LOCUS       NM_152626               3165 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 92 (ZNF92), transcript variant 2,
            mRNA.
ACCESSION   NM_152626
VERSION     NM_152626.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3165)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3165)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3165)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3165)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3165)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3165)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3165)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
REFERENCE   8  (bases 1 to 3165)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP284170.1, BC040594.1, BX647875.1, DB342562.1, T52873.1 and
            AC092685.2.
            
            On Jun 2, 2019 this sequence version replaced NM_152626.3.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU668348.1, SRR1660809.248445.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328747.12/ ENSP00000332595.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BP284170.1         57-58
            3-2996              BC040594.1         1-2994
            2997-3114           BX647875.1         2774-2891
            3115-3157           DB342562.1         7-49                c
            3158-3164           T52873.1           1-7                 c
            3165-3165           AC092685.2         171003-171003
FEATURES             Location/Qualifiers
     source          1..3165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..3165
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /note="zinc finger protein 92"
                     /db_xref="GeneID:168374"
                     /db_xref="HGNC:HGNC:13168"
                     /db_xref="MIM:603974"
     exon            1..146
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1904
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein HTF12; epididymis luminal protein 203"
                     /codon_start=1
                     /product="zinc finger protein 92 isoform 2"
                     /protein_id="NP_689839.1"
                     /db_xref="CCDS:CCDS34646.1"
                     /db_xref="GeneID:168374"
                     /db_xref="HGNC:HGNC:13168"
                     /db_xref="MIM:603974"
                     /translation="MGPLTFRDVKIEFSLEEWQCLDTAQRNLYRDVMLENYRNLVFLG
                     IAVSKPDLITWLEQGKEPWNLKRHEMVDKTPVMCSHFAQDVWPEHSIKDSFQKVILRT
                     YGKYGHENLQLRKDHKSVDACKVYKGGYNGLNQCLTTTDSKIFQCDKYVKVFHKFPNV
                     NRNKIRHTGKKPFKCKNRGKSFCMLSQLTQHKKIHTREYSYKCEECGKAFNWSSTLTK
                     HKIIHTGEKPYKCEECGKAFNRSSNLTKHKIIHTGEKPYKCEECGKAFNRSSTLTKHK
                     RIHTEEKPYKCEECGKAFNQFSILNKHKRIHMEDKPYKCEECGKAFRVFSILKKHKII
                     HTGEKPYKCEECGKAFNQFSNLTKHKIIHTGEKPYKCDECGKAFNQSSTLTKHKRIHT
                     GEKPYKCEECGKAFKQSSTLTEHKIIHTGEKPYKCEKCGKAFSWSSAFTKHKRNHMED
                     KPYKCEECGKAFSVFSTLTKHKIIHTREKPYKCEECGKAFNQSSIFTKHKIIHTEGKS
                     YKCEKCGNAFNQSSNLTARKIIYTGEKPYKYEECDKAFNKFSTLITHQIIYTGEKPCK
                     HECGRAFNKSSNYTKEKLQT"
     exon            147..273
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /inference="alignment:Splign:2.1.0"
     exon            274..369
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /inference="alignment:Splign:2.1.0"
     exon            370..3165
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /note="hexamer: AATAAA"
     polyA_site      3110
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /note="major polyA site"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
                     /note="hexamer: ATTAAA"
     polyA_site      3165
                     /gene="ZNF92"
                     /gene_synonym="HEL-203; HPF12; HTF12; TF12"
ORIGIN      
        1 gtctctcgct gcagccggcg ctccacgtct agtcttcact gctctgcgtc ctgtgctgat
       61 aaaggctcgc cgctgtgacc ctgttacctg caagaacttg gaggttcaca gctaagacgc
      121 caggaccccc tggaagccta gaaatgggac cactgacatt tagggatgtg aaaatagaat
      181 tctctctaga ggaatggcaa tgcctggaca ctgcgcagcg gaatttatat agagatgtga
      241 tgttagagaa ctacagaaac ctggtcttcc ttggtattgc tgtctctaag ccagacctga
      301 tcacctggct ggagcaagga aaagagccct ggaatctgaa gagacatgag atggtagaca
      361 aaaccccagt tatgtgttct cattttgccc aagatgtttg gccagagcac agcataaaag
      421 attctttcca aaaagtgata ctgagaacat atggaaaata tggacatgag aatttacagc
      481 taagaaaaga ccataaaagt gtggatgcat gtaaggtgta caaaggaggt tataatggac
      541 ttaaccagtg tttgacaact actgacagca agatatttca gtgtgataaa tatgtgaaag
      601 tctttcataa atttccaaat gtaaatagaa ataagataag acatactgga aagaaacctt
      661 tcaaatgtaa aaaccgtggc aaatcatttt gcatgctttc acaattaact caacataaga
      721 aaattcatac tagagagtat tcttacaaat gtgaagaatg tggtaaagcc tttaactggt
      781 cctcaaccct tactaaacat aagataattc atactggaga aaaaccctac aaatgtgaag
      841 aatgtggcaa agcttttaac cggtcctcaa atcttactaa acataaaata attcatactg
      901 gagagaaacc ctacaaatgt gaagaatgtg gcaaagcttt taaccggtcc tcaaccctta
      961 ctaaacataa aagaattcat acagaagaga aaccctacaa atgtgaagaa tgtggcaagg
     1021 cctttaacca gttctcgatt cttaataaac ataagagaat tcatatggaa gataaaccct
     1081 acaaatgtga agaatgtggc aaagccttta gagtattctc aattcttaaa aaacataaga
     1141 taatccatac tggggaaaaa ccatacaaat gtgaagaatg tggcaaagcc tttaaccagt
     1201 tctcaaacct tactaaacat aagataattc atactggaga gaaaccctac aaatgtgatg
     1261 aatgtggcaa agcctttaac cagtcctcaa cccttactaa acataaaaga attcatacgg
     1321 gagaaaaacc ctacaaatgt gaagaatgtg gcaaagcttt taaacagtcc tcaaccctta
     1381 ctgaacataa gataattcat actggagaga aaccctacaa atgtgaaaaa tgtggcaagg
     1441 cctttagctg gtcctcagct tttactaaac ataagagaaa tcatatggaa gataaaccct
     1501 acaaatgtga agaatgtggc aaagccttta gtgtattctc aacccttact aaacataaaa
     1561 taattcatac tagagaaaaa ccctacaaat gtgaagaatg tggcaaagcc tttaaccagt
     1621 cctcaatttt tactaaacat aagataattc acactgaagg gaaatcctac aaatgtgaaa
     1681 aatgtggcaa tgcttttaac cagtcctcaa accttactgc acgtaagata atttatactg
     1741 gagagaaacc ctacaaatat gaagaatgtg acaaagcctt taacaagttc tcaaccctta
     1801 ttacacatca gataatttat actggagaga aaccctgcaa acatgaatgt ggcagagcct
     1861 ttaacaaatc ctcaaattat actaaagaga aactacaaac ctgaaagatg tgacaatgat
     1921 tttcactaca cctcaaactt ttctaaacat aaaccatatt ggtgccctag aaatgtgagg
     1981 aatatgacaa ggactttaaa tggttgtcac gcttgattgt aggtaagata atttatattg
     2041 gagaaaaatc ctccaagtat gaagaatgtg gcaaactttt aaccaatcct cacaccttat
     2101 tgcacaggaa agcatttata cttgagaaaa attgtataaa gaatatggaa aagccattta
     2161 tatctgctca catgtaaaaa catcagttca tacttaataa aatgcaatta ccgtcaaatc
     2221 tttcagaaaa tataagcctt taatacgagg aagagtattc ttaagatgaa cattacaaat
     2281 agaaagaggg ttgtagtacc tttagtttta tgatagatct tattgtacac attttgtacc
     2341 agaggaaaac cctaaagcat tagttgctca aactttgttc gacatcaggg aatttgtatt
     2401 ggagaaaaac cctgcaaatg taataaatat ggaaaaacat tttttcaaaa actacagctt
     2461 ggaaaacatc agagagttca tactaaaata tatttttgca gatgcagtaa atatgaaaaa
     2521 tatttaatcc caaattaagt ctatgtaaat atcagaattc acagtagaaa tcataaggca
     2581 taaggcactg atacttcaga cattacacta aattagagtg ttgagtatag gagatccaaa
     2641 actaaaattg ttaggtaagt tatttatata taactttaaa agaagtagaa gattttttgg
     2701 agatttataa ttacattcaa agtatacttt tttcttgaaa aaaattacag attttttgaa
     2761 aagcaattga tgtaatttaa ctctcaaatt catgtttttc ttcattccta ttatattcac
     2821 atgtgaaagc aagtgatctg ttgttgctga atcagagata tgagagattc ttttttatag
     2881 gtgggcatta tttatgcccc tttctgtgga agagtaagaa aattaaaata caagatgcat
     2941 gaggaaaatg tagagatgct ctttgtgatt aacttagaat attaagtgct acttgaggta
     3001 catgttcaga ctaacattct tttgcagtat agtgagaaaa aaacatttta aaattaatta
     3061 tcattttgtt gattgtgctt ttatgtaata aaatgcagta ctttaaaaca tttagattgt
     3121 gtgtgaactt aattttgtaa ttaaacattt tttttagcat gctaa
//
