LOCUS       NM_001137674            3217 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 860 (ZNF860), mRNA.
ACCESSION   NM_001137674 XM_001132136 XM_001133293 XM_001723798 XM_001725698
            XM_001725699 XM_496634
VERSION     NM_001137674.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Pan,H.X., Bai,H.S., Guo,Y. and Cheng,Z.Y.
  TITLE     Bioinformatic analysis of the prognostic value of ZNF860 in
            recurrence-free survival and its potential regulative network in
            gastric cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (1), 162-170 (2019)
   PUBMED   30767193
  REMARK    GeneRIF: The gastric cancer (GC) tissues had significantly
            upregulated ZNF860 expression. High ZNF860 RNA expression was
            independently associated with shorter recurrence-free survival in
            patients with early GC. Six genes (OSBPL10, FAM208A, TOPBP1,
            SPTY2D1, NAB1, and CMTM6) were positively co-expressed with ZNF860,
            suggesting that ZNF860 probably acts as a transcription enhancer in
            GC.
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Shaffer,J.R., Polk,D.E., Wang,X., Feingold,E., Weeks,D.E.,
            Lee,M.K., Cuenco,K.T., Weyant,R.J., Crout,R.J., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association study of periodontal health measured by
            probing depth in adults ages 18-49 years
  JOURNAL   G3 (Bethesda) 4 (2), 307-314 (2014)
   PUBMED   24347629
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108485.2, AK294003.1 and BQ268755.1.
            
            On May 17, 2019 this sequence version replaced NM_001137674.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294003.1, SRR7346977.1374638.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360311.5/ ENSP00000373274.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC108485.2         141595-141618
            25-2212             AK294003.1         1-2188
            2213-2745           AC108485.2         150564-151096
            2746-3217           BQ268755.1         18-489              c
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p23-p22.3"
     gene            1..3217
                     /gene="ZNF860"
                     /note="zinc finger protein 860"
                     /db_xref="GeneID:344787"
                     /db_xref="HGNC:HGNC:34513"
     exon            1..153
                     /gene="ZNF860"
                     /inference="alignment:Splign:2.1.0"
     exon            154..3217
                     /gene="ZNF860"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..2472
                     /gene="ZNF860"
                     /codon_start=1
                     /product="zinc finger protein 860"
                     /protein_id="NP_001131146.2"
                     /db_xref="CCDS:CCDS46784.1"
                     /db_xref="GeneID:344787"
                     /db_xref="HGNC:HGNC:34513"
                     /translation="MLREEAAQKRKEKEPGMALPQGHLTFRDVAIEFSLEEWKCLDPT
                     QRALYRAMMLENYRNLHSVDISSKCMMKKFSSTAQGNTEVDTGTLERHESHHIGDFCF
                     QKIGKDIHDFEFQWQEDKRNSHEATMTQIKKLTGSTDRYDRRHPGNKPIKDQLGLSFH
                     SHLPELHIFQTKGKVGNQVEKSINDASSVLTSQRISSRPKIHISNNYENNFFHSSLLT
                     LKQEVHIREKSFQCNESGKAFNCSSLLRKHQIIYLGGKQYKCDVCGKVFNQKRYLACH
                     HRCHTGEKPYKCNECGKVFNQQSNLASHHRLHTGEKPYKCEECDKVFSRKSNLERHRR
                     IHTGEKPYKCKVCEKAFRRDSHLTQHTRIHTGEKPYKCNECGKAFSGQSTLIHHQAIH
                     GIGKLYKCNDCHKVFSNATTIANHWRIHNEERSYKCNKCGKFFRRRSYLVVHWRTHTG
                     EKPYKCNECGKTFHHNSALVIHKAIHTGEKPYKCNECGKTFRHNSALVIHKAIHTGEK
                     PYKCNECGKVFNQQATLARHHRLHTGEKPYKCEECDTVFSRKSHHETHKRIHTGEKPY
                     KCDDFDEAFSQASSYAKQRRIHMGEKHHKCDDCGKAFTSHSHRIRHQRIHTGQKSYKC
                     HKRGKVFS"
     regulatory      3100..3105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF860"
                     /note="hexamer: AATACA"
     polyA_site      3126
                     /gene="ZNF860"
                     /note="major polyA site"
ORIGIN      
        1 gcacactccc tctctcggtc ttccgcacac gatgctgcgc cagacgctcc tacacagtaa
       61 cctggaaatt atcaccggcg gagcaaagtc acagctcagg gaggccctcc gcgttgtctg
      121 gcggaggagg ggagtggcag gtgatcctca cagtcactct aggaaagcca gctgccatga
      181 cataaggata ctcaggccac caatggatag cccaggcagg aggcatgaag gtgtgccagc
      241 cactgtgtca gtcaccttat aagcagattt tctgagacct gctaacagcc atgtgagtga
      301 ccttggaagt aggttgtcac cagtcaagcc ttgagatgac tgcagccatg acccacagct
      361 tgactacaac ccagagagac actgagccag gaacacccag ctgaagtgcc tccaaacccc
      421 gacccacagc gactgtgaga taatcagtgt ttgttgcctt aagccacgaa gtttgtgata
      481 atttgtttct cggaaacaga taactaatac agagcaggaa gcagatcgcc tcagtgaagg
      541 tcacactgca gcactattga tttctaaaga ctcatgttac gtgaggaagc agctcagaag
      601 aggaaagaaa aggagccagg catggctctt cctcagggac acttgacttt tagggatgtg
      661 gctatagaat tctctttgga ggagtggaaa tgcctggacc ctacgcagag ggctttatac
      721 agggccatga tgttggagaa ctacaggaac ctgcattctg tggatatctc ttccaaatgc
      781 atgatgaaga agttctcatc aacagcgcaa ggcaatacag aagtggacac agggacatta
      841 gaaagacatg aaagtcatca cattggagat ttttgcttcc agaaaattgg gaaagatatt
      901 catgactttg agtttcaatg gcaagaagac aaaagaaata gccatgaagc aactatgaca
      961 caaatcaaaa agttgactgg tagcaccgac agatatgatc gaaggcatcc tggaaacaag
     1021 cctatcaaag atcagcttgg attaagcttt cattcgcatc ttcctgaact ccacatattt
     1081 cagaccaaag ggaaagttgg taatcaagtt gagaagtcta tcaacgatgc ttcctcagtt
     1141 ctaacgtccc aaagaatttc ttctaggccc aaaatccata tttctaataa ctatgaaaat
     1201 aatttcttcc attcatcatt actcacacta aaacaggaag tacacataag agaaaaatct
     1261 ttccaatgta atgagagtgg caaagccttt aattgtagct cactcttaag gaaacatcag
     1321 ataatctatt taggagggaa acaatataaa tgtgatgtat gtggcaaggt ctttaatcag
     1381 aagcgatacc ttgcatgcca tcatagatgt cacactggtg agaaacctta caagtgtaat
     1441 gaatgtggca aggtttttaa tcaacaatca aaccttgcaa gtcatcatag acttcatact
     1501 ggagagaaac cttacaaatg tgaagaatgt gacaaagttt ttagtcgcaa atcaaatctt
     1561 gaaagacata ggagaattca tactggagag aaaccataca aatgtaaggt ttgtgaaaag
     1621 gctttcaggc gtgattcaca cctcacacaa cacactagaa ttcacactgg agagaaacct
     1681 tacaagtgta atgagtgtgg caaagccttt agtgggcagt caacacttat tcaccatcaa
     1741 gcaatccatg gtatagggaa actttataaa tgtaatgatt gtcacaaagt cttcagtaat
     1801 gctacaacca ttgcaaatca ttggagaatc cataatgaag agagatctta caagtgtaat
     1861 aaatgtggca aattttttag acgtcgttca tatctcgtag ttcattggcg aactcatact
     1921 ggagagaaac cttacaagtg taatgagtgt ggcaagacct tccatcacaa ttcagccctt
     1981 gtaattcata aggcaattca tactggagag aaaccttaca agtgtaatga gtgtggcaag
     2041 accttccgtc acaattcagc ccttgtaatt cataaggcaa ttcatactgg agagaaacct
     2101 tacaagtgta atgaatgtgg caaggttttt aatcaacaag caacccttgc acgtcatcat
     2161 agacttcata ctggagagaa accttacaaa tgtgaagaat gtgacacagt tttcagtcgc
     2221 aaatcacacc atgaaacaca taagagaatt catactggag agaaacctta caaatgtgat
     2281 gattttgacg aggccttcag tcaagcttca tcttatgcaa aacaaaggag aattcatatg
     2341 ggagagaaac atcacaagtg tgatgattgt ggcaaagcct ttacttcaca ttcacatcgc
     2401 attagacatc agagaatcca taccggacag aaatcttaca aatgtcataa gcgtggcaag
     2461 gtcttcagtt agaggtcact ccttgcaaaa catcagaaaa ttcattcctg agataattgt
     2521 tccaaatgca atgagtatag caaaccatca agcattaatt gacattagag tcaattcagc
     2581 attgacttga gtttcagttg acttgacatt gagttcaagc attaattgac attaaagtgt
     2641 ttacgttaag aggattgggc tgggcagggt ggcttatacc tgtaatccca gcactgtggg
     2701 aggtcaagac ggatagatca cttgaggtca ggagtttgag accatcctgg ccaaaagacg
     2761 tgagccactt ttcctagcct gttttttgtt tctgataggg atttttatgg gtattgtgtt
     2821 gaatctaaat cacattgggt tatataatca tttaacaata ttaatctttc caatccatca
     2881 atatgggtca tatctctatt tatataagtt tttaatcatt ttgatcaatg tttgtagatt
     2941 tcaaggtaca aacttctcac ctttttacgt ttattcctaa atatttctta ctgtaagttc
     3001 tctagcaaat ggaagtgttt tcttaatttt cttttaacat tgtttattgt taatgtatgg
     3061 aaatttaact aatttttggt actgatattg tattctgcaa atacactgtg tttattagct
     3121 tcagtagtat tttagttgac tctgtgattt tctacacagc agatcatgtc atctacaaac
     3181 aaatacaatt ttacttcttt ctttctgaaa aaaaaaa
//
