LOCUS       NM_001330668            1662 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Zn regulated GTPase metalloprotein activator 1E
            (ZNG1E), transcript variant 5, mRNA.
ACCESSION   NM_001330668 XM_005272748
VERSION     NM_001330668.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
REFERENCE   2  (bases 1 to 1662)
  AUTHORS   Fan,Y., Newman,T., Linardopoulou,E. and Trask,B.J.
  TITLE     Gene content and function of the ancestral chromosome fusion site
            in human chromosome 2q13-2q14.1 and paralogous regions
  JOURNAL   Genome Res 12 (11), 1663-1672 (2002)
   PUBMED   12421752
REFERENCE   3  (bases 1 to 1662)
  AUTHORS   Page,N., Butlin,D., Manyonda,I. and Lowry,P.
  TITLE     The development of a genetic profile of placental gene expression
            during the first trimester of pregnancy: a potential tool for
            identifying novel secreted markers
  JOURNAL   Fetal Diagn Ther 15 (4), 237-245 (2000)
   PUBMED   10867487
REFERENCE   4  (bases 1 to 1662)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX284632.11.
            
            On Nov 18, 2020 this sequence version replaced NM_001330668.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.197070.1,
                                           SRR3476690.1083403.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382405.8/ ENSP00000371842.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               BX284632.11        171186-171388       c
            204-290             BX284632.11        168064-168150       c
            291-387             BX284632.11        165646-165742       c
            388-479             BX284632.11        164459-164550       c
            480-539             BX284632.11        156290-156349       c
            540-577             BX284632.11        154708-154745       c
            578-624             BX284632.11        148755-148801       c
            625-711             BX284632.11        146979-147065       c
            712-756             BX284632.11        144302-144346       c
            757-813             BX284632.11        138358-138414       c
            814-865             BX284632.11        127224-127275       c
            866-934             BX284632.11        115618-115686       c
            935-1000            BX284632.11        115449-115514       c
            1001-1130           BX284632.11        114194-114323       c
            1131-1662           BX284632.11        113275-113806       c
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..1662
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /note="Zn regulated GTPase metalloprotein activator 1E"
                     /db_xref="GeneID:220869"
                     /db_xref="HGNC:HGNC:24584"
     exon            1..203
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1237
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /note="isoform d is encoded by transcript variant 5;
                     dopamine responsive protein; COBW domain-containing
                     protein 5; COBW-like placental protein; cobalamin
                     synthetase W domain-containing protein 5; cobalamin
                     synthase W domain-containing protein 5; COBW
                     domain-containing protein 3; Cobalamin synthase W
                     domain-containing protein 3; COBW domain containing 5;
                     zinc-regulated GTPase metalloprotein activator 1E"
                     /codon_start=1
                     /product="zinc-regulated GTPase metalloprotein activator
                     1E isoform d"
                     /protein_id="NP_001317597.1"
                     /db_xref="CCDS:CCDS83367.1"
                     /db_xref="GeneID:220869"
                     /db_xref="HGNC:HGNC:24584"
                     /translation="MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPV
                     TIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLE
                     LRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVTSMFWVDAELGSDI
                     YLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRT
                     TIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVT
                     ITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGV
                     HELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQ
                     VCT"
     exon            204..290
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            291..387
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            388..479
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            480..539
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            540..577
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            578..624
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            625..711
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            712..756
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            757..813
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            814..865
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            866..934
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1000
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1130
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1662
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1271..1276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /note="hexamer: AATAAA"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /note="hexamer: AATAAG"
     polyA_site      1295
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
                     /note="major polyA site"
     polyA_site      1303
                     /gene="ZNG1E"
                     /gene_synonym="CBWD3; CBWD5; DC36"
ORIGIN      
        1 gtgttggtcc cagcggttca gctgaggtag ggacgtgccg taggccggaa tgttaccggc
       61 tgttggatct gtggatgagg aagaggatcc tgcggaggag gattgtcctg aattggttcc
      121 cattgagacg acgcaaagcg aggaggagga aaagtctggc ctcggcgcca agatcccagt
      181 cacaattatc accgggtatt taggtgctgg gaagacaaca cttctgaact atattttgac
      241 agagcaacat agtaaaagag tagcggtcat tttaaatgaa tctggggaag gaagtgcgct
      301 ggagaaatcc ttagctgtca gccaaggtgg agagctctat gaagagtggc tggaacttag
      361 aaacggttgc ctctgctgtt cagtgaagga caatggcctt agagctattg agaatttgat
      421 gcaaaagaag gggaaatttg atgacatact gttagagacc actggattag cagaccctgg
      481 tgcagtgact tctatgtttt gggttgatgc tgaattaggg agtgatattt accttgatgg
      541 tatcataact attgtggatt caaaatatgg attaaaacat ttaacagaag agaaacctga
      601 tggccttatc aatgaagcta ctaggcaagt tgctttggca gatatcattc tcattaataa
      661 aacagacttg gttccagaag aagatgtaaa gaaattaaga acgacaatta gatccataaa
      721 tggactagga caaatcttag aaacacaaag atcaagagtt gatctctcta atgtattaga
      781 tcttcatgcc tttgatagtc tctctggaat aagtttgcag aaaaaacttc agcatgtgcc
      841 aggaacacaa cctcaccttg atcagagtat tgttacaatc acatttgaag taccaggaaa
      901 tgcaaaggaa gaacatctta atatgtttat tcagaatctc ctgtgggaaa agaatgtgag
      961 aaacaaggac aatcactgca tggaggtcat aaggctgaag ggattggtgt caatcaaaga
     1021 caaatcacaa caagtgattg tccagggtgt ccatgagctc tatgatctgg aggagactcc
     1081 agtgagctgg aaggatgaca ctgagagaac aaatcgattg gtcctcattg gcagaaattt
     1141 agataaggat atccttaaac agctgtttat agctactgtg acagaaacag aaaagcagtg
     1201 gacaacacat ttcaaagaag atcaagtttg tacataacac tagtggcatt tcttatcaaa
     1261 aggattggat aataaaaata agtttctact gggtatattt caagcattta tttattactt
     1321 tagttacgaa ttccaatata ctttaaaatg gtatttgttt tacagcatac ataaaatgta
     1381 gcaaatcagt actgtaaaac atttaacatt catacaatta tatataatat cctttttttt
     1441 aaagaatggt atttcacaaa aatatctttt gaaattggct ttggagttta catatactga
     1501 acatgaaagt ttataataat gatgatacaa ctttcaacat cgtcattttt tcttagaact
     1561 tcagctgatt gcagagatat aatgattaca ttgttattaa atttttttaa cacaagtaag
     1621 tgtcaccatt ttatgacatg aaataaaagg ttatgactgt ta
//
