LOCUS       NP_001073873             531 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein 878 [Homo sapiens].
ACCESSION   NP_001073873 XP_001131188
VERSION     NP_001073873.2
DBSOURCE    REFSEQ: accession NM_001080404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA007842.1, BQ222464.1 and AC022415.5.
            
            On May 11, 2011 this sequence version replaced NP_001073873.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ222464.1, SRR1163657.260315.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547628.2/ ENSP00000447931.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     Protein         1..531
                     /product="zinc finger protein 878"
                     /calculated_mol_wt=61409
     Region          3..44
                     /region_name="KRAB"
                     /note="KRAB box; pfam01352"
                     /db_xref="CDD:460171"
     Region          122..521
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          145..165
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          173..193
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          201..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(206,208,210,212..213,216..217,220,234,236,240..241,
                     244..245,248,262,264,266,268..269,272..273,276)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          229..249
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          257..277
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          285..305
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          313..333
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          341..361
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          369..389
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          397..417
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(402,404,406,408..409,412..413,416,430,432,436..437,
                     440..441,444,458,460,462,464..465,468..469,472)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          425..445
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          453..473
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          481..501
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..529
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..531
                     /gene="ZNF878"
                     /coded_by="NM_001080404.3:161..1756"
                     /db_xref="CCDS:CCDS45984.2"
                     /db_xref="GeneID:729747"
                     /db_xref="HGNC:HGNC:37246"
ORIGIN      
        1 mdsvafedva vnftqeewal ldpsqknlyr evmqetlrnl tsigkkwnnq yiedehqnpr
       61 rnlrrliger lseskeshqh gevltqvpdd tlkkktpgvq syessvcgei giglsslnrh
      121 lrafsysssl aihgrthtge kpyeckecgk afrfpssvrr herihsakkp yeckqcgkaf
      181 sfpssvrrhe rihsakkpye ckqcgkalsy lvsfqthmrm htgerphkcn icgkaffsps
      241 slkrheksht gekrykckqc dkafncpssf qyherthsge kpyectqcrk afrsvkylrv
      301 herkhtgekp yecklcgkgf isstsfryhe kthtgekpye ckkcvkafsf vkdlrihert
      361 htgekpfeck qcgktftssn sfhyhertht gekpyeckqc gkafrsasvl qkhirthtge
      421 kpygckqcgk vfrvasqlkm herthtgekp yeckqcgkaf issnsiryhk rthtgekpyk
      481 ckqcgkafis snsflyheri htgekpyeck qcgkafrsas ilqkhvrtha g
//
