LOCUS       NM_176814               4473 bp    mRNA    linear   PRI 10-NOV-2024
DEFINITION  Homo sapiens zinc finger protein 800 (ZNF800), mRNA.
ACCESSION   NM_176814
VERSION     NM_176814.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4473)
  AUTHORS   Lin,L., DeMartino,J., Wang,D., van Son,G.J.F., van der Linden,R.,
            Begthel,H., Korving,J., Andersson-Rolf,A., van den Brink,S.,
            Lopez-Iglesias,C., van de Wetering,W.J., Balwierz,A.,
            Margaritis,T., van de Wetering,M., Peters,P.J., Drost,J., van
            Es,J.H. and Clevers,H.
  TITLE     Unbiased transcription factor CRISPR screen identifies ZNF800 as
            master repressor of enteroendocrine differentiation
  JOURNAL   Science 382 (6669), 451-458 (2023)
   PUBMED   37883554
  REMARK    GeneRIF: Unbiased transcription factor CRISPR screen identifies
            ZNF800 as master repressor of enteroendocrine differentiation.
REFERENCE   2  (bases 1 to 4473)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   3  (bases 1 to 4473)
  AUTHORS   Civelek,M., Wu,Y., Pan,C., Raulerson,C.K., Ko,A., He,A.,
            Tilford,C., Saleem,N.K., Stancakova,A., Scott,L.J., Fuchsberger,C.,
            Stringham,H.M., Jackson,A.U., Narisu,N., Chines,P.S., Small,K.S.,
            Kuusisto,J., Parks,B.W., Pajukanta,P., Kirchgessner,T.,
            Collins,F.S., Gargalovic,P.S., Boehnke,M., Laakso,M., Mohlke,K.L.
            and Lusis,A.J.
  TITLE     Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic
            Traits
  JOURNAL   Am J Hum Genet 100 (3), 428-443 (2017)
   PUBMED   28257690
REFERENCE   4  (bases 1 to 4473)
  AUTHORS   Washietl,S., Pedersen,J.S., Korbel,J.O., Stocsits,C., Gruber,A.R.,
            Hackermuller,J., Hertel,J., Lindemeyer,M., Reiche,K., Tanzer,A.,
            Ucla,C., Wyss,C., Antonarakis,S.E., Denoeud,F., Lagarde,J.,
            Drenkow,J., Kapranov,P., Gingeras,T.R., Guigo,R., Snyder,M.,
            Gerstein,M.B., Reymond,A., Hofacker,I.L. and Stadler,P.F.
  TITLE     Structured RNAs in the ENCODE selected regions of the human genome
  JOURNAL   Genome Res 17 (6), 852-864 (2007)
   PUBMED   17568003
REFERENCE   5  (bases 1 to 4473)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA888007.1, AK309674.1, BC110623.1, BU581251.1 and BG112338.1.
            
            On Nov 23, 2018 this sequence version replaced NM_176814.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.255945.1,
                                           SRR1660807.174429.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265827.8/ ENSP00000265827.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                DA888007.1         17-114
            99-439              AK309674.1         109-449
            440-3628            BC110623.1         1-3189
            3629-4162           BU581251.1         1-534               c
            4163-4473           BG112338.1         275-585
FEATURES             Location/Qualifiers
     source          1..4473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.33"
     gene            1..4473
                     /gene="ZNF800"
                     /note="zinc finger protein 800"
                     /db_xref="GeneID:168850"
                     /db_xref="HGNC:HGNC:27267"
                     /db_xref="MIM:621007"
     exon            1..649
                     /gene="ZNF800"
                     /inference="alignment:Splign:2.1.0"
     exon            650..768
                     /gene="ZNF800"
                     /inference="alignment:Splign:2.1.0"
     CDS             708..2702
                     /gene="ZNF800"
                     /codon_start=1
                     /product="zinc finger protein 800"
                     /protein_id="NP_789784.2"
                     /db_xref="CCDS:CCDS5795.1"
                     /db_xref="GeneID:168850"
                     /db_xref="HGNC:HGNC:27267"
                     /db_xref="MIM:621007"
                     /translation="MPLRDKYCQTDHHHHGCCEPVYILEPGDPPLLQQPLQTSKSGIQ
                     QIIECFRSGTKQLKHILLKDVDTIFECKLCRSLFRGLPNLITHKKFYCPPSLQMDDNL
                     PDVNDKQSQAINDLLEAIYPSVDKREYIIKLEPIETNQNAVFQYISRTDNPIEVTESS
                     STPEQTEVQIQETSTEQSKTVPVTDTEVETVEPPPVEIVTDEVAPTSDEQPQESQADL
                     ETSDNSDFGHQLICCLCRKEFNSRRGVRRHIRKVHKKKMEELKKYIETRKNPNQSSKG
                     RSKNVLVPLSRSCPVCCKSFATKANVRRHFDEVHRGLRRDSITPDIATKPGQPLFLDS
                     ISPKKSFKTRKQKSSSKAEYNLTACKCLLCKRKYSSQIMLKRHMQIVHKITLSGTNSK
                     REKGPNNTANSSEIKVKVEPADSVESSPPSITHSPQNELKGTNHSNEKKNTPAAQKNK
                     VKQDSESPKSTSPSAAGGQQKTRKPKLSAGFDFKQLYCKLCKRQFTSKQNLTKHIELH
                     TDGNNIYVKFYKCPLCTYETRRKRDVIRHITVVHKKSSRYLGKITASLEIRAIKKPID
                     FVLNKVAKRGPSRDEAKHSDSKHDGTSNSPSKKYEVADVGIEVKVTKNFSLHRCNKCG
                     KAFAKKTYLEHHKKTHKANASNSPEGNKTKGRSTRSKALV"
     exon            769..864
                     /gene="ZNF800"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1008
                     /gene="ZNF800"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..2701
                     /gene="ZNF800"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..4473
                     /gene="ZNF800"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4135..4140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF800"
                     /note="hexamer: AATAAA"
     polyA_site      4166
                     /gene="ZNF800"
                     /note="major polyA site"
     regulatory      4450..4455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF800"
                     /note="hexamer: ATTAAA"
     polyA_site      4473
                     /gene="ZNF800"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtcgc tccctgtcgc tgccggagag tctctgcttc ccccttccta cgcgctccgc
       61 ggcggtagct cgggctctcc ggaggagggg gcgacagagt aaaagagagg ctgacttaat
      121 aaagtttcct gaaacaacaa ctaccaccga aaaggcccaa ggttggggga gacccccatt
      181 tttctccgcc cctctcctaa agcctgaggg accgttgcag gtggagcggc gctggtggga
      241 cccgggttgc ggcggcagcc gttgccccgg cgagggaagc ctcaggtcct gcccgctccg
      301 gttccggctc cttcggtggt ggcggcggca gctgctgccg ggcggttcct cctgtcaact
      361 gcctccgccc gcgcgcctcc cgcctagcca cacagcgcgg aggacgccgt gagccgccgc
      421 cgcagtcgtc tcggcccgcg gagggacgtg gtgagctgtg gcgcttccgc gtcagcgccg
      481 gcggggactc tttgggagcg cgtcgggccc gagtccgggt tcccccgcgt ggtcagcgga
      541 ggctgcgcca ggtggggccc gcagccgcct cccacgccag gctgtccccg cggccgcccg
      601 gcctgccttc cttccttccg cccgcccgcc ggcccgccct aagagttgac cacgccgcaa
      661 tgaagagctt cttacagtga aagcaaagta ggtcgagtcc actgaaaatg cctttaaggg
      721 acaaatactg tcagactgac caccatcatc acggatgctg tgaaccagtt tatatcctgg
      781 aacctggaga tcctcctttg ttacagcaac cactacagac atccaaatct ggtattcaac
      841 aaataattga gtgctttcga tcaggaacta aacaacttaa gcatatttta ttaaaagatg
      901 tggacactat ttttgaatgt aagttatgcc gcagtctctt cagaggatta ccaaatttaa
      961 ttacccataa aaaattctac tgcccaccaa gtctccagat ggatgacaac cttcctgatg
     1021 taaatgataa acaaagccaa gccataaatg atctcctaga agccatatat ccaagtgtgg
     1081 acaaacgaga atatattatt aagctagaac ccatagaaac taatcaaaat gcagtatttc
     1141 aatatatttc gaggactgat aatcctattg aagtcacaga gtcaagcagt actcctgaac
     1201 aaaccgaagt tcagatacag gaaactagca ctgaacagtc aaaaacagta ccggttacag
     1261 atacagaggt ggaaactgta gagccccctc ctgttgagat tgttacagat gaagttgcac
     1321 ctacatctga tgaacaacct caggagtcgc aggctgactt ggaaacttct gacaattctg
     1381 attttggtca ccagttgata tgttgtcttt gtagaaaaga attcaattct agacgaggtg
     1441 ttcgccgtca cattcgaaaa gtacacaaga aaaagatgga agaactaaaa aagtacattg
     1501 aaacacgaaa gaatccaaac caatcctcta aaggacgcag taagaatgtt ctagttccat
     1561 taagtaggag ttgtccagta tgttgtaaat catttgctac aaaagcgaat gtaaggaggc
     1621 attttgatga agttcataga ggactaagga gggattcaat tactcctgat atagcaacaa
     1681 agcctgggca acctttgttc ctggattcta tttctcctaa aaaatctttt aagactcgaa
     1741 aacaaaagtc ttcttcaaag gctgaataca atttaactgc atgcaaatgc ctcctttgca
     1801 agaggaaata tagttcacaa ataatgctta aaagacatat gcaaattgtc cacaagataa
     1861 ctctttctgg aacaaactct aaaagagaaa aaggccctaa taatactgcc aacagttcag
     1921 aaataaaagt taaagttgaa ccagcagatt ctgtagaatc ttcaccccct tccattaccc
     1981 attctccaca gaatgaatta aagggaacaa atcattcaaa tgaaaaaaag aacacaccgg
     2041 cagcacagaa aaataaagtt aaacaagact ctgaaagccc taaatcaact agtccgtcgg
     2101 ctgcaggtgg ccagcaaaaa accagaaaac caaaactttc agctggcttt gactttaagc
     2161 aactttactg taaactttgt aaacgtcagt ttacttccaa acagaacttg actaaacaca
     2221 tcgagttgca cacagatgga aataacattt atgttaaatt ctacaagtgt cctctttgca
     2281 cttatgaaac tcgtcggaaa cgtgatgtga tacgacatat aactgtggtt cataaaaagt
     2341 catctcgtta tcttgggaaa ataacagcca gtttagagat cagagctata aaaaagccta
     2401 ttgattttgt tctaaataaa gtggcaaaaa gaggcccttc gagggatgaa gcaaaacata
     2461 gtgattcaaa acatgatggc acttctaact ctcctagtaa aaagtatgaa gtagctgacg
     2521 tcggtattga agtaaaagtc acaaaaaact tttctcttca cagatgcaat aaatgtggaa
     2581 aggcatttgc caaaaagact taccttgaac atcataagaa aactcataag gcaaatgctt
     2641 ccaattcacc tgaaggaaac aaaaccaaag gccgaagtac aagatctaag gctcttgtct
     2701 gataacttca agtgatgtac gaaaaggttt ggagttcatt tttgtggaaa gactttaaat
     2761 tggtgttaga accactaaac atcttcaaat ggtactatga ggaaaaaaag aaaaacattt
     2821 ttctaaatat tcaactataa ctgctgtttt ctgactaaaa taaccatcta accacttgtt
     2881 tctaaggcac tgcctattcc agcactttca agtagctgtg atattacatg ttgtcatcac
     2941 agtccatcag ctatccaccc ttgaccttgt gcatttggtc gacagtttct acaaaaatgt
     3001 tacaaatttt gttttctaaa caatttgttg attaagtgat caacaacctg aagaaaatat
     3061 caatttttaa ttgacaaaga ctttatatct tagtgatttt agttttgttt ctctttattt
     3121 ggcaacattt tcatctgaat tgtatagata tatgattttc tagtgagtgt atgttaggaa
     3181 caaaagacaa aatagtatca acacattata aatatttagc ttactaaata tttgtaatta
     3241 tttttacatc catttatttc tagcttgttc tccagcactt cagtgtttga aagtttcatc
     3301 ctaaaatata tactacagga aagctgcagt tcattttcat gcatggatca ttacattttt
     3361 cacttgtaaa tgtaggtttt tatgaaaatt aaacattccc ctatttttct ttaaatttta
     3421 tacaaagcac tttaatgata gatgcaacct tatttttcag ttcctatttt tttaaagacc
     3481 acacatttac taatgttaat atgaaggtaa taaatagctt actgatattt tatggatgca
     3541 gacaatccat gcacaaccac ttcttatgat actagtttat ttccttaaat attgctacaa
     3601 aaggaagatg cgggtgtaag ccctgatttt tttttctccc aagaaaaatc ttaaaggacc
     3661 actttagata atatttgatt cctactgtaa aatttagaaa atgatgaatt cttgtccatt
     3721 tttgtaatca agattttagg aaaaacagaa gtacatctat ctttatgaaa ttttgggcag
     3781 gtttttgtgt atcaatattt tgtactttta gggaatattt tattttttag ttatttgtgt
     3841 caaattataa ttataaaagg tacagcagaa aatataccat gtttttatat aggttcacac
     3901 ctgtacttag gagggaccct gtccatctat atactttttg tataaaattt taaaatgtta
     3961 aagatccaca aggtcttaat aaaatgattc tatagctaga aaaacattta ccttcccagt
     4021 gctttgcact aaaatatact gtgaaaggaa actagaaaga ctgtaactat tgctggaaat
     4081 gttctatatt gaatgtacat gctcttgttg gaaaaatgta ctatatgtga tggaaataaa
     4141 ccagaatcga agttatttca gctaaatgtg cttcagcaaa ggtgcattgg ttgaaactta
     4201 aatgttttat tatcaaattt aaacttattc agtgactatg agcagctaca cttgaattat
     4261 attctgatag ttttatttct aagaaataga gtaataattt ctctttaatt taaaaacaga
     4321 tttactttcc cacatattga aaatttgtac ttatagatct aactttaata actaatagta
     4381 taatatattt agggaactaa atgtgtaggt ggtatttcat ttataagcca tcttcattag
     4441 ttgcacatta ttaaacctat atgtttgact ttt
//
