LOCUS       NM_001145434            2258 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 880 (ZNF880), mRNA.
ACCESSION   NM_001145434 XR_039381 XR_039390 XR_039621
VERSION     NM_001145434.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Dong,X., Zhang,Y., Sun,Y., Nan,Q., Li,M., Ma,L., Zhang,L., Luo,J.,
            Qi,Y. and Miao,Y.
  TITLE     Promoter hypermethylation and comprehensive regulation of ncRNA
            lead to the down-regulation of ZNF880, providing a new insight for
            the therapeutics and research of colorectal cancer
  JOURNAL   BMC Med Genomics 16 (1), 148 (2023)
   PUBMED   37370088
  REMARK    GeneRIF: Promoter hypermethylation and comprehensive regulation of
            ncRNA lead to the down-regulation of ZNF880, providing a new
            insight for the therapeutics and research of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC419753.1, AK297834.1, AF086165.1 and AI754748.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001145434.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC360343.1, SRR1803613.3357.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422689.3/ ENSP00000406318.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC419753.1         7-34
            29-1855             AK297834.1         1-1827
            1856-2140           AF086165.1         134-418
            2141-2258           AI754748.1         22-139              c
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2258
                     /gene="ZNF880"
                     /note="zinc finger protein 880"
                     /db_xref="GeneID:400713"
                     /db_xref="HGNC:HGNC:37249"
     exon            1..55
                     /gene="ZNF880"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1777
                     /gene="ZNF880"
                     /note="zinc finger protein LOC400713"
                     /codon_start=1
                     /product="zinc finger protein 880"
                     /protein_id="NP_001138906.1"
                     /db_xref="CCDS:CCDS46164.1"
                     /db_xref="GeneID:400713"
                     /db_xref="HGNC:HGNC:37249"
                     /translation="MLRRGHLAFRDVAIEFPQEEWKCLDPAQRTLYREVMVENYRNLV
                     FLGICLPDLSVISMLEQRRDPRNLQSEVKIANNPGGRECIKGVNAESSSKLGSNAGNK
                     SLKNQLGLTFQLHLSELQLFQAERNISGCKHVEKPINNSLVSPLQKIYSSVKSHILNK
                     YRNDFDDSPFLPQEQKAQIREKPCECNEHGKAFRVSSRLANNQVIHTADNPYKCNECD
                     KVFSNSSNLVQHQRIHTGEKPYKCHECGKLFNRISLLARHQRIHTGEKPYKCHECGKV
                     FTQNSHLANHHRIHTGEKPYKCNECGKVFNRNAHLARHQKIHSGEKPYKCKECGKAFS
                     GGSGLTAHLVIHTGEKLYKCNKCGKVFNRNAHLTRHQRIHTGEKPYECKECGKVFRHK
                     FCLTNHHRMHTGEQPYKCNECGKAFRDCSGLTAHLLIHTGEKPYKCKECAKVFRHRLS
                     LSNHQRFHTGEKPYRCDECGKDFTRNSNLANHHRIHTGEKPYKCSECHKVFSHNSHLA
                     RHRQIHTGEKSYKCNECGKVFSHKLYLKKHERIHTGEKPYRCHECGKDFTRNSNLANH
                     HRIHTGEKPYR"
     exon            56..182
                     /gene="ZNF880"
                     /inference="alignment:Splign:2.1.0"
     exon            183..311
                     /gene="ZNF880"
                     /inference="alignment:Splign:2.1.0"
     exon            312..2258
                     /gene="ZNF880"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF880"
                     /note="hexamer: ATTATA"
     polyA_site      2258
                     /gene="ZNF880"
                     /note="major polyA site"
ORIGIN      
        1 agtttcctgg agacccggaa gcagattacg tggagtgacg gtcatgctgc ggcgtggaca
       61 cttggcattc agggacgtgg ccatagaatt ccctcaggag gagtggaaat gtctggaccc
      121 tgctcagagg actttataca gggaagtgat ggtggagaac tacaggaacc tggtctttct
      181 gggaatctgt cttcctgacc tgagtgttat ctccatgttg gagcaaagga gagatccccg
      241 gaatctgcag agtgaagtga aaatagcaaa caatccaggt ggcagggagt gcatcaaagg
      301 tgtgaacgca gagagcagct ctaaattggg aagcaatgcc ggaaacaagt ctcttaaaaa
      361 tcaacttgga ttaacctttc agttacatct gagtgaactg cagctatttc aagctgaaag
      421 gaatatttct ggatgtaaac atgtcgaaaa acctatcaac aattccttag tttcaccact
      481 tcaaaaaatt tattctagtg tcaaatccca cattttaaat aaatacagaa atgattttga
      541 tgattctcca tttctcccac aagaacaaaa agcacaaata agggaaaaac cgtgtgaatg
      601 taatgagcat ggcaaagcct ttagagtgtc ttcaagactt gctaacaatc aagtaatcca
      661 cactgcagat aacccttaca aatgtaatga atgtgacaag gtcttcagta acagttcaaa
      721 ccttgtacaa catcaaagaa ttcatactgg agagaagcct tacaagtgtc atgaatgtgg
      781 caagctcttc aatcgaattt cactccttgc acgacatcag agaatacata ctggagagaa
      841 accttacaaa tgtcatgagt gtggcaaagt cttcactcaa aattctcacc ttgcaaatca
      901 tcacagaatc cacactggag agaaacctta caaatgtaat gagtgtggca aggtcttcaa
      961 cagaaatgca caccttgcac gacatcagaa aattcatagt ggagagaaac cttacaaatg
     1021 taaggaatgt ggcaaagcat tttcaggggg ttcaggcctt actgctcatc ttgtaattca
     1081 cactggagag aaactttaca aatgtaataa atgtggcaag gtcttcaatc gaaatgcaca
     1141 ccttaccaga catcaaagaa tccatactgg agagaaacct tatgaatgta aagaatgtgg
     1201 caaggtcttc aggcacaagt tttgtctaac caatcatcat agaatgcaca cgggagagca
     1261 accttacaaa tgtaatgaat gtggcaaagc atttagagac tgttcaggcc ttactgccca
     1321 tctactaatt cacactggag agaaacctta caaatgtaaa gaatgtgcca aggtcttcag
     1381 gcatagatta tccctaagca atcatcagag atttcatact ggagagaaac cttacagatg
     1441 tgatgaatgt ggcaaggact tcactcgaaa ttcaaacctt gcaaatcatc acagaatcca
     1501 tactggagag aaaccttaca aatgcagtga atgtcacaaa gtctttagtc acaattcaca
     1561 ccttgcacga cataggcaaa ttcatactgg agagaagtct tacaaatgca atgaatgtgg
     1621 caaggtcttc agccacaagt tatacctaaa aaaacatgag agaattcata ctggggagaa
     1681 accgtacaga tgtcatgaat gtggtaagga cttcactcga aattcaaacc tggcaaatca
     1741 tcacagaatc catactggag agaaaccgta cagatgaaat gtgtgtggta agatctttag
     1801 taataattca caccttgcac agcatgagat aattcattca tgagagagtt cttacaaact
     1861 gagtatggca aactcttcat gctaagttct agcattaatc aacatcagag attccatact
     1921 aaagagaaat catagcaatg tatgtgaatc aggtctcttg aggcctgcca aatgactaga
     1981 tatcaaaaca tacatcttgg atgaaaccat acagatggat tatgtatgct gaggctatta
     2041 ttcaaggacc attactatgg aacatgataa gatttacaca agcgataatt cagtctctag
     2101 ttctccaata tttatgatac tgcatgctgc agaaaagtca cagctccaaa tacgttgaat
     2161 ctcatgacgc gatgcatgtc gaaggtccaa gggcatgtgg aaatggtcag ttatattcag
     2221 gcaattaaaa aacctaatta tatggggttt tttgaaaa
//
