LOCUS       NM_001393938            4144 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 888 (ZNF888), transcript variant
            7, mRNA.
ACCESSION   NM_001393938 XM_005259451
VERSION     NM_001393938.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010487.7.
            
            On Mar 23, 2021 this sequence version replaced XM_005259451.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.952341.1,
                                           SRR14038191.2829916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638862.2/ ENSP00000491567.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC010487.7         74409-74468         c
            61-179              AC010487.7         69859-69977         c
            180-252             AC010487.7         68899-68971         c
            253-379             AC010487.7         66236-66362         c
            380-4144            AC010487.7         55455-59219         c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..4144
                     /gene="ZNF888"
                     /note="zinc finger protein 888"
                     /db_xref="GeneID:388559"
                     /db_xref="HGNC:HGNC:38695"
     exon            1..60
                     /gene="ZNF888"
                     /inference="alignment:Splign:2.1.0"
     exon            61..179
                     /gene="ZNF888"
                     /inference="alignment:Splign:2.1.0"
     exon            180..252
                     /gene="ZNF888"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2394
                     /gene="ZNF888"
                     /note="isoform b is encoded by transcript variant 7;
                     CTD-2331H12.6"
                     /codon_start=1
                     /product="zinc finger protein 888 isoform b"
                     /protein_id="NP_001380867.1"
                     /db_xref="CCDS:CCDS86801.1"
                     /db_xref="GeneID:388559"
                     /db_xref="HGNC:HGNC:38695"
                     /translation="MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLDISSKCMMEFSSIGKGNTEVIHTGTLQRLASHHIGECCFQEIEKDIHDFVFQWQE
                     DETNGHEAPMTEIKELTGSTDQYDQRHAGNKPIKYQLGSSFHSHLPELHIFQPEGKIG
                     NQLEKSINNASSVSTSQRISCRPKTHISNNYGNNFFHSSLLTQKQDVHRKEKSFQFNE
                     SGKSFNCSSLFKKHQIIHLGEKQYKCDVCGKDFNQKRYLAHHRRCHTGEKPYMCNKCG
                     KVFNKKAYLARHYRRHTGEKPYKCNECGKTFSDKSALLVHKTIHTGEKPYKCNECGKV
                     FNQQSNLARHHRVHTGEKPYQCKECDKVFSRKSYLERHRRIHTGEKPYKCKVCDKAFR
                     HDSHLAQHIVIHTREKPYKCNECGKTFGENSALLVHKTIHTGEKPYKCNECGKVFNQQ
                     SNLARHHRLHTGEKPYKCKECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRRDSH
                     LAQHTVIHTGEKPYKCNECGKTFVQNSSLVMHKVIHTGEKRYKCNECGKSFNHKSSLA
                     YHHRLHTGEKPYKCNECGKVFRTQSQLACHHRLHTGEKPYKCEECDKVFNIKSHLEIH
                     RRVHTGEKPYKCRVCDKAFGRDSYLAQHQRVHTGEKPYKCKVCDKAFKCYSHLAQHTR
                     IHTGEKPFKCSECGKAFRAQSTLIHHQAIHGVGKLD"
     exon            253..379
                     /gene="ZNF888"
                     /inference="alignment:Splign:2.1.0"
     exon            380..4144
                     /gene="ZNF888"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4123..4128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF888"
                     /note="hexamer: AATAAA"
     polyA_site      4144
                     /gene="ZNF888"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtagat tcgcccggac caggaagcgg atcgcgtgga ctggaagtca cactgcggcg
       61 agtctcactc tgtcctccag gctgtgagtg cactgtcatg atcttggctc actgcaacct
      121 ctgtctcctg ggttcaagtg attcttgtgc ctcaacctcc caagtagctg agattacaga
      181 ctctgggtat gtgaagaaga aactcagaag aggaagagga aagcaaagga gtcagggatg
      241 gctcttcctc agggtctatt gacattcagg gatgtggcca tagaattctc tcaggaggag
      301 tggaaatgcc tggaccctgc tcagaggact ctatacagag acgtgatgct ggagaattat
      361 aggaacctgg tctccctgga tatctcttcc aaatgcatga tggagttctc atcaataggg
      421 aaaggcaata cagaagtgat ccacacaggg acattgcaaa gactggcaag tcatcacatt
      481 ggagaatgtt gcttccagga aattgagaaa gacattcatg actttgtgtt tcagtggcaa
      541 gaagatgaaa caaatggcca tgaagcaccc atgacagaaa tcaaagagtt gacgggtagt
      601 acagaccaat atgatcaaag gcatgctgga aacaagccta ttaaatatca gcttggatca
      661 agctttcatt cacatctgcc tgaactgcac atatttcagc ccgaagggaa aattggtaat
      721 caacttgaga agtctatcaa caatgcttcc tcagtttcaa catcccaaag aatttcttgt
      781 aggcccaaaa cccatatttc taataactat gggaataatt tcttccattc ttcattactc
      841 acacagaaac aggatgtaca caggaaagaa aaatctttcc aatttaatga gagtggcaaa
      901 tcctttaatt gtagctcact ctttaaaaaa catcagataa ttcatctagg agagaaacaa
      961 tataaatgtg atgtatgtgg caaagacttt aatcagaagc gataccttgc acaccatcgt
     1021 agatgtcaca ctggtgagaa accttacatg tgtaataaat gtggcaaggt ttttaataaa
     1081 aaagcatacc ttgcacgtca ttatagacgt catactggag aaaaacctta caagtgtaat
     1141 gagtgtggca agacgttcag tgacaagtca gccctcttag ttcacaagac aattcatact
     1201 ggagagaaac cttacaagtg taatgaatgt ggcaaggttt ttaatcaaca atcaaacctt
     1261 gcacgtcatc atagagttca tactggagag aaaccttacc aatgtaaaga atgtgacaaa
     1321 gttttcagtc gcaaatcata ccttgaaaga cataggagaa ttcacactgg tgagaaacca
     1381 tacaaatgta aggtttgtga caaggctttc agacatgatt cacacctggc acagcatatt
     1441 gtaattcaca ctagagagaa accttacaag tgtaatgagt gtggcaaaac gtttggtgaa
     1501 aattcagccc tcttagttca caagacaatt catactggag agaaacctta caagtgtaat
     1561 gaatgtggca aggttttcaa tcaacaatca aaccttgcac gtcatcatag acttcatact
     1621 ggagagaaac cttacaaatg taaagaatgt gacaaagttt tcagtcgcaa atcacacctt
     1681 gaaagacata ggagaattca cactggtgag aaaccataca aatgtaaggt ttgtgacaag
     1741 gctttcagac gtgattcaca cctggcacaa catactgtaa ttcacactgg agagaaacct
     1801 tacaagtgta atgagtgtgg caagaccttc gttcaaaatt catctcttgt aatgcataag
     1861 gtcattcata ctggagagaa acgttacaag tgtaatgaat gtggcaaaag ttttaatcac
     1921 aaatcaagcc ttgcatatca tcatagactt catactggag agaaacctta caagtgtaat
     1981 gaatgtggca aggtttttag gacacagtca caacttgcat gtcatcatag acttcatact
     2041 ggagagaaac cttacaaatg tgaagaatgt gacaaagttt tcaatatcaa atcacacctt
     2101 gaaatacata ggagagttca tactggagag aaaccataca aatgtagggt ttgcgacaag
     2161 gcttttgggc gtgattcata ccttgcacaa catcagagag ttcacactgg agagaaacca
     2221 tacaaatgta aggtttgtga caaggctttc aagtgttact cacacctggc acaacatact
     2281 agaattcata ctggagagaa acctttcaag tgtagtgagt gtggcaaagc ctttcgtgca
     2341 cagtcaacac ttattcacca tcaggcaatc catggtgtag ggaaacttga ctaatgtaat
     2401 gattgtcacc aagtcttcag taacgctaca accattgcaa atcattgaag aatccataat
     2461 gaatagagat cttacaagtg tagtaaatgt ggcaaatttt tcagacatcg ttcatacgct
     2521 gtagttcatg ggtgaactca tactggagag aaaccttaca aatgtcatga ttgaggcaag
     2581 gtcttcagtc aagcttcatc ctatgcaaaa caggagaatt catacaggag agaaacctca
     2641 caagtgtgat gattgtgagc aaagccttta cttcacgttc acacctcatt agacatcaaa
     2701 gaatccatac tggacagaaa tcttacaaat gtcatcagtg tggcaaggtc ttcagtctga
     2761 gatcactcct tgcagaatat cagaaaattt atttttgaga taatagttcc gaatgcaatg
     2821 agtatagcaa accatcaagc attaattgac actagagtca gttcagcatt gacttgagtt
     2881 tgagttgact taacgttgag ttcaagcatt aattgacatt aaagtgttta tgttaagagg
     2941 attaggctga gtgcggtggc tcacacctgt aatgctagca ctgtgggagg ccaaggtggg
     3001 tggatctctt gaggtcagga gtttgagact agtgtggcca acaggcgtga gccacttttc
     3061 ccagcctgtt ttttgtttct ttaacaaaaa cagatacaga tttttttttt ttttaatcac
     3121 ctgggtgcag gcaagctgag tccgaaaaga gagtcaggga agggagatgg ggtggggccg
     3181 ttttatagga tttgggtagg tagtggaaag ttacaatcaa agggggttgt tctctggctg
     3241 gcagaggtgg gggtcacaag gtgctcagtg ggggagtttt tgagccagga tgagccagga
     3301 gaaggaattt cacaaggtaa tgtcatcagt taaggcaggg accagccaat ttcacttctt
     3361 ttgtggtgga atgtcaactg ataggcattt ttatgggtac cgtgttgaat ctaaatcaca
     3421 ttgggttata taattactta acaatattaa tttttccaaa ctatcaatat gggttgtatc
     3481 tctatgtatg tttttaatca ttttgatcaa catttataga tttcaaggta caaacttctc
     3541 agctttgtac gtttattcct aagtatttct tactttaagt tctctagcaa atggaagtgt
     3601 ttttaaattt tcttttaaaa ttgtttattg ttaatgtgtg gaaattcaag taatttttgg
     3661 tgccgatatt gtattgtgca aatccactga atttatttag tagttttgag ggaagagaga
     3721 gaccctctca tattgtttta tattgtttta tactcagtac ctgttttagg aaaaaaacaa
     3781 ggaagtgaaa tcaaagacag gcagcccggc gccaggcctg aaaccaggcc tgggcctgcc
     3841 tggcctaaac ccagtagtta aaaatcaact cataacttag aaactgatgt tattcataga
     3901 ttccagacat tgtatagaag aacattgtga aactccctgc tctgttcttt tccactctga
     3961 acaccggtgc atgcagcccc tgtcacatac ccactgcttg ctcaaatcaa tcacgaccgt
     4021 ttcatgtgaa atccttagtg ttgtgagccc ttaaaaagga cagaaattgt gcattagggg
     4081 agctcagatt ttaaggcagt agcttgccga tgctcccagc tgaataaagc ccttccttct
     4141 gcaa
//
