LOCUS       NM_031218               2763 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 93 (ZNF93), mRNA.
ACCESSION   NM_031218
VERSION     NM_031218.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2763)
  AUTHORS   Jacobs,F.M., Greenberg,D., Nguyen,N., Haeussler,M., Ewing,A.D.,
            Katzman,S., Paten,B., Salama,S.R. and Haussler,D.
  TITLE     An evolutionary arms race between KRAB zinc-finger genes ZNF91/93
            and SVA/L1 retrotransposons
  JOURNAL   Nature 516 (7530), 242-245 (2014)
   PUBMED   25274305
REFERENCE   2  (bases 1 to 2763)
  AUTHORS   Duan,Z., Choy,E., Harmon,D., Yang,C., Ryu,K., Schwab,J., Mankin,H.
            and Hornicek,F.J.
  TITLE     ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and
            PM00104 (Zalypsis) in human cancer cell lines
  JOURNAL   PLoS One 4 (9), e6967 (2009)
   PUBMED   19742314
  REMARK    GeneRIF: zinc finger proteins, and ZNF93 in particular, are
            involved in resistance to ET-743 and PM00104
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2763)
  AUTHORS   Caporaso,N., Gu,F., Chatterjee,N., Sheng-Chih,J., Yu,K., Yeager,M.,
            Chen,C., Jacobs,K., Wheeler,W., Landi,M.T., Ziegler,R.G.,
            Hunter,D.J., Chanock,S., Hankinson,S., Kraft,P. and Bergen,A.W.
  TITLE     Genome-wide and candidate gene association study of cigarette
            smoking behaviors
  JOURNAL   PLoS One 4 (2), e4653 (2009)
   PUBMED   19247474
REFERENCE   4  (bases 1 to 2763)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 2763)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   6  (bases 1 to 2763)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
REFERENCE   7  (bases 1 to 2763)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070372.1, BC136718.1 and AC007204.1.
            
            On May 17, 2019 this sequence version replaced NM_031218.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.248446.1,
                                           SRR1660803.100552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343769.6/ ENSP00000342002.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               BC070372.1         1-115
            116-2105            BC136718.1         1-1990
            2106-2763           AC007204.1         42547-43204
FEATURES             Location/Qualifiers
     source          1..2763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2763
                     /gene="ZNF93"
                     /gene_synonym="HPF34; HTF34; TF34; ZNF505"
                     /note="zinc finger protein 93"
                     /db_xref="GeneID:81931"
                     /db_xref="HGNC:HGNC:13169"
                     /db_xref="MIM:603975"
     exon            1..146
                     /gene="ZNF93"
                     /gene_synonym="HPF34; HTF34; TF34; ZNF505"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2006
                     /gene="ZNF93"
                     /gene_synonym="HPF34; HTF34; TF34; ZNF505"
                     /note="zinc finger protein 505; zinc finger protein HTF34"
                     /codon_start=1
                     /product="zinc finger protein 93"
                     /protein_id="NP_112495.2"
                     /db_xref="CCDS:CCDS32973.1"
                     /db_xref="GeneID:81931"
                     /db_xref="HGNC:HGNC:13169"
                     /db_xref="MIM:603975"
                     /translation="MGPLQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG
                     IVVSKPDLIAHLEQGKKPLTMKRHEMVANPSVICSHFAQDLWPEQNIKDSFQKVILRR
                     YEKRGHGNLQLIKRCESVDECKVHTGGYNGLNQCSTTTQSKVFQCDKYGKVFHKFSNS
                     NRHNIRHTEKKPFKCIECGKAFNQFSTLITHKKIHTGEKPYICEECGKAFKYSSALNT
                     HKRIHTGEKPYKCDKCDKAFIASSTLSKHEIIHTGKKPYKCEECGKAFNQSSTLTKHK
                     KIHTGEKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYVCEECGKAFKYSRILTTHKRI
                     HTGEKPYKCNKCGKAFIASSTLSRHEFIHMGKKHYKCEECGKAFIWSSVLTRHKRVHT
                     GEKPYKCEECGKAFKYSSTLSSHKRSHTGEKPYKCEECGKAFVASSTLSKHEIIHTGK
                     KPYKCEECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFNQSSSLTKHKKIHTGEKP
                     YKCEECGKAFNQSSTLIKHKKIHTREKPYKCEECGKAFHLSTHLTTHKILHTGEKPYR
                     CRECGKAFNHSATLSSHKKIHSGEKPYECDKCGKAFISPSSLSRHEIIHTGEKP"
     exon            147..273
                     /gene="ZNF93"
                     /gene_synonym="HPF34; HTF34; TF34; ZNF505"
                     /inference="alignment:Splign:2.1.0"
     exon            274..369
                     /gene="ZNF93"
                     /gene_synonym="HPF34; HTF34; TF34; ZNF505"
                     /inference="alignment:Splign:2.1.0"
     exon            370..2763
                     /gene="ZNF93"
                     /gene_synonym="HPF34; HTF34; TF34; ZNF505"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctctcggt gcagccggag ctccaggtct cctcttcact actctgtgtc ctgtgctcct
       61 acaggcccag cctctgtggc cctgtgacct gcaggtattg ggagatccac agctaagaca
      121 ccaggacccc tggaagccta gaaatgggac cattgcaatt tagagatgtg gccatagaat
      181 tctctctgga ggagtggcat tgcctggaca ctgcacagcg gaatctatat aggaatgtga
      241 tgttagagaa ctacagtaac ctggtcttcc ttggtattgt tgtctctaag ccagacctga
      301 tcgcccatct ggagcaagga aaaaaacctt tgactatgaa gagacatgag atggtagcca
      361 acccctcagt tatatgttct cattttgccc aagatctttg gccagagcag aacataaaag
      421 attctttcca aaaagtgata ctgagaagat atgaaaaacg tggacatgga aatttacagt
      481 taataaaaag gtgtgaaagt gtagatgagt gtaaggtgca cacaggaggt tataatggac
      541 ttaaccagtg tagtacaact acccagagca aagtatttca atgtgataaa tatgggaaag
      601 tctttcataa attttcaaat tcaaatagac ataatataag acatactgaa aaaaaacctt
      661 tcaaatgcat agaatgtggc aaagctttta accagttctc aacccttata acacataaga
      721 aaattcatac tggagagaaa ccctacattt gtgaagaatg tggcaaagcc tttaagtact
      781 cctctgccct taatacacat aagagaattc atactggaga gaaaccatac aagtgtgata
      841 aatgtgacaa agcctttatt gcatcctcaa cccttagtaa acatgagatc attcatactg
      901 gaaagaaacc ctacaagtgt gaagaatgtg gcaaagcttt taaccaatcc tcgacactta
      961 ctaaacataa gaaaattcat actggagaga aaccctacaa atgtgaagaa tgtggcaaag
     1021 cttttaacca atcctcaaca cttactaaac ataagaaaat tcatactgga gagaagccct
     1081 acgtttgtga agaatgtggc aaagccttta agtactcccg tatccttact acacataaga
     1141 gaattcatac tggagagaaa ccatacaagt gtaataaatg tggcaaagcc tttattgcat
     1201 cctcaaccct tagtagacat gagttcattc atatgggaaa gaaacattac aaatgtgaag
     1261 aatgtggcaa agccttcatt tggtcctcag tcctaactag acataagaga gttcatactg
     1321 gagagaagcc ctacaaatgt gaagaatgtg gcaaagcctt taagtactcc tctaccctta
     1381 gttcacataa gagaagtcat actggagaga aaccctacaa atgtgaagaa tgtggcaaag
     1441 cctttgttgc atcctcaacc cttagtaaac atgagatcat tcatactgga aagaaaccct
     1501 acaagtgtga agaatgtggc aaagctttta accagtcctc atcccttact aaacataaga
     1561 aaattcatac tggagagaaa ccctacaaat gtgaagaatg tggcaaagct tttaaccagt
     1621 cctcttccct tactaaacat aagaaaattc atactggaga gaaaccctac aaatgtgaag
     1681 aatgtggcaa agcttttaac cagtcctcaa cccttattaa acataagaaa attcatacta
     1741 gagagaaacc ctacaaatgt gaagaatgtg gcaaagcttt tcacctatcc acacacctta
     1801 ctacacataa gatacttcat actggagaga aaccttatag atgtagagaa tgtggcaaag
     1861 cttttaacca ttctgcaacc ctttcttcac ataagaaaat ccattctgga gagaaaccat
     1921 acgagtgtga taaatgtggc aaagccttta tttcaccctc aagccttagt agacatgaga
     1981 taattcatac tggggagaaa ccctagaagt gtgaagaatg tggcaaagcc ttcaagtggt
     2041 cctcacacct tactatacac tgagagttct gaacttactc tgtaaccatc ccaaactcct
     2101 cccaggcaca gtctggcaga ggtcctgcca tttcggagac ctggaggaag tggcccattt
     2161 acagccatgt aggcaggcct gcagaccttg gcctttacta cggtacctga agtggttcaa
     2221 tgactcagtt tcagttacct gagccacagc ttaaggtcag ttctgcctat atagaaaccc
     2281 acacagttaa cctgaggaaa tgctctctgg tactcactga aagccacact catccacatc
     2341 ctgatacaag gcccaccata tgcagacctg actgccaaaa catgccctag tgtctgccgt
     2401 acagagtgaa gtcctgaagg atatttagtc tgtccaaaac taaaatgaag atttcaactc
     2461 cccaaccccc tctaacaagc cagctaaagg tggactatag tgcagaccca gcaaccttgt
     2521 gaccaggcta aaacccctca tcactacaaa ttcagagggc atctcatcac cctaagggcc
     2581 caacgaaaga tctttacctt ctaacatcag tttatgaaaa cttgaaaagg tgtttgctcc
     2641 atcaaattca gacaccagta caaaactata ttatgcccat tgtctggttc tattttaatg
     2701 tagcactgga agtgtgtggc agaagaatta gtcaaagaaa taaaaatagc cattgaaatt
     2761 gaa
//
