LOCUS       NM_001077624            4255 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens zinc finger protein 846 (ZNF846), transcript variant
            1, mRNA.
ACCESSION   NM_001077624 XM_001130932 XM_091914
VERSION     NM_001077624.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008752.6.
            
            On Aug 10, 2021 this sequence version replaced NM_001077624.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC118576.1, SRR18074967.3141212.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397902.7/ ENSP00000380999.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AC008752.6         86327-86776
            451-550             AC008752.6         90030-90129
            551-677             AC008752.6         91657-91783
            678-764             AC008752.6         92897-92983
            765-847             AC008752.6         95123-95205
            848-4255            AC008752.6         96301-99708
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4255
                     /gene="ZNF846"
                     /note="zinc finger protein 846"
                     /db_xref="GeneID:162993"
                     /db_xref="HGNC:HGNC:27260"
     exon            1..450
                     /gene="ZNF846"
                     /inference="alignment:Splign:2.1.0"
     exon            451..550
                     /gene="ZNF846"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..2137
                     /gene="ZNF846"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 420 pseudogene"
                     /codon_start=1
                     /product="zinc finger protein 846 isoform 1"
                     /protein_id="NP_001071092.1"
                     /db_xref="CCDS:CCDS42496.1"
                     /db_xref="GeneID:162993"
                     /db_xref="HGNC:HGNC:27260"
                     /translation="MDSSQHLVTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNL
                     IILAGSELFKRSLMSGLEQMEELRTGVTGVLQELDLQLKTKGSPLLQDISAERSPNGV
                     QLERSNTAEKLYDSNHSGKVFNEHPFLMTHMITHIGEKTSEDNQSGKALRKNFPHSFY
                     KKSHAEGKMPKCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDCWRTFLNQSSLKLHIR
                     SHNGDKHYVCKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHIRTH
                     SGEKPYKCKECGKAFTHSSYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG
                     EKPYECKECGKAFIHSSYLTKHVRIHSGEKLYLCKACGKAFTRSSGLVLHMRTHTGEK
                     PYECKECGKAFNNSSMLSQHVRIHTGEKPYECKECGKAFTQSSGLSTHLRTHTGEKAC
                     ECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTYLNVHTRTHTGAKPYEC
                     KKCGKNFTQSSALAKHLRTKACEKT"
     exon            551..677
                     /gene="ZNF846"
                     /inference="alignment:Splign:2.1.0"
     exon            678..764
                     /gene="ZNF846"
                     /inference="alignment:Splign:2.1.0"
     exon            765..847
                     /gene="ZNF846"
                     /inference="alignment:Splign:2.1.0"
     exon            848..4255
                     /gene="ZNF846"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF846"
                     /note="hexamer: AATAAA"
     polyA_site      4255
                     /gene="ZNF846"
                     /note="major polyA site"
ORIGIN      
        1 atacgtattc cccgctctcc agcagcttcc tagctgggtt ttcacctcag ccagcgctca
       61 tgctcaacct aggcagggcg gggcaggagg gcctagcggg aggcggagcg agggtcggag
      121 ggtgacgctc cggacttctg ctaggtctga gacgcgccgg cctcccgctg ctgctccgga
      181 gaagcggcgc ctcctccccg ccaggacccc gaggcggggg gttcccgcct tctcttctga
      241 gcgcctcttc ccgctgcgcc cgcatcagtc tgggcctggc ccagggtccc cggtggagac
      301 gtgttttttt ctccaaccac cgtgcccctc tgtttaaaag cagccagtca acctttgtgt
      361 cctttctcca gaaggaaaag catctcagct gttgtggaaa agggccccag cgtcctcttg
      421 tcaccgacag ggcgattgca gtgcgttccg gtcatttttt ccaggacact ttctgtcttc
      481 atgacaggaa catcgagaag ccaaggctag tggctgggtt actgatggat tactgatgga
      541 ttcttctcag cacttagtga cctttgagga tgtggctgtg gactttaccc aggaggagtg
      601 gactttgttg gatcaagccc agagagatct ctacagagat gtgatgttgg agaactacaa
      661 gaatctcatt atactagcag ggtctgaatt attcaaacgt agtctcatgt ctggattgga
      721 acaaatggaa gagctgagga caggagtgac aggagttctg caggaattgg atttgcaact
      781 caaaaccaaa ggctccccac tgctgcaaga tatttctgca gaaagatcac caaatggagt
      841 acaattggag agaagcaata ctgcagagaa actgtatgac tctaaccatt ctggaaaagt
      901 cttcaatgaa cacccatttc ttatgactca catgataact cacattggag agaaaacttc
      961 tgaggataat cagagtggaa aagccttaag aaagaacttt cctcatagtt tttacaagaa
     1021 aagtcatgct gaggggaaaa tgcctaagtg tgttaaacat gaaaaagcct tcaaccagtt
     1081 tccaaatctt actaggcaga ataaaactca cacacaagag aaattgtgtg aatgcaaaga
     1141 ctgttggaga acttttctta atcagtcatc ccttaagtta catataagat ctcacaatgg
     1201 agacaaacac tatgtatgta aggaatgtgg gaaagccttc agtaattcct cacaccttat
     1261 aggacatgga agaattcaca gtggagagaa gccctatgtc tgtaaagaat gtggtaaagc
     1321 tttcactcaa tccacaggac ttaaattaca catcagaact cacagtggag aaaaaccata
     1381 taaatgtaaa gagtgtggga aagccttcac ccattcttca taccttactg atcatacaag
     1441 aatccacagt ggaaagaagc cctatgtatg tatggaatgt ggaaaagcct tcactagatc
     1501 cacaggactt attttacaca tgcgaattca cactggagaa aagccatatg aatgtaagga
     1561 gtgtggaaaa gcttttattc attcctcata ccttacaaaa catgtaagga ttcacagtgg
     1621 agagaagctg tatttatgta aggcatgtgg gaaagctttt actcgttcct caggacttgt
     1681 tttacacatg agaacacata ctggagaaaa gccctatgaa tgtaaagaat gtgggaaagc
     1741 ctttaataat tcctcaatgc ttagtcaaca tgtaaggatt cacactggag agaagccata
     1801 tgaatgcaaa gaatgtggga aagctttcac tcaatcctcg ggccttagta cccatttaag
     1861 aactcacact ggagaaaagg cctgtgaatg taaggaatgc ggtaaagcat ttgctcgttc
     1921 cacaaatctt aatatgcaca tgcgaacgca cacaggagaa aagccttatg catgtaaaga
     1981 atgtgggaaa gccttcaggt attccacata ccttaacgtt cacacacgaa ctcacactgg
     2041 agcaaaacca tatgaatgta agaaatgtgg gaaaaacttc actcaatctt cagcacttgc
     2101 taaacatcta agaactaagg catgtgaaaa aacctgaagt gttcctcaga tcttagtatt
     2161 tacatctaaa ctcatctgga aaaaaatcat aggaaggtaa agaatatgaa caaccttcac
     2221 tgaatttcca tatcttatat aataggaatg aatttaacat ggacacaagt cccagtgata
     2281 taaggaatag gcaagagtag taattcttca catcttataa agtgtaagaa ctcacctttg
     2341 ggagaaaaat ctggttctaa ggcatgtggt aaagcctttg tttcttccac tattgtttat
     2401 ttttcttttt tttttttgag acagagtctc tctctctcac ccaggctgga gtacagtggc
     2461 atgaccttgg cccactgcaa cctctgcctc ctgggttcaa ggaattctcc cacctcagcc
     2521 tcccgagtag ctgggactac gggcatgtgc caccatgccc agctaatttt ttgtattttt
     2581 agtagagaca gggtttcacc atgttagcca ggatggtctc gatctcccga tctcatgatc
     2641 tgcccgcctt ggccttccaa agtactggga ttacaggctt gagccaccac acccagcata
     2701 ttgtttattt ttcataacaa aaattactgt aaaagccaat tgaaggtaag aatgagagat
     2761 agccttaaaa tacttcacaa accttcatag tacttcataa tcaacactgg agaaaaaccc
     2821 tctgtatgta aggaatgtga taaaacattt acttagtgct caggacttaa tatctacatg
     2881 agaattcaca gtggtataaa accctacaaa tgtaaaggct acaagatctt cacttatgcc
     2941 ttttaataac tcaacatcaa agaactcaca gtgggcagat agcctatata tgtaagaaat
     3001 ctgggacagc cttcagaaat ttctgacagt ttcagatata agaaacctca tcaatttaag
     3061 atgtgttaag aattcttcca gtgttactaa gtcagtcaac atgcgttgga gagaaactct
     3121 atgaaggtaa gatgtgggaa atctttactt ctgtctcatg tgttaatatt tggtaatctc
     3181 aaagaggcca gaaacattat gaatgttaga aatatgggaa tgtctttata tatatatata
     3241 tatatatata tatatatata tatatacaca cacacacaca cacatatata tgcacacaca
     3301 catacacaca cgtatgtatt atttcatcct ttaatataaa tgataattca tactggagag
     3361 aaatcttgat aatacagaat gagggaaatg ttgcatccat tttacaagtc ttactatact
     3421 tgtgaaaacc cacactgcaa acaagctata tgaatgtgaa aatatgagaa tatgctgggc
     3481 gtggtgactc atgcttgtaa tcccagcact ttaggaggcc gaggtgggca gatcatttga
     3541 ggtcaggagt ttgagaccag cctgccaaca tggttaaacc tcatctctac taaaaataca
     3601 aaaattagcc aagtatggtg gcgggtgcct ttaatcccaa ttgcttggga ggctgaggca
     3661 ggagaattgt gtgaacccag gagacagagg ttgcagtgag ccaagatttt gccactacac
     3721 tccagcctgg gtgacagagc aaaactccat ctcaaaaaaa aaaaaaatct ggtaatactt
     3781 tttttttttt tttttttttt tttttttttt ttgagacgga gtctcgctct gtcgcccagg
     3841 ctggagtgca gtggcgggat ctcggctcac tgcaagctcc gcctcccggg ttcacgccat
     3901 tctcctgcct cagcctccca agtagctggg actacaggcg cccgccacta cgcccggcta
     3961 attttttgta tttttagtag agacggggtt tcaccgtttt agccgggatg gtctcgatct
     4021 cctgaccttg tgatccgccc gcttcggcct cccaaagtgc tgggattaca ggcgtgagcc
     4081 accgcgcccg gcctggtaat acttttagca gtacatattc cttaagtgcc tctgaaaata
     4141 ctcactggaa gaataaacta tgaatctgag gagttatggg aagctttcag atactactgt
     4201 tactgtacac aagatcatac tagaggagaa attgaaataa atgacatgaa aatga
//
