LOCUS       NM_001085457            1672 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Zn regulated GTPase metalloprotein activator 1F
            (ZNG1F), transcript variant 1, mRNA.
ACCESSION   NM_001085457 XM_001128684 XM_001128714 XM_001128727 XM_001128742
VERSION     NM_001085457.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX255923.13.
            
            On Sep 15, 2020 this sequence version replaced NM_001085457.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000377391.8/ ENSP00000366608.4
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               BX255923.13        15840-16052
            214-300             BX255923.13        19078-19164
            301-397             BX255923.13        21497-21593
            398-489             BX255923.13        22691-22782
            490-549             BX255923.13        30805-30864
            550-587             BX255923.13        32408-32445
            588-634             BX255923.13        38327-38373
            635-721             BX255923.13        40070-40156
            722-766             BX255923.13        42780-42824
            767-823             BX255923.13        48718-48774
            824-875             BX255923.13        59825-59876
            876-944             BX255923.13        71415-71483
            945-1010            BX255923.13        71587-71652
            1011-1140           BX255923.13        72800-72929
            1141-1672           BX255923.13        73317-73848
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p11.2"
     gene            1..1672
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /note="Zn regulated GTPase metalloprotein activator 1F"
                     /db_xref="GeneID:644019"
                     /db_xref="HGNC:HGNC:31978"
     exon            1..213
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1247
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /note="isoform 1 is encoded by transcript variant 1; COBW
                     domain-containing protein 6; cobalamin synthetase W
                     domain-containing protein 6; cobalamin synthase W
                     domain-containing protein 6; COBW domain containing 7;
                     putative COBW domain-containing protein 7; putative
                     cobalamin synthase W domain-containing protein 7; COBW
                     domain containing 6; zinc-regulated GTPase metalloprotein
                     activator 1F"
                     /codon_start=1
                     /product="zinc-regulated GTPase metalloprotein activator
                     1F isoform 1"
                     /protein_id="NP_001078926.1"
                     /db_xref="CCDS:CCDS43827.1"
                     /db_xref="GeneID:644019"
                     /db_xref="HGNC:HGNC:31978"
                     /translation="MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPV
                     TIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLE
                     LRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDI
                     YLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRT
                     TLRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVT
                     ITFDVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGV
                     HELCDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQ
                     VCT"
     exon            214..300
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            301..397
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            398..489
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            490..549
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            550..587
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            588..634
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            635..721
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            722..766
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            767..823
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            824..875
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            876..944
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1010
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1140
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1672
                     /gene="ZNG1F"
                     /gene_synonym="CBWD6; CBWD7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtacggc gtgttggtcc cagcggttca gctgaggtag ggacgtgctg taggccggaa
       61 tgttaccggc tgttggatct gtggatgagg aagaggatcc tgcggaggag gattgtcctg
      121 aattggttcc cattgagacg acgcaaagcg aggaggagga aaagtctggc ctcggcgcca
      181 agatcccagt cacaattatc accgggtatt taggtgctgg gaagacaaca cttctgaact
      241 atattttgac agagcaacat agtaaaagag tagcggtcat tttaaatgaa tctggggaag
      301 gaagtgcgct ggagaaatcc ttagctgtca gccaaggtgg agagctctat gaagagtggc
      361 tggaacttag aaacggttgc ctctgctgtt cagtgaagga caatggcctt agagctattg
      421 agaatttgat gcaaaagaag gggaaatttg atgacatact gttagagacc actggattag
      481 cagaccctgg tgcagtggct tctatgtttt gggttgatgc cgaattaggg agtgatattt
      541 accttgatgg tatcataact attgtggatt caaaatatgg attaaaacat ttaacagaag
      601 agaaacctga tggccttatc aatgaagcta ctaggcaagt tgctttggca gatatcattc
      661 tcattaataa aacagacttg gtcccagaag aagatgtaaa gaaattaaga acgacactta
      721 gatccataaa tggactagga caaatcttag aaacacaaag atcaagagtt gatctctcta
      781 atgtattaga tcttcatgcc tttgatagtc tctctggaat aagtttgcag aaaaaacttc
      841 agcatgtgcc aggaacacaa cctcaccttg atcagagtat tgttacaatc acatttgacg
      901 taccaggaaa tgcaaaggaa gaacatctta atatgtttat tcagaatctt ctgtgggaaa
      961 agaatgtgag aaacaaggac aatcactgca tggaggtcat aaggctgaag ggattggtgt
     1021 caatcaaaga caaatcacaa caagtgattg tccagggtgt ccatgagctc tgtgatctgg
     1081 aggagactcc agtgagctgg aaggatgaca ctgagagaac aaatcgattg gtcctcattg
     1141 gcagaaattt agataaggat atccttaaac agctgtttat agctactgtg acagaaacag
     1201 aaaagcagtg gacaacacat ttcaaagaag atcaagtttg tacataacac tagaggcatt
     1261 tcttatcaaa aggattggat aataaaaata agtttctact gggtatattt caagcattta
     1321 tttattactt tagttacgaa ttccaatata ctttaaaatg gtatttgttt tacagcatac
     1381 ataaaatgta gcaaatcagt actgtaaaac atttaacatt catacaatta tatacaatat
     1441 cctttttttt aaagaatggt atttcacaaa aatatctttt gaaattggct ttggagttta
     1501 catatactga acatgaaagt ttataataat gatgatacaa ctttcaacat tgtcattttt
     1561 tcttagaact tcagctgatt gcagagatat aatgattaca ttgttattaa atttttttaa
     1621 cacaagtaag tgtcaccatt ttatgacatg aaataaaagg ttatgactgt ta
//
