LOCUS       NM_001306215            7651 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 827 (ZNF827), transcript variant
            1, mRNA.
ACCESSION   NM_001306215 XM_011531644
VERSION     NM_001306215.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7651)
  AUTHORS   Kim,K.Y., Kim,J.O., Kim,Y.S., Choi,J.E., Park,J.M., Han,K.,
            Park,D.H., Park,Y.C., Kim,B.T. and Hong,K.W.
  TITLE     Genome-wide association of individual vulnerability with
            alcohol-associated liver disease: A Korean genome and epidemiology
            study
  JOURNAL   Hepatology 75 (2), 391-402 (2022)
   PUBMED   34387878
  REMARK    GeneRIF: Genome-wide association of individual vulnerability with
            alcohol-associated liver disease: A Korean genome and epidemiology
            study.
REFERENCE   2  (bases 1 to 7651)
  AUTHORS   Hollensen,A.K., Thomsen,H.S., Lloret-Llinares,M., Kamstrup,A.B.,
            Jensen,J.M., Luckmann,M., Birkmose,N., Palmfeldt,J., Jensen,T.H.,
            Hansen,T.B. and Damgaard,C.K.
  TITLE     circZNF827 nucleates a transcription inhibitory complex to balance
            neuronal differentiation
  JOURNAL   Elife 9, e58478 (2020)
   PUBMED   33174841
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7651)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7651)
  AUTHORS   Yang,S.F., Sun,A.A., Shi,Y., Li,F. and Pickett,H.A.
  TITLE     Structural and functional characterization of the RBBP4-ZNF827
            interaction and its role in NuRD recruitment to telomeres
  JOURNAL   Biochem J 475 (16), 2667-2679 (2018)
   PUBMED   30045876
  REMARK    GeneRIF: RBBP4 forms a negatively charged channel that binds to
            ZNF827 through a network of electrostatic interactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7651)
  AUTHORS   Conomos,D., Reddel,R.R. and Pickett,H.A.
  TITLE     NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold
            for homologous recombination
  JOURNAL   Nat Struct Mol Biol 21 (9), 760-770 (2014)
   PUBMED   25150861
  REMARK    GeneRIF: NuRD-ZNF827 recruitment to human telomeres causes
            remodeling of telomeric chromatin and creates an environment that
            promotes telomere-telomere recombination and integrates and
            controls multiple elements of Alternative lengthening of telomeres
            activity.
REFERENCE   6  (bases 1 to 7651)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   7  (bases 1 to 7651)
  AUTHORS   Chambers,J.C., Zhang,W., Sehmi,J., Li,X., Wass,M.N., Van der
            Harst,P., Holm,H., Sanna,S., Kavousi,M., Baumeister,S.E.,
            Coin,L.J., Deng,G., Gieger,C., Heard-Costa,N.L., Hottenga,J.J.,
            Kuhnel,B., Kumar,V., Lagou,V., Liang,L., Luan,J., Vidal,P.M., Mateo
            Leach,I., O'Reilly,P.F., Peden,J.F., Rahmioglu,N., Soininen,P.,
            Speliotes,E.K., Yuan,X., Thorleifsson,G., Alizadeh,B.Z.,
            Atwood,L.D., Borecki,I.B., Brown,M.J., Charoen,P., Cucca,F.,
            Das,D., de Geus,E.J., Dixon,A.L., Doring,A., Ehret,G.,
            Eyjolfsson,G.I., Farrall,M., Forouhi,N.G., Friedrich,N.,
            Goessling,W., Gudbjartsson,D.F., Harris,T.B., Hartikainen,A.L.,
            Heath,S., Hirschfield,G.M., Hofman,A., Homuth,G., Hypponen,E.,
            Janssen,H.L., Johnson,T., Kangas,A.J., Kema,I.P., Kuhn,J.P.,
            Lai,S., Lathrop,M., Lerch,M.M., Li,Y., Liang,T.J., Lin,J.P.,
            Loos,R.J., Martin,N.G., Moffatt,M.F., Montgomery,G.W., Munroe,P.B.,
            Musunuru,K., Nakamura,Y., O'Donnell,C.J., Olafsson,I.,
            Penninx,B.W., Pouta,A., Prins,B.P., Prokopenko,I., Puls,R.,
            Ruokonen,A., Savolainen,M.J., Schlessinger,D., Schouten,J.N.,
            Seedorf,U., Sen-Chowdhry,S., Siminovitch,K.A., Smit,J.H.,
            Spector,T.D., Tan,W., Teslovich,T.M., Tukiainen,T.,
            Uitterlinden,A.G., Van der Klauw,M.M., Vasan,R.S., Wallace,C.,
            Wallaschofski,H., Wichmann,H.E., Willemsen,G., Wurtz,P., Xu,C.,
            Yerges-Armstrong,L.M., Abecasis,G.R., Ahmadi,K.R., Boomsma,D.I.,
            Caulfield,M., Cookson,W.O., van Duijn,C.M., Froguel,P., Matsuda,K.,
            McCarthy,M.I., Meisinger,C., Mooser,V., Pietilainen,K.H.,
            Schumann,G., Snieder,H., Sternberg,M.J., Stolk,R.P., Thomas,H.C.,
            Thorsteinsdottir,U., Uda,M., Waeber,G., Wareham,N.J.,
            Waterworth,D.M., Watkins,H., Whitfield,J.B., Witteman,J.C.,
            Wolffenbuttel,B.H., Fox,C.S., Ala-Korpela,M., Stefansson,K.,
            Vollenweider,P., Volzke,H., Schadt,E.E., Scott,J., Jarvelin,M.R.,
            Elliott,P. and Kooner,J.S.
  CONSRTM   Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes
            Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic
            Investigation of Anthropometric Traits (GIANT) Consortium; Global
            Lipids Genetics Consortium; Genetics of Liver Disease (GOLD)
            Consortium; International Consortium for Blood Pressure
            (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits
            Consortium (MAGIC)
  TITLE     Genome-wide association study identifies loci influencing
            concentrations of liver enzymes in plasma
  JOURNAL   Nat Genet 43 (11), 1131-1138 (2011)
   PUBMED   22001757
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7651)
  AUTHORS   Kim,Y.J., Go,M.J., Hu,C., Hong,C.B., Kim,Y.K., Lee,J.Y.,
            Hwang,J.Y., Oh,J.H., Kim,D.J., Kim,N.H., Kim,S., Hong,E.J.,
            Kim,J.H., Min,H., Kim,Y., Zhang,R., Jia,W., Okada,Y., Takahashi,A.,
            Kubo,M., Tanaka,T., Kamatani,N., Matsuda,K., Park,T., Oh,B.,
            Kimm,K., Kang,D., Shin,C., Cho,N.H., Kim,H.L., Han,B.G., Lee,J.Y.
            and Cho,Y.S.
  CONSRTM   MAGIC consortium
  TITLE     Large-scale genome-wide association studies in East Asians identify
            new genetic loci influencing metabolic traits
  JOURNAL   Nat Genet 43 (10), 990-995 (2011)
   PUBMED   21909109
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7651)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 7651)
  AUTHORS   Bubb,K.L., Bovee,D., Buckley,D., Haugen,E., Kibukawa,M.,
            Paddock,M., Palmieri,A., Subramanian,S., Zhou,Y., Kaul,R., Green,P.
            and Olson,M.V.
  TITLE     Scan of human genome reveals no new Loci under ancient balancing
            selection
  JOURNAL   Genetics 173 (4), 2165-2177 (2006)
   PUBMED   16751668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX112429.1, AK225805.1, AK091130.1, AK094136.1, BC033248.1 and
            BU616184.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001306215.1.
            
            Transcript Variant: This variant (1) represents longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225805.1, BC117407.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508784.6/ ENSP00000421863.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               BX112429.1         138-325
            189-3647            AK225805.1         1-3459
            3648-3648           AK091130.1         3264-3264
            3649-4556           AK225805.1         3461-4368
            4557-5518           AK094136.1         1983-2944
            5519-7640           BC033248.1         819-2940
            7641-7651           BU616184.1         18-28               c
FEATURES             Location/Qualifiers
     source          1..7651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21-q31.22"
     gene            1..7651
                     /gene="ZNF827"
                     /note="zinc finger protein 827"
                     /db_xref="GeneID:152485"
                     /db_xref="HGNC:HGNC:27193"
                     /db_xref="MIM:617962"
     exon            1..459
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..3662
                     /gene="ZNF827"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 827 isoform 1"
                     /protein_id="NP_001293144.1"
                     /db_xref="CCDS:CCDS77968.1"
                     /db_xref="GeneID:152485"
                     /db_xref="HGNC:HGNC:27193"
                     /db_xref="MIM:617962"
                     /translation="MPRRKQEQPKRLPSHVSRQEEAEGELSEGEHWYGNSSETPSEAS
                     YGEVQENYKLSLEDRIQEQSTSPDTSLGSTTPSSHTLELVALDSEVLRDSLQCQDHLS
                     PGVSSLCDDDPGSNKPLSSNLRRLLEAGSLKLDAAATANGRVESPVNVGSNLSFSPPS
                     HHAQQLSVLARKLAEKQEQNDQYTPSNRFIWNQGKWLPNSTTTCSLSPDSAILKLKAA
                     ANAVLQDKSLTRTEETMRFESFSSPFSSQSASSTLAALSKKVSERSLTPGQEHPPPAS
                     SFLSLASMTSSAALLKEVAARAAGSLLAEKSSLLPEDPLPPPPSEKKPEKVTPPPPPP
                     PPPPPPPPPQSLELLLLPVPKGRVSKPSNSASEEESGKPFQCPICGLVIKRKSYWKRH
                     MVIHTGLKSHQCPLCPFRCARKDNLKSHMKVHQHQDRGETFQCQLCPFTSSRHFSLKL
                     HMRCHQHFLRTEAKVKEEIPDPDVKGSPHLSDSACLGQQREGGGTELVGTMMTSNTPE
                     RTSQGGAGVSPLLVKEEPKEDNGLPTSFTLNAADRPANHTKLKDPSEYVANSASALFS
                     QDISVKMASDFLMKLSAANQKEPMNLNFKVKEEPKEGESLSTTLPRSSYVFSPESEVS
                     APGVSEDALKPQEGKGSVLRRDVSVKAASELLMKLSAESYKETQMVKIKEEPMEVDIQ
                     DSHVSISPSRNVGYSTLIGREKTEPLQKMPEGRVPPERNLFSQDISVKMASELLFQLS
                     EKVSKEHNHTKENTIRTTTSPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEK
                     IVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLHTEERKYKCHLCPYAAKC
                     RANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVS
                     HMSLHVDKEQWMFSICCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLS
                     ALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGFECVFCNFVCKT
                     KNMFERHLQIHLITRMFECDVCHKFMKTPEQLLEHKKCHTVPTGGLNSGQW"
     exon            460..1509
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1682
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2163
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2397
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2637
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2695
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2799
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2937
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3109
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3276
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3468
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3646
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3679
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..7651
                     /gene="ZNF827"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6250..6255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF827"
                     /note="hexamer: AATAAA"
     polyA_site      6271
                     /gene="ZNF827"
     regulatory      7175..7180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF827"
                     /note="hexamer: AAGAAA"
     polyA_site      7193
                     /gene="ZNF827"
                     /note="major polyA site"
     regulatory      7625..7630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF827"
                     /note="hexamer: ATTAAA"
     polyA_site      7651
                     /gene="ZNF827"
                     /note="major polyA site"
ORIGIN      
        1 gacattagtg ttaggggctc ggagacacag agcgcggcca tagacaccgc cgcaccggca
       61 ctcatttatt tatacctccc atcacacacg cgagcatagg acacacacac actcacacct
      121 attagatccg tttccattga agaatattac gctcggggac aagccaggtg cacgaccaaa
      181 aatttaaaaa aaaaaaaaaa aggaaaaaag aaaggaaaga aaagaagaaa acccctcttc
      241 tggctccagg aaacaagctt caacccattg cacacaccgg agaaggggtt tccccctgcc
      301 cgcccgcccg ccccccaact acctccccgc tcctgccagt gtctgcctct ctgcccccac
      361 gggggtttat ttgatctcac attaaccaag gaggagaatg tgagaaaagg gggaaaatgc
      421 ccaggaggaa gcaggagcag cccaagcgcc ttccctcaca tgttagtagg caggaagagg
      481 cggagggaga gctcagtgaa ggagaacact ggtatggaaa ctcttcagag actccgtcag
      541 aagcatccta tggggaagtc caggagaact ataagttgtc tctggaggac cggatccagg
      601 agcagtccac gtccccggac acctccttgg gaagcacgac tcccagcagc cacacgttgg
      661 agctggtggc actggacagt gaggtcctgc gagactcact gcagtgtcaa gatcaccttt
      721 ccccgggagt gtcttctttg tgtgacgatg acccaggctc caacaagccc ctgagcagca
      781 atttgaggcg gctgctggag gctggttccc tcaaactcga tgctgcagcc acggctaatg
      841 gcagagtgga gtcccccgta aacgttggct cgaacctctc cttttccccg ccttcccacc
      901 acgcccagca gctcagtgtt ctggccagga agttggccga gaagcaggaa cagaatgacc
      961 aatacactcc aagtaaccgt tttatatgga atcaaggtaa gtggttgcca aactcaacca
     1021 ccacctgcag cttgtctccg gattcagcca tcctaaaact gaaagctgca gccaatgccg
     1081 ttctgcagga caaatctctc accaggactg aggagaccat gcgatttgag tccttttcct
     1141 ccccttttag ctcccagtct gccagttcta ccttggccgc tttgtccaag aaggtcagtg
     1201 aaagaagttt gactcctggt caggagcacc ctccaccggc cagctccttc ctttccctgg
     1261 cttctatgac ctcctcagcg gcccttctga aggaggtggc cgcaagggct gcgggcagtc
     1321 ttctggctga gaaatcatcg ctgctgcctg aggaccctct accgcccccg ccttcagaga
     1381 agaaaccaga aaaagtcact ccgccacctc caccgccacc tccaccacct ccaccaccac
     1441 caccacaatc cctggaatta ttattactcc cagttcctaa gggaagagtt tctaaaccct
     1501 ccaattcagc ctcagaagag gaaagtggaa agcctttcca gtgtccaata tgtggtttgg
     1561 ttattaaaag gaagagttac tggaagcggc acatggtgat tcacacaggt ttaaaaagtc
     1621 atcagtgtcc gctctgtcca ttccggtgtg ctcgcaagga caatctcaaa tcccacatga
     1681 aggttcatca gcaccaggat cggggagaga cctttcagtg ccagctgtgc ccttttactt
     1741 cctcacgcca cttcagcctg aaactccaca tgcgttgcca tcagcacttc ctgaggacag
     1801 aagccaaggt gaaggaggag atcccagacc cagatgtcaa gggatctccc cacctcagtg
     1861 acagtgcctg cctggggcag caaagggaag gaggagggac agagctagtg gggaccatga
     1921 tgacgtctaa cactccagag aggactagcc agggaggggc tggcgtctcg cctttgctgg
     1981 tgaaggagga acccaaggaa gataacggcc tgcccacctc ctttactttg aatgctgccg
     2041 acaggcccgc caaccacaca aagctgaaag acccctccga gtatgtggcc aacagtgcgt
     2101 cagcattgtt cagccaggac atctctgtta agatggcgtc tgattttctc atgaagctgt
     2161 cagctgcaaa tcagaaggag cccatgaatc ttaattttaa agtgaaagag gagcctaagg
     2221 aaggggagtc cctaagcacg actttgcctc ggtccagcta tgtgttcagc ccggaatctg
     2281 aagtgtcagc cccaggcgtc tctgaggacg cactaaagcc ccaggaaggg aagggaagtg
     2341 tgctaaggcg ggatgtgtca gtcaaagcag cctctgaact tctcatgaaa ctctcagcgg
     2401 aaagctacaa ggaaacacag atggtgaaga ttaaagagga acccatggag gttgacatcc
     2461 aggactccca tgtctcgata tcacccagcc ggaatgttgg ctacagcact ttaatcgggc
     2521 gagagaaaac cgaaccctta cagaagatgc cagagggcag agtaccccca gagagaaacc
     2581 tcttcagtca ggatatctct gtgaaaatgg cttccgagct cctctttcaa ctgtcagaaa
     2641 aagtgagcaa agagcacaat catacaaaag aaaacaccat ccggaccacg accagccctt
     2701 tcttttcaga agacacattt agacaatcac cattcacctc caattcaaaa gaactgctgc
     2761 ccagtgactc cgtgctgcac ggaagaatat cagctccaga aacagaaaag atagtcctag
     2821 aggcaggaaa tggattacca tcctggaaat tcaatgacca gctttttccc tgtgacgtgt
     2881 gtgggaaagt gtttggccga cagcagacat tgtcccgaca cctctcgctg cacacagagg
     2941 aaagaaaata caaatgccac ttgtgcccct atgctgctaa gtgccgtgca aatctgaacc
     3001 agcacttgac cgtccattcc gtgaagctgg tgagtacaga caccgaggac attgtcagcg
     3061 ccgtcacctc tgaaggcagt gatgggaaga aacatcctta ttattacagt tgtcacgtgt
     3121 gtggatttga gaccgagctc aatgtccagt ttgtcagcca catgtcactc cacgtggaca
     3181 aggagcagtg gatgttttcg atctgctgca ctgcctgcga cttcgtcacc atggaggaag
     3241 cagagataaa gactcacatt ggcaccaagc acacagggga agacaggaag acccccagcg
     3301 aatcaaatag cccctcttca tcctccctct cagctctgag tgattcagcc aacagcaaag
     3361 atgattcaga tggctcccag aaaaacaagg gcgggaacaa tctgctggtc atctctgtca
     3421 tgcctgggag ccagccctca ctgaacagtg aggaaaagcc agagaaaggg ttcgaatgtg
     3481 ttttttgcaa ctttgtctgc aagacgaaga acatgtttga gcgtcatctg cagatacacc
     3541 tcatcacccg gatgtttgag tgtgatgtgt gccacaagtt catgaagacc cccgaacagc
     3601 tgctggagca taagaaatgc cacactgtcc ccaccggtgg gctcaactca ggacagtggt
     3661 gagtttcaga ctcctctagg tgcccattct gcatttattc caccaaccgc cccgctgcca
     3721 tggagtgcca cctcaagacc cactacaaga tggagtacaa gtgccggatc tgccagacgg
     3781 tgaaggccaa ccagctggag ctggagacgc acacccggga gcaccgcctg ggcaaccact
     3841 acaagtgcga ccagtgcggc tacctgtcca agaccgccaa caagctcatc gagcacgtgc
     3901 gcgtccacac cggggagcgg cccttccact gtgaccagtg cagctacagc tgcaagcgca
     3961 aggacaatct caacctgcac aagaagctga agcacgcccc acgccagacc ttcagctgcg
     4021 aagagtgcct gttcaagacc acacaccctt tcgtcttcag ccgccacgtc aagaagcacc
     4081 agagtgggga ctgccccgag gaggacaaga agggcctgtg tccagccccc aaggaaccgg
     4141 ccggcccggg ggccccgctc ctggtggtcg ggagctcccg gaatctcctg tctcccctgt
     4201 cagttatgtc tgcctcccag gctctgcaga ccgtggccct gtcggcagcc cacggcagca
     4261 gctcagagcc caacctggca ctcaaggctt tggccttcaa cggctcccct ttgcgctttg
     4321 acaagtaccg gaactcagat tttgcccatc tcattccctt gacaatgtta taccccaaga
     4381 accacttgga tctcacattc caccctcccc gacctcagac tgcgcctccc agcatcccct
     4441 cacccaaaca ctccttcctg gcctatctcg gactgagaga aagagcagag actgtctgag
     4501 ggcagccatg ttctgtacca aaaacagaga gacaaaagac aaaaaaaaaa aaaaaaacca
     4561 caaaacttaa acacaacccc agcaggtgta tgttgctgca aaacctacag accccgatgg
     4621 gtctggaaca tgtgtactgt atatctttag taaggaatag aaaattggct ctgtgtgtat
     4681 acctattgca ttgacctgaa agctgcttta tccaatcttc agagaggtga cctactgcat
     4741 acttctacct tcagaggcat gcctccccag ccacccactc ccactctcag cccttctccg
     4801 tacttttctc tgaaaggaat cttgtcttgt taaaccctaa agagagtgtc cttaatagca
     4861 atcagcactt gtaagcttat atactggtgc atttggtttt ctgttgggtg aatgcggtgt
     4921 gtgggcgttt gtggattctg aaagagaaag ccgtgtgtcg tgtgccatga catttctatt
     4981 gcacattctt tgtactggct tctttaacag cgatgaacgt tcttttccct cctgggttgt
     5041 tcatccacga cagtctctcc ctgtgctcct tcatcacctt tccctctctc tttgatggct
     5101 acagagtggt agggcctggt gcttagtcga tgaaggaatg gtagccatct acagtgctgc
     5161 tggagatttc cgccagagcg ctggagacct tgcgctcaga tcttctctgg tgatgaagag
     5221 gcgaggaatc aagtgactga tctggaagaa atatctcgca gcactgcagc taacatcaca
     5281 gaacttaagt gtgttttgtg tgtgtgccca cacgtagaca aatgtgtacg gtgcacacac
     5341 acagtgcatc attttttaag ggcagattat atatatatat gagatgtatt aattcagtgg
     5401 ttaccatttg tttgcaggaa aaagaaatgt atgggtgaaa aaatttatgg ttgataaatc
     5461 cagccaagga gattaaaagg ggtttggata aattctgggt ataaatgctc agactaaaaa
     5521 aaagaaatgg cagttttgca cagtgctatg gtcttgcact agtttttgtt tctcatctga
     5581 aaaaaaaaaa gtaaaataaa aggaagaaaa tgtacctttt ttatggaatg agtagactgt
     5641 atgtttgaag atttagccac aacctctttg acatataatg acgcaacaaa aaggtgctgt
     5701 ttagtcctat ggttcagttt atgcccctga caagtttcca ttgtgttttg ccgatcttct
     5761 ggctaatcgt ggtatcctcc atgttattag taattctgta ttccattttg ttaacgcctg
     5821 gtagatgtaa cctgctagga ggctaacttt atacttattt aaaagctctt attttgtggt
     5881 cattaaaatg gcaatttatg tgcagcactt tattgcagca ggaagcaggt gtgggttggt
     5941 tgtaaagctc tttgctaatc ttaaaaagta atgggtgatt taaaaagaaa aaaggaaaaa
     6001 aatctttggc tgaatatgtt cattgcttgt atttttaaaa caacagaatt tccagtatga
     6061 aacaggctga aagagcagga agaaatgttc tttgtataat aatgggaagt ttggaatata
     6121 aaagtttata tattatttat ctattggaga actggtgtac aggaggaaca ttttcttact
     6181 gtgttgctgt tttccatcat gtgttatcct aagagttggg gttttttaaa atctgtttca
     6241 ccaggggaaa ataaaagcat ccctaatgtt cttcctctag tcagtttgct ttgctgaaag
     6301 ctccctggaa attagtacag ttctacagga agccagaaga ctgtactgtc tgtccacacc
     6361 atggtctcct cagtcccctc cacgccagcc cctcttcccc acacctagta ggtgtgctac
     6421 acctcccttt gccagtcatc ccgccatgga tggggagcct acttggtgcc ctggcaaacc
     6481 tgtttacact aaggagatgc ccacagggag cgggaagctc ccaaaccctc agtcattctc
     6541 cagcagagac ctttgctctt ggccaggttt gaaacgatgt tcaacctcgc cacgtcaatg
     6601 tctcagtaaa agacactata gatagttatg gacaatacac tccaagaata ctgggcttat
     6661 gggtgggttg gttttttgtt ttgttttgtt ttgttttcaa gtcatgtctt tatccccata
     6721 taatggagaa tgtgccactt ggctaataat gtgttttcaa aactacaagt tcagtgatga
     6781 caggaaagag ggctaaagta gtcccacaga ggctggtaga aaaggcgaat cacacttaag
     6841 caccagcagg ttaaaaacct gaaagggtgg ccctgacaat tcagactata ggttttacag
     6901 catgccactt gtgcaatagg aggtctaggg ttgaaacttt caagaacgag aggaggtgaa
     6961 ggaaggagac gtttactgct caaatgccat gcatttcact gcttgccact gaacttgtat
     7021 ttgaatgact tagtaatgct taatataatt gggcaacttt tttagcactt tggaaagagt
     7081 catcaatctt tctggtaaat tataaaagtt ttctgagtga gaaaaggtgt gtttggagtt
     7141 tgtttgactt tttatattat tattgttatt aataaagaaa aaaatctaca gcatttttca
     7201 gactccaccc tagaaaatat gtacccctga atttggtttg cagtttgata ctcagggaag
     7261 gatgtattcc atagatatcc tttccgtata aaacactaac atctttgaga aattcaccta
     7321 ccaactaact tcaattgttg tcactatgca ttcttcaatg aaaactagct tatttttcca
     7381 tatagtaatg cagttagggt tctcagcact ttctttcttc tatccttttt ttaactcttc
     7441 atattatgtt cagatgatca tactgtcaag gtttgtgtac attactgaaa atttgtattg
     7501 tataaagctt tttgcattac gaggctgtac agggtcattt tgacagtaac tggtatattc
     7561 ctttgcatct tatgttgcat tgccaatttc tagtgtatcc agtttgaaag tataatatac
     7621 tctaattaaa aaaaaaaaaa ggttggctat a
//
