggaagt
      181 ctgggggagg tctccacagc gtagctgagg gggtgcggct aagtccagag cctggcaggg
      241 agggagtaag ggacttagca ggggcggagg agttcggcgg cggagaggag gggacagggc
      301 tgacagggat aaaggagata ggggatggag aggaaggaag tggacaaagg ccagaggaaa
      361 taccgatgga cctaacggta gtgaagcagg aaattataga ctggccaggt acagaaggca
      421 ggttggctgg ccagtgggta gaacaggagg tggaggatag gcctgaggtg aaggatgaga
      481 acgcaggcgt attggaggtg aagcaggaga cggatagtag tttagtggta aaagaagcga
      541 aggtgggtga accagaggta aaggaagaga aggtaaagga agaggtaatg gactggtcag
      601 aagtgaagga agagaaggat aacttggaga taaaacagga ggagaagttt gttggtcaat
      661 gcataaaaga ggaattgatg catggagagt gtgtaaaaga agagaaggat ttcctgaaga
      721 aagaaatcgt ggatgataca aaggtgaaag aagagcctcc gataaatcac ccggtgggct
      781 gcaagcggaa actggccatg tcaaggtgtg agacttgtgg tacagaagaa gcaaagtaca
      841 gatgtccacg ttgtatgcga tattcctgca gtttgccctg tgtaaagaaa cacaaagcag
      901 aactgacatg taatggagtt cgagataaaa ctgcatacat ttcaatacaa cagtttactg
      961 aaatgaatct cctaagtgat tatcgatttt tggaagatgt ggcaagaaca gcggaccata
     1021 tttctagaga tgcttttttg aagagaccaa taagcaataa atatatgtac tttatgaaaa
     1081 atcgtgcccg gaggcaaggt attaacttaa aacttctacc caatggattc accaagagga
     1141 aggagaattc aacctttttt gataagaaaa aacaacagtt ttgttggcat gtgaagctcc
     1201 agtttcctca aagtcaagct gagtacatag aaaaaagagt accagatgat aaaactatta
     1261 atgaaatcct aaaaccttac attgatcctg aaaagtctga tcctgtaatt cgtcaaaggt
     1321 tgaaagccta cattcgctct cagactgggg ttcagatttt aatgaagatt gaatatatgc
     1381 agcaaaattt agtaagatat tatgaactag atccttataa aagtctccta gacaatttga
     1441 ggaacaaagt gatcattgag tatccaacat tacatgtggt attgaaagga tccaataatg
     1501 acatgaaagt tcttcaccaa gtgaagagtg aatctaccaa gaacgttggc aatgaaaatt
     1561 gagcattttt tctggaagaa gaaagtgaaa acttccagac aactgcagca gactctgcat
     1621 tgatgggctg ttggctgatt ggggtattgt caatgggtga ttggaatttt ttctttgtat
     1681 gaaaaataag cttaactctt ttaaaaaatg tattttataa cctcttgaat taattgactt
     1741 gtaagaccca tttattcata ttaagaactc tcctttgcac ttgatcagca tagtacttat
     1801 taggccctgg ctttttaata tgcttaattg cttaattcca taaactgaaa actttttttt
     1861 tcttttttct ttcttttttt gagatggggt cttggagtgc aagtggtatg agcatagctt
     1921 cctcaaattc ctgggctcga atggtcctct cactgcagcc tcccaacagg ctggtaccac
     1981 cacactcagc taagtttttt gttgttgttt ttttttggta gagacagggt tgcgctcttt
     2041 cgcccaggct ggtctcaaat ttgtggcctc aagcaatcct tccacctcag actccaaagc
     2101 attgggatta caggcatcag ccaccacacc tggccttgaa cattttttat ttgttaattt
     2161 catgcgtgac gaaacccaag gatcacccat gtcaaccaca aagttggcat tccctttagt
     2221 agaacctcac taaacggaaa ggctgtacaa cgcaccgtct agccacagga gaactaatct
     2281 tctatcagtt gccctttctt ctttggagtt tttatgtaac ttacccttgt gagacaagtt
     2341 ttctacttga gaaactccta gtacaatgtc ttatactaga agcctggata aatactatta
     2401 actactgttt cttatattca cttcagaaaa tcagtggctc cacattgttt gagccattag
     2461 tgataacaaa tttggatcta cttactcaag tcttatgaat tctgtgcctt tcatcacatt
     2521 cctagcccac tctcatcatt actgcagaag ggtgttgtga tgaccagttt tatactgtgt
     2581 tttgatatgt ctagcaataa cttaaagaaa aaaaaacctg ggaaatcttc aacatgttat
     2641 tggaacatat atgtatgtat taatgtatat acatggctta acttatacgt tatggcagct
     2701 ctgtatacag tttgatctca tgtactgaaa aaaaattctt aattttattg gagtttatac
     2761 cactgtgaaa ctgcaatatg actgtaagag agtaaaaaga ttgttacatc tatattgtat
     2821 gtgtgtactt aatggttaaa aagcaatgat aaaactggac attaatgaaa ttgattttta
     2881 gttacagttg gaataagttt tttaccaaaa agaaaccaga gacgttagtt aaggagactt
     2941 aaaaagatct gaaatatgaa aagagaatga gaagatgagc agaagataaa tttgtgggac
     3001 acaagtataa cttggggtag aaactggaga agagaatcga aaaacaataa tgccagaagg
     3061 acccttggta tgaaagtact aatggaatgt gattcataga aagttcatag aaagtgagtc
     3121 cttgcaactt gagaaacata catacatata tatttataat ctctaaagca acatcaggaa
     3181 tcttctaata tatgataaag aatttgtgta gaattacgtt gttcacagta ttattggaga
     3241 gacaaataag atttcaagga attcatttat aatcaaaagt gaaatgtgtc ttcttgaaac
     3301 cagcaagaaa tagatgaatt gagtgaaacg tgttgttatt aggagaagtg ggataacgta
     3361 tacaaaaaga acttgcgatc tgaatatgat ctgaatatga gggtggatag gaattttttg
     3421 acagtgaaat ctgttatgat gtagtctcat ttccaagaaa agtcttgagt tccatccccc
     3481 cttctgaatt taaattgaaa cctggacaga aaacaaacta tcctgtagtt tccactgctc
     3541 aggaggaaaa aaagaaatct atattatcta atgcatcttt gccatcttta ttttctagaa
     3601 ttctattaga cttttcaatt ataggctatt aggaaagaat ataactctta gaattcccct
     3661 aaatataatt atcaactcat ttgattaata tgcatatttt ttcccgtaag atttacaata
     3721 cacgtgtgtt ttagtgaatt accaatggct tggagagaat gaaattggaa taactaactg
     3781 aaaaccctag atgtttgtag cattgagacc caatatcttt ttggaggccc tctccatgtt
     3841 agcttattgt caaattctgg tgtgtaaaca aactccttga cccatgttaa gttcagcatc
     3901 ctgcattttg ttcatgaatc acattttaaa aggagaaaag ctccacctgg ttttctttat
     3961 ttttttaaac agtgatttca aagagaagat aggcctttca taattgctaa ttatacatat
     4021 aggattaata gtcataaatt atagtaaata aaacttgtac ctattccttt tataaatatg
     4081 aattggctag gcacagtggc tcacagctgt aatcccagca ctttgggagg ctgaggcggg
     4141 cagatcacaa ggtcaggtgt ttgagactag cctggccaac atggcaaaac cctgtgtcta
     4201 ctaaaaatac aaaaattagc caggcgtggt ggcaggcacc tgtaattcca gctactcagg
     4261 aagctggggc acgagaatca cttgaaccct ggtggcagag tttgcagtga gctgagattg
     4321 ttccactgca ttcctgggca ctgcctgggt gacagaatga gactctgcct caaaaaaaaa
     4381 aaaagttatt aaaaatagat atttaagatt ccaaaatgta gttgatccag tttgtttccc
     4441 tgtagcaagt agtgggattt gggtttcatg acatataatt aaaatgttaa tcacataact
     4501 ataatgccaa caattttctt tatacatttt tgtttaatta tgttgacata tactttgtgt
     4561 tgtaccttat ttcatgttac taaattttac ataaagatgc tggtctattt ttatttaatc
     4621 atatactgtt atggtttgaa tatagtttgt tcctaccaaa actcatgttg aaattagatt
     4681 ccccatgtgc tagtgttggg aggcagagcc taatggaagg tgtttgggtc atgggggcag
     4741 atagatccca catgaataaa ctaatgccct cctactgggg tgagtgagtt ctcattcttg
     4801 ctgtcgtggg aatggattag ttctcacaag caagggttac taaagagtct ggctttcttg
     4861 attttctcct ttttgcctcc tgccttccca tgtgatctct ttgcacatac ctactcccct
     4921 ttcactttgt accaagagtg gaagcaacat gagaccctca ccagatacag ctgcccaatc
     4981 ttgagccttc cagccaccag aatcatgagc caaataaaac tctttttaaa aataagttac
     5041 ccagtcttag atattctatt atagcgacac aaaatggact aagctgtact ctgttgcatt
     5101 aaaatgtgtt gtttatatgc aagtgacaaa aactcaaaat agtgtcagca tgaagggcag
     5161 ttcattggct tatatacagg gaagtccagg caatgactgg gtcctgggtc caaacgtcaa
     5221 aagcagtcat cttgccatcc tacacacttg gctctgatta ttttcttctt tatggattgg
     5281 ttttcttttc agattttccc tttggggata ttctgtatgg gatgaggaac agtgaggtga
     5341 gaggatggtg gataacagca attgacattt tcagcttacc ttagcataac aaggctgaaa
     5401 gcttttataa agcaagctat gtaaaatttt ggagaagtac ttttattttg cccagattgg
     5461 atcacattcc gttcctgagc taatcaagag aggaattcac ccaaaggagg gggaaatttt
     5521 tagaagaaag ccagaatgta gggagcaggt gaggaaaggt agttactggg aatacgaaag
     5581 taacacattc attgcaccct gtttgaattt gagtagcaag aagtttctga tttgtactaa
     5641 cagaaggagt aaagttcaga tttaatctgc aagtcttgat tgtttttaac tagagatttt
     5701 aatctcttct tcttattatt gctgctttga gttgccatta taggtttttg gatttttttt
     5761 ttaatgccat ccatttttat ttgacatcat gttgttgcta gtttgagcag atgcacatag
     5821 catatgtttc cattaccaat ttggaaattt ttcccagtgg catcagcatt tgagagatac
     5881 tgattttgaa attagagtac taggggaaaa tgcttcaaaa atgaagacta cttaaataaa
     5941 aattggcttt aaataaacct ttggggatct gtacttgact aaaaagtatt ttctttaaac
     6001 tttggtcttt gaaaactaaa gtgtgtgtgc atgtgttcat taaaatgacc tataacatga
     6061 acattttcca tactggagtg tgatgtactg tactcatttt gaactttaga accaaatgca
     6121 tcctttagca tttgatgagc tgctatataa ttctatttcc agttttattt tcttgccaaa
     6181 taaagtacca aagctcagcc tga
//
