LOCUS       NM_001136116            3252 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 879 (ZNF879), transcript variant
            1, mRNA.
ACCESSION   NM_001136116 XM_001714318 XM_001715681 XM_001717115
VERSION     NM_001136116.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Imbeault,M., Helleboid,P.Y. and Trono,D.
  TITLE     KRAB zinc-finger proteins contribute to the evolution of gene
            regulatory networks
  JOURNAL   Nature 543 (7646), 550-554 (2017)
   PUBMED   28273063
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Wang,J., Wang,J. and Tian,C.Y.
  TITLE     Evolution of KRAB-containing zinc finger proteins and their roles
            in species evolution
  JOURNAL   Yi Chuan 38 (11), 971-978 (2016)
   PUBMED   27867147
  REMARK    Review article
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Wang,W., Cai,J., Lin,Y., Liu,Z., Ren,Q., Hu,L., Huang,Z., Guo,M.
            and Li,W.
  TITLE     Zinc fingers function cooperatively with KRAB domain for nuclear
            localization of KRAB-containing zinc finger proteins
  JOURNAL   PLoS One 9 (3), e92155 (2014)
   PUBMED   24647005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Santoni de Sio,F.R.
  TITLE     Kruppel-associated box (KRAB) proteins in the adaptive immune
            system
  JOURNAL   Nucleus 5 (2), 138-148 (2014)
   PUBMED   24699165
  REMARK    Review article
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Razin,S.V., Borunova,V.V., Maksimenko,O.G. and Kantidze,O.L.
  TITLE     Cys2His2 zinc finger protein family: classification, functions, and
            major members
  JOURNAL   Biochemistry (Mosc) 77 (3), 217-226 (2012)
   PUBMED   22803940
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC350553.1, AK300504.1,
            BX648737.1, BX114675.1, BM971752.1 and AC104117.2.
            
            On May 17, 2019 this sequence version replaced NM_001136116.2.
            
            Summary: This gene encodes a kruppel-associated box-containing zinc
            finger protein (KRAB-ZFP). The encoded protein contains an
            N-terminal kruppel-associated box (KRAB) domain and thirteen
            C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent
            the largest family of mammalian transcriptional repressors, which
            function through the recruitment of the nuclear co-factor
            KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and
            induce heterochromatin formation. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648737.1, SRR1660807.116381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444149.7/ ENSP00000414887.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DC350553.1         53-91
            40-847              AK300504.1         1-808
            848-1179            BX648737.1         847-1178
            1180-2194           AK300504.1         1141-2155
            2195-2437           BX648737.1         2194-2436
            2438-2574           BX114675.1         383-519
            2575-2575           BM971752.1         18-18               c
            2576-3252           AC104117.2         150397-151073
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..3252
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /note="zinc finger protein 879"
                     /db_xref="GeneID:345462"
                     /db_xref="HGNC:HGNC:37273"
     exon            1..101
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /inference="alignment:Splign:2.1.0"
     exon            102..169
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1828
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /codon_start=1
                     /product="zinc finger protein 879"
                     /protein_id="NP_001129588.1"
                     /db_xref="CCDS:CCDS47352.1"
                     /db_xref="GeneID:345462"
                     /db_xref="HGNC:HGNC:37273"
                     /translation="MARRLLPAHVQESVTFRDVAVFFSQDEWLHLDSAQRALYREVML
                     ENYSILVSLGILFSKPKVISQLEQGEDPWMVESGVPQGAHLGWESLFGTIVSKEENQE
                     VMKKLIIDGTFDFKLEKTYINEDKLEKQQGKKNRLFSKVLVTIKKVYMKERSFKGVEF
                     GKNLGLKSSLIRKPRIVSRGRRPRSQQYSVLFKQLGVNTVRKCYKCNICGKIFLHSSS
                     LSKHQRIHTGEKLYKCKECRKAFSQSSSLTQHLRVHTGEKPYICSECGKAFSFTTSLI
                     GHQRMHTGERPYKCKECGKTFKGSSSLNNHQRIHTGEKPYKCNECGRAFSQCSSLIQH
                     HRIHTGEKPYECTQCGKAFTSISRLSRHHRIHTGEKPFHCNECGKVFSYHSALIIHQR
                     IHTGEKPYACKECGKAFSQSSALIQHQRIHTGEKPYKCNECGKAFSWISRLNIHHRIH
                     TGEKPYNCKECGKAFSSHSGVNTHRKIHTGEKPYKCNDCEKAFNQSSALIQHQRIHTG
                     EKPYNCKVCGKAFRQSSSLMTHMRIHTGEKPYKCKECGKAFSQSSSLTNHQRTHN"
     exon            170..296
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /inference="alignment:Splign:2.1.0"
     exon            297..392
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /inference="alignment:Splign:2.1.0"
     exon            393..3252
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2553..2558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /note="hexamer: AGTAAA"
     polyA_site      2575
                     /gene="ZNF879"
                     /gene_synonym="DKFZp686E2433"
                     /note="major polyA site"
ORIGIN      
        1 gcagttgcgc ccggcagcga cgggaaacgt ctctgaatta ggtgttccgc tcgcctcttg
       61 tgcggtgtgg agctgcgcgc cccccgccga ggcgggccca ggtgccttct ccaagagagg
      121 cagcagggag ggagaaatgg caaggaggtt gctgccagcc catgtacagg agtccgtgac
      181 gttcagggat gtggccgtgt tcttcagcca ggacgagtgg ttgcacctgg actctgccca
      241 gagagccttg taccgggagg tgatgctgga gaactacagc atcctggtct cactggggat
      301 tctcttttcc aagccaaagg tcatctccca gttagagcaa ggagaagacc cctggatggt
      361 ggagagtgga gttccccaag gcgcacatct cggatgggaa agcttgtttg gaaccatagt
      421 ttctaaagaa gaaaatcagg aagtcatgaa aaaactcata attgatggca catttgactt
      481 caagttggag aagacctaca taaatgaaga taagttagag aagcaacaag gcaaaaagaa
      541 cagacttttc agtaaagtgt tagttaccat caaaaaagtc tacatgaagg agaggagctt
      601 taaaggtgtt gaatttggga aaaatcttgg tctaaaatca tcgcttatta gaaaaccgag
      661 aatagtttcc agaggaagga gaccccgttc acagcagtat tcagttctct ttaaacaact
      721 gggggtcaac acagtgcgta aatgttataa atgtaatatc tgtgggaaaa tcttcctcca
      781 cagttcctcc ctgagtaaac accagagaat ccacactgga gagaagctct ataaatgtaa
      841 ggaatgtagg aaagccttca gccaaagctc atccctaact cagcacttga gggttcatac
      901 aggagagaaa ccttatatat gtagtgaatg tggaaaagcc ttcagtttca ccacatctct
      961 tattggacac cagagaatgc atactggaga gagaccttat aaatgcaagg aatgtggaaa
     1021 aacatttaaa ggtagttcat ctcttaataa tcaccagcga attcacacag gagagaagcc
     1081 ctataagtgt aatgaatgtg ggagggcctt cagtcagtgc tcatctctca ttcagcacca
     1141 cagaattcat actggggaga aaccgtatga atgtactcag tgtgggaaag ccttcacttc
     1201 aatatcgcgg ctaagtaggc accatcgaat tcatactgga gagaaaccct ttcattgtaa
     1261 cgagtgtgga aaagtattca gctatcactc agcccttatc atacatcaga gaattcacac
     1321 tggtgagaaa ccatatgcat gcaaagaatg tgggaaagcc ttcagccaaa gctcagctct
     1381 catacaacat caaagaattc acactggaga aaaaccctac aaatgtaatg aatgtgggaa
     1441 agccttctct tggatttcac ggcttaatat acatcacaga attcacactg gagagaaacc
     1501 atataattgt aaggaatgtg gaaaagcctt cagttcccac tcaggcgtta atactcatcg
     1561 aaaaattcat actggagaaa aaccttataa atgtaatgac tgtgagaaag ccttcaacca
     1621 aagctcagct ctaattcagc accagagaat tcatactgga gagaaaccat ataattgtaa
     1681 agtgtgtggg aaagccttca gacagagttc atcccttatg acacacatga gaattcatac
     1741 aggggaaaaa ccttataaat gtaaagaatg tgggaaggct tttagtcaga gctcatctct
     1801 tactaatcat caaaggactc ataattgaga aaaactgtat aaatgcatgt aggaactgaa
     1861 gttatattcc atactgagta tcaaaaaatt cattgtgggg agaaagtgat gaagagtagt
     1921 taatcatagg taaaacttca gcattagacc tcatcacaca tcagagactt catgatgcag
     1981 ggtaaccttg ggaatgctag aaaagcttct ataaaatgtt tattcatatg ttcttaagtt
     2041 attaccatga aatggagaat ttttaagatt gcagggttag tatttgattg tctagtgatg
     2101 tacgataaca gccaccagct ttcctgagca tcactgggaa gcctgctgtt tatgtacaag
     2161 tacagccata aaatccagac acagataaat ctaggaatct attttttgaa actattatgc
     2221 aagccagtgg tactagaaag aatgttttag aaaagaaata tgtacaggtg acccatagct
     2281 acctcactgt cactaaaatg ttttttaata atcttaaagc agattctgca cttcatggta
     2341 aagactttga attgtttctc tgctttctaa gccattcacc tgagaagaaa atcactccat
     2401 aaactatgca gacgtactgt ctttgcgttt tcttcctgac tacttgttcc aaactctgag
     2461 tcagatctaa agtcacttta agtcacagaa cgcatggtat ttcacttgtt tttctcatta
     2521 aaagtgatta cctttgctgt attaaattga taagtaaagg tcattcagac aaccactgct
     2581 tttgcaattt actgaaaaat gttataaatt atctcagaat gtagccaata gcaagcacag
     2641 ctcagctccc agggtctgcc tgcttctgtg agctttctgg ttaccagcca ccagaaggcc
     2701 caggaacaat gtagaactca ggtcatcatc cttggaggta aaatgaacca gatgattttc
     2761 acccttactt ccactttttc gccttcatca gacaaggttc actttctccc cacactctaa
     2821 aggtcactgg gcaaatattt aggctctgag ttcagatact ctttcttcca gcaaatggac
     2881 ttacactctt caacaagtga tttagctcat ttcagcattt ctaaaatgtg aatcataaga
     2941 ttagcaagct aaaaacagtt atctcacaag tcaaaattgt tgggctttac agaggctaac
     3001 atctagttta gccaagttta tcaggagggg gcaagcactt aagggctgaa acgacccatt
     3061 tcataaagtg ctaagttttt ctgccaagga actttaaaaa atagaaaact ggctgggtgc
     3121 agtggctcac gcctgtaatc ccggcacttt gggaggccaa gacgggcaga tcatgaggtc
     3181 aggagatcga gaccatcctg gctaacatgg tgaaaccacg tctccactaa aaatacaaaa
     3241 aaaaaaaaaa aa
//
