LOCUS       NM_001099220            6942 bp    mRNA    linear   PRI 01-NOV-2024
DEFINITION  Homo sapiens zinc finger protein 862 (ZNF862), mRNA.
ACCESSION   NM_001099220 XM_935653 XM_937178
VERSION     NM_001099220.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6942)
  AUTHORS   Zhu,Y., Zhao,T., Wu,Y., Xie,S., Sun,W. and Wu,J.
  TITLE     ZNF862 induces cytostasis and apoptosis via the p21-RB1 and
            Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts
  JOURNAL   J Periodontal Res 59 (3), 599-610 (2024)
   PUBMED   38482719
  REMARK    GeneRIF: ZNF862 induces cytostasis and apoptosis via the p21-RB1
            and Bcl-xL-Caspase 3 signaling pathways in human gingival
            fibroblasts.
REFERENCE   2  (bases 1 to 6942)
  AUTHORS   Wu,J., Chen,D., Huang,H., Luo,N., Chen,H., Zhao,J., Wang,Y.,
            Zhao,T., Huang,S., Ren,Y., Zhai,T., Sun,W., Li,H. and Li,W.
  TITLE     A novel gene ZNF862 causes hereditary gingival fibromatosis
  JOURNAL   Elife 11, e66646 (2022)
   PUBMED   35142290
  REMARK    GeneRIF: A novel gene ZNF862 causes hereditary gingival
            fibromatosis.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU164247.1, AB011115.1, AC004877.1, DA724031.1, BC113087.1 and
            BQ270712.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001099220.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000223210.5/ ENSP00000223210.4
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               BU164247.1         9-671
            664-1361            AB011115.1         254-951
            1362-1362           AC004877.1         114724-114724
            1363-2396           AB011115.1         953-1986
            2397-2397           DA724031.1         482-482
            2398-3260           AB011115.1         1988-2850
            3261-3981           BC113087.1         279-999
            3982-6463           AC004877.1         119814-122295
            6464-6942           BQ270712.1         8-486
FEATURES             Location/Qualifiers
     source          1..6942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..6942
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /note="zinc finger protein 862"
                     /db_xref="GeneID:643641"
                     /db_xref="HGNC:HGNC:34519"
                     /db_xref="MIM:620974"
     exon            1..261
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..3747
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /codon_start=1
                     /product="zinc finger protein 862"
                     /protein_id="NP_001092690.1"
                     /db_xref="CCDS:CCDS47741.1"
                     /db_xref="GeneID:643641"
                     /db_xref="HGNC:HGNC:34519"
                     /db_xref="MIM:620974"
                     /translation="MEPRESGKAPVTFDDITVYLLQEEWVLLSQQQKELCGSNKLVAP
                     LGPTVANPELFRKFGRGPEPWLGSVQGQRSLLEHHPGKKQMGYMGEMEVQGPTRESGQ
                     SLPPQKKAYLSHLSTGSGHIEGDWAGRNRKLLKPRSIQKSWFVQFPWLIMNEEQTALF
                     CSACREYPSIRDKRSRLIEGYTGPFKVETLKYHAKSKAHMFCVNALAARDPIWAARFR
                     SIRDPPGDVLASPEPLFTADCPIFYPPGPLGGFDSMAELLPSSRAELEDPGGDGAIPA
                     MYLDCISDLRQKEITDGIHSSSDINILYNDAVESCIQDPSAEGLSEEVPVVFEELPVV
                     FEDVAVYFTREEWGMLDKRQKELYRDVMRMNYELLASLGPAAAKPDLISKLERRAAPW
                     IKDPNGPKWGKGRPPGNKKMVAVREADTQASAADSALLPGSPVEARASCCSSSICEEG
                     DGPRRIKRTYRPRSIQRSWFGQFPWLVIDPKETKLFCSACIERPNLHDKSSRLVRGYT
                     GPFKVETLKYHEVSKAHRLCVNTVEIKEDTPHTALVPEISSDLMANMEHFFNAAYSIA
                     YHSRPLNDFEKILQLLQSTGTVILGKYRNRTACTQFIKYISETLKREILEDVRNSPCV
                     SVLLDSSTDASEQACVGIYIRYFKQMEVKESYITLAPLYSETADGYFETIVSALDELD
                     IPFRKPGWVVGLGTDGSAMLSCRGGLVEKFQEVIPQLLPVHCVAHRLHLAVVDACGSI
                     DLVKKCDRHIRTVFKFYQSSNKRLNELQEGAAPLEQEIIRLKDLNAVRWVASRRRTLH
                     ALLVSWPALARHLQRVAEAGGQIGHRAKGMLKLMRGFHFVKFCHFLLDFLSIYRPLSE
                     VCQKEIVLITEVNATLGRAYVALESLRHQAGPKEEEFNASFKDGRLHGICLDKLEVAE
                     QRFQADRERTVLTGIEYLQQRFDADRPPQLKNMEVFDTMAWPSGIELASFGNDDILNL
                     ARYFECSLPTGYSEEALLEEWLGLKTIAQHLPFSMLCKNALAQHCRFPLLSKLMAVVV
                     CVPISTSCCERGFKAMNRIRTDERTKLSNEVLNMLMMTAVNGVAVTEYDPQPAIQHWY
                     LTSSGRRFSHVYTCAQVPARSPASARLRKEEMGALYVEEPRTQKPPILPSREAAEVLK
                     DCIMEPPERLLYPHTSQEAPGMS"
     exon            262..373
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     exon            374..478
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     exon            479..1176
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1354
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1459
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..3571
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..6942
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6917..6922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /note="hexamer: AATAAA"
     polyA_site      6942
                     /gene="ZNF862"
                     /gene_synonym="GINGF6"
                     /note="major polyA site"
ORIGIN      
        1 agtgaccgta aagctgttcg ctcggtgcga cgcaagtctc agctcagcgc gcttatcctg
       61 ggtccaccgg cgctaccgcc ccccgacgtg agagagcgaa gttcttgggc cgcgctccct
      121 ccctacctgg gtgccctccc cctccgggag cctgggtccc cggggcggtc gcggcggctg
      181 catcctcagg ccaggccgcg gggggagggg gcggcacggg cctccgaaag cggggccatg
      241 gagcccagag agtcggggaa ggctcctgtg acgtttgatg acatcactgt gtacttactc
      301 caggaggaat gggtgctgct gagccagcaa cagaaggagc tctgtggttc caacaagctg
      361 gtggcaccac tgggaccaac tgttgccaat cctgagctgt tccgcaagtt cggacgaggg
      421 ccagagccat ggcttggcag cgtccagggc cagaggagcc ttctggagca tcacccagga
      481 aaaaaacaga tgggctacat gggagaaatg gaggtgcaag gtcccaccag ggagagtgga
      541 cagtccctcc cgcctcagaa gaaagcctac ctttcccacc tcagtacagg cagtggacac
      601 atcgagggag actgggccgg aagaaacagg aaacttctga agccccggtc catccagaag
      661 tcgtggtttg tgcagtttcc gtggctgatc atgaatgagg agcagacggc tctgttctgc
      721 tctgcttgcc gagaataccc ctccatcagg gacaaacggt caagactaat agaaggttat
      781 acaggaccat tcaaggtgga gactctcaaa taccacgcga agagcaaggc ccacatgttc
      841 tgtgtcaatg ccttggcagc gagggacccc atctgggcag cccggttccg gagcatcaga
      901 gacccacctg gagatgttct ggccagcccg gagccgctct tcactgcaga ttgccccata
      961 ttctaccccc cagggcctct gggaggattt gatagcatgg ctgagctcct gccaagttca
     1021 agagctgaac tagaggaccc tgggggggat ggagcaattc ctgcaatgta tctagactgc
     1081 atttcagatt tgaggcaaaa agaaatcact gatggcatcc acagctcctc agacattaat
     1141 attttatata atgatgcagt agaatcctgc attcaggacc cttctgcaga ggggctgtcg
     1201 gaggaggttc ctgtggtgtt tgaggagctg ccggtggtgt tcgaggatgt ggcagtgtat
     1261 ttcacccggg aggagtgggg catgctagac aagcggcaga aggagctgta cagagacgtg
     1321 atgcggatga actacgagct gttggcatcc ttgggacctg ccgctgccaa gccagacttg
     1381 atctccaaac tggagcggag ggctgcaccc tggatcaagg acccaaatgg gccaaagtgg
     1441 gggaaaggtc gtcctccagg gaacaagaag atggtggcag tgagagaggc agacacacag
     1501 gcctcggctg cagactccgc gttgcttcca ggctctcccg tggaggcccg tgcctcctgc
     1561 tgcagttcca gcatttgtga ggaaggagat ggacctagga gaatcaagag gacatacagg
     1621 ccccgttcca ttcagaggtc atggtttggg cagttcccat ggttagtaat tgaccccaaa
     1681 gagaccaaac tcttctgctc agcctgcata gaaagaccta atctccatga taaatcatct
     1741 cggttagtca gaggttacac ggggcctttt aaagtggaga ctttaaaata ccatgaagtc
     1801 agcaaagcgc acaggctctg tgtcaacacg gttgaaatca aggaagacac ccctcacact
     1861 gccctcgttc cagagatctc cagcgacctc atggccaaca tggagcactt tttcaatgcc
     1921 gcctactcca ttgcatacca ctcaaggccc ctgaatgact ttgagaagat cctgcagctc
     1981 ctccaaagca cggggaccgt gatattaggc aagtaccgca atcgcacggc gtgcactcag
     2041 ttcatcaagt acatctcaga gaccctgaag agggagatcc tggaggacgt gcggaactcg
     2101 ccctgtgtga gcgtgctgct ggacagctcc accgacgcct ccgagcaggc ctgcgtgggg
     2161 atttacatcc gctacttcaa gcagatggag gtgaaagagt cctacatcac tctggcccct
     2221 ctctacagtg agacagcaga tgggtacttc gagaccatcg tttctgccct ggatgagctg
     2281 gacatcccct tccggaagcc tggctgggtg gtggggctgg ggacggatgg ctcagccatg
     2341 ttgagctgca gaggaggcct tgtggaaaag ttccaggagg tcatcccgca gctgctgcct
     2401 gtccactgcg tggcccaccg gctgcacctg gctgtggtgg acgcctgcgg gagcatcgat
     2461 ctggtgaaga agtgtgaccg gcacatccgc accgtcttca agttttatca gtcctcaaac
     2521 aagaggctga acgagctgca ggaaggtgcg gcgcctctgg agcaggagat catccgcctg
     2581 aaggatctga atgcggtccg ctgggtggcc agcaggaggc gcacgctgca cgcgctgctc
     2641 gtgagctggc ccgccctggc caggcacctc cagagggtgg cagaggctgg gggccagatt
     2701 gggcaccggg ccaaagggat gctgaagctc atgcgcggct tccactttgt caagttctgc
     2761 cacttcctgt tggacttcct gagcatctac aggcctctgt ccgaggtgtg ccagaaggag
     2821 atcgtgctga ttacagaggt gaacgccacg ctgggccgcg cctacgtggc actggagagc
     2881 ctccgtcacc aggcagggcc caaagaggaa gaattcaacg ccagcttcaa ggatgggcgg
     2941 ctccacggca tctgcttgga caaactggag gtagcggaac agcggttcca ggcggatagg
     3001 gagaggacag tcctgacggg gattgagtac ctccagcaga ggtttgacgc agaccgaccc
     3061 ccacagctga agaacatgga ggtgtttgac accatggcct ggccaagtgg gattgaactt
     3121 gccagttttg ggaatgatga cattctcaac ctggccaggt atttcgagtg ctccctccca
     3181 acaggataca gtgaggaagc tctgctggag gagtggctgg gcctgaaaac cattgcccag
     3241 cacctcccgt tctccatgct ctgcaaaaac gccctggccc agcactgccg cttccccctg
     3301 ctaagcaagc tcatggccgt ggtggtctgt gtgcccatct ccacctcttg ctgtgagcgg
     3361 gggttcaagg ccatgaaccg aatcaggacc gatgagagga ccaagctctc caacgaggtg
     3421 ctcaacatgc tcatgatgac agctgtgaac ggcgtggccg tcacggagta cgacccccag
     3481 cccgccatcc agcactggta cctgacctcc tcaggccggc gtttcagcca tgtctacacc
     3541 tgtgcccagg tgccagcccg ctcccctgca agcgccaggc tcaggaagga ggagatggga
     3601 gccctctatg tggaggagcc caggacccag aagccaccca tcctgccctc cagggaagca
     3661 gcggaggttc tgaaggactg catcatggag cctcccgaga gactcctgta tccccacacc
     3721 agccaggagg cccccgggat gtcctgaggg acagggagtc cttgggactg ccttggagac
     3781 gcctctgtga tcactgggac aggctctgca gattctaggc tgccctagga tcttctgctg
     3841 gtggcgatgg tctctaagca ccaggaagtg ggcagtggca tcccagagca gcaggggtat
     3901 caggaggtgc atgacctgtt tcctgaggcc ccactcagca cagccatgcc tcacagcaca
     3961 caaatgtgcc agaaggttct atatctcaag ttcattttta aggtgctgca gaaaataacc
     4021 ccatcatgaa aggtttcagc ccctgagttt tggtggcaag aggagtgtcc tggtagggga
     4081 gactgttgga catccctggg gaatgttcca gggaggctgc ccacagtcta agtgggaatg
     4141 ggaaagacca ccttgttaga gggggaggtt gcccctgctc tagggacagc tggcctggct
     4201 gcaagagccc ccagaggcat tgttctggga cttcctaccc tggctcccac agcagaagca
     4261 gtgaggccgt ggtctcgtgc ggaactctac ctcttcccag ggcttccttt agggcgaaac
     4321 aatcacaagc cctttgcaca gagcacccaa gaaagttctc ttcctgcagc tccagatggt
     4381 ggagctgggc tcttctggca gggggtctgg tgcttcccgg agagccgagc cgcgtttaac
     4441 ccgtggcatg cccggcccgg tttacccagg agaggatggg acgaagttgg agttgggagg
     4501 cttgggatgc agccccagct ctgctgcagg cagtggtctg attaatccct tcctctttgt
     4561 gcctcagttt ccctctccat gaagtggcag cagagatcca agtgcctgct gactccccat
     4621 ctgccctagg attagtgaat gagagcctcg agctccctca aagacctctg gctgcagtgt
     4681 ggacttagct gccatctgcc ccatcctcgt ccttagtggg acaggtagga atttgtctcc
     4741 aaagtccttg ttgtaggagt tgctctctga atgcaccatc tgcacgacag gctagtccac
     4801 tcttctctga gctgccctgg ggactctgca ccaggatctc cagggcccac tgagacatcc
     4861 ccgaatgggc gctcagtgac aagggctttg aacaacctcc tccagggact ttgggcctgc
     4921 tctagcttca gaaccacaga accaccgccc tagaggcaca gaggggcttc tggcactgct
     4981 aggttcacac cctcctcgcc ccgatcttcc ttccacctaa agtgaagcac ttttccttcc
     5041 aagggcagct ccgtcttggc aggctcagga ggccgcttat caggaggagg atgattttgt
     5101 ctaggttctg ccttccttaa ccatgggcag gaaatgaggc aagtcagcag gcagggtttc
     5161 tctgccctgc ctgatacttg ttttaaacag gcaggaagtg ggcgccatcc atcccagctt
     5221 gcttgctgcc tggctcaggc aggtcctgtg ctgtgctgca ggcccctgtg ggtgggccct
     5281 ttctccatag tctgccgctt cccattccca gggtagatgc tggcatctga gcacctgagt
     5341 acccttccta ttcccagggt agaagctgct gtctgagtac ccttcccatt cccagggtag
     5401 atgctggcat ctgagcacct gagtaccctt cctattccca gggtagaagc tgctgtctga
     5461 gtacccttcc cattcccagg gtagatgctg gcgtccgagc ccctccctgg taccgcaggt
     5521 accctggtac cccacctgcc ctttcatccc caccccagta cttagcctta gcactgttgc
     5581 tttcgtgtca ttttcagttc tagtcaggaa ttcctttctt gctttctgcc tttgacctgt
     5641 ggaaatgtct cccagccctg tgggtctggc ggtcagaggg accccacagg cctgtggtgc
     5701 gggagctctg ggaggtgtta ctatctgcgt ggctaaggca cacacaggcc tccttctccc
     5761 catcaccgtc tccatgggcg ttcaggaact tgcccaggtc aggcactgtg gatgtgaact
     5821 cgtggaaagg gagggagaaa ggctttttta ggtggggcta tagcctctgc cctacccaca
     5881 gggattccac atcaaggtgc tgttccagca cacatgcttc ctgcggcctc ttcatccttg
     5941 aagaatccct cagagcagga ggccatcctg tgagcagccg tgagtgggtc tctgtgggag
     6001 tagttctgga gctgaggtgg aagctagggg aagcaactcg ccctctccac gtcagcatca
     6061 gcgtgctccg aggacaccgg ccagtgcctt ccttaggtgg tgggaaaggg gggtccctgt
     6121 gcagcggggc cactgagaat gctgtttgtc ataaaatttg cactacccga tttctcaagg
     6181 ggcacaggcc tgctccgttc ccctttgtca gccaatggcc aagaaggaag aagatgactg
     6241 ccatcttatt cctgaacttc ctcattcagg acccccgtgg aaacacagtg agcatcctta
     6301 tcagaggccc tggcccaggc tggccccttt gctttgtttg gagaggctgg ctgagtttca
     6361 gcccctagtg ctggagaccc ccttgttgga gaggcttcct gtttatgcct cacaagaaga
     6421 aaaaccacag ggctctggga ggggaagaag catgcactcc cgctttggct ggagtcccag
     6481 cgcttgtcgc caccctcctc cttgcctgta gtcttgacag catccgtatg tacgtgtcct
     6541 ggcatttccc ctccctctcc ctgatgactg atacccaccg ggtctgacat tccaagtaac
     6601 cagtatgtaa ctggtagttt gatcccaata gccatagcga ctccaggtgg gagtgaggga
     6661 gcccagcccc ctgtcctgga agatacctta gagtatgtga ccgcgctcca gacccttgct
     6721 tctctctcct gcagaggatg agtttctagg gtgctaagta cctatcagaa cagtgtggag
     6781 gggcgggtcc ctcatacagg tgtgtgctta gccaaataca gtaactgtga ctggcccagg
     6841 gatgttctct cctctatttt caaagatgaa aggaggtttt aaaaaccatg tttgattcct
     6901 aaccttttgc tacctgaata aagcagagtc tatttcaaca ca
//
