LOCUS       NM_017560               3864 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 853 (ZNF853), transcript variant
            1, mRNA.
ACCESSION   NM_017560 XM_001715278 XM_001716278 XM_001716628 XM_001723503
VERSION     NM_017560.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3864)
  AUTHORS   Imbeault,M., Helleboid,P.Y. and Trono,D.
  TITLE     KRAB zinc-finger proteins contribute to the evolution of gene
            regulatory networks
  JOURNAL   Nature 543 (7646), 550-554 (2017)
   PUBMED   28273063
REFERENCE   2  (bases 1 to 3864)
  AUTHORS   Razin,S.V., Borunova,V.V., Maksimenko,O.G. and Kantidze,O.L.
  TITLE     Cys2His2 zinc finger protein family: classification, functions, and
            major members
  JOURNAL   Biochemistry (Mosc) 77 (3), 217-226 (2012)
   PUBMED   22803940
  REMARK    Review article
REFERENCE   3  (bases 1 to 3864)
  AUTHORS   Dephoure,N., Zhou,C., Villen,J., Beausoleil,S.A., Bakalarski,C.E.,
            Elledge,S.J. and Gygi,S.P.
  TITLE     A quantitative atlas of mitotic phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 105 (31), 10762-10767 (2008)
   PUBMED   18669648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073343.6 and BG056932.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017560.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304715.663153.1, BX386524.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457543.4/ ENSP00000455585.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               AC073343.6         850-1426
            578-695             AC073343.6         2430-2547
            696-3863            AC073343.6         6362-9529
            3864-3864           BG056932.1         13-13               c
FEATURES             Location/Qualifiers
     source          1..3864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..3864
                     /gene="ZNF853"
                     /note="zinc finger protein 853"
                     /db_xref="GeneID:54753"
                     /db_xref="HGNC:HGNC:21767"
     exon            1..577
                     /gene="ZNF853"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..2545
                     /gene="ZNF853"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 853 isoform 1"
                     /protein_id="NP_060030.1"
                     /db_xref="CCDS:CCDS59048.1"
                     /db_xref="GeneID:54753"
                     /db_xref="HGNC:HGNC:21767"
                     /translation="MLHQPTPGNRGLTARMEVGPATETFVLELQCLEDGGPGPDTLSG
                     GSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQ
                     QPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQ
                     PQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQ
                     QQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQ
                     QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQE
                     LEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVE
                     LGAQQQEVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQELMVLP
                     AVAAPAVVAIPGPAGSAALTPARQRRRRRARDRPTICGECGKGFSRSTDLVRHQATHT
                     GERPHRCGECGKGFSQHSNLVTHQRIHTGEKPYACSYCAKRFSESSALVQHQRTHTGE
                     RPYACGDCGKRFSVSSNLLRHRRTHSGERPYVCEDCGERFRHKVQIRRHERQLHGAGR
                     SRGLGLLRASRPAALGGPARAEQAATATAPADKAL"
     exon            578..695
                     /gene="ZNF853"
                     /inference="alignment:Splign:2.1.0"
     exon            696..3864
                     /gene="ZNF853"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF853"
                     /note="hexamer: AATAAA"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF853"
                     /note="hexamer: ATTAAA"
     polyA_site      3859
                     /gene="ZNF853"
     polyA_site      3864
                     /gene="ZNF853"
                     /note="major polyA site"
ORIGIN      
        1 gcccccggcc cggccagcgg cccgcacgga cgcactcccg ggcgggcggg cgagcccagg
       61 gggacccggc cttgccgcgg cgcccgcccc gcccccgccc cggcccccgc gcggcccggc
      121 ccaggccgcc cgcaggctcc gggcacctgt agcccccgag gacccgcgtc gcctggccgc
      181 cgccgacccc aggcggggcc accccgtggt gccgaccccg ggcgccggcc tggatcccgc
      241 tgcccgcgat ggtcccgggg ggccggccct gagccccgcg cgggattcgg ggccctgcct
      301 cccgccccag cccccgccgg agagtctcca ccaacttctg ctcggccgct cctctcagcc
      361 ccttcccttg gcccagggcg acctcggcag cccagagggc gtggaccctc cggagtgccc
      421 agaaagcccc cggggtggcc ctgcgcctcc tggctctttc tggatggagg cgcctccgga
      481 aggagccggc tgcacgccgt ggccttcacc tcgcagcctc tgctgaccac acctccctag
      541 cgcagaggct gcccgggagc aggaaatgct ccaccagccg actcccggga atcggggtct
      601 gaccgccagg atggaagtgg ggccagccac cgagaccttc gtgctggaac ttcaatgtct
      661 tgaggatggg ggcccagggc ctgacaccct ctcaggtggc agcggtggga gcgagagtca
      721 ggaggaggaa gagcctcagg agaggaacag cagtccacag cggccagcag tctcggcccc
      781 agtgggggcc agtgaaatcg ctgaggaaac ccggccggga caacgagagt tgcaactgca
      841 gcagttagaa cagcagcccg agccgcagca acagccgcaa cacgagcagc tgcaacagcc
      901 gcagccacac ctagaactgc aacagcagcc gcagcaagat gggcaacaac agctatctca
      961 actacaacag gaaaaacacc aatccgtgca ccatcaggaa ctgaaaccag aactgcagct
     1021 aatgcaccag cagcaacagt tacagccaca gcaagtgcaa gagcaacagc ggttgcagca
     1081 gcagcaggag cagttacaga cgcagcaagc acaagagcaa caggtattgc agcagcagga
     1141 acagctacag cagcaagtgc aagagcaaca gctgttacag caacagcagg aacagttaca
     1201 gcagcagcag ctgctacaac agcaggaaca gttacagcag caacagtttc aacagcagca
     1261 ggaacagtta cagcagcagc agcagctact attgctgcag cagcagggac agttacagca
     1321 gcaactgttg cagcagcagc aggcacagtt acaacagcag ctgctggaac agcagcaggc
     1381 acagttacag cagcagctac tgctgcagca gcaggaacag ttacagcagc agcagcaaca
     1441 gcagctgttg caacagcagc aggaacaatt gcagcagcaa caactgcagc ctcctcccct
     1501 ggagcccgag gaggaggaag aggtggagct ggagctcatg ccggtggacc tggggtcaga
     1561 gcaggagctg gagcagcagc ggcaggagtt ggagcggcag caggagctgg aacggcagca
     1621 ggagcagcgg cagctgcagc tcaaactgca ggaggagctg cagcagctgg agcaacagct
     1681 ggagcagcag cagcagcagc tggagcagca ggaggtgcag ctggagctga ccccggtgga
     1741 gctaggcgcc cagcagcagg aggtgcagct ggagctgacc cccgtgcagc cggagctgca
     1801 gctggaactg gtgccagccg cagggggcgg cggagcggcg gtcccggggg ctccggccgc
     1861 ggtcgtggtg gctcccccgg gctacgtggt ggtgcaggag ctcatggtgc tgcccgccgt
     1921 ggcagcgccg gccgtggtgg ccatcccggg cccggcaggc agcgcggcgt tgacccctgc
     1981 acggcagcgg cggcggcggc gcgctcggga ccggccgacc atctgcgggg agtgcggcaa
     2041 gggcttcagc cgcagcacgg acctggtgcg ccaccaggcc acgcacacgg gtgagcggcc
     2101 acaccgctgc ggcgagtgcg gcaagggctt ctcgcagcac tcgaatctgg tgacgcacca
     2161 acgcatccac acgggcgaga aaccctacgc ctgctcctac tgcgccaagc gcttcagcga
     2221 gagctcggcg ctcgtgcagc accagcgcac gcacaccggg gagcgaccct acgcctgcgg
     2281 ggactgtggc aagcgcttca gcgtctcctc caacctgctg cgccaccggc gcacgcactc
     2341 gggcgagcgg ccctacgtgt gcgaggactg tggcgagcgc ttccgacaca aggtgcagat
     2401 ccgccgccac gagcgccagc tgcacggcgc gggccgctcc aggggcctcg gcctgctgcg
     2461 cgcctcgcgg ccggcggccc tcggtggccc agcccgcgcg gagcaggccg ctacagccac
     2521 tgcgcccgca gacaaggcgc tgtgagggcc gtgatcgggg ctgcctggcc gggaggggac
     2581 cccccacccg cctccacctg aaaagctcct tgacccgggt tcatgggcgc tggaggcgtc
     2641 ctggaatatc cctggagtaa aaggcttcca ccatcatcat catcatcatc ttccggattc
     2701 cctgagaaaa taccaggttc acagatttca ccgccagaaa aatccatccg ccaaaagaga
     2761 agtggaccgg ggctgaaaca gcacacggga cacgtttgtc tgccctttga ggggtctgcc
     2821 aaaggttttc cctccgggaa aactggactt actacgaacg aggaaaaacc cccagtggcg
     2881 agacgattaa tgacactggc cgaggactgg acacccacca gggaatcaag acgtggtgag
     2941 acacacgtgg aaaatcttcg atcctggtga aaatgatcgc aaggagaaat tcggggagga
     3001 agcaaacttg tttgcactat gtagaaactg accaaggcat cgaatcgtcc tcagaggcat
     3061 ttgccttgaa aatactttcc aagatgaaaa ttcatcaggg tgggtataat tctgatgaaa
     3121 acgcctgtgt tcatcaacac agggtcagag cgctcaccgg gtcgatgtgc aaatccaagc
     3181 caggaagtcc tgctccgggt ggaaggtaaa accttccctc cagggaacca ggggctccgg
     3241 cgggcatcgg aggcagcttc ttggcctctg ctgctgtgtc ccccagtccc cccagcccgc
     3301 attaatgtcc tctggaataa gagcctgtgg ctgaagcaga gggccttctg ggagagctct
     3361 ccaaggtctg gaaggagggt cccccagaag gagctccggg gtagccccac tgtggccccc
     3421 ctggactcca ccagcttcat gcttctcaga tgctacccag gggccggccc ggggagacca
     3481 gggcagattt ctcccgcacc aggctgtgga ggtttggagg gctgcctgag cagacactgt
     3541 gccattgctg gggctgggga aagaatatct gagacgacgt ttgggagcaa tgctctttac
     3601 cacgttcacc aagtcgtctg gggcaggggt tgtgagctgc agcagttgct ggtgccttgt
     3661 gggaaggtgg ggcagggagg aggctgcccg ccacctctgc ccccagtcac ttcctgcttg
     3721 acctgactct tcacatgtgg ctgcttaatt cctgcccctc tccccccagc tgcttctcct
     3781 ttactaacac acctgctaca ttttacacat gtgttggtaa gtgagaaaca gaaacgaaaa
     3841 ataaattaaa atgcagaaat acaa
//
