LOCUS       NM_006349                728 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger HIT-type containing 1 (ZNHIT1), mRNA.
ACCESSION   NM_006349
VERSION     NM_006349.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 728)
  AUTHORS   Anantha,J., Wilson,F.E., McCarthy,E., Morales-Prieto,N.,
            Mazzocchi,M., Collins,L.M., Sullivan,A.M. and O'Keeffe,G.W.
  TITLE     A combined proteomics and bioinformatics analysis of
            ZNHIT1-interacting proteins reveals a significant enrichment in
            proteins associated with mitochondrial function
  JOURNAL   J Chem Neuroanat 131, 102288 (2023)
   PUBMED   37178741
  REMARK    GeneRIF: A combined proteomics and bioinformatics analysis of
            ZNHIT1-interacting proteins reveals a significant enrichment in
            proteins associated with mitochondrial function.
REFERENCE   2  (bases 1 to 728)
  AUTHORS   Wei,W., Tang,X., Jiang,N., Ni,C., He,H., Sun,S., Yu,M., Yu,C.,
            Qiu,M., Yan,D., Zhou,Z., Song,Y., Liu,H., Zhao,B. and Lin,X.
  TITLE     Chromatin remodeler Znhit1 controls bone morphogenetic protein
            signaling in embryonic lung tissue branching
  JOURNAL   J Biol Chem 298 (10), 102490 (2022)
   PUBMED   36115458
REFERENCE   3  (bases 1 to 728)
  AUTHORS   Ebeid,S.A., Abd El Moneim,N.A., El-Benhawy,S.A., Ramadan,R. and
            Ismail,S.E.
  TITLE     Znhit1 and HIF-2alpha are correlated with cancer stem cell markers
            in breast cancer patients
  JOURNAL   Sci Rep 12 (1), 13918 (2022)
   PUBMED   35978075
  REMARK    GeneRIF: Znhit1 and HIF-2alpha are correlated with cancer stem cell
            markers in breast cancer patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 728)
  AUTHORS   McCarthy,E., Barron,A., Morales-Prieto,N., Mazzocchi,M.,
            McCarthy,C.M., Collins,L.M., Sullivan,A.M. and O'Keeffe,G.W.
  TITLE     Gene Co-expression Analysis of the Human Substantia Nigra
            Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects
            Against alpha-Synuclein-Induced Impairments in Neurite Growth and
            Mitochondrial Dysfunction in SH-SY5Y Cells
  JOURNAL   Mol Neurobiol 59 (5), 2745-2757 (2022)
   PUBMED   35175558
  REMARK    GeneRIF: Gene Co-expression Analysis of the Human Substantia Nigra
            Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects
            Against alpha-Synuclein-Induced Impairments in Neurite Growth and
            Mitochondrial Dysfunction in SH-SY5Y Cells.
REFERENCE   5  (bases 1 to 728)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 728)
  AUTHORS   Cuadrado,A., Lafarga,V., Cheung,P.C., Dolado,I., Llanos,S.,
            Cohen,P. and Nebreda,A.R.
  TITLE     A new p38 MAP kinase-regulated transcriptional coactivator that
            stimulates p53-dependent apoptosis
  JOURNAL   EMBO J 26 (8), 2115-2126 (2007)
   PUBMED   17380123
  REMARK    GeneRIF: p18(Hamlet) is a new cell-fate regulator that links the
            p38 MAPK and p53 pathways and contributes to the establishment of
            p53-regulated stress responses.
REFERENCE   7  (bases 1 to 728)
  AUTHORS   Ruhl,D.D., Jin,J., Cai,Y., Swanson,S., Florens,L., Washburn,M.P.,
            Conaway,R.C., Conaway,J.W. and Chrivia,J.C.
  TITLE     Purification of a human SRCAP complex that remodels chromatin by
            incorporating the histone variant H2A.Z into nucleosomes
  JOURNAL   Biochemistry 45 (17), 5671-5677 (2006)
   PUBMED   16634648
REFERENCE   8  (bases 1 to 728)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   9  (bases 1 to 728)
  AUTHORS   Cai,Y., Jin,J., Florens,L., Swanson,S.K., Kusch,T., Li,B.,
            Workman,J.L., Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60
            histone acetyltransferase and SRCAP complexes
  JOURNAL   J Biol Chem 280 (14), 13665-13670 (2005)
   PUBMED   15647280
REFERENCE   10 (bases 1 to 728)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017333.2 and BC001877.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006349.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001877.1, BC017333.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305105.3/ ENSP00000304593.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               BC017333.2         462-1185
            725-728             BC001877.1         1065-1068
FEATURES             Location/Qualifiers
     source          1..728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..728
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /note="zinc finger HIT-type containing 1"
                     /db_xref="GeneID:10467"
                     /db_xref="HGNC:HGNC:21688"
                     /db_xref="MIM:618617"
     exon            1..53
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..496
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /note="putative cyclin G1 interacting protein; zinc
                     finger, HIT domain containing 1; H_DJ0747G18.14; zinc
                     finger, HIT type 1; zinc finger protein, subfamily 4A (HIT
                     domain containing), member 1; p18Hamlet; p18 Hamlet;
                     cyclin-G1-binding protein 1; zinc finger protein subfamily
                     4A member 1"
                     /codon_start=1
                     /product="zinc finger HIT domain-containing protein 1"
                     /protein_id="NP_006340.1"
                     /db_xref="CCDS:CCDS5716.1"
                     /db_xref="GeneID:10467"
                     /db_xref="HGNC:HGNC:21688"
                     /db_xref="MIM:618617"
                     /translation="MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDP
                     HAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYL
                     TACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV"
     exon            54..224
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..304
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..474
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..728
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      707..712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /note="hexamer: AATAAA"
     polyA_site      728
                     /gene="ZNHIT1"
                     /gene_synonym="CG1I; p18(Hamlet); ZNFN4A1"
                     /note="major polyA site"
ORIGIN      
        1 agcagtttct tccgacagtt gtgttgtgcc aatggtggag aagaaaactt cggttcgctc
       61 ccaggacccc gggcagcggc gggtgctgga ccgggctgcc cggcagcgtc gcatcaaccg
      121 gcagctggag gccctggaga atgacaactt ccaggatgac ccccacgcgg gactccctca
      181 gctcggcaag agactgcctc agtttgatga cgatgcggac actggaaaga aaaagaagaa
      241 aacccgaggt gatcatttta aacttcgctt ccgaaaaaac tttcaggccc tgttggagga
      301 gcagaacttg agtgtggccg agggccctaa ctacctgacg gcctgtgcgg gacccccatc
      361 gcggccccag cgccccttct gtgctgtctg tggcttccca tccccctaca cctgtgtcag
      421 ctgcggtgcc cggtactgca ctgtgcgctg tctggggacc caccaggaga ccaggtgtct
      481 gaagtggact gtgtgagcct gggcattccc agagaggaag ggccgctgtg cactgcccgg
      541 ccttcagaaa gacagaattt catcacccaa tgcaggggga gctcttcctg gaccaaggga
      601 ggagccgctc attcacccaa caaaactgtg tcttatctgc caggaaagac cagcctcact
      661 cctgggaact gtctggcagg taggctgggc cccccagtgc tgttagaata aaaagcctcg
      721 tgccggaa
//
