LOCUS       NM_001300951            5304 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens zinc finger protein 91 (ZNF91), transcript variant 2,
            mRNA.
ACCESSION   NM_001300951 XM_006722879
VERSION     NM_001300951.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5304)
  AUTHORS   Zeng,Z., Zhao,Y., Chen,Q., Zhu,S., Niu,Y., Ye,Z., Hu,P., Chen,D.,
            Xu,P., Chen,J., Hu,C., Hu,Y., Xu,F., Tang,J., Wang,F., Han,S.,
            Huang,M., Wang,C. and Zhao,G.
  TITLE     Hypoxic exosomal HIF-1alpha-stabilizing circZNF91 promotes
            chemoresistance of normoxic pancreatic cancer cells via enhancing
            glycolysis
  JOURNAL   Oncogene 40 (36), 5505-5517 (2021)
   PUBMED   34294845
  REMARK    GeneRIF: Hypoxic exosomal HIF-1alpha-stabilizing circZNF91 promotes
            chemoresistance of normoxic pancreatic cancer cells via enhancing
            glycolysis.
REFERENCE   2  (bases 1 to 5304)
  AUTHORS   Jacobs,F.M., Greenberg,D., Nguyen,N., Haeussler,M., Ewing,A.D.,
            Katzman,S., Paten,B., Salama,S.R. and Haussler,D.
  TITLE     An evolutionary arms race between KRAB zinc-finger genes ZNF91/93
            and SVA/L1 retrotransposons
  JOURNAL   Nature 516 (7530), 242-245 (2014)
   PUBMED   25274305
REFERENCE   3  (bases 1 to 5304)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
REFERENCE   4  (bases 1 to 5304)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5304)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 5304)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   7  (bases 1 to 5304)
  AUTHORS   Nishimura,T., Narita,T., Miyazaki,E., Ito,T., Nishimoto,N.,
            Yoshizaki,K., Martial,J.A., Bellfroid,E.J., Vissing,H. and
            Taniyama,T.
  TITLE     Characterization of the human Fc gamma RIIB gene promoter: human
            zinc-finger proteins (ZNF140 and ZNF91) that bind to different
            regions function as transcription repressors
  JOURNAL   Int Immunol 13 (8), 1075-1084 (2001)
   PUBMED   11470777
REFERENCE   8  (bases 1 to 5304)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
REFERENCE   9  (bases 1 to 5304)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
REFERENCE   10 (bases 1 to 5304)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB068854.1, AK300294.1, L11672.1, AK291256.1, AC016628.6,
            AC010300.8 and AI590336.1.
            
            On May 31, 2019 this sequence version replaced NM_001300951.1.
            
            Summary: The ZNF91 gene encodes a zinc finger protein of the KRAB
            (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993
            [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 2, which lacks an internal segment and is shorter, compared
            to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.196202.1, AK300294.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DB068854.1         90-114
            26-444              AK300294.1         1-419
            445-551             L11672.1           518-624
            552-846             AK300294.1         527-821
            847-1176            AK291256.1         939-1268
            1177-2299           AK300294.1         1152-2274
            2300-3510           AK291256.1         2392-3602
            3511-3548           AK300294.1         3486-3523
            3549-3759           AK291256.1         3641-3851
            3760-3766           L11672.1           3833-3839
            3767-4318           AC016628.6         29837-30388         c
            4319-4833           AC010300.8         73170-73684         c
            4834-5304           AI590336.1         8-478               c
FEATURES             Location/Qualifiers
     source          1..5304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..5304
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="zinc finger protein 91"
                     /db_xref="GeneID:7644"
                     /db_xref="HGNC:HGNC:13166"
                     /db_xref="MIM:603971"
     exon            1..147
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3597
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 91 (HPF7, HTF10); zinc finger protein
                     HTF10; zinc finger protein HPF7"
                     /codon_start=1
                     /product="zinc finger protein 91 isoform 2"
                     /protein_id="NP_001287880.1"
                     /db_xref="CCDS:CCDS74322.1"
                     /db_xref="GeneID:7644"
                     /db_xref="HGNC:HGNC:13166"
                     /db_xref="MIM:603971"
                     /translation="MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLE
                     NYRNLAFLGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENLQLRKGCKSVDECKV
                     HKEGYNKLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFC
                     IRLHKTQHKCVYITEKSCKCKECEKTFHWSSTLTNHKEIHTEDKPYKCEECGKAFKQL
                     STLTTHKIICAKEKIYKCEECGKAFLWSSTLTRHKRIHTGEKPYKCEECGKAFSHSST
                     LAKHKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLA
                     NHKITHTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIH
                     KFIHTGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRHKR
                     IHTGEKPYKCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIH
                     SREKPYKCKECGKAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTG
                     EKSYKCEECGKAFLWSSTLRRHKRIHTGEKPYKCEECGKAFSHSSALAKHKRIHTGEK
                     PYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLY
                     KCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKC
                     KECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKE
                     CGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECD
                     KAFIWSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKA
                     FSQSSTLTTHKIIHTGEKPYKCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFS
                     QSSTLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISS
                     STLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTGEKPYKCGECGKAFKESSA
                     LTKHKIIHTGEKPYKCEKCGKAFNQSSILTNHKKIHTITPVIPLLWEAEAGGSRGQEM
                     ETILANTVKPLLY"
     exon            148..274
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     exon            275..5304
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5269..5274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="hexamer: AATAAA"
     polyA_site      5304
                     /gene="ZNF91"
                     /gene_synonym="HPF7; HTF10"
                     /note="major polyA site"
ORIGIN      
        1 gtctctcgct gccgccggag tttccaggtc tcgacttcac tgctctgtgt cctctgctcc
       61 aggaggccca gcctgtgtgg ccctgtgacc tgcaggtatt ggagagccac agctaagatg
      121 ccaggaaccc ctggaagcct agaaatggga ctgttgacat ttagggatgt ggccatagaa
      181 ttctctccgg aggagtggca atgtctggac actgcacagc agaatttata taggaatgtg
      241 atgttagaga actacagaaa cctggccttc ctgggtatat gtcctcattt tcctcaagac
      301 ttttggccag agcagagcat ggaagattct tttcaaaaag tattactgag aaaatatgaa
      361 aaatgtggac atgagaattt acagttaaga aaaggttgta aaagtgtgga tgagtgtaag
      421 gtgcacaaag aaggttataa taaacttaac cagtgtctca caactgccca gagcaaagta
      481 tttcaatgtg ggaaatattt gaaagtcttc tataaatttt taaattcaaa cagacatacg
      541 ataagacata ctggaaagaa atgcttcaaa tgtaaaaaat gtgtcaagtc attttgcatc
      601 cgtttacaca aaacccaaca taaatgcgtt tatattacag agaagtcctg taaatgtaaa
      661 gaatgtgaaa aaacctttca ttggtcctca acccttacta atcataagga aattcatact
      721 gaagataaac cctacaaatg tgaagaatgt ggcaaagctt ttaagcagct ctcaaccctt
      781 actacacata aaataatctg tgctaaagag aaaatctaca agtgtgaaga atgtggcaaa
      841 gcatttctat ggtcctcaac cctaactaga cataagagga tacacactgg agagaaaccc
      901 tacaaatgtg aagaatgtgg caaagctttt agccattctt caacccttgc taaacataag
      961 agaattcata ctggagagaa accctacaaa tgtgaagaat gtggcaaagc ttttagccgt
     1021 tcttcaaccc ttgctaaaca taagagaatt catactggag agaaacccta caaatgtaaa
     1081 gaatgtggca aagcttttag caattcctca acccttgcta atcataagat aactcatact
     1141 gaagagaaac cctacaaatg taaagaatgt gacaaagctt ttaagcgact ctcaaccctt
     1201 actaaacata aaataataca tgctggagag aaactctaca aatgtgaaga atgtggcaaa
     1261 gcttttaatc gatcttcaaa tcttactata cataagttta ttcatactgg agagaaacct
     1321 tacaagtgtg aagaatgtgg caaagcattt aactggtcct caagccttac taaacataaa
     1381 agatttcata ctagagagaa acccttcaaa tgtaaagaat gtggcaaagc atttatatgg
     1441 tcttcaaccc taactagaca taagaggata cacactggag agaagcccta caaatgtgaa
     1501 gaatgtggca aagcttttag gcaatcctca acccttacta aacataagat aattcatact
     1561 ggagagaaac cctacaaatt tgaagaatgt ggcaaagctt ttagacaatc cttaaccctt
     1621 aataaacata agataattca tagtagagag aaaccctaca aatgtaaaga atgtggcaaa
     1681 gcttttaagc aattctcaac ccttactaca cataaaataa ttcatgctgg aaagaaactc
     1741 tacaaatgtg aagaatgtgg caaagctttt aatcattcct caagtctttc tacacataag
     1801 ataattcata ctggagagaa gtcttacaag tgtgaagaat gtggcaaagc atttctatgg
     1861 tcctcaaccc taagaagaca taagaggata cacactggag agaaacccta caaatgtgaa
     1921 gaatgtggca aagcttttag ccattcttca gcccttgcta aacataagag aattcatact
     1981 ggagagaaac cctacaaatg taaagaatgt ggcaaagctt ttagcaattc ctcaaccctt
     2041 gctaatcata agataactca tactgaagag aaaccctaca aatgtaaaga atgtgacaaa
     2101 acttttaagc gactctcaac ccttactaaa cataaaataa tacatgctgg agagaaactc
     2161 tacaaatgtg aagaatgtgg caaagctttt aatcgatctt caaatcttac tatacataag
     2221 tttattcata ctggagagaa accttacaag tgtgaagaat gtggcaaagc atttaactgg
     2281 tcctcaagcc ttactaaaca taaaagaatt catactagag agaaaccctt caaatgtaaa
     2341 gaatgtggca aagcatttat atggtcttca accctaacta gacataagag gatacacact
     2401 ggagagaagc cctacaaatg tgaagaatgt ggcaaagctt ttagccgttc ctcaaccctt
     2461 actaagcata agacaattca tactggagag aaaccctaca aatgtaaaga atgtggcaaa
     2521 gcttttaagc actcctcagc ccttgctaaa cataaaataa tacatgctgg agagaaactc
     2581 tacaaatgtg aggaatgtgg caaagctttt aatcaatctt caaatcttac gacacataag
     2641 ataattcata ctaaagagaa accttccaag agtgaagaat gtgacaaagc atttatctgg
     2701 tcctcaaccc ttactgaaca taagagaatt cataccagag agaaaaccta caaatgtgaa
     2761 gaatgtggca aagcatttag ccagccttca caccttacta cacataagag gatgcacact
     2821 ggagagaaac cctacaaatg tgaagaatgt ggcaaagctt ttagccaatc ctcaaccctt
     2881 actacacata agataattca tactggagag aaaccctaca aatgtgaaga atgtggcaaa
     2941 gcttttagga aatcttcaac tcttactgaa cataagataa ttcatactgg agagaaaccc
     3001 tacaaatgtg aagaatgtgg caaagcattt agccaatcct caaccctaac tagacatacg
     3061 aggatgcaca ctggagagaa accatacaaa tgtgaagaat gtggcaaagc ttttaatcga
     3121 tcctcaaagc ttactacaca taagataatt catactggag agaaacctta caagtgtgaa
     3181 gaatgtggca aagcatttat atcatcctca accctaaatg gacataagag aattcatact
     3241 agagagaaac cctacaaatg tgaagaatgt ggcaaagcat ttagccaatc ttcaacccta
     3301 actagacata agaggttgca caccggagag aaaccctaca aatgtggaga atgtggcaaa
     3361 gcctttaaag agtcctcagc tcttactaaa cataagataa ttcacactgg agagaaaccc
     3421 tacaaatgtg aaaaatgtgg caaagccttt aaccagtctt caatccttac taaccataag
     3481 aaaattcata ctatcacacc tgtaatccca ctactttggg aggccgaggc gggcggatca
     3541 cgaggtcagg agatggagac catcctggct aacacagtga aaccccttct ctactaaaaa
     3601 atacaaaaaa ttagccgggc gtggtggcgg gcgcctgtag tcccagctat gcgagaggct
     3661 gaggcaggag aatggcgtga acccgggagg cggagcttgc agtgagccga gatcacgcca
     3721 ctgcactcaa gcctgggcga cagagcgaga ctccgtctca aaaaaaaaaa aaagaaaatt
     3781 catactagag agaaacccta caaatataaa gaatgtggca aatcttttaa ccggtcttca
     3841 acctttacta aacataaggt aattcatact ggagtaaaac tctacaaatg tgaagaatgt
     3901 ggcaaatcct ttttctggtc ctcagcccta accagacata agaaaattca tactggacag
     3961 caaccctaca aacaggaaaa atttggcaaa gcctttaacc agttttcaca ccttactaca
     4021 gataagataa ctcatattgg agagaaatct tacaagtgtg aataatgtgg taaagtctat
     4081 aaaaagtcct gaattcttaa cagacataat attattcata ctggagagaa actctacaaa
     4141 cctgaaagat gtgccaacgc ttttgacaag tcaaactttt ctaaacatca agaaaatcat
     4201 gctgctgaga aatcctagaa atgtgaagaa tgtgacaaag cctctaaatg attgtcacac
     4261 ttgatcgtag gtaagataat tcatactgga gaaaactacc agtgtgaaca atgtggccaa
     4321 gctttgaact aatgctcaca ccttaatgca taggaaagca tttatgcttg agaaaaagtg
     4381 aacaaatata gacaaaaagc cattaatacc tgctcacatc gtactcaaat tcagagcgtt
     4441 catactaaat aagaagtgta attactgtca aacgactgat cagaaaatat gtctttaaag
     4501 tacagaagag tattttgaaa aagcattaca aatatgaaga ggcattattt atgacctttt
     4561 ctatggaaag gtaaggacat taaaaatgta agatgcatga tgaaaattta agtagagagg
     4621 atctttatgg ttaacttata atatcgagtg atgcatgagg tagatgttca gattaatatt
     4681 ctgcattatt atgaaagaaa aacattctta attttagtta aagtttagta tgatttattg
     4741 tatttttatg aaatatatgt agcatatttt taaattataa attgcatgtg aacttttcaa
     4801 ccaaacagtt ttaacatgtt aaatactatc atgaattcaa tgaagtgtta ttatgccagt
     4861 aactttaacc tattccacct tactcaaggg tgtaggtaaa agatggtaaa aatacactat
     4921 ttggtaagat aatggactga catctctagt gatttttttt gccagtgagt tttaattgcc
     4981 attaagttaa agaatattgt tcccataggc taaattttta tttttatttt ctcatttaaa
     5041 tgtatttgac ttaatttttg tggataccta atatgtgtac atattatgcc atatgtggca
     5101 tattttgata cggacacaca atatataaca atcgcattag actaaatgcg gtctccatta
     5161 cctctagcat ttattctttg tattacaaat aattcaattc tacagtttta gttattttta
     5221 aatgtacaat taaattgttg ttgactacag gattattttt atggtcataa taaaacttat
     5281 atacaaacat aagtaaaatc cata
//
