LOCUS       NM_001353803            2785 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 875 (ZNF875), transcript variant
            49, mRNA.
ACCESSION   NM_001353803 XM_017026678
VERSION     NM_001353803.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Zeng,Q., Chen,X., Ning,C., Zhu,Q., Yao,Y., Zhao,Y. and Luan,F.
  TITLE     Methylation of the genes ROD1, NLRC5, and HKR1 is associated with
            aging in Hainan centenarians
  JOURNAL   BMC Med Genomics 11 (1), 7 (2018)
   PUBMED   29394898
  REMARK    GeneRIF: the methylation profile combination of HKR1, ROD1, and
            NLRC5 could be a promising biomarker for aging in Hainan
            centenarians
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Nishimura,A., Yamamoto,K., Oyama,M., Kozuka-Hata,H., Saito,H. and
            Tatebayashi,K.
  TITLE     Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and
            Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the
            Kss1 Mitogen-Activated Protein Kinase
  JOURNAL   Mol Cell Biol 36 (7), 1109-1123 (2016)
   PUBMED   26787842
  REMARK    GeneRIF: Ahk1 is a scaffold protein in the HKR1 subbranch and
            prevents incorrect signal flow from Hkr1 to Kss1
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Oguri,T., Katoh,O., Takahashi,T., Isobe,T., Kuramoto,K., Hirata,S.,
            Yamakido,M. and Watanabe,H.
  TITLE     The Kruppel-type zinc finger family gene, HKR1, is induced in lung
            cancer by exposure to platinum drugs
  JOURNAL   Gene 222 (1), 61-67 (1998)
   PUBMED   9813242
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Ruppert,J.M., Kinzler,K.W., Wong,A.J., Bigner,S.H., Kao,F.T.,
            Law,M.L., Seuanez,H.N., O'Brien,S.J. and Vogelstein,B.
  TITLE     The GLI-Kruppel family of human genes
  JOURNAL   Mol Cell Biol 8 (8), 3104-3113 (1988)
   PUBMED   2850480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016590.7 and AC008806.4.
            
            On Aug 13, 2020 this sequence version replaced NM_001353803.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1757490.1,
                                           SRR14038197.2662338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392153.8/ ENSP00000375994.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC016590.7         26605-26738         c
            135-223             AC016590.7         26130-26218         c
            224-350             AC016590.7         14071-14197         c
            351-446             AC016590.7         13515-13610         c
            447-2785            AC008806.4         124600-126938       c
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2785
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /note="zinc finger protein 875"
                     /db_xref="GeneID:284459"
                     /db_xref="HGNC:HGNC:4928"
                     /db_xref="MIM:165250"
     exon            1..134
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..223
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2113
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /note="isoform c is encoded by transcript variant 49;
                     oncogene HKR1; Krueppel-related zinc finger protein 1;
                     HKR1, GLI-Kruppel zinc finger family member"
                     /codon_start=1
                     /product="zinc finger protein 875 isoform c"
                     /protein_id="NP_001340732.1"
                     /db_xref="CCDS:CCDS82338.1"
                     /db_xref="GeneID:284459"
                     /db_xref="HGNC:HGNC:4928"
                     /db_xref="MIM:165250"
                     /translation="MATGLLRAKKEAFVAFRDVAVYFTQEEWRLLSPAQRTLHREVML
                     ETYNHLVSLEIPSSKPKLIAQLERGEAPWREERKCPLDLCPESKPEIQLSPSCPLIFS
                     SQQALSQHVWLSHLSQLFSSLWAGNPLHLGKHYPEDQKQQQDPFCFSGKAEWIQEGED
                     SRLLFGRVSKNGTSKALSSPPEEQQPAQSKEDNTVVDIGSSPERRADLEETDKVLHGL
                     EVSGFGEIKYEEFGPGFIKESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTH
                     SGGKPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSG
                     LKPYVCKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEK
                     PYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPY
                     VCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLSTHQRTHSGEKPFVC
                     AECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFRHKRAHSGAFVCRECG
                     QGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQRTHSGEKPYICRKCGRG
                     FSRKSNLIRHQRTHSG"
     exon            224..350
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..446
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..2785
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /note="hexamer: AATAAA"
     polyA_site      2785
                     /gene="ZNF875"
                     /gene_synonym="HKR1"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtc ggtggcccag gcgcgttaag ctggttggga cccgggaagg cctccctctt
       61 aaggtctttc ccacacctct gcaccttgtt acctgacttt cggcttcagg atccgcagcg
      121 tgcacccgcg ttccatctgt cttctgagac tttgcccttc tccaggaaga gcactcagga
      181 gaccaggaaa atggccacag ggctcctgag agccaaaaaa gaggcgttcg tggcattcag
      241 ggatgtggct gtgtacttca cccaggagga gtggaggttg ttgagccctg ctcagaggac
      301 cctgcacagg gaggtgatgc tggagactta taaccatctg gtctcactgg aaattccatc
      361 ttctaaacca aaactcattg ctcagctgga gcgaggggaa gcgccctgga gagaggagag
      421 aaaatgtcca ctggacctct gtccagaatc gaagccagaa attcaactta gtccctcctg
      481 ccctctgatt ttctccagtc agcaagctct cagccaacat gtgtggctga gtcatctctc
      541 tcagctgttt tcaagtttat gggcaggaaa tcctctccac ctgggaaaac actatccaga
      601 agatcagaaa caacagcagg atccattctg ctttagtggc aaagcagaat ggattcaaga
      661 gggagaagac tccagactcc tgtttgggag agtaagcaaa aatggcactt caaaggcact
      721 ttccagccca cctgaagaac aacagccagc acagtccaag gaagacaaca cagtggtgga
      781 tatagggtcc agccctgaac ggagggcaga tctagaggaa acagacaaag tattgcatgg
      841 tttagaagtc tcaggatttg gagaaatcaa atatgaagag tttgggccag gctttatcaa
      901 ggagtcaaac ctccttagcc tccagaagac acaaactggg gagacacctt acatgtacac
      961 tgagtgggga gacagctttg gcagtatgtc agtcctcatc aaaaacccaa ggacacactc
     1021 tgggggaaag ccttatgtgt gcagggaatg tgggcgaggc tttacgtgga agtcaaacct
     1081 gatcacacat cagaggacac actcagggga gaaaccttat gtgtgcaagg attgtggacg
     1141 aggctttact tggaagtcga acctctttac acatcagcgg acacactcag ggctcaagcc
     1201 ttatgtgtgc aaggaatgtg ggcagagctt tagcctgaag tcaaacctca ttacccacca
     1261 gagggcgcac actggggaga agccttatgt ttgcagggaa tgtgggcgtg gctttcgcca
     1321 gcattcacac ctggtcagac acaagaggac acattcagga gagaagcctt acatttgcag
     1381 ggagtgtgag caaggcttta gccagaagtc acacctcatc agacacttaa ggacacacac
     1441 aggagagaag ccttatgtat gcacagaatg tgggcgtcac tttagctgga aatcaaacct
     1501 caaaacacac cagaggacac actcaggggt taaaccttat gtctgcctgg agtgcgggca
     1561 gtgctttagc ctgaagtcaa accttaacaa acaccagagg tcacacacgg gggagaagcc
     1621 atttgtatgt acggagtgtg ggcgaggctt tacccggaaa tcaaccctga gcacgcacca
     1681 gaggacacac tcaggggaga agccatttgt atgtgctgag tgtggacgag gctttaatga
     1741 taagtccacc ctcatttcac accagaggac acattcaggg gaaaagcctt ttatgtgcag
     1801 ggagtgtggc agaaggtttc ggcagaagcc taacctgttt aggcacaaga gggcacactc
     1861 aggtgccttt gtgtgcaggg agtgtgggca aggcttttgt gctaagttaa ctctcattaa
     1921 acaccagaga gcacacgcag gggggaagcc tcatgtgtgc agggagtgtg ggcaaggctt
     1981 tagccggcag tcacacctca ttagacacca gaggacacat tcaggagaga agccttatat
     2041 ttgcagaaag tgtggacggg gctttagtcg gaagtccaac cttatcagac atcagaggac
     2101 acactcagga tagaaacttt atgtgtatag ggaatgtggt acagccttta gccaggagtc
     2161 atacttcatc agacaccaga ggacacacac agtgctgtgg ctttttcagc cattgctaga
     2221 taccaaagtg gagacattct gtgtgtgatt atgcatgaga ctgtactggt aagacttgta
     2281 tctccatcca cctgaaggag aattgctggc tcattttcag gagccctgcc cttcctcact
     2341 gtggatggtg ggttgtggaa acccggtcag gtaatgatag tggcaggagg cagtcaaatg
     2401 cccaggcaga taggggtggg tacctggtga aacccaacct taaagctgaa gacagtcccg
     2461 gctaaatcct catactgaat tgagaacctg tcttcccatt tggtgtgctt tcctccgatt
     2521 gatcccaacc cttcacctat tttacgtata cctgcccttt cctaattggt ttttacactg
     2581 ctgtgcccac cttttgagtg gtgcctttgc atacttacaa atcagtcaac gtgtattccc
     2641 ctattctgag cccataaaag acccagactc agctgcagtg aggagagaaa tcaccctgct
     2701 gtgggggttg gggaccactc cctgcatccc ctctccactg agagctgttc ttttgctcaa
     2761 taaaattctt ttctacccat cctca
//
