LOCUS       NM_001013659            7117 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 793 (ZNF793), mRNA.
ACCESSION   NM_001013659 XM_372726
VERSION     NM_001013659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7117)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   2  (bases 1 to 7117)
  AUTHORS   Yu,M., O'Leary,R.M., Kaz,A.M., Morris,S.M., Carter,K.T., Chak,A.,
            Chandar,A., Willis,J.E., Moinova,H.R., Markowitz,S.D.,
            Brenner,D.E., Anandabapasathy,S., Westerhoff,M., Wong,C.J.,
            Shaheen,N.J., Chen,Y., Barnholtz-Sloan,J.S. and Grady,W.M.
  TITLE     Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for
            Barrett's Esophagus
  JOURNAL   Cancer Epidemiol Biomarkers Prev 24 (12), 1890-1897 (2015)
   PUBMED   26545406
  REMARK    GeneRIF: B3GAT2 and ZNF793 are hypermethylated in BE, and the
            methylation status of these genes can be used to detect BE in
            tissue samples.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131417.1, DB180171.1, BX537524.1, AC022148.6, BE219465.1 and
            BU683546.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001013659.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803612.454228.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142348, SAMEA2144120 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000627814.3/ ENSP00000487183.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-575               AK131417.1         1-575
            576-762             DB180171.1         371-557
            763-1365            AK131417.1         763-1365
            1366-1721           BX537524.1         1841-2196
            1722-6167           AC022148.6         126512-130957       c
            6168-6733           BE219465.1         1-566               c
            6734-7117           BU683546.1         20-403              c
FEATURES             Location/Qualifiers
     source          1..7117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..7117
                     /gene="ZNF793"
                     /note="zinc finger protein 793"
                     /db_xref="GeneID:390927"
                     /db_xref="HGNC:HGNC:33115"
     exon            1..28
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     exon            29..167
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     exon            168..296
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     exon            297..412
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     exon            413..457
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1663
                     /gene="ZNF793"
                     /codon_start=1
                     /product="zinc finger protein 793"
                     /protein_id="NP_001013681.2"
                     /db_xref="CCDS:CCDS46062.1"
                     /db_xref="GeneID:390927"
                     /db_xref="HGNC:HGNC:33115"
                     /translation="MIEYQIPVSFKDVVVGFTQEEWHRLSPAQRALYRDVMLETYSNL
                     VSVGYEGTKPDVILRLEQEEAPWIGEAACPGCHCWEDIWRVNIQRKRRQDMLLRPGAA
                     ISKKTLPKEKSCEYNKFGKISLLSTDLFSSIQSPSNWNPCGKNLNHNLDLIGFKRNCA
                     KKQDECYAYGKLLQRINHGRRPNGEKPRGCSHCEKAFTQNPALMYKPAVSDSLLYKRK
                     RVPPTEKPHVCSECGKAFCYKSEFIRHQRSHTGEKPYGCTDCGKAFSHKSTLIKHQRI
                     HTGVRPFECFFCGKAFTQKSHRTEHQRTHTGERPFVCSECGKSFGEKSYLNVHRKMHT
                     GERPYRCRECGKSFSQKSCLNKHWRTHTGEKPYGCNECGKAFYQKPNLSRHQKIHARK
                     NAYRNENLIIVGNT"
     exon            458..584
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     exon            585..680
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     exon            681..7117
                     /gene="ZNF793"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7089..7094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF793"
                     /note="hexamer: AATAAA"
     polyA_site      7117
                     /gene="ZNF793"
                     /note="major polyA site"
ORIGIN      
        1 attcaggatg ggacgacctt ataccgcggc tctttctggc aaaggtaatg acatacgcat
       61 ctgtgccagc atcccaagag tgaggctggt ttctggaaat ccattctgac tctgtgacag
      121 cggggatgga tgtgaccttg cccgtggtta gaaaacaaat ttactgagtt ctctgggtgc
      181 cctgcagacc tttggatcct gccaccttgc tggacgggag ggctctctag ctcctgccag
      241 cccttagagc cacaggacct tggtcacaac atctacagaa ggccctgcag ctaagtgatc
      301 taatccagga tcatatgctg cctttaggtg acacatccct ttagtctcct ttaatcagga
      361 gcagtttctc agtgttcatc ttccatgaag tcgacatttt tgaagagtat aggtgtcaga
      421 tctttttcaa gaacagcaga aaatgatcga ataccagata cctgtgtcat tcaaagatgt
      481 ggttgtgggc ttcacccaag aggagtggca ccggctgagt cctgctcaga gggccctgta
      541 ccgggatgtg atgctggaaa cctatagcaa cctcgtctca gtgggttatg aaggcaccaa
      601 accagatgtg atcctcagac tggagcagga agaagcacca tggattggtg aggcagcatg
      661 cccgggctgc cactgttggg aagacatctg gcgagttaat atccagagga aaagacggca
      721 agacatgctt ttgaggccag gcgcagccat aagcaagaaa acattgccca aggagaaaag
      781 ctgtgaatat aataagtttg ggaaaatatc acttctgagc actgatcttt tttcttcaat
      841 ccagagccct agtaactgga acccttgtgg aaagaatttg aaccataatt tagacttgat
      901 tggttttaag agaaactgtg caaaaaagca agatgagtgt tatgcttatg ggaaattgct
      961 tcagcgtata aatcatggta gacgacctaa tggagaaaag ccccggggtt gcagtcactg
     1021 tgagaaagct ttcacccaga acccggcact tatgtataaa ccagcagtaa gtgattctct
     1081 cttgtacaaa cggaagaggg ttccacctac agaaaaaccc cacgtctgta gtgagtgtgg
     1141 gaaagccttc tgctacaagt ctgaattcat taggcatcag agaagtcaca ctggggagaa
     1201 gccttatggc tgcactgact gtgggaaagc cttttcacat aagtcaaccc tcatcaaaca
     1261 ccagagaatt cacactgggg taagaccctt tgaatgtttt ttttgtggga aagcctttac
     1321 ccagaagtca caccgcacag aacatcagag aacacacaca ggagagagac cctttgtctg
     1381 cagtgaatgc gggaaatcgt ttggtgagaa gtcatacctc aatgtacatc gaaaaatgca
     1441 cacaggagaa agaccgtatc gttgcagaga atgtggaaaa tccttcagcc agaagtcatg
     1501 cctcaataaa cattggagaa ctcacacagg agagaagccc tatgggtgca atgaatgtgg
     1561 gaaagctttc taccagaagc caaacctcag cagacatcag aaaattcatg ctcggaagaa
     1621 tgcctacagg aatgaaaact taataattgt gggaaatact tgagcaaaat atctggtttc
     1681 atggtatgta gggaattttt tttttttttt tttgagttgg aatctcactt tgtcacccag
     1741 gctggagtgc agtggcgcga tctcggctta ctgcaagctc tgcctcccgg gttcacgcca
     1801 ttctcctgcc tcagcctccc gagtagctgg gactacaggt gcccaccacc atgcccggct
     1861 aatttttttt ttgtattttt agtagagacg gggtttcacc gtgttagcca ggatggtctc
     1921 gatctcctga ccttgtgatc tgcccgcctt gtcctcccaa agtgctggga ttacaggcgt
     1981 gagccaccgc gcctggccgg tatgtaggga atttatcctt aggagaaatc ttatcatttt
     2041 aatgaatttg aacagtgtgt ttttatttta tttatttatt tattttgagt tgtattctct
     2101 gtttcccagg ctggagtgca atggcactat ctcggctcac tgtaacctca gcctcccagg
     2161 ttcaagcagt tctcctgcct cagcctccca agtagctggg attacaggca cctgccacca
     2221 cgcctggcta atttttgtat ttttagtaga gatggggttt caccatgttg gtcaggctgg
     2281 tctctttggc taggctggtc tcgaactcct gacctcgtga taccccccaa ccccccgccc
     2341 ttggcctccc aaagtgttgg gattacaggc atgagccaac gcgcccaacc gacagtgttg
     2401 tatcataatg gaaatcatga tctaattgtg atacaaactt ttctagaaaa tactttctca
     2461 aacataagca tggacaccct ggcatgtaaa cgtttaaaaa tgtattaaat ggaataacag
     2521 cagaatacaa aatatctgtg aagagactta aaggcatact ctggtatatt ccacagtgag
     2581 ccatacaatc agcattattt gtattttgga gttgtaaatg tgaaattaac ataaaatgtg
     2641 aatatcagac acatgtcaca caacatatag aatgccattc agaaaacttt tccactttaa
     2701 atatcatcat tgtcttttga tgtcttaaca atacaaaaaa ataacaacaa catggcccac
     2761 tattgttaaa agaactttat tataccagct acatttttcc acctttttgt aatacatgta
     2821 aatggctata gaggttgtta ctgtcctctg cagaaataat aaagcagtgt ttttaaatgt
     2881 atttggataa tttggccaaa aattttacta aaatgtagtt atttatatta aaaatgcaag
     2941 ctaaggaata gtttaagaac ctgatactgg gtaaatgaaa cactgtaaac tatttgacaa
     3001 aatgtagtgt caccctggtg tacagtacac tgttcatatt ttcttagtct tgcttaaaat
     3061 atcttgtagc aaattagtag cattgctaca ctattctaga tacactattc tatatacagg
     3121 ttgtataact cagaaatgtt tcatgcgtag accactgaag gagaatttct tttctctcta
     3181 tccctctgca aattaattca agaatattca tttttttcat ataaatttcc ttgcaagtgt
     3241 cctagacact aaatcccaag gttttaatta tttcaatgtt tggaaagaag tctgcttccc
     3301 tgagttgcta tgtcatccat attagaaaat aaatggccat gtggaatcta catttttcaa
     3361 gatttccctc catgtaagac tgcctgatcc agaatgagaa aggagacata accacagata
     3421 tcaatatgat tttttaagtg ataaaaagat acctcataca actctaatca acatattttt
     3481 taaaaagagg aggtggatgc ttttctaata aacttaagtt atgaaaactg caataagaag
     3541 tagaaaactt ggtaggatag ttaacattga aaaactcaaa aaagctatta aagatctata
     3601 atgggaaaat gctccaggct cagaagagtt catgcttagt tctatctttt aaagaaagag
     3661 taataccagt gttatttatt atatggatgt aatacaatcc atgaactgta ctcatttatt
     3721 ttattaagtc agaataaatt ttaacaccaa aatcaaatac agatagttga aaaaagaaaa
     3781 cttctgctgg gtgcggtggc tcacgcctgt aatcccaaca ctttgggagg ccgaggcagg
     3841 tggatcatga ggtcagaagt tcgagatggt gaaaccccat ctctactaaa aatacaaaaa
     3901 ttagccgggt gtggtggcac acacctgtag tcccagctac ttgggaggtt gaggcatgag
     3961 gcaggagaat tgcttgtacc caggaggtag aggttgcggt gagccaagat cgtgccatcc
     4021 agcctgggtg acaagagcga aactccgtca aaaaaaaaaa aaaaaaaaga aaacttcaga
     4081 ccagtcttac tcatgaatat agaaacaaaa attatagtta aaatactagc aaatagaatt
     4141 cagccatata cccaaagagt gacatagtaa gagtcatccc aagaatgcca aaccagttca
     4201 gttaatagga aatgcatcaa tcaaattaac agtttaaagg agaagaatca tatgaactct
     4261 caacagatac tgagaaggca tttcatagaa tgtgttaatt tacattgtaa tagatgggaa
     4321 ccacttaaag cggtttttct taaaaaaaat tttttttaac ccaaacccca aagcatatat
     4381 tatgccaaag ccatttttta aaatcaggaa ttcaatattg gcttagagat tccagtgaag
     4441 gcaataaaaa gaaatgaatt ggtataaaca gcagaaaagg taaaactatc catttttact
     4501 gatgatatgg ttgtacacca ataaatgaaa agactatttt ttgagttaac ttttctaaga
     4561 agacagggta ccaaaatcaa gagctgttct ccatactgac aagaaaacat aatttatatg
     4621 tacttctttt ggaattacac taaatctcaa tgattttttg acaatcattg aaaaaaatat
     4681 atgaaaaaaa tcataccatg tataaaaaca tcacatgtac ccaataaata tatacaacaa
     4741 ttatatatct ataataatta aaaattttta aaatgccatg ctagatacca gaagataaca
     4801 tgaagccatt ctaatgaaat taatattgta ttggcaaagg aacaggtaaa tacatcatta
     4861 gaacacagta gaaaattcag aaatagactt cgatatatat gaactttttc atatgtgaaa
     4921 aaggtgaaat ctgaaaccac aggggaaaag agtagtttac ttaaaaagaa ttctggaaca
     4981 gaacctttta atcttaaagg aagaaaattt ggattaacag cacaaaaata aattctgggt
     5041 ggctttaaga cgtaaaattt taaagcaaca gaattcttaa aagaaaatca aaggagccta
     5101 tgtgtacaat ctaggagttg ggagatatta actttaccaa cacaggacac tcagaagcta
     5161 tttagaaata agcagttgaa ggctgggtgc agtggctcat gcctgtaatc ccaacacttt
     5221 gggaggctga ggcaggagga tcacctgagg ttaggagttc aagactagtc tggtcaacat
     5281 ggtgaaaccc catctccact aaaaatacaa aaattagctg ggtgtggtgg cacatgcctg
     5341 tagtcccagc tacttgggag gctgaggcag gagaatcact tgaacctgga aggcaggggt
     5401 tgaagtgagc tgagattgca ccactgcact ccagcctggg caacagagca agactccatc
     5461 tcagaaaaaa agaaaaagaa aaaaaaaagg aaacaaacat ttgactacgt agaatctttt
     5521 ggtacaatct tttgggtgac aaaagatgcc atcagcaaac tcaagagata atagattgtg
     5581 gggaaatatt tgtaaagctg atcagagaga aggcattcat gaaatggaca ggaaaaaaac
     5641 ccaatagcaa aatgtggcaa agaatatgag ttgacagttg tgagaagagc aaatctaagt
     5701 ggccaatgga cctgtccaaa aatgtttatc ctcagtagtc actgggggat gcagatttaa
     5761 agttaaaatc aaataacact gtgtaacagc atttttagct atcagaacaa aagatgttac
     5821 acactgctgg tggagaaata aattttgaaa aacaatgcaa attactgttt tggaaagaaa
     5881 tctggtaata tttaggctgg gcgtggtggc tcacacctgt aatcctagca ctttgggagg
     5941 ccgaggcagg caaattgtct gaggtcggga gttcgagaac agcctggcca gcatggtgaa
     6001 accccgtctc tactaaaaat acaaaaatta gctgggcatg gtggcaggca cctgtgatcc
     6061 cagctactcg ggaggctgag gcaggagaat cacttgaacc caggaggcag aggttgcagt
     6121 gagccaagat cgcgccattg cactccaacc tgggcaacag agcaaaaaga ttccatctca
     6181 aaagaaaaga aaagaaatct gttaatatta ttaaaatatt tatgtcactt tggagaatct
     6241 tcccttagaa gtaaaagctc caatacataa aagacagatg aacatgtgaa catggacatt
     6301 tattgtaaaa attgttctta atggcaaaaa aacccccaaa accaaagcaa acactagaat
     6361 caaagtaaat acccatcaac tgggaaattg tagaaaggaa aaaactatag tgtatccatt
     6421 ccatagaatg ttaatatagc cattaaggtg gacaaattaa aactatgcta gtggacttga
     6481 gtggaattcc acaatgttct cttgagtgaa aaatgcaagg tagatattaa gtatgttaaa
     6541 tatgactcca tttttttaaa tcattaacaa aatgtctcta ggtgtttgtc agcaataaac
     6601 ggtatctata tatgtttatt tgattttatg tgcatgaaga aaagtataga agagtatgca
     6661 ttgacttgga gggaggtggg taatgcaggt aggttatggg ggagtcaggg gtgtagggaa
     6721 aaggaaaacc aaaaaagaaa aatacataaa tgactgaatc acgggtgata ccacaaatgt
     6781 gtgagttagt aaatttggct ggggatgggg gagctagaat tttgctaatt tgtggggatg
     6841 ttcatggtat atattgtaaa aagggaaaat ttcataataa tgtatacgat tctattttta
     6901 aaaaaagtaa aaactcctgt gtgtgtatat atgcatgtgg atgtttatat gaacatagaa
     6961 aagtgtagaa gaatacacac gaaggtgtta acattcattg gttaccttgg tggagaaggg
     7021 taataagttt tctgaatacc tttgcattgt cttgttcaca tatattgctt ttgtaatttg
     7081 aaaaacaaaa taaaggggga aaacatttca aactgaa
//
