LOCUS       NM_201453               1685 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Zn regulated GTPase metalloprotein activator 1C
            (ZNG1C), transcript variant 1, mRNA.
ACCESSION   NM_201453
VERSION     NM_201453.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Wong,A., Vallender,E.J., Heretis,K., Ilkin,Y., Lahn,B.T.,
            Martin,C.L. and Ledbetter,D.H.
  TITLE     Diverse fates of paralogs following segmental duplication of
            telomeric genes
  JOURNAL   Genomics 84 (2), 239-247 (2004)
   PUBMED   15233989
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Fan,Y., Newman,T., Linardopoulou,E. and Trask,B.J.
  TITLE     Gene content and function of the ancestral chromosome fusion site
            in human chromosome 2q13-2q14.1 and paralogous regions
  JOURNAL   Genome Res 12 (11), 1663-1672 (2002)
   PUBMED   12421752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353608.20 and FQ976557.1.
            
            On Jan 29, 2020 this sequence version replaced NM_201453.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY344633.1, SRR14038195.2121384.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360171.11/ ENSP00000353295.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AL353608.20        21431-21633
            204-290             AL353608.20        24661-24747
            291-387             AL353608.20        27061-27157
            388-479             AL353608.20        28254-28345
            480-539             FQ976557.1         162-221
            540-577             AL353608.20        37980-38017
            578-624             AL353608.20        43916-43962
            625-711             AL353608.20        45668-45754
            712-756             AL353608.20        48382-48426
            757-813             AL353608.20        54330-54386
            814-865             AL353608.20        65437-65488
            866-934             AL353608.20        77028-77096
            935-1000            AL353608.20        77200-77265
            1001-1130           AL353608.20        78412-78541
            1131-1685           AL353608.20        78929-79483
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..1685
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /note="Zn regulated GTPase metalloprotein activator 1C"
                     /db_xref="GeneID:445571"
                     /db_xref="HGNC:HGNC:18519"
                     /db_xref="MIM:611080"
     exon            1..203
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1237
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cobalamin synthetase W domain-containing protein 3;
                     cobalamin synthase W domain-containing protein 3; COBW
                     domain containing 3; zinc-regulated GTPase metalloprotein
                     activator 1C"
                     /codon_start=1
                     /product="zinc-regulated GTPase metalloprotein activator
                     1C isoform 1"
                     /protein_id="NP_958861.2"
                     /db_xref="CCDS:CCDS35038.2"
                     /db_xref="GeneID:445571"
                     /db_xref="HGNC:HGNC:18519"
                     /db_xref="MIM:611080"
                     /translation="MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPV
                     TIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLE
                     LRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDI
                     YLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRT
                     TIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVT
                     ITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGV
                     HELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQ
                     VCT"
     exon            204..290
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            291..387
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..479
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..539
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            540..577
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..624
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..711
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..756
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..813
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..865
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..934
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1000
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1130
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1685
                     /gene="ZNG1C"
                     /gene_synonym="bA561O23.1; CBWD3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttggtcc cagcggttca gctgaggtag ggacgtgctg taggccggaa tgttaccggc
       61 tgttggatct gtggatgagg aagaggatcc tgcggaggag gattgtcctg aattggttcc
      121 cattgagacg acgcaaagcg aggaggagga aaagtctggc ctcggcgcca agatcccagt
      181 cacaattatc accgggtatt taggtgctgg gaagacaaca cttctgaact atattttgac
      241 agagcaacat agtaaaagag tagcggtcat tttaaatgaa tctggggaag gaagtgcgct
      301 ggagaaatcc ttagctgtca gccaaggtgg agagctctat gaagagtggc tggaacttag
      361 aaacggttgc ctctgctgtt cagtgaagga caatggcctt agagctattg agaatttgat
      421 gcaaaagaag gggaaatttg atgacatact gttagagacc actggattag cagaccctgg
      481 tgcagtggct tctatgtttt gggttgatgc tgaattaggg agtgatattt accttgatgg
      541 tatcataact attgtggatt caaaatatgg attaaaacat ttaacagaag agaaacctga
      601 tggccttatc aatgaagcta ctaggcaagt tgctttggca gatatcattc tcattaataa
      661 aacagacttg gttccagaag aagatgtaaa gaaattaaga acgacaatta gatccataaa
      721 tggactagga caaatcttag aaacacaaag atcaagagtt gatctctcta atgtattaga
      781 tcttcatgcc tttgatagtc tctctggaat aagtttgcag aaaaaacttc agcatgtgcc
      841 aggaacacaa cctcaccttg atcagagtat tgttacaatc acatttgaag taccaggaaa
      901 tgcaaaggaa gaacatctta atatgtttat tcagaatctt ctgtgggaaa agaatgtgag
      961 aaacaaggac aatcactgca tggaggtcat aaggctgaag ggattggtgt caatcaaaga
     1021 caaatcacaa caagtgattg tccagggtgt ccatgagctc tatgatctgg aggagactcc
     1081 agtgagctgg aaggatgaca ctgagagaac aaatcgattg gtcctcattg gcagaaattt
     1141 agataaggat atccttaaac agctgtttat agctactgtg acagaaacag aaaagcagtg
     1201 gacaacacat ttcaaagaag atcaagtttg tacataacac tagaggcatt tcttatcaaa
     1261 aggattggat aataaaaata agtttctact gggtatattt caagcattta tttattactt
     1321 tagttacgaa ttccaatata ctttaaaatg gtatttgttt tacagcatac ataaaatgta
     1381 gcaaatcagt actgtaaaac atttaacatt catacaatta tatataatat cctttttttt
     1441 aaagaatggt atttcacaaa aatatctttt gaaattggct ttggagttta catatactga
     1501 acatgaaagt ttataataat gatgatacaa ctttcaacat tgtcattttt tcttagaact
     1561 tcagctgatt gcagagatat aatgattaca ttgttattaa atttttttaa cacaagtaag
     1621 tgtcaccatt ttatgacatg aaataaaagg ttatgactgt tattgatgtt gatgttgacg
     1681 acctg
//
