LOCUS       NM_001136499            3877 bp    mRNA    linear   PRI 05-MAR-2025
DEFINITION  Homo sapiens zinc finger protein 841 (ZNF841), transcript variant
            1, mRNA.
ACCESSION   NM_001136499 XM_005258807 XR_015252 XR_015660
VERSION     NM_001136499.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3877)
  AUTHORS   Ma,D., Chen,J., Shi,Y., Gao,H., Wei,Z., Fan,J. and Wang,L.
  TITLE     Dysregulation of TCONS_00006091 contributes to the elevated risk of
            oral squamous cell carcinoma by upregulating SNAI1, IRS and HMGA2
  JOURNAL   Sci Rep 14 (1), 9616 (2024)
   PUBMED   38671227
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3877)
  AUTHORS   Wu,A.C., Himes,B.E., Lasky-Su,J., Litonjua,A., Peters,S.P.,
            Lima,J., Kubo,M., Tamari,M., Nakamura,Y., Qiu,W., Weiss,S.T. and
            Tantisira,K.
  TITLE     Inhaled corticosteroid treatment modulates ZNF432 gene variant's
            effect on bronchodilator response in asthmatics
  JOURNAL   J Allergy Clin Immunol 133 (3), 723-8 (2014)
   PUBMED   24280104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011468.8.
            
            On Aug 14, 2020 this sequence version replaced NM_001136499.1.
            
            Transcript Variant: This variant (1), as well as variants 3, 6, 7,
            and 8, encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1293342.1,
                                           SRR14038191.1864085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000594440.6/ ENSP00000470100.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC011468.8         111264-111454       c
            192-317             AC011468.8         109535-109660       c
            318-383             AC011468.8         104626-104691       c
            384-475             AC011468.8         100476-100567       c
            476-602             AC011468.8         92647-92773         c
            603-731             AC011468.8         91733-91861         c
            732-3876            AC011468.8         80155-83299         c
            3877-3877           AC011468.8         80154-80154         c
FEATURES             Location/Qualifiers
     source          1..3877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3877
                     /gene="ZNF841"
                     /note="zinc finger protein 841"
                     /db_xref="GeneID:284371"
                     /db_xref="HGNC:HGNC:27611"
     exon            1..191
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     exon            192..317
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     exon            318..383
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     exon            384..475
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..3235
                     /gene="ZNF841"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TCONS_00006091"
                     /codon_start=1
                     /product="zinc finger protein 841 isoform 1"
                     /protein_id="NP_001129971.1"
                     /db_xref="CCDS:CCDS46161.1"
                     /db_xref="GeneID:284371"
                     /db_xref="HGNC:HGNC:27611"
                     /translation="MALPQGSLTFRDVAVEFSQEEWKCLDPVQKALYRDVMLENYRNL
                     GFLGLCLPDLNIISMLEQGKEPWTVVSQVKIARNPNCGECMKGVITGISPKCVIKELP
                     PIQNSNTGEKFQAVMLEGHESYDTENFYFREIRKNLQEVDFQWKDGEINYKEGPMTHK
                     NNLTGQRVRHSQGDVENKHMENQLILRFQSGLGELQKFQTAEKIYGCNQIERTVNNCF
                     LASPLQRIFPGVQTNISRKYGNDFLQLSLPTQDEKTHIREKPYIGNECGKAFRVSSSL
                     INHQMIHTTEKPYRCNESGKAFHRGSLLTVHQIVHTRGKPYQCDVCGRIFRQNSDLVN
                     HRRSHTGDKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNRCGKCFSQSSSLATHQ
                     TVHTGDKPYKCNECGKTFKRNSSLTAHHIIHAGKKPYTCDVCGKVFYQNSQLVRHQII
                     HTGETPYKCNECGKVFFQRSRLAGHRRIHTGEKPYKCNECGKVFSQHSHLAVHQRVHT
                     GEKPYKCNECGKAFNWGSLLTVHQRIHTGEKPYKCNVCGKVFNYGGYLSVHMRCHTGE
                     KPLHCNKCGMVFTYYSCLARHQRMHTGEKPYKCNVCGKVFIDSGNLSIHRRSHTGEKP
                     FQCNECGKVFSYYSCLARHRKIHTGEKPYKCNDCGKAYTQRSSLTKHLVIHTGENPYH
                     CNEFGEAFIQSSKLARYHRNPTGEKPHKCSECGRTFSHKTSLVYHQRRHTGEMPYKCI
                     ECGKVFNSTTTLARHRRIHTGEKPYKCNECGKVFRYRSGLARHWSIHTGEKPYKCNEC
                     GKAFRVRSILLNHQMMHTGEKPYKCNECGKAFIERSNLVYHQRNHTGEKPYKCMECGK
                     AFGRRSCLTKHQRIHSSEKPYKCNECGKSYISRSGLTKHQIKHAGENLTTKLNVERPL
                     DVVLTSGIPK"
     exon            476..602
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     exon            603..731
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     exon            732..3877
                     /gene="ZNF841"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3857..3862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF841"
                     /note="hexamer: ATTAAA"
     polyA_site      3877
                     /gene="ZNF841"
                     /note="major polyA site"
ORIGIN      
        1 acacccggaa gcagatcgcg ctggggaaag gccacgtcgc tatgagtgtg tttcagtcta
       61 cctggattaa acgtttgctt ctcttcgtct accttgatta aacgtgcact tcgcagtcct
      121 cggttctcca tacccgtgac ctggggatcg ctacggacct taaaataccc gcaacagccc
      181 cttcgtccca agctggagag cagtggcatg atctcggctc actgcagctt ctacttcctg
      241 gcctcaagca gtctttccac ctcagcctct caacgcactg gaattacaga tgtgagccac
      301 cacactaggc ctacaagtgg tccttacacc agattaattt atcttgaaat ggcgggcaac
      361 tgaatcgcac acctcaatct atgatttgac ttttaaagaa ttaattatat tgactgagag
      421 agaggcccag gagagaaaga agaaagaaaa ggagccaggg atggctcttc ctcagggatc
      481 tttgacattc agggatgtgg ctgtagaatt ctctcaggag gagtggaaat gcctggaccc
      541 tgttcagaaa gctttgtaca gggacgtgat gttggagaac tacaggaacc tcggcttcct
      601 gggactctgt cttcctgacc tgaatattat ctccatgttg gagcaaggga aagagccctg
      661 gactgtggtg agccaagtga aaatagcgag gaacccaaac tgtggggaat gcatgaaagg
      721 cgtgatcacc ggtatctctc ctaaatgtgt gatcaaggaa ttaccaccaa tacagaacag
      781 taacacagga gaaaaattcc aagcagtgat gttggaagga catgaaagct atgacactga
      841 aaatttttac ttcagggaaa tccggaaaaa tctacaggaa gttgactttc aatggaaaga
      901 tggtgaaata aattataaag aagggccgat gacccataaa aacaatctta ctggtcaaag
      961 agttcgacat agtcaagggg acgtagaaaa caagcatatg gaaaatcagc ttatattaag
     1021 gtttcagtcc ggtctgggtg aattgcagaa atttcaaact gcagagaaaa tttatggatg
     1081 taatcaaatt gagaggacag ttaataattg ttttttagct tcaccacttc aaagaatttt
     1141 tcctggtgtc caaaccaaca tttctaggaa atatgggaat gattttttgc aactttcgtt
     1201 acctacacaa gacgagaaaa cacatattag ggaaaaacct tacataggta atgagtgtgg
     1261 caaagccttc agagtgtctt caagtcttat taatcatcag atgatacata ctacagagaa
     1321 accttacaga tgcaatgagt ctggtaaagc ctttcatcgg ggctcactac taacagtaca
     1381 tcagatagtc catacaagag ggaaaccata ccaatgtgat gtatgtggca ggatcttcag
     1441 acaaaattca gatcttgtaa atcaccggag aagtcacact ggagacaaac cctacatatg
     1501 taatgaatgt ggcaagtcct ttagtaaaag ttcccacctt gcagttcatc agagaattca
     1561 tactggagag aaaccttaca aatgtaatcg atgtgggaag tgctttagtc aaagttcctc
     1621 tcttgcaact catcagacag ttcatactgg agacaaaccc tacaaatgta atgaatgtgg
     1681 caaaaccttt aaacggaact caagcctcac tgcacatcat ataatccatg caggaaagaa
     1741 accatataca tgtgatgtat gtggcaaggt cttttatcag aattcacaac ttgtaaggca
     1801 ccagataatt catactggag agacacctta caaatgtaat gaatgtggca aggtcttctt
     1861 tcaacgttca cgtcttgcag ggcaccggag aattcatact ggagagaaac cctacaaatg
     1921 taatgaatgt ggcaaggtct tcagtcaaca ttcacatctt gcagtgcatc agagagttca
     1981 tactggagag aaaccttaca aatgtaatga atgtggcaaa gcctttaatt ggggctcatt
     2041 actaactgta catcagagaa ttcataccgg agagaaacct tacaaatgta atgtgtgtgg
     2101 caaggtcttt aattacggtg gatacctttc ggttcatatg agatgtcata ctggagagaa
     2161 acctctccat tgtaataaat gtggcatggt cttcacttac tattcatgcc tagcacgtca
     2221 tcaaagaatg cataccggag agaaacctta caaatgtaat gtgtgtggca aggtcttcat
     2281 tgacagtgga aacctttcaa ttcataggcg aagtcatacc ggagagaaac ctttccagtg
     2341 taacgaatgc ggcaaggtct tcagttacta ctcatgccta gcacgtcatc ggaaaattca
     2401 taccggagag aaaccttata aatgtaatga ttgtggcaaa gcctatactc agcgttcaag
     2461 cctcactaaa catctggtaa ttcatactgg agagaaccct taccactgta atgaatttgg
     2521 tgaggctttt atccaaagtt caaaacttgc aagatatcac agaaatccta ctggggagaa
     2581 accacacaaa tgtagtgaat gtggtagaac ttttagtcat aaaacaagtc tggtgtacca
     2641 tcagagaaga catactggag agatgccata caaatgtatt gaatgtggga aagtctttaa
     2701 ctccactaca accctggcaa ggcatcggag aattcatact ggagagaaac cttacaaatg
     2761 taatgaatgt ggcaaggtct tccgttatcg ctcaggcctc gcacgtcatt ggagtattca
     2821 tactggagag aaaccttaca aatgtaatga gtgtggcaaa gcctttagag tacgttcaat
     2881 tctgcttaat catcagatga tgcatactgg agagaaacct tataaatgta atgaatgtgg
     2941 taaagctttt atcgaaaggt caaacttggt ttaccatcag agaaaccata ctggagagaa
     3001 gccatacaaa tgtatggaat gtggcaaggc gtttgggcgg cggtcttgcc tcactaaaca
     3061 ccaacgaatt cattctagtg aaaaacctta taaatgtaat gagtgtggca aatcttacat
     3121 tagtcgctca ggcctcacta aacatcagat aaaacatgct ggagagaacc ttacaactaa
     3181 actcaatgtg gaaaggccgt tagatgttgt cctaacctct gggatcccca aataatttat
     3241 acttactcat atagcttgta tatttgtcct ttccctttga agtctcatgt ggaattgtag
     3301 taatctccag tattggaggt ggagcctagt gggaggtgat tggatgatgg gggtggcttt
     3361 ctcaagaaag ttttagtacc atccccttgt tgctgtcctt gtgatagttc tcatgaggtc
     3421 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggcggatc acttgaggtc
     3481 aggagttcaa gagcagcctg gccaacatgg tgaaaccctg tttctgccaa aaatacaaaa
     3541 attagctggg cttcgtggcg ggtactggta gtaccagcta ctcgagaggc tgagtcagga
     3601 gaattgcttg aaccctggag gcggaggttg cagtgagccg agatcgcgcc actgcactct
     3661 agcctgggtg acagagtgag actccatcac gcacacgcac gcacgaaagt gaatggcacc
     3721 tccctcttgt ttgttcttct ggccatgtga catgcccttc acctcccacc atcattttaa
     3781 ccttcctcag gtttcccgag agggtgaaca gacgtcagcg ccatgtttcc tataaagcct
     3841 gcaaaattgt gagtcaatta aacctcttta tacatta
//
