LOCUS       NM_018300               2553 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 83 (ZNF83), transcript variant 5,
            mRNA.
ACCESSION   NM_018300 XM_001127292 XM_001131483
VERSION     NM_018300.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Lyu,Z.J., Wang,Y., Huang,J.L., Chen,M., Wu,S.Y., Yan,Q., Zhang,Y.,
            Tang,Y., Jiang,C., Li,L., Jia,Y.Z., Liu,Y.C., Mei,H.B., Wang,F.,
            Li,R.H., Chen,Y.C., Lin,X., Cai,Z.M. and Guan,X.Y.
  TITLE     Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression
            through the NF-kappaB Pathway via Transcriptional Dysregulation of
            S100A8
  JOURNAL   Mol Ther 29 (1), 275-290 (2021)
   PUBMED   33002420
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Marine,J.C., Bellefroid,E.J., Bourguignon,C., Riviere,M.,
            Lecoq,P.J., Poncelet,D.A., Szpirer,J., Martial,J.A. and Szpirer,C.
  TITLE     Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome
            19q13.3-q13.4
  JOURNAL   Genomics 21 (1), 285-286 (1994)
   PUBMED   8088807
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Bellefroid,E.J., Lecocq,P.J., Benhida,A., Poncelet,D.A., Belayew,A.
            and Martial,J.A.
  TITLE     The human genome contains hundreds of genes coding for finger
            proteins of the Kruppel type
  JOURNAL   DNA 8 (6), 377-387 (1989)
   PUBMED   2505992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA183557.1, DR761375.1, DA107683.1, DB107467.1, BG741860.1,
            BG260506.1 and AA883993.1.
            
            On Aug 13, 2020 this sequence version replaced NM_018300.3.
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 1. All variants (1-5 and 10-21) encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4406031.1,
                                           SRR14038192.233979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301096.8/ ENSP00000301096.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA183557.1         37-72
            37-373              DR761375.1         11-347
            374-829             DA107683.1         1-456               c
            830-1272            DB107467.1         118-560
            1273-1812           BG741860.1         187-726
            1813-2122           BG260506.1         107-416
            2123-2553           AA883993.1         8-438               c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2553
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /note="zinc finger protein 83"
                     /db_xref="GeneID:55769"
                     /db_xref="HGNC:HGNC:13158"
                     /db_xref="MIM:194558"
     exon            1..44
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /inference="alignment:Splign:2.1.0"
     exon            45..132
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /inference="alignment:Splign:2.1.0"
     exon            133..2553
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1916
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /note="zinc finger protein 816B; zinc finger protein HPF1"
                     /codon_start=1
                     /product="zinc finger protein 83"
                     /protein_id="NP_060770.3"
                     /db_xref="CCDS:CCDS12854.1"
                     /db_xref="GeneID:55769"
                     /db_xref="HGNC:HGNC:13158"
                     /db_xref="MIM:194558"
                     /translation="MHGRKDDAQKQPVKNQLGLNPQSHLPELQLFQAEGKIYKYDHME
                     KSVNSSSLVSPPQRISSTVKTHISHTYECNFVDSLFTQKEKANIGTEHYKCSERGKAF
                     HQGLHFTIHQIIHTKETQFKCDICGKIFNKKSNLASHQRIHTGEKPYKCNECGKVFHN
                     MSHLAQHRRIHTGEKPYKCNECGKVFNQISHLAQHQRIHTGEKPYKCNECGKVFHQIS
                     HLAQHRTIHTGEKPYECNKCGKVFSRNSYLVQHLIIHTGEKPYRCNVCGKVFHHISHL
                     AQHQRIHTGEKPYKCNECGKVFSHKSSLVNHWRIHTGEKPYKCNECGKVFSHKSSLVN
                     HWRIHTGEKPYKCNECGKVFSRNSYLAQHLIIHAGEKPYKCDECDKAFSQNSHLVQHH
                     RIHTGEKPYKCDECGKVFSQNSYLAYHWRIHTGEKAYKCNECGKVFGLNSSLAHHRKI
                     HTGEKPFKCNECGKAFSMRSSLTNHHAIHTGEKHFKCNECGKLFRDNSYLVRHQRFHA
                     GKKSNTCN"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /note="hexamer: AATAAA"
     polyA_site      2553
                     /gene="ZNF83"
                     /gene_synonym="HPF1; ZNF816B"
                     /note="major polyA site"
ORIGIN      
        1 aaacccggaa gcggattatg tggagtgaaa gttacaccgt ggcggattga cttctaagga
       61 ctcttggtac atgaggaaga aacccggaag gggaagagga aagcaaaggc gtcaggaatg
      121 gttcttcctc aggtattttt tctaaatgtg agatcaagga attaccacca aaaaaggaga
      181 gtaatacagg agaaatattc cagacagtaa tgttggaaag acatgaaagc cacgacatac
      241 aagatttttg cttcagagaa acccagaaaa atgtacatga ctctcagtgt ctgtggaaac
      301 atgattgaag acattataag cgagtgcgtg tgacctataa ggaaagtctc attggtagaa
      361 gagacatgca tgggagaaag gatgatgcac aaaagcagcc tgttaaaaat cagcttggat
      421 taaacccgca gtcacatcta ccagaactgc agctatttca agctgaaggg aaaatatata
      481 aatatgatca catggaaaaa tctgtcaaca gtagttcctt agtttcccca ccccaacgta
      541 tttcttctac tgtcaaaacc cacatttctc atacatatga atgtaatttt gtggattcat
      601 tattcacaca aaaagagaaa gcaaatattg ggacagaaca ctacaaatgt agtgagcgtg
      661 gcaaggcctt tcatcaaggc ttacatttta ctatacatca aataatccat actaaagaga
      721 cgcaatttaa atgtgatata tgtggcaaga tcttcaataa aaaatcaaac cttgcaagtc
      781 atcaaagaat tcatactgga gagaagccat ataaatgtaa tgaatgtggc aaggtcttcc
      841 ataatatgtc acaccttgca cagcatcgca ggattcatac tggagagaaa ccatataaat
      901 gtaatgaatg tggcaaggtc tttaatcaaa tttcacacct tgcacaacat caaagaattc
      961 ataccggaga gaaaccttat aaatgtaatg aatgtggaaa ggtcttccat caaatttcac
     1021 accttgcaca acatcggaca attcatactg gagaaaaacc ttacgaatgt aacaaatgtg
     1081 gcaaggtgtt cagtcgcaat tcctaccttg tacaacatct gatcattcat actggagaga
     1141 aaccttacag atgtaatgta tgtggaaagg tcttccatca tatttcacac cttgcacaac
     1201 atcagagaat ccacactgga gagaaacctt acaaatgtaa tgagtgtggc aaggtcttca
     1261 gtcacaagtc atccctagta aatcactgga gaattcatac tggagagaaa ccttacaaat
     1321 gtaatgagtg tggcaaggtc ttcagtcaca agtcatccct agtaaatcac tggagaatcc
     1381 acactggaga gaaaccttac aaatgtaatg aatgtggcaa ggtcttcagt cgcaattcat
     1441 accttgccca acatctgata attcatgccg gtgagaaacc ttataagtgt gatgaatgtg
     1501 acaaagcatt cagtcaaaat tcacatcttg tacaacatca cagaatccat actggagaga
     1561 aaccttacaa atgtgatgaa tgtggcaaag tcttcagtca aaattcatac cttgcatatc
     1621 attggagaat tcatactgga gaaaaagctt ataaatgtaa tgaatgtggg aaggtcttcg
     1681 gtctaaactc atccctagca catcatcgga aaattcacac tggagagaaa cctttcaaat
     1741 gtaatgaatg tggcaaagct tttagtatgc gttcaagcct cactaatcat catgcgatcc
     1801 acactggaga gaaacatttc aaatgtaatg aatgtggcaa actcttccgc gacaattcat
     1861 atcttgtacg tcatcagaga tttcatgccg gaaagaaatc taacacatgt aattaatgtg
     1921 gcagagtgtt cagttagcat taaagccttg taagacatac aataatttat actggagaaa
     1981 aactttgcaa gtataatgaa tgtagcagag cctttagttt ttgttcaagg cttaataacc
     2041 gttagctaga ccatagagga cagaaacttt actaatgtac tgaatgtggc aaggtcttaa
     2101 ggtaaaatct gagaccagga ttcttcaaag aattcttgct ggtgagaaac ctaacaaatg
     2161 taatgaatgt ggcaaggtct tctggcacaa ttctcacatt gtacaatatt gcaaaaattc
     2221 atgcttgaga gaaacaaaaa cactgagagt gggaaaccat tatgacttca aacattcatc
     2281 aacatcagag aatccatact aaagagcatt tataataatt atatgtgata gagattttcc
     2341 gcaggccaaa gtctcactag gcatcaaaaa cttttttgat gaaaccatac aaatgtaacg
     2401 tgcatgctta agcttttacc caggcatcaa aaccggaaca tcacagggtt tatactggag
     2461 agtaactaca caaagataat gtaataagcc tttcagtgta atattcatga ttttgtcgtg
     2521 agagatccac tcaataaaaa ccaggcaaat gta
//
