LOCUS       NM_003429               2333 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 85 (ZNF85), transcript variant 1,
            mRNA.
ACCESSION   NM_003429
VERSION     NM_003429.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Carnevale,S., Giovanetti,M., Benvenuto,D., Ciccozzi,M. and
            Broccolo,F.
  TITLE     Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein a
            Potential Basis for Autoimmune Responses in Vaccinated and
            Naturally Infected Patients?
  JOURNAL   Semin Thromb Hemost 49 (1), 103-104 (2023)
   PUBMED   35021248
  REMARK    GeneRIF: Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike
            Protein a Potential Basis for Autoimmune Responses in Vaccinated
            and Naturally Infected Patients?
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Poncelet,D.A., Bellefroid,E.J., Bastiaens,P.V., Demoitie,M.A.,
            Marine,J.C., Pendeville,H., Alami,Y., Devos,N., Lecocq,P.,
            Ogawa,T., Muller,M. and Martial,J.A.
  TITLE     Functional analysis of ZNF85 KRAB zinc finger protein, a member of
            the highly homologous ZNF91 family
  JOURNAL   DNA Cell Biol 17 (11), 931-943 (1998)
   PUBMED   9839802
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Ogawa,T., Poncelet,D.A., Kinoshita,Y., Noce,T., Takeda,M.,
            Kawamoto,K., Udagawa,K., Lecocq,P.J., Marine,J.C., Martial,J.A. and
            Hosaka,M.
  TITLE     Enhanced expression in seminoma of human zinc finger genes located
            on chromosome 19
  JOURNAL   Cancer Genet Cytogenet 100 (1), 36-42 (1998)
   PUBMED   9406578
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008739.5, BP199573.1, U35376.1, BC047646.1 and DB524732.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003429.4.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 3, resulting in
            an isoform (a) that is shorter than isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U35376.1, SRR1803613.204486.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328178.13/ ENSP00000329793.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC008739.5         119130-119131       c
            3-37                BP199573.1         1-35
            38-379              U35376.1           6-347
            380-2330            BC047646.1         681-2631
            2331-2333           DB524732.1         463-465
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2333
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /note="zinc finger protein 85"
                     /db_xref="GeneID:7639"
                     /db_xref="HGNC:HGNC:13160"
                     /db_xref="MIM:603899"
     exon            1..153
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1938
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 85 (HPF4, HTF1)"
                     /codon_start=1
                     /product="zinc finger protein 85 isoform a"
                     /protein_id="NP_003420.2"
                     /db_xref="CCDS:CCDS32977.1"
                     /db_xref="GeneID:7639"
                     /db_xref="HGNC:HGNC:13160"
                     /db_xref="MIM:603899"
                     /translation="MGPLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLG
                     ITVSKPDLITCLEQGKEAWSMKRHEIMVAKPTVMCSHFAQDLWPEQNIKDSFQKVTLK
                     RYGKCRHENLPLRKGCESMDECKMHKGGCNGLNQCLTATQSKIFQCDKYVKVAHKFSN
                     SNRHEIRHTKKKPFKCTKCGKSFGMISCLTEHSRIHTRVNFYKCEECGKAFNWSSTLT
                     KHKRIHTGEKPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTFNRFSTLTTH
                     KIIHTGEKPYKCKECGKAFNRSSTLTTHRKIHTGEKPYKCEECGKAFKQSSNLTTHKI
                     IHTGEKPYKCKKCGKAFNQSAHLTTHEVIHTGEKPYKCEKCGKAFNHFSHLTTHKIIH
                     TGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLTEHKKIHTG
                     EKPYECEKCGKAFNQSSNLTRHKKSHTEEKPYKCEECGKGFKWPSTLTIHKIIHTGEK
                     PYKCEECGKAFNQSSKLTKHKKIHTGEKPYTCEECGKAFNQSSNLTKHKRIHTGEKPY
                     KCEECDKAFKWSSVLTKHKIIHTGEKLQI"
     exon            154..280
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..379
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..2333
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /note="hexamer: AATAAA"
     polyA_site      2333
                     /gene="ZNF85"
                     /gene_synonym="HPF4; HTF1"
                     /note="major polyA site"
ORIGIN      
        1 gcctttgtct ctcgctgcag cctgagctct aggtcttgtt ttccctgctt tgtgttttct
       61 gctcgtggac gcccagcctc tgtggccctg tggcctgcag gtattgggag atccacagct
      121 aagacgccgg gaccccctgg aagcctagaa atgggaccat tgacatttag ggatgtggcc
      181 atagaattct ctctgaagga gtggcaatgc ctggacactg cacagcggaa tttatataga
      241 aatgtgatgt tagagaacta cagaaacctg gtcttcctgg gtattactgt ttctaagcca
      301 gacctgatca cttgtctgga gcaagggaaa gaggcctgga gtatgaagag acatgagatc
      361 atggtggcca aacccacagt tatgtgttct cattttgccc aagacctttg gccggagcag
      421 aatataaaag attctttcca aaaagtgaca ctgaaaagat atggaaaatg tagacatgaa
      481 aatttaccat taagaaaagg ctgtgaaagt atggatgagt gtaagatgca caaaggaggt
      541 tgtaatggac ttaaccaatg tctcacagct acccagagca aaatatttca atgtgataaa
      601 tatgtaaaag tcgctcataa attttcaaat tcaaacagac atgagataag acatactaaa
      661 aagaaacctt tcaaatgtac aaaatgtggc aaatcatttg gcatgatttc atgcctaact
      721 gaacatagca gaattcatac tagagtaaat ttctacaaat gtgaagaatg tggaaaagcc
      781 tttaactggt cctcaaccct tactaaacat aagagaattc atacgggaga gaaaccttac
      841 aaatgtgaag aatgtggtaa agcctttaac cagtcctcaa accttattaa acataagaaa
      901 attcatactg gagagaaacc ctacaaatgt gaagaatgtg gcaaaacttt taaccgattc
      961 tcaactctta ctacccataa gataattcat actggagaga aaccctacaa atgtaaagaa
     1021 tgtggtaaag cttttaaccg atcttcaacc cttactaccc atagaaaaat tcatactgga
     1081 gagaaacctt acaaatgtga agaatgtggc aaagccttta agcagtcctc aaaccttact
     1141 acacataaga taattcatac tggagagaaa ccctacaaat gtaaaaaatg tggaaaagcc
     1201 tttaaccagt ctgcacacct taccacacat gaggtaattc atactggaga gaaaccctac
     1261 aaatgtgaaa aatgtggaaa agcctttaat catttctcac accttactac acataagata
     1321 attcatactg gagagaaacc ttacaaatgt aaagaatgtg gtaaagcttt taaacactct
     1381 tcaaccctta ctaaacataa gataattcat actggagaga agccttacaa atgtaaagaa
     1441 tgtgaaaaag cttttaacca atcctcaaaa cttactgaac ataagaaaat tcatactgga
     1501 gagaaaccct atgaatgtga aaaatgtggc aaagctttta accagtcctc aaatcttact
     1561 agacataaga aaagtcatac agaagagaaa ccttacaaat gtgaagaatg tggcaaaggt
     1621 tttaaatggc cctcaaccct tactatccat aagataattc atactggaga gaaaccatac
     1681 aaatgtgaag aatgtggcaa agcttttaac caatcctcaa aacttaccaa acataagaaa
     1741 attcatactg gagagaaacc ctacacatgt gaagaatgtg gcaaagcctt taaccagtcc
     1801 tcaaacctta ctaaacataa gagaattcat actggagaaa aaccttacaa atgtgaagaa
     1861 tgtgacaaag cttttaaatg gtcctcagtc cttactaaac ataagataat tcataccgga
     1921 gaaaaattac aaatatgaaa attatggcaa agctttaatc aatttacaag tcttactaaa
     1981 cataagaaaa tttatactgg agagaaacta ctaacctgaa agatgtgaca ataattttga
     2041 caacacctca gacttataaa agtaatcata ctggtgagaa attctaaaaa tgtgaagact
     2101 atggcaaagt ctttaaatgg ttgtcacact ttaggtaaga taattcatat tggaacaaac
     2161 tacaagtgca aacaatgtgg caaaacttaa tttatgctca caccttactg cacagaaaag
     2221 aatttttagt tgagaaaaag tatacaaata taaagaatgt ggaaaagccg ttaatatctg
     2281 ctcacatctt actcagcatc agaaagtact taataaaagc attataaatg gaa
//
