LOCUS       NM_194250               4527 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens zinc finger protein 804A (ZNF804A), mRNA.
ACCESSION   NM_194250 XM_040403
VERSION     NM_194250.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4527)
  AUTHORS   Shen,G., Chen,L., Liu,Y., Zhu,Q., Kang,Y., Luo,X., Wang,F. and
            Wang,W.
  TITLE     ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms: genetic
            interaction for emotional and behavioral symptoms of alcohol
            withdrawal syndrome
  JOURNAL   BMC Psychiatry 24 (1), 335 (2024)
   PUBMED   38702695
  REMARK    GeneRIF: ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms:
            genetic interaction for emotional and behavioral symptoms of
            alcohol withdrawal syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4527)
  AUTHORS   Aabdien,A., Sichlinger,L., Borgel,Z., Jones,M.R., Waston,I.A.,
            Gatford,N.J.F., Raval,P., Tanangonan,L., Powell,T.R., Duarte,R.R.R.
            and Srivastava,D.P.
  TITLE     Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical
            neurons
  JOURNAL   Eur J Neurosci 59 (8), 2102-2117 (2024)
   PUBMED   38279611
  REMARK    GeneRIF: Schizophrenia risk proteins ZNF804A and NT5C2 interact in
            cortical neurons.
REFERENCE   3  (bases 1 to 4527)
  AUTHORS   Shen,G., Wu,Y., Wang,K., Niculescu,M., Liu,Y., Kang,Y., Luo,X.,
            Wang,W., Chen,Y.H., Liu,Y., Wang,F. and Chen,L.
  TITLE     Impulsivity and aggression in alcohol withdrawal syndrome is
            modulated by the interaction of ZNF804A and mTOR polymorphism
  JOURNAL   Pharmacol Biochem Behav 236, 173708 (2024)
   PUBMED   38216065
  REMARK    GeneRIF: Impulsivity and aggression in alcohol withdrawal syndrome
            is modulated by the interaction of ZNF804A and mTOR polymorphism.
REFERENCE   4  (bases 1 to 4527)
  AUTHORS   Novaes de Oliveira Roldan,A.C., Fernandes Junior,L.C.C., de
            Oliveira,C.E.C. and Nunes,S.O.V.
  TITLE     Impact of ZNF804A rs1344706 or CACNA1C rs1006737 polymorphisms on
            cognition in patients with severe mental disorders: A systematic
            review and meta-analysis
  JOURNAL   World J Biol Psychiatry 24 (3), 195-208 (2023)
   PUBMED   35786202
  REMARK    GeneRIF: Impact of ZNF804A rs1344706 or CACNA1C rs1006737
            polymorphisms on cognition in patients with severe mental
            disorders: A systematic review and meta-analysis.
            Review article
REFERENCE   5  (bases 1 to 4527)
  AUTHORS   Guardiola-Ripoll,M., Almodovar-Paya,C., Lubeiro,A., Sotero,A.,
            Salvador,R., Fuentes-Claramonte,P., Salgado-Pineda,P., Papiol,S.,
            Ortiz-Gil,J., Gomar,J.J., Guerrero-Pedraza,A., Sarro,S.,
            Maristany,T., Molina,V., Pomarol-Clotet,E. and Fatjo-Vilas,M.
  TITLE     A functional neuroimaging association study on the interplay
            between two schizophrenia genome-wide associated genes (CACNA1C and
            ZNF804A)
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 272 (7), 1229-1239 (2022)
   PUBMED   35796825
  REMARK    GeneRIF: A functional neuroimaging association study on the
            interplay between two schizophrenia genome-wide associated genes
            (CACNA1C and ZNF804A).
REFERENCE   6  (bases 1 to 4527)
  AUTHORS   Riley,B., Thiselton,D., Maher,B.S., Bigdeli,T., Wormley,B.,
            McMichael,G.O., Fanous,A.H., Vladimirov,V., O'Neill,F.A., Walsh,D.
            and Kendler,K.S.
  TITLE     Replication of association between schizophrenia and ZNF804A in the
            Irish Case-Control Study of Schizophrenia sample
  JOURNAL   Mol Psychiatry 15 (1), 29-37 (2010)
   PUBMED   19844207
  REMARK    GeneRIF: This study suggested that there is a consistent link
            between the A allele of rs1344706, increased expression of ZNF804A
            and risk for schizophrenia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4527)
  AUTHORS   Esslinger,C., Walter,H., Kirsch,P., Erk,S., Schnell,K., Arnold,C.,
            Haddad,L., Mier,D., Opitz von Boberfeld,C., Raab,K., Witt,S.H.,
            Rietschel,M., Cichon,S. and Meyer-Lindenberg,A.
  TITLE     Neural mechanisms of a genome-wide supported psychosis variant
  JOURNAL   Science 324 (5927), 605 (2009)
   PUBMED   19407193
  REMARK    GeneRIF: healthy carriers of rs1344706 risk genotype show no
            changes in regional activity but pronounced gene dosage-dependent
            alteration in functional coupling of dorsolateral prefrontal cortex
            across hemispheres & with hippocampus & abnormal coupling of
            amygdala
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4527)
  AUTHORS   O'Donovan,M.C., Craddock,N., Norton,N., Williams,H., Peirce,T.,
            Moskvina,V., Nikolov,I., Hamshere,M., Carroll,L., Georgieva,L.,
            Dwyer,S., Holmans,P., Marchini,J.L., Spencer,C.C., Howie,B.,
            Leung,H.T., Hartmann,A.M., Moller,H.J., Morris,D.W., Shi,Y.,
            Feng,G., Hoffmann,P., Propping,P., Vasilescu,C., Maier,W.,
            Rietschel,M., Zammit,S., Schumacher,J., Quinn,E.M., Schulze,T.G.,
            Williams,N.M., Giegling,I., Iwata,N., Ikeda,M., Darvasi,A.,
            Shifman,S., He,L., Duan,J., Sanders,A.R., Levinson,D.F.,
            Gejman,P.V., Cichon,S., Nothen,M.M., Gill,M., Corvin,A.,
            Rujescu,D., Kirov,G., Owen,M.J., Buccola,N.G., Mowry,B.J.,
            Freedman,R., Amin,F., Black,D.W., Silverman,J.M., Byerley,W.F. and
            Cloninger,C.R.
  CONSRTM   Molecular Genetics of Schizophrenia Collaboration
  TITLE     Identification of loci associated with schizophrenia by genome-wide
            association and follow-up
  JOURNAL   Nat Genet 40 (9), 1053-1055 (2008)
   PUBMED   18677311
  REMARK    GeneRIF: genome-wide association study of schizophrenia;
            meta-analysis provided strongest evidence for association around
            ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected
            phenotype included bipolar disorder (P = 9.96 x 10(-9))
            GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 4527)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 4527)
  AUTHORS   Islam,T.C., Asplund,A.C., Lindvall,J.M., Nygren,L., Liden,J.,
            Kimby,E., Christensson,B., Smith,C.I. and Sander,B.
  TITLE     High level of cannabinoid receptor 1, absence of regulator of G
            protein signalling 13 and differential expression of Cyclin D1 in
            mantle cell lymphoma
  JOURNAL   Leukemia 17 (9), 1880-1890 (2003)
   PUBMED   12970790
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY327407.1 and AC010747.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_194250.1.
            
            Summary: The protein encoded by this gene is a zinc finger binding
            protein. Polymorphisms in this gene, especially rs1344706, are
            thought to confer increased susceptibility to schizophrenia,
            bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150198.1, AY327407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302277.7/ ENSP00000303252.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4522              AY327407.1         164-4685
            4523-4527           AC010747.10        74033-74037         c
FEATURES             Location/Qualifiers
     source          1..4527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..4527
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /note="zinc finger protein 804A"
                     /db_xref="GeneID:91752"
                     /db_xref="HGNC:HGNC:21711"
                     /db_xref="MIM:612282"
     exon            1..542
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..4061
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /codon_start=1
                     /product="zinc finger protein 804A"
                     /protein_id="NP_919226.1"
                     /db_xref="CCDS:CCDS2291.1"
                     /db_xref="GeneID:91752"
                     /db_xref="HGNC:HGNC:21711"
                     /db_xref="MIM:612282"
                     /translation="MECYYIVISSTHLSNGHFRNIKGVFRGPLSKNGNKTLDYAEKEN
                     TIAKALEDLKANFYCELCDKQYYKHQEFDNHINSYDHAHKQRLKELKQREFARNVASK
                     SRKDERKQEKALQRLHKLAELRKETVCAPGSGPMFKSTTVTVRENCNEISQRVVVDSV
                     NNQQDFKYTLIHSEENTKDATTVAEDPESANNYTAKNNQVGDQAQGIHRHKIGFSFAF
                     PKKASVKLESSAAAFSEYSDDASVGKGFSRKSRFVPSACHLQQSSPTDVLLSSEEKTN
                     SFHPPEAMCRDKETVQTQEIKEVSSEKDALLLPSFCKFQLQLSSDADNCQNSVPLADQ
                     IPLESVVINEDIPVSGNSFELLGNKSTVLDMSNDCISVQATTEENVKHNEASTTEVEN
                     KNGPETLAPSNTEEVNITIHKKTNFCKRQCEPFVPVLNKHRSTVLQWPSEMLVYTTTK
                     PSISYSCNPLCFDFKSTKVNNNLDKNKPDLKDLCSQQKQEDICMGPLSDYKDVSTEGL
                     TDYEIGSSKNKCSQVTPLLADDILSSSCDSGKNENTGQRYKNISCKIRETEKYNFTKS
                     QIKQDTLDEKYNKIRLKETHEYWFHKSRRKKKRKKLCQHHHMEKTKESETRCKMEAEN
                     SYTENAGKYLLEPISEKQYLAAEQLLDSHQLLDKRPKSESISLSDNEEMCKTWNTEYN
                     TYDTISSKNHCKKNTILLNGQSNATMIHSGKHNLTYSRTYCCWKTKMSSCSQDHRSLV
                     LQNDMKHMSQNQAVKRGYNSVMNESERFYRKRRQHSHSYSSDESLNRQNHLPEEFLRP
                     PSTSVAPCKPKKKRRRKRGRFHPGFETLELKENTDYPVKDNSSLNPLDRLISEDKKEK
                     MKPQEVAKIERNSEQTNQLRNKLSFHPNNLLPSETNGETEHLEMETTSGELSDVSNDP
                     TTSVCVASAPTKEAIDNTLLEHKERSENINLNEKQIPFQVPNIERNFRQSQPKSYLCH
                     YELAEALPQGKMNETPTEWLRYNSGILNTQPPLPFKEAHVSGHTFVTAEQILAPLALP
                     EQALLIPLENHDKFKNVPCEVYQHILQPNMLANKVKFTFPPAALPPPSTPLQPLPLQQ
                     SLCSTSVTTIHHTVLQQHAAAAAAAAAAAAAGTFKVLQPHQQFLSQIPALTRTSLPQL
                     SVGPVGPRLCPGNQPTFVAPPQMPIIPASVLHPSHLAFPSLPHALFPSLLSPHPTVIP
                     LQPLF"
     exon            543..686
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /inference="alignment:Splign:2.1.0"
     exon            687..817
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /inference="alignment:Splign:2.1.0"
     exon            818..4527
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4499..4504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /note="hexamer: AATAAA"
     polyA_site      4527
                     /gene="ZNF804A"
                     /gene_synonym="C2orf10"
                     /note="major polyA site"
ORIGIN      
        1 aactccgagt gcaggcgccg agcgcggggg atgctgccgc cgccgccgct tctgctgccg
       61 cgcgggcggc tcccgcagcc ccgctccgcc cggccaccgc gcgggcactg actcccgctc
      121 ggttccgttt cgccggcccg gccccctcct aggctggaat cctcccgcgg ggctcgtcgt
      181 cccgacgcga atctgaggag aaacaggagc gagagactga ggggagagcg cggcgagcat
      241 gcggaggcgg gggagcctcg gcgctcacca cagaggggtg cagtgagcca gtctccagag
      301 gacgtgccgg gggtggctgc gtgccctcgt ggcgggttcc cagcccaccg tcgccggccc
      361 cggcgcgctg cggctgtggg cgcggggtgc gtggaagcgg cggctgcggc ggaggaggcg
      421 gcggctgccc catggagtgt tactacattg tcatcagctc cacgcatctc agcaacggac
      481 actttcgcaa catcaaggga gttttccggg gccctctcag caagaacggg aacaaaactc
      541 tggactatgc tgagaaggaa aataccatag caaaagctct ggaagatctg aaggcaaatt
      601 tttactgtga actctgtgac aagcagtact ataagcacca ggagtttgac aatcacatta
      661 attcatatga ccatgctcac aagcagaggc tcaaggaact gaaacaaagg gaatttgctc
      721 gaaatgtagc atctaaatcc aggaaagatg aaagaaaaca ggaaaaggca ctccaacgcc
      781 tgcacaagct ggctgagcta agaaaggaaa ctgtatgtgc tcctggaagt ggccccatgt
      841 tcaaatcaac aactgttact gtgagagaaa actgtaatga aatttcccaa cgagttgttg
      901 tggattcagt taataaccag caagatttca aatatacttt gattcatagt gaagagaata
      961 ctaaagatgc taccactgtt gctgaagatc cagaaagtgc aaataattat acagcaaaaa
     1021 ataaccaagt tggggatcaa gcccagggga ttcacagaca caaaatcggc ttttcttttg
     1081 catttccaaa gaaagcgtcc gtgaagctag agtcctcagc tgcagccttc tctgaataca
     1141 gtgatgatgc ctcagtggga aaaggattta gcagaaaaag tagatttgtc cccagtgctt
     1201 gtcatcttca acaatcttca ccaacagatg tgcttttgag ttctgaggag aaaactaact
     1261 cttttcatcc accagaggca atgtgcagag acaaagaaac tgttcaaact caagagataa
     1321 aagaagtctc tagtgaaaaa gatgcattat tattaccttc attttgcaag tttcaacttc
     1381 agttatcttc tgatgcagat aattgtcaaa attcagtccc attagcagat caaataccac
     1441 tagagagtgt tgttattaat gaagacatac ctgttagtgg taacagtttt gagttgttag
     1501 gaaataaatc cacagttctt gacatgtcta atgattgcat atctgtgcaa gctaccacag
     1561 aggaaaatgt taagcataac gaggcatcca caactgaggt tgaaaataaa aatggtcccg
     1621 agacattggc cccttcaaat actgaagagg ttaacataac tatacataag aaaacaaatt
     1681 tctgcaaaag acaatgtgag ccatttgtac ctgtccttaa caaacacaga tctacagttc
     1741 ttcagtggcc atcagaaatg ctggtttata caactacgaa accatcaatt tcctatagct
     1801 gtaatcctct atgttttgac ttcaagtcta ctaaagtaaa taataatcta gataaaaata
     1861 agccagactt aaaagatctt tgttctcagc agaagcagga agacatttgc atgggaccac
     1921 tttcagatta caaggatgta tctacagaag gactcactga ttatgaaatt ggaagtagca
     1981 aaaataaatg cagccaagtc actcctcttt tggctgatga tattctctcc agtagttgtg
     2041 attctggaaa aaatgagaac acaggtcaga ggtataaaaa catttcctgt aagatcagag
     2101 aaacagaaaa gtataatttt actaaaagtc aaataaaaca ggacactcta gatgaaaaat
     2161 acaacaaaat aaggttgaaa gagacccatg aatactggtt ccataaaagt agaagaaaga
     2221 aaaaaagaaa aaagttatgt cagcatcatc atatggagaa aaccaaagaa tcagaaactc
     2281 gctgcaaaat ggaagcagag aatagttaca ctgaaaatgc tgggaaatat ctattggaac
     2341 caatttcaga aaagcagtat ttagctgcag agcaattatt agactcacat cagttacttg
     2401 ataaaaggcc caaatcagaa tccatatcct taagtgacaa tgaagaaatg tgtaaaacat
     2461 ggaatactga atacaacact tatgatacta tcagttctaa aaaccactgt aaaaagaaca
     2521 caatactttt aaatggacaa tcaaatgcaa caatgataca ttctgggaaa cataatttaa
     2581 catattctag aacttactgt tgttggaaaa ccaaaatgtc aagctgtagt caggatcaca
     2641 gaagcttagt tcttcaaaat gatatgaaac acatgagtca gaatcaggct gttaaaagag
     2701 gttacaattc tgtcatgaat gaatcagaaa gattctatcg aaaacgtaga caacattcac
     2761 attcttattc ttcagatgaa agtttaaatc gacagaatca tttaccagaa gaatttttga
     2821 ggccaccaag tacttcagtt gctccctgca agcctaaaaa gaaacggagg cgaaaaagag
     2881 gcagattcca ccccggattt gaaactttag aactcaaaga aaatacagat tatcccgtga
     2941 aagacaattc ttccttaaat cctctggata ggttaataag tgaagacaaa aaagagaaaa
     3001 tgaaaccaca agaagttgca aaaatcgaaa ggaactcaga acaaacaaac caattaagaa
     3061 acaaactgtc tttccaccct aacaatctcc ttccttctga aaccaatggt gaaactgagc
     3121 atttagaaat ggagaccact tctggtgaat tgtcagatgt ttccaatgat cccaccacat
     3181 ctgtctgtgt agctagtgcc ccaacaaaag aagcaattga caataccctg cttgaacaca
     3241 aagaaagaag tgagaatata aatcttaatg aaaagcaaat tccttttcag gtgcctaata
     3301 ttgaaaggaa ctttagacag tcacagccta aatcctatct ttgccattat gaactggctg
     3361 aggcccttcc acaaggaaag atgaatgaga caccaactga gtggctgcgt tataattcag
     3421 gaatccttaa cacacaacca ccattaccat tcaaagaagc acatgtcagt ggtcatactt
     3481 ttgtaacagc tgagcaaatc ctggctccat tagctttacc agagcaagca ttattgatcc
     3541 cactagaaaa ccatgacaaa ttcaaaaatg taccatgtga ggtctaccag cacattctgc
     3601 agccaaacat gctggccaac aaggttaaat ttacctttcc tccagctgcc ctcccacccc
     3661 ctagcacacc tctgcagcct ttgcctttgc agcagtcctt atgttctacc tctgtaacca
     3721 ctatccatca cactgttttg cagcagcacg ctgcagctgc tgcagctgca gctgcagccg
     3781 cagctgcagg aacctttaaa gtgcttcagc cacaccaaca gtttctttcc caaatcccag
     3841 ctctcaccag aacctcatta cctcagctct cagtaggacc agtaggaccg aggctttgtc
     3901 ctgggaacca gccaactttt gttgctcctc ctcagatgcc aatcattcca gcttccgttc
     3961 ttcatcctag ccatctggct ttcccatctt taccccatgc actctttcct tcactgcttt
     4021 ccccacaccc tactgtcatc cctttgcaac ctctcttcta gtcatcacca taatgggaaa
     4081 aaaatactct tgtgaaaact attgctatat gcgttaagtg ttcatctatg tgggtacatg
     4141 gctatttaac tggtggaaat aaactggccg atacatggcg tcattggttt gaaatcattt
     4201 actgtaagtg caatgatgca aataaatccc taagtttctg atatataata ttattaaagc
     4261 actgaatagt ttgaaaatca atacaatata tgctatatat taaaatgatg tcttaagagt
     4321 atgtataatg tacataaaat atatttatag tactctaatt tatgttgtaa agtatgctcc
     4381 cttggttttt cttaatcttt gtgtatttgc acctatttaa tgtttagaca aagctgatgg
     4441 cactatgttt tgtatcatgt tccttgaaac tgtaaattca gtgaaaaata tctcttgcaa
     4501 taaatttttg ttaactattt aagtaaa
//
