LOCUS       NM_052857               2238 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 830 (ZNF830), mRNA.
ACCESSION   NM_052857
VERSION     NM_052857.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2238)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2238)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2238)
  AUTHORS   Chen,G., Chen,J., Qiao,Y., Shi,Y., Liu,W., Zeng,Q., Xie,H., Shi,X.,
            Sun,Y., Liu,X., Li,T., Zhou,L., Wan,J., Xie,T., Wang,H. and Wang,F.
  TITLE     ZNF830 mediates cancer chemoresistance through promoting
            homologous-recombination repair
  JOURNAL   Nucleic Acids Res 46 (3), 1266-1279 (2018)
   PUBMED   29244158
  REMARK    GeneRIF: ZNF830 mediates cancer chemoresistance through promoting
            homologous recombination repair.
REFERENCE   4  (bases 1 to 2238)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2238)
  AUTHORS   De,I., Bessonov,S., Hofele,R., dos Santos,K., Will,C.L., Urlaub,H.,
            Luhrmann,R. and Pena,V.
  TITLE     The RNA helicase Aquarius exhibits structural adaptations mediating
            its recruitment to spliceosomes
  JOURNAL   Nat Struct Mol Biol 22 (2), 138-144 (2015)
   PUBMED   25599396
REFERENCE   6  (bases 1 to 2238)
  AUTHORS   Ciomborowska,J., Rosikiewicz,W., Szklarczyk,D., Makalowski,W. and
            Makalowska,I.
  TITLE     'Orphan' retrogenes in the human genome
  JOURNAL   Mol Biol Evol 30 (2), 384-396 (2013)
   PUBMED   23066043
REFERENCE   7  (bases 1 to 2238)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (bases 1 to 2238)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB030670.1, BG766126.1, BC009044.1, AI866097.1 and AC022903.12.
            
            On Nov 22, 2018 this sequence version replaced NM_052857.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660805.101091.1, SRR1803612.49665.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361952.5/ ENSP00000354518.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB030670.1         11-46
            37-546              BG766126.1         19-528
            547-1378            BC009044.1         120-951
            1379-1647           AI866097.1         1-269               c
            1648-2238           AC022903.12        31330-31920         c
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2238
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="zinc finger protein 830"
                     /db_xref="GeneID:91603"
                     /db_xref="HGNC:HGNC:28291"
     exon            1..2238
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1146
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="coiled-coil domain containing 16; coiled-coil
                     domain-containing protein 16; hypothetical protein
                     MGC20398; orphan maintenance of genome 1"
                     /codon_start=1
                     /product="zinc finger protein 830"
                     /protein_id="NP_443089.3"
                     /db_xref="CCDS:CCDS32618.1"
                     /db_xref="GeneID:91603"
                     /db_xref="HGNC:HGNC:28291"
                     /translation="MASSASARTPAGKRVINQEELRRLMKEKQRLSTSRKRIESPFAK
                     YNRLGQLSCALCNTPVKSELLWQTHVLGKQHREKVAELKGAKEASQGSSASSAPHSVK
                     RKAPDADDQDVKRAKATLVPQVQPSTSAWTTNFDKIGKEFIRATPSKPSGLSLLPDYE
                     DEEEEEEEEEGDGERKRGDASKPLSDAQGKEHSVSSSREVTSSVLPNDFFSTNPPKAP
                     IIPHSGSIEKAEIHEKVVERRENTAEALPEGFFDDPEVDARVRKVDAPKDQMDKEWDE
                     FQKAMRQVNTISEAIVAEEDEEGRLDRQIGEIDEQIECYRRVEKLRNRQDEIKNKLKE
                     ILTIKELQKKEEENADSDDEGELQDLLSQDWRVKGALL"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="hexamer: AATAGA"
     polyA_site      1507
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="major polyA site"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="hexamer: CATAAA"
     polyA_site      1647
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="major polyA site"
     regulatory      1939..1944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="hexamer: CATAAA"
     polyA_site      1972
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
                     /note="hexamer: AATAAA"
     polyA_site      2238
                     /gene="ZNF830"
                     /gene_synonym="CCDC16; OMCG1"
ORIGIN      
        1 agaatcgttt tgggtctggt cgccaagatg gcgtcctccg cctccgcccg gactccggca
       61 gggaagcgag tgataaatca ggaagaattg cggcggttaa tgaaggagaa gcagcgtctg
      121 agcaccagtc ggaaacggat agaatctcca ttcgcgaagt acaaccgttt ggggcagctg
      181 agttgtgccc tgtgtaacac tccggttaag agcgagctcc tgtggcagac tcacgtcctg
      241 ggaaagcagc accgagagaa agtggccgag ctgaaaggcg cgaaggaagc cagccagggt
      301 tcgtccgcca gttcagcgcc tcattccgtc aagaggaaag cgccggacgc agacgaccaa
      361 gatgtcaaga gagcgaaggc caccttggtg cctcaggtac agccctccac atctgcgtgg
      421 accaccaact ttgacaaaat aggaaaggag ttcattagag cgactcccag taagccttca
      481 ggactcagtt tactccccga ttatgaagat gaggaggagg aggaagagga ggaggaagga
      541 gatggagaaa gaaaaagggg ggacgccagc aagccgctct ccgacgcaca gggcaaggag
      601 cactcagttt cctcttcacg ggaggtaaca agtagtgtgc tgccaaacga tttctttagt
      661 actaatcctc ccaaggcccc cataattcct cattcagggt caattgagaa agcagaaata
      721 catgaaaaag tggtggaaag gagagaaaac accgcggaag cgttaccgga aggttttttt
      781 gacgaccctg aggtagatgc aagagtacga aaggttgatg ctccaaaaga tcagatggac
      841 aaagagtggg acgaattcca aaaagccatg aggcaggtca acactatttc cgaagccata
      901 gttgccgaag aggatgagga gggacggttg gaccgccaga ttggggagat cgatgagcag
      961 atagagtgtt accgacgggt ggaaaagcta cggaatcgcc aggatgaaat aaaaaataaa
     1021 cttaaagaaa tcctgaccat aaaagaactg cagaaaaagg aagaagagaa tgctgacagc
     1081 gatgatgagg gggaactaca ggatttgttg tctcaggatt ggagggtgaa aggggcattg
     1141 ttatagggtt ttaaagaccc aaggtttcta acagcctctg ctgttgtata aaaagtgctg
     1201 tctctcagta gtatagcggt tacttcatgc ctcaagattt gggtacctgg attgctaaac
     1261 tggattgttg agataaaatg agccagtgag ctacagcact ttggaaaatt tgtgtaacat
     1321 gtttttgagg taaagttgtt tttgaaattt ctgaagtgtt atataccaaa atgccaacat
     1381 ttccacgaca gacttaactg tataatttcg ttgtaaaatc tgtaagttgt aaatattgta
     1441 catagttaaa tctgtattct gttttgaatt tttttaatta atagaaagac caaccggcaa
     1501 actttcagat gaatgcttac tgtggtattt ggaatgtatg tatcttctga accctacatc
     1561 aagttgaaaa ggtttgtttt cttgtttctt tggtttttgt atggtttttt agaacacttc
     1621 ataaacacat aagtcattgt aggttaatca gttctcttag tgtgctttat tttaaaaaca
     1681 taagaaaact atatgccaaa catgaccaaa ccaatgatgg tcagatgtgg ttgcacatga
     1741 gagtcaccta tgaagcatta aaataattaa agtgtctgag gccttcccct tcaataaatc
     1801 tgggattggg cccaggcaac tgtgtttttt aagcacccag gttattctaa tatatgccag
     1861 ggttagagag taactgccct aaatccagaa cccatttatg tttttcaggt tttttctttt
     1921 tctttaaata acacattcca taaatttgct gtttcttgaa tgaaggaaaa aatattatct
     1981 tttatttatt tcatccagcc ttaaattttg ttatttggtg gtaaattagg gttccttgtt
     2041 tgcaggtcct atctattgta gaaagaatat ttaagttgtc tttccagcag taacaattgg
     2101 ctcttgctgg tcattgatag tttaaatcac tccttccttt agagattgag gtactcaaat
     2161 aggaaaaggg aattagcagt gttctggagt tgaaatgcat acagcatatt caaataaaag
     2221 tgagcaataa taataata
//
