LOCUS       NM_001201552            1987 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 821 (ZNF821), transcript variant
            1, mRNA.
ACCESSION   NM_001201552
VERSION     NM_001201552.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Nonaka,Y., Muto,H., Aizawa,T., Okabe,E., Myoba,S., Yokoyama,T.,
            Saito,S., Tatami,F., Kumaki,Y., Kamiya,M., Kikukawa,T.,
            Mizuguchi,M., Takiya,S., Kinjo,M., Demura,M. and Kawano,K.
  TITLE     STPR, a 23-amino acid tandem repeat domain, found in the human
            function-unknown protein ZNF821
  JOURNAL   Biochemistry 49 (38), 8367-8375 (2010)
   PUBMED   20795678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA324992.1, AK313693.1,
            AK296603.1 and BC004563.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001201552.1.
            
            Summary: This gene encodes a protein with two C2H2 zinc finger
            motifs and a score-and-three (23)-amino acid peptide repeat (STPR)
            domain. The STPR domain of the encoded protein binds to double
            stranded DNA and may also contain a nuclear localization signal,
            suggesting that this protein interacts with chromosomal DNA.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Jan
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.977143.1,
                                           SRR3476690.1113273.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425432.6/ ENSP00000398089.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DA324992.1         333-362             c
            31-441              AK313693.1         1-411
            442-1865            AK296603.1         435-1858
            1866-1987           BC004563.2         1828-1949
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..1987
                     /gene="ZNF821"
                     /note="zinc finger protein 821"
                     /db_xref="GeneID:55565"
                     /db_xref="HGNC:HGNC:28043"
     exon            1..275
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     exon            276..338
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     exon            339..455
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1654
                     /gene="ZNF821"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 821 isoform 1"
                     /protein_id="NP_001188481.1"
                     /db_xref="CCDS:CCDS56006.1"
                     /db_xref="GeneID:55565"
                     /db_xref="HGNC:HGNC:28043"
                     /translation="MSRRKQTNPNKVHWDQVFAGLEEQARQAMMKTDFPGDLGSQRQA
                     IQQLRDQDSSSSDSEGDEEETTQDEVSSHTSEEDGGVVKVEKELENTEQPVGGNEVVE
                     HEVTGNLNSDPLLELCQCPLCQLDCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALS
                     SPGSLGRHLLIHSEDQRSNCAVCGARFTSHATFNSEKLPEVLNMESLPTVHNEGPSSA
                     EGKDIAFSPPVYPAGILLVCNNCAAYRKLLEAQTPSVRKWALRRQNEPLEVRLQRLER
                     ERTAKKSRRDNETPEEREVRRMRDREAKRLQRMQETDEQRARRLQRDREAMRLKRANE
                     TPEKRQARLIREREAKRLKRRLEKMDMMLRAQFGQDPSAMAALAAEMNFFQLPVSGVE
                     LDSQLLGKMAFEEQNSSSLH"
     exon            456..581
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     exon            582..727
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     exon            728..832
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     exon            833..999
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1987
                     /gene="ZNF821"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF821"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="ZNF821"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcgagc cgcgcgctcc cgccgcccgc gtcgccatct ttttccccct ccgtctgtct
       61 gtctgctgtt ggctttgtcc gtctgcagcg ccgcccctcg gctccccgcc accggctcgg
      121 ctcggcccgg agccccttcc gctcgccggg gcccagtccc ggagcgcccc ggcccggctg
      181 gcttgggctg cggtcccggg tccattgtcc ggcggtccgt ctgtccggag gcggggccca
      241 gggacccaga gcgcagcgca gcgccgaggc gccggataca gatcacttgg attcagtcga
      301 gtttgctttg ctccgtggga actgcaccag agctggaggt tagcatcttg caaggaggta
      361 gtaacatatc cagtcgtgaa actgggaaag accagagctc ttgcatcagg gaaacatgtc
      421 ccgtcggaaa cagacaaatc caaataaagt tcactgggat caagtatttg ctgggctaga
      481 agagcaagcc cgccaggcga tgatgaaaac tgattttcct ggagaccttg gcagtcagcg
      541 acaagctatc caacaactaa gagatcagga ctccagtagc agtgacagtg agggtgatga
      601 agaggagacg acacaagatg aagtctcttc ccacacatca gaggaagatg gaggggtggt
      661 caaagtggag aaagagttag aaaatacaga acagcctgtt ggtgggaacg aagtggtaga
      721 gcacgaggtc acagggaatt tgaattctga ccccttgctt gaactctgcc agtgtcccct
      781 ctgccagcta gactgcggga gccgggagca gttgattgct cacgtgtacc agcacactgc
      841 agcagtggtg agcgccaaga gctacatgtg tcctgtctgt ggccgggccc ttagctcccc
      901 ggggtcattg ggtcgccacc tcttaatcca ctcggaggac cagcgatcta actgtgctgt
      961 gtgtggagcc cggttcacca gccatgccac ttttaacagt gagaaacttc ctgaagtact
     1021 aaatatggaa tccctaccca cagtccacaa tgagggtccc tccagtgctg aggggaagga
     1081 tattgccttt agtcctccag tgtaccctgc tggaattctg cttgtgtgca acaactgtgc
     1141 tgcctaccgt aaactgctgg aagcccagac tcccagtgta cgcaagtggg ctctacgtcg
     1201 acagaatgag cctttggaag tacggctgca gcggctggaa cgagagcgca cggccaagaa
     1261 gagccggcgg gacaatgaga cccccgagga gcgggaggtg aggcgcatga gggaccgtga
     1321 agccaagcgc ttgcagcgca tgcaggagac agacgagcag cgggcacgcc ggctgcagcg
     1381 ggatcgggag gccatgaggc tgaagcgggc caatgaaacc ccggaaaagc ggcaggcccg
     1441 gctcatccga gagcgagagg ccaagcggct caagaggagg ctggagaaaa tggacatgat
     1501 gttgcgagct cagtttggcc aggacccttc tgccatggca gccttagcag ctgaaatgaa
     1561 cttcttccag ctgcctgtaa gtggggtgga gttggacagc cagcttctgg gcaagatggc
     1621 ctttgaagag cagaacagca gctctctgca ctgaaccaca ccctcctgcc tgccctcctt
     1681 cccacctacc tacccaccca cccacaccca cagccacgag gaccagtgct gctgccaccc
     1741 acgaggccct gtccttgctg ccagaggcag gcctgggttt attgcaggtg gacctgagca
     1801 gcccttgcat atgggaacag gatgatgggg tcaggaggga cctggctcaa ggcagctctg
     1861 gacaagggag caggcagtcc agagaactgg cctccccagc ccactgccac aggctgtgct
     1921 tctaggactg tggggcccct gtgtggccca tgaagttgtg aagtcaaata aattaatttt
     1981 atcttta
//
