LOCUS       NM_001289971            6811 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 84 (ZNF84), transcript variant 3,
            mRNA.
ACCESSION   NM_001289971 XM_005266184
VERSION     NM_001289971.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6811)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6811)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6811)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 6811)
  AUTHORS   Li,P., Guo,H., Zhou,G., Shi,H., Li,Z., Guan,X., Deng,Z., Li,S.,
            Zhou,S., Wang,Y. and Wang,S.
  TITLE     Increased ZNF84 expression in cervical cancer
  JOURNAL   Arch Gynecol Obstet 297 (6), 1525-1532 (2018)
   PUBMED   29610946
  REMARK    GeneRIF: ZNF84 expression was increased in CC [cervical cancer ]
            tissues and associated with tumor size. ZNF84 promoted cell
            proliferation which might involve Akt signal.
REFERENCE   5  (bases 1 to 6811)
  AUTHORS   Rosati,M., Rocchi,M., Storlazzi,C.T. and Grimaldi,G.
  TITLE     Assignment to chromosome 12q24.33, gene organization and splicing
            of the human KRAB/FPB containing zinc finger gene ZNF84
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 127-130 (2001)
   PUBMED   11856868
  REMARK    GeneRIF: FISH assignment to chromosome 12q24.33; gene organization
            and splicing
REFERENCE   6  (bases 1 to 6811)
  AUTHORS   Rosati,M., Marino,M., Franze,A., Tramontano,A. and Grimaldi,G.
  TITLE     Members of the zinc finger protein gene family sharing a conserved
            N-terminal module
  JOURNAL   Nucleic Acids Res 19 (20), 5661-5667 (1991)
   PUBMED   1945843
REFERENCE   7  (bases 1 to 6811)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073911.38.
            
            On Jun 2, 2019 this sequence version replaced NM_001289971.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 4. Variants 1, 2, 3, and 4 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.266294.1,
                                           SRR1803616.236264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539354.6/ ENSP00000445549.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC073911.38        54535-54571         c
            38-242              AC073911.38        50598-50802         c
            243-369             AC073911.38        43999-44125         c
            370-465             AC073911.38        43232-43327         c
            466-6811            AC073911.38        28781-35126         c
FEATURES             Location/Qualifiers
     source          1..6811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..6811
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /note="zinc finger protein 84"
                     /db_xref="GeneID:7637"
                     /db_xref="HGNC:HGNC:13159"
                     /db_xref="MIM:618554"
     exon            1..37
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            38..242
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2444
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /note="zinc finger protein HPF2"
                     /codon_start=1
                     /product="zinc finger protein 84"
                     /protein_id="NP_001276900.1"
                     /db_xref="CCDS:CCDS31940.1"
                     /db_xref="GeneID:7637"
                     /db_xref="HGNC:HGNC:13159"
                     /db_xref="MIM:618554"
                     /translation="MTMLQESFSFDDLSVDFTQKEWQLLDPSQKNLYKDVMLENYSSL
                     VSLGYEVMKPDVIFKLEQGEEPWVGDGEIPSSDSPEVWKVDGNMMWHQDNQDKLKIIK
                     RGHECDAFGKNFNLNMNFVPLRKSNSEGDLDGLILKHHLDLLIPKGDYGKAESDDFNV
                     FDNFFLHSKPEDTDTWLKYYDCDKYKESYKKSQIIIYHRNRLGEKLYECSECRKRFSK
                     KPSLIKHQSRHIRDIAFGCGNCGKTFPQKSQFITHHRTHTGEKPYNCSQCGKAFSQKS
                     QLTSHQRTHTGEKPYECGECGKAFSRKSHLISHWRTHTGEKPYGCNECGRAFSEKSNL
                     INHQRIHTGEKPFECRECGKAFSRKSQLVTHHRTHTGTKPFGCSDCRKAFFEKSELIR
                     HQTIHTGEKPYECSECRKAFRERSSLINHQRTHTGEKPHGCIQCGKAFSQKSHLISHQ
                     MTHTGEKPFICSKCGKAFSRKSQLVRHQRTHTGEKPYECSECGKAFSEKLSLTNHQRI
                     HTGEKPYVCSECGKAFCQKSHLISHQRTHTGEKPYECSECGKAFGEKSSLATHQRTHT
                     GEKPYECRDCEKAFSQKSQLNTHQRIHTGEKPYECSLCRKAFFEKSELIRHLRTHTGE
                     KPYECNECRKAFREKSSLINHQRIHTGEKPFECSECGKAFSRKSHLIPHQRTHTGEKP
                     YGCSECRKAFSQKSQLVNHQRIHTGEKPYRCIECGKAFSQKSQLINHQRTHTVKKS"
     exon            243..369
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..465
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..6811
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3089..3094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /note="hexamer: AATAAA"
     polyA_site      3114
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
     regulatory      6789..6794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /note="hexamer: AATAAA"
     polyA_site      6811
                     /gene="ZNF84"
                     /gene_synonym="HPF2"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgcgc gggcgcgact cggcggcggc gtctttttcc acagatcctg gtccctacaa
       61 ataagcctgc tcatgtgaga taagaaagga gttcctggaa ccaggaattc attctcagtg
      121 tagaagacct agctgagacc tcactccaca gttttggggc agaagcagaa gagacgcaca
      181 gtagaaccga tctcagcctt gctgatcatc tcgtacagca gcagaaaatg accatgttac
      241 aggagtcatt ctcatttgac gatttatctg tggacttcac ccaaaaggag tggcagctac
      301 tggatccctc tcagaagaat ttatacaagg atgtgatgtt ggagaactat agcagcctag
      361 tgtcactggg gtatgaagtt atgaaaccag atgtcatctt caaattggag caaggagaag
      421 agccgtgggt aggagatgga gaaattccaa gttcagattc tccagaagtc tggaaagtag
      481 atggtaacat gatgtggcac caggataacc aagacaagct taaaattata aaaagaggtc
      541 atgaatgtga tgcatttgga aaaaatttca atctgaacat gaactttgtt cctttaagga
      601 aatcaaacag tgaaggtgac ttagatggat tgattttaaa acatcattta gatttgctta
      661 ttccaaaagg agattatgga aaagcagaat cagatgactt taatgtgttt gataattttt
      721 ttctccattc caagcctgag gatactgata cctggttaaa atactatgac tgtgataaat
      781 ataaagagag ctataaaaag tcacagatta tcatatatca tagaaatcgt ttaggggaga
      841 aactctatga atgcagtgaa tgtaggaagc gcttcagtaa gaaaccaagt ctcattaaac
      901 atcagagcag acatataaga gacatagcct ttggctgtgg taattgtggc aaaacctttc
      961 cccagaagtc tcagtttatt acacatcaca gaactcatac aggagaaaaa ccttataatt
     1021 gtagccagtg tgggaaagcc ttctcccaaa agtcacagct cacatcccat cagcggacac
     1081 atacaggaga gaaaccttat gagtgtggtg aatgtgggaa agccttctcc cggaagtcac
     1141 atctcatatc gcattggaga acacacacag gagagaaacc ctatggatgc aatgaatgtg
     1201 ggagggcctt tagtgaaaag tccaatctca ttaaccatca gagaattcat accggtgaga
     1261 agccttttga atgcagggaa tgtgggaaag ccttcagcag gaagtcacaa ctcgttacac
     1321 atcacagaac tcacacagga acaaaaccct ttggatgtag tgattgtaga aaagcattct
     1381 ttgagaagtc agagcttatt agacatcaga caattcatac tggagagaaa ccctatgaat
     1441 gcagcgagtg taggaaagca tttagagaga ggtcgagtct cattaatcat cagagaacac
     1501 atacaggaga gaaacctcat ggatgcattc agtgtgggaa ggccttctcc cagaagtcac
     1561 atctcatatc acatcagatg acacacacag gagaaaaacc ctttatatgc agtaaatgtg
     1621 ggaaagcctt cagcaggaaa tcacagctcg ttagacatca gagaactcat acgggagaaa
     1681 aaccgtatga atgcagtgag tgtgggaaag ctttcagtga aaaattaagt ctcactaatc
     1741 atcaaagaat tcatacagga gaaaaaccat atgtatgcag tgaatgtggg aaagcctttt
     1801 gtcagaagtc acatctcata tcacatcaga ggacacatac aggggagaaa ccctatgaat
     1861 gcagtgaatg tgggaaggcc tttggtgaga agtcaagtct tgcaactcat cagagaactc
     1921 atactggaga aaaaccgtat gaatgcaggg actgtgaaaa agctttctcc cagaaatcac
     1981 agctaaatac ccatcagaga attcacactg gagagaaacc ctatgaatgc agtctttgta
     2041 ggaaagcttt ttttgagaag tcggagctaa ttagacatct gagaactcat acaggagaaa
     2101 aaccttatga atgcaatgaa tgtagaaaag ccttcaggga gaagtcaagt ctcatcaatc
     2161 atcagagaat acatacagga gagaagcctt ttgaatgcag tgagtgtggc aaagctttct
     2221 ctcggaagtc acaccttata ccacatcaaa ggacacatac gggtgagaaa ccctatggat
     2281 gcagtgaatg taggaaggcc ttctctcaga agtcacagct ggttaatcat cagagaattc
     2341 atacaggaga gaagccttat cgatgcattg aatgtgggaa agctttctca cagaagtcac
     2401 agctcatcaa tcatcagaga actcatacag taaaaaaatc ctaggaatac agttaatagt
     2461 agtctttgac agatcatctt ggacttcagg aaatgcaatt atgataacgt ttgtagacag
     2521 tcacgtcatg ttaggtgttt gtactccatg aggatgagaa ctctaaatga ggtggtgtat
     2581 ggaaagccga tcataattca tagagtagag tgaacctatg actgcagtgg atctcaaaaa
     2641 cttttaaaac catagacaag ccttatagag tagaacattc acagcaaaga agaatcctgt
     2701 gaatgtccaa aagccttcca gaagtcaagt ctcttaagct attagaaata ttcccactgg
     2761 ggatgaggga aaaccccatg aatgcgggaa atgaggcaat atttttaaga aatgacagtt
     2821 cattgtacat aagaaaatgc tcttaggaat gaagttctat gaaagtacta aatatgggac
     2881 agtgcaacaa gtaacgagac tattttgtat tttggagaat tcatattatg gagaacctaa
     2941 caatttaaag acactgggaa cacttgcccc tcagtatagt actgtcaagg gaagccatac
     3001 actttttgta gacatgggta ccaaaaatac ccaattctaa gtggttgaca gatgttcact
     3061 ttgaagtgtg aagttttaaa aatacgtgaa taaattggtt attgaaacat ctaagacatt
     3121 tcttagtggt atttgtggct tatcttctag tgtcacgtat gttttgtgtt ttggacttac
     3181 ctataattta atgtaattgg gagtatgaaa tgcatatgcc ttttagtgcc tctgatgtct
     3241 gtgaagacaa cactacacac cactggtttt tattttttaa caataatata aaaaatggaa
     3301 actcatgtaa catgactaca tgaataagta ccttaagtga taacccgttt cttttaactt
     3361 atagacatac ataaggggtc ttttgttttt atggaccttt ctattcagta actgaagcca
     3421 acattgtgta agtcttctgc atcctcagag tctgagtaac agtttatata aaataaatat
     3481 gcaaaggcag gaaccacaga ataaccatag taatatataa ctgaatgagc aaaataaagg
     3541 tgtgtgaact acattacaac acccaaacta aatgaaataa agtagtgctg tattaaatct
     3601 ttttctcatt tagtgaggtg cctccatata gtatatatat atgtatctta agtgatatgt
     3661 aacccaaatg tcactatttt aatttactgt gataaagtat catggatatt ttgtgctgct
     3721 gttatgcttt ttgtgttgca taaaatatct tgtaaaaatt agatggataa atgaattatt
     3781 aaaaaatcac atttctgaag atgtaaagta ttagggaatt ttgtgctgga aaaacatttt
     3841 tgacattcaa ggatgcctat tttatcttct agcaaatttc tgtggtccct ggaaaagtac
     3901 agatgatcct ggacttacag tggggttacc tcccaataaa cccattgtaa gttgaaaaca
     3961 ttgtaagtca aaaatgcatt taatacaccc aacttaccaa acatcatagc ttagcgtagc
     4021 ctaccttaaa cattctcaga acacattcta atgcatcatc tattttataa aaaggtgttg
     4081 aatatctgat gtaattattg aatactgaag gtgaaaaata gtagtgtatg gataccattg
     4141 taatgttgag aaactgtaag tcacatcctc ttaagtcagg aactatctgt ataaggaaac
     4201 aagatttcca ttttatcatt tgaaatgtat ttgactttgt ttcactagtt gcattatccc
     4261 catggaaaac ttcacattga gaacttacca ttatatattt ccataaaaat gcatgaacca
     4321 tcccttagct aagtaaggat tttgtaatgt tctctcaata atgttgcttg gcaaagttaa
     4381 tattttttgt atgctgatga aatttagaaa agtccaatat tgagcttgat tgcaaactta
     4441 gaaaaactca agacttctcc ttttatgttc aaattgttgt atcagtatgg tattttgcac
     4501 ctttacctta aacaatattt tctcctttaa ttattgattt tgcaacattt tgggaaagtt
     4561 ggaattttaa ataaatgaat aattttctaa accagaatac cagttcaaca gccaaataat
     4621 tctgtctttc catgctgtaa ttttaaagca tttaattttc caactttttg ttcatactca
     4681 agtgtatgaa cttcctggct gggcacagtg gctcatgcct gtaatcccag cactttggga
     4741 ggctgaggac ctcaagtgga gacctcaagt ggatcacttg aggtcaggag ttgaagacca
     4801 gcatgttcat ggccaacatg gcaaaaccct gtcttaaatt agccgggcat ggttgtgcgt
     4861 gcctgtaatc ccagttactc aggaggctga ggcaggagaa tcacttgaac ctgagaggca
     4921 gaggttgcag tgagccaaga ttgtgcagcc tgggcgacag agcgagcctc tgtcaaaaaa
     4981 agaaaagaaa aagaacttcc tactttttaa tatctcaaat tcattttact agacgtggga
     5041 gaccaactaa tgcaaatgaa cagttacagg gtgatgttgt actttgtgat ttttgcccta
     5101 ttttttcttt ccatctatca ccattctctt tccaatccca gagattgatt tattaggtct
     5161 tggaaattct agattattcc attaactatt aagcagttaa acctgatact tcctacacta
     5221 gataatggaa cttcaacatt agcctattga ttgcccaaga acaaacattt ttttctaaat
     5281 gtcaggtgtt atggggagga ttgatgctga cagcagaggt ctagttaaaa actgatgcag
     5341 aggttcaaat acgttgtgca gtaatcacta gaactcacct tctaaagtgt catgagagct
     5401 ctgattctgc aattagagat tttttaatgt gtttttgaaa ttaccttgta aaccacaaat
     5461 ctgtgtctct gcattgcccc ttattgtttc ctaccacaaa ttctacatca agaagaaagt
     5521 tttaaagtta gactggattt atttgtgatt ttatggagca caataaggta cattgagata
     5581 gcatactaaa ggaggccaaa tacaggaagc atcatctttt cttattctct tactgcctgg
     5641 attttcccac tgacctggaa ttgtgcacag ttctacaaag gacaattgac attgttttcc
     5701 ttttactaag tagtgggttt tccttaaggt ccagactgaa ttttgagacc tgtatcagga
     5761 ttgccttctg tgtgactttt tcttgcagga tctgacatca ttacctatgg gtccatatat
     5821 ttgtgatact ttggtttcgg gaacatcact tttagaatgt tgacataaaa tgcacccaca
     5881 gaatgccgta tttatcaaaa gtaactttct agcaaaatct acagcagtag gcatttggaa
     5941 tctgcatttg agacctctgc agtcatttgg tcattccagc aatctatgtc caggttgtca
     6001 atttcagagg tcttattagt ctatacaggt accaatgagc tttcagatgt tcaacaccta
     6061 cccctggcct aactgctgat aaccaaccat aacccttgca gatgcatgca tgttttctgc
     6121 accttgctat catttttcag tccatttttc acatgtatac atagtgatta tttttaaatg
     6181 caaccctgat ttcacatgcc tcatgttgaa atatcgtgtg gcttattgtg gacttaaagt
     6241 gtaacattct ccttatggta tgtaaggact tttgtataaa ccaatgccta tctatctatc
     6301 atttctgaaa actttttcct cctatgcaat attttctggc ctctgtgaac aacttgtagt
     6361 tccttgagat ttctattatc acttatgttt ttgcaaatct gcaattgaaa tgcccttgtt
     6421 ccttgttaat gcctattgaa tctatatgaa cctgtacgtg tgtttctcac tgtgataata
     6481 taatcattgc atgttttatc tttcccacta gaaagcttct agaaagctag tactatcttt
     6541 tttgtctgtg taatttttgc atcacaagct atatttaaat gtgggtgcag tgagtggctg
     6601 ttttctgcca catggagaaa catggtctgc agtgagagag aagaatgaag ccatgatgaa
     6661 agcaaaatca agaaagagtc ccgattgtgt tccagtacct ggttcttctg gtcttcatgt
     6721 tcaggtccac ctctgccctt ttcatgtctt gattgttgaa ttcttctgtg agatactcca
     6781 aatatcctaa taaattctca tgtttgcttc a
//
