LOCUS       NM_172003               1827 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens Zn regulated GTPase metalloprotein activator 1B
            (ZNG1B), transcript variant 1, mRNA.
ACCESSION   NM_172003 XM_001716392
VERSION     NM_172003.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290072.1 and DA296279.1.
            
            On May 9, 2009 this sequence version replaced NM_172003.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290072.1, SRR1660807.22225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259199.9/ ENSP00000259199.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1501              AK290072.1         1-1501
            1502-1827           DA296279.1         241-566
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..1827
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /note="Zn regulated GTPase metalloprotein activator 1B"
                     /db_xref="GeneID:150472"
                     /db_xref="HGNC:HGNC:17907"
                     /db_xref="MIM:611079"
     exon            1..332
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1366
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /note="isoform 1 is encoded by transcript variant 1; COBW
                     domain-containing protein 2; cobalamin synthetase W
                     domain-containing protein 2; cobalamin synthase W
                     domain-containing protein 2; COBW domain containing 2;
                     zinc-regulated GTPase metalloprotein activator 1B"
                     /codon_start=1
                     /product="zinc-regulated GTPase metalloprotein activator
                     1B isoform 1"
                     /protein_id="NP_742000.1"
                     /db_xref="CCDS:CCDS2116.1"
                     /db_xref="GeneID:150472"
                     /db_xref="HGNC:HGNC:17907"
                     /db_xref="MIM:611079"
                     /translation="MLPAVGSADEEEDPAEEDCPELVPMETTQSEEEEKSGLGAKIPV
                     TIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLE
                     LRNGCLCCSVKDNGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDI
                     YLDGIITIVDSKYGLKHLAEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRA
                     TIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVT
                     ITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGV
                     HELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTHFKEDQ
                     VCT"
     exon            333..419
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..516
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..608
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..668
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..706
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..753
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..840
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..885
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..942
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..994
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1063
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1129
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1259
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1827
                     /gene="ZNG1B"
                     /gene_synonym="CBWD2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagggacgag gcgcttctcg tccagagccc aggtaatccg ggcgggatca gcgagcgtcg
       61 cgatgtgatg acgtcaggcc ccgggcaggc cgggagtggc gtgctgggcg tgcgcggctg
      121 cggtacggcg tgttggtccc agcggttcag ctgaggtagg gacgtgctgt aggccggaat
      181 gttaccggct gttggatctg cggatgagga ggaggatcct gcggaggagg attgtcctga
      241 attggttccc atggagacga cgcaaagcga ggaggaggaa aagtctggcc tcggcgccaa
      301 gatcccagtc acaattatca ccgggtattt aggtgctggg aagacaacac ttctgaacta
      361 tattttgaca gagcaacata gtaaaagagt agcggtcatt ttaaatgaat ttggggaagg
      421 aagtgcgctg gagaaatcct tagctgtcag ccaaggtgga gagctctatg aagagtggct
      481 ggaacttaga aacggttgcc tctgctgttc agtgaaggac aatggcctta gagctattga
      541 gaatttgatg caaaagaagg ggaaatttga ttacatactg ttagagacca ctggattggc
      601 agacccaggt gcagtggctt ctatgttttg ggttgatgct gaattaggga gtgatattta
      661 ccttgatggt atcataacta tagtggattc aaaatatgga ttaaaacatt tagcagaaga
      721 gaaacctgat ggccttatca atgaagctac taggcaagtt gctttggcag atgccattct
      781 cattaataaa acagacttgg ttccagaaga agatgtaaag aaattaagag cgacaattag
      841 atccataaat ggactaggac aaatcttaga aacacaaaga tcaagagttg atctctctaa
      901 tgtattagat cttcatgcct ttgatagtct ctctggaata agtttgcaga aaaaacttca
      961 gcatgtgcca ggaacacaac ctcaccttga tcagagtatt gttacaatca catttgaagt
     1021 accaggaaat gcaaaggaag aacatcttaa tatgtttatt cagaatctcc tgtgggaaaa
     1081 gaatgtgaga aacaaggaca atcactgcat ggaggtcata aggctgaagg gattggtgtc
     1141 aatcaaagac aaatcacaac aagtgattgt ccagggtgtc catgagctct atgatctgga
     1201 ggagactcca gtgagctgga aggatgacac tgagagaaca aatcgattgg tcctccttgg
     1261 cagaaattta gataaggata tccttaaaca gctgtttata gctactgtga cagaaacaga
     1321 aaagcagtgg acaacacatt tcaaagaaga tcaagtttgt acataacact agaggcattt
     1381 cttatcaaaa ggattggata ataaaaataa gtttctactg ggtatatttc aagcatttat
     1441 ttattacttt agttacgaat tccaatatac tttaaaatgg tatttgtttt acagcataca
     1501 taaaatgtag caaatcggta ctgtaaaaca tttaacattc atacagttat atataatatc
     1561 ctttttttta aagaatggta tttcacaaaa atgtcttttg aaattggctt tggagtttac
     1621 atatactgaa catgaaagtt tataataatg atgatacaac tttcaacatt gtcatttttt
     1681 cttagaactt cagctgattg cagagatata atgattacat tgttattaaa tttttttaac
     1741 acaagtaagt gtcaccattt tatgacatga aataaaaggt tatgactgtt attgatgttg
     1801 atgttgacga cctgatcacc tggctga
//
