LOCUS       NM_003430               5400 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens zinc finger protein 91 (ZNF91), transcript variant 1,
            mRNA.
ACCESSION   NM_003430
VERSION     NM_003430.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5400)
  AUTHORS   Zeng,Z., Zhao,Y., Chen,Q., Zhu,S., Niu,Y., Ye,Z., Hu,P., Chen,D.,
            Xu,P., Chen,J., Hu,C., Hu,Y., Xu,F., Tang,J., Wang,F., Han,S.,
            Huang,M., Wang,C. and Zhao,G.
  TITLE     Hypoxic exosomal HIF-1alpha-stabilizing circZNF91 promotes
            chemoresistance of normoxic pancreatic cancer cells via enhancing
            glycolysis
  JOURNAL   Oncogene 40 (36), 5505-5517 (2021)
   PUBMED   34294845
  REMARK    GeneRIF: Hypoxic exosomal HIF-1alpha-stabilizing circZNF91 promotes
            chemoresistance of normoxic pancreatic cancer cells via enhancing
            glycolysis.
REFERENCE   2  (bases 1 to 5400)
  AUTHORS   Jacobs,F.M., Greenberg,D., Nguyen,N., Haeussler,M., Ewing,A.D.,
            Katzman,S., Paten,B., Salama,S.R. and Haussler,D.
  TITLE     An evolutionary arms race between KRAB zinc-finger genes ZNF91/93
            and SVA/L1 retrotransposons
  JOURNAL   Nature 516 (7530), 242-245 (2014)
   PUBMED   25274305
REFERENCE   3  (bases 1 to 5400)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
REFERENCE   4  (bases 1 to 5400)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5400)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 5400)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   7  (bases 1 to 5400)
  AUTHORS   Nishimura,T., Narita,T., Miyazaki,E., Ito,T., Nishimoto,N.,
            Yoshizaki,K., Martial,J.A., Bellfroid,E.J., Vissing,H. and
            Taniyama,T.
  TITLE     Characterization of the human Fc gamma RIIB gene promoter: human
            zinc-finger proteins (ZNF140 and ZNF91) that bind to different
            regions function as transcription repressors
  JOURNAL   Int Immunol 13 (8), 1075-1084 (2001)
   PUBMED   11470777
REFERENCE   8  (bases 1 to 5400)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
REFERENCE   9  (bases 1 to 5400)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
REFERENCE   10 (bases 1 to 5400)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB068854.1, AK291256.1, AK300294.1, L11672.1, AC016628.6,
            AC010300.8 and AI590336.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003430.3.
            
            Summary: The ZNF91 gene encodes a zinc finger protein of the KRAB
            (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993
            [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.271042.1, AK291256.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300619.12/ ENSP00000300619.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB068854.1         90-93
            5-893               AK291256.1         1-889
            894-942             AK300294.1         773-821
            943-1272            AK291256.1         939-1268
            1273-2395           AK300294.1         1152-2274
            2396-3606           AK291256.1         2392-3602
            3607-3706           L11672.1           3584-3683
            3707-3855           AK291256.1         3703-3851
            3856-3862           L11672.1           3833-3839
            3863-4414           AC016628.6         29837-30388         c
            4415-4929           AC010300.8         73170-73684         c
            4930-5400           AI590336.1         8-478               c
FEATURES             Location/Qualifiers
     source          1..5400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..5400
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="zinc finger protein 91"
                     /db_xref="GeneID:7644"
                     /db_xref="HGNC:HGNC:13166"
                     /db_xref="MIM:603971"
     exon            1..147
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3693
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 91 (HPF7, HTF10); zinc finger protein
                     HTF10; zinc finger protein HPF7"
                     /codon_start=1
                     /product="zinc finger protein 91 isoform 1"
                     /protein_id="NP_003421.2"
                     /db_xref="CCDS:CCDS42541.1"
                     /db_xref="GeneID:7644"
                     /db_xref="HGNC:HGNC:13166"
                     /db_xref="MIM:603971"
                     /translation="MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLE
                     NYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTGICPHFPQDFWPEQSMED
                     SFQKVLLRKYEKCGHENLQLRKGCKSVDECKVHKEGYNKLNQCLTTAQSKVFQCGKYL
                     KVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFCIRLHKTQHKCVYITEKSCKCKECEKT
                     FHWSSTLTNHKEIHTEDKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKCEECGKAFL
                     WSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCEECGKAFSRS
                     STLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLST
                     LTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLT
                     KHKRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKH
                     KIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFSTLTTHKI
                     IHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRIH
                     TGEKPYKCEECGKAFSHSSALAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTE
                     EKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEK
                     PYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPY
                     KCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSALAKHKIIHAGEKLYKC
                     EECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKCEE
                     CGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECG
                     KAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEKPYKCEECGKA
                     FNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHKRIHTREKPYKCEECGKAFS
                     QSSTLTRHKRLHTGEKPYKCGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQS
                     SILTNHKKIHTITPVIPLLWEAEAGGSRGQEMETILANTVKPLLY"
     exon            148..274
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     exon            275..370
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     exon            371..5400
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5365..5370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="hexamer: AATAAA"
     polyA_site      5400
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="major polyA site"
ORIGIN      
        1 gtctctcgct gccgccggag tttccaggtc tcgacttcac tgctctgtgt cctctgctcc
       61 aggaggccca gcctgtgtgg ccctgtgacc tgcaggtatt ggagagccac agctaagatg
      121 ccaggaaccc ctggaagcct agaaatggga ctgttgacat ttagggatgt ggccatagaa
      181 ttctctccgg aggagtggca atgtctggac actgcacagc agaatttata taggaatgtg
      241 atgttagaga actacagaaa cctggccttc ctgggtattg ctctctctaa gccagacctg
      301 attacttatc tggagcaagg aaaagagccc tggaatatga agcaacatga gatggtggat
      361 gaacccacag gtatatgtcc tcattttcct caagactttt ggccagagca gagcatggaa
      421 gattcttttc aaaaagtatt actgagaaaa tatgaaaaat gtggacatga gaatttacag
      481 ttaagaaaag gttgtaaaag tgtggatgag tgtaaggtgc acaaagaagg ttataataaa
      541 cttaaccagt gtctcacaac tgcccagagc aaagtatttc aatgtgggaa atatttgaaa
      601 gtcttctata aatttttaaa ttcaaacaga catacgataa gacatactgg aaagaaatgc
      661 ttcaaatgta aaaaatgtgt caagtcattt tgcatccgtt tacacaaaac ccaacataaa
      721 tgcgtttata ttacagagaa gtcctgtaaa tgtaaagaat gtgaaaaaac ctttcattgg
      781 tcctcaaccc ttactaatca taaggaaatt catactgaag ataaacccta caaatgtgaa
      841 gaatgtggca aagcttttaa gcagctctca acccttacta cacataaaat aatctgtgct
      901 aaagagaaaa tctacaagtg tgaagaatgt ggcaaagcat ttctatggtc ctcaacccta
      961 actagacata agaggataca cactggagag aaaccctaca aatgtgaaga atgtggcaaa
     1021 gcttttagcc attcttcaac ccttgctaaa cataagagaa ttcatactgg agagaaaccc
     1081 tacaaatgtg aagaatgtgg caaagctttt agccgttctt caacccttgc taaacataag
     1141 agaattcata ctggagagaa accctacaaa tgtaaagaat gtggcaaagc ttttagcaat
     1201 tcctcaaccc ttgctaatca taagataact catactgaag agaaacccta caaatgtaaa
     1261 gaatgtgaca aagcttttaa gcgactctca acccttacta aacataaaat aatacatgct
     1321 ggagagaaac tctacaaatg tgaagaatgt ggcaaagctt ttaatcgatc ttcaaatctt
     1381 actatacata agtttattca tactggagag aaaccttaca agtgtgaaga atgtggcaaa
     1441 gcatttaact ggtcctcaag ccttactaaa cataaaagat ttcatactag agagaaaccc
     1501 ttcaaatgta aagaatgtgg caaagcattt atatggtctt caaccctaac tagacataag
     1561 aggatacaca ctggagagaa gccctacaaa tgtgaagaat gtggcaaagc ttttaggcaa
     1621 tcctcaaccc ttactaaaca taagataatt catactggag agaaacccta caaatttgaa
     1681 gaatgtggca aagcttttag acaatcctta acccttaata aacataagat aattcatagt
     1741 agagagaaac cctacaaatg taaagaatgt ggcaaagctt ttaagcaatt ctcaaccctt
     1801 actacacata aaataattca tgctggaaag aaactctaca aatgtgaaga atgtggcaaa
     1861 gcttttaatc attcctcaag tctttctaca cataagataa ttcatactgg agagaagtct
     1921 tacaagtgtg aagaatgtgg caaagcattt ctatggtcct caaccctaag aagacataag
     1981 aggatacaca ctggagagaa accctacaaa tgtgaagaat gtggcaaagc ttttagccat
     2041 tcttcagccc ttgctaaaca taagagaatt catactggag agaaacccta caaatgtaaa
     2101 gaatgtggca aagcttttag caattcctca acccttgcta atcataagat aactcatact
     2161 gaagagaaac cctacaaatg taaagaatgt gacaaaactt ttaagcgact ctcaaccctt
     2221 actaaacata aaataataca tgctggagag aaactctaca aatgtgaaga atgtggcaaa
     2281 gcttttaatc gatcttcaaa tcttactata cataagttta ttcatactgg agagaaacct
     2341 tacaagtgtg aagaatgtgg caaagcattt aactggtcct caagccttac taaacataaa
     2401 agaattcata ctagagagaa acccttcaaa tgtaaagaat gtggcaaagc atttatatgg
     2461 tcttcaaccc taactagaca taagaggata cacactggag agaagcccta caaatgtgaa
     2521 gaatgtggca aagcttttag ccgttcctca acccttacta agcataagac aattcatact
     2581 ggagagaaac cctacaaatg taaagaatgt ggcaaagctt ttaagcactc ctcagccctt
     2641 gctaaacata aaataataca tgctggagag aaactctaca aatgtgagga atgtggcaaa
     2701 gcttttaatc aatcttcaaa tcttacgaca cataagataa ttcatactaa agagaaacct
     2761 tccaagagtg aagaatgtga caaagcattt atctggtcct caacccttac tgaacataag
     2821 agaattcata ccagagagaa aacctacaaa tgtgaagaat gtggcaaagc atttagccag
     2881 ccttcacacc ttactacaca taagaggatg cacactggag agaaacccta caaatgtgaa
     2941 gaatgtggca aagcttttag ccaatcctca acccttacta cacataagat aattcatact
     3001 ggagagaaac cctacaaatg tgaagaatgt ggcaaagctt ttaggaaatc ttcaactctt
     3061 actgaacata agataattca tactggagag aaaccctaca aatgtgaaga atgtggcaaa
     3121 gcatttagcc aatcctcaac cctaactaga catacgagga tgcacactgg agagaaacca
     3181 tacaaatgtg aagaatgtgg caaagctttt aatcgatcct caaagcttac tacacataag
     3241 ataattcata ctggagagaa accttacaag tgtgaagaat gtggcaaagc atttatatca
     3301 tcctcaaccc taaatggaca taagagaatt catactagag agaaacccta caaatgtgaa
     3361 gaatgtggca aagcatttag ccaatcttca accctaacta gacataagag gttgcacacc
     3421 ggagagaaac cctacaaatg tggagaatgt ggcaaagcct ttaaagagtc ctcagctctt
     3481 actaaacata agataattca cactggagag aaaccctaca aatgtgaaaa atgtggcaaa
     3541 gcctttaacc agtcttcaat ccttactaac cataagaaaa ttcatactat cacacctgta
     3601 atcccactac tttgggaggc cgaggcgggc ggatcacgag gtcaggagat ggagaccatc
     3661 ctggctaaca cagtgaaacc ccttctctac taaaaaatac aaaaaattag ccgggcgtgg
     3721 tggcgggcgc ctgtagtccc agctatgcga gaggctgagg caggagaatg gcgtgaaccc
     3781 gggaggcgga gcttgcagtg agccgagatc acgccactgc actcaagcct gggcgacaga
     3841 gcgagactcc gtctcaaaaa aaaaaaaaag aaaattcata ctagagagaa accctacaaa
     3901 tataaagaat gtggcaaatc ttttaaccgg tcttcaacct ttactaaaca taaggtaatt
     3961 catactggag taaaactcta caaatgtgaa gaatgtggca aatccttttt ctggtcctca
     4021 gccctaacca gacataagaa aattcatact ggacagcaac cctacaaaca ggaaaaattt
     4081 ggcaaagcct ttaaccagtt ttcacacctt actacagata agataactca tattggagag
     4141 aaatcttaca agtgtgaata atgtggtaaa gtctataaaa agtcctgaat tcttaacaga
     4201 cataatatta ttcatactgg agagaaactc tacaaacctg aaagatgtgc caacgctttt
     4261 gacaagtcaa acttttctaa acatcaagaa aatcatgctg ctgagaaatc ctagaaatgt
     4321 gaagaatgtg acaaagcctc taaatgattg tcacacttga tcgtaggtaa gataattcat
     4381 actggagaaa actaccagtg tgaacaatgt ggccaagctt tgaactaatg ctcacacctt
     4441 aatgcatagg aaagcattta tgcttgagaa aaagtgaaca aatatagaca aaaagccatt
     4501 aatacctgct cacatcgtac tcaaattcag agcgttcata ctaaataaga agtgtaatta
     4561 ctgtcaaacg actgatcaga aaatatgtct ttaaagtaca gaagagtatt ttgaaaaagc
     4621 attacaaata tgaagaggca ttatttatga ccttttctat ggaaaggtaa ggacattaaa
     4681 aatgtaagat gcatgatgaa aatttaagta gagaggatct ttatggttaa cttataatat
     4741 cgagtgatgc atgaggtaga tgttcagatt aatattctgc attattatga aagaaaaaca
     4801 ttcttaattt tagttaaagt ttagtatgat ttattgtatt tttatgaaat atatgtagca
     4861 tatttttaaa ttataaattg catgtgaact tttcaaccaa acagttttaa catgttaaat
     4921 actatcatga attcaatgaa gtgttattat gccagtaact ttaacctatt ccaccttact
     4981 caagggtgta ggtaaaagat ggtaaaaata cactatttgg taagataatg gactgacatc
     5041 tctagtgatt ttttttgcca gtgagtttta attgccatta agttaaagaa tattgttccc
     5101 ataggctaaa tttttatttt tattttctca tttaaatgta tttgacttaa tttttgtgga
     5161 tacctaatat gtgtacatat tatgccatat gtggcatatt ttgatacgga cacacaatat
     5221 ataacaatcg cattagacta aatgcggtct ccattacctc tagcatttat tctttgtatt
     5281 acaaataatt caattctaca gttttagtta tttttaaatg tacaattaaa ttgttgttga
     5341 ctacaggatt atttttatgg tcataataaa acttatatac aaacataagt aaaatccata
//
