LOCUS       NM_001002836            1940 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 787 (ZNF787), transcript variant
            1, mRNA.
ACCESSION   NM_001002836 XM_058999
VERSION     NM_001002836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Zhang,L., Zhu,B., Zhou,X., Ning,H., Zhang,F., Yan,B., Chen,J. and
            Ma,T.
  TITLE     ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability in an In
            Vitro Model of Alzheimer's Disease Microenvironment
  JOURNAL   Neurotox Res 42 (1), 12 (2024)
   PUBMED   38329647
  REMARK    GeneRIF: ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability
            in an In Vitro Model of Alzheimer's Disease Microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024580.6, BC077728.1, KF573663.1 and AI037960.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001002836.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC077728.1, SRR1163655.155293.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610935.2/ ENSP00000478557.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC024580.6         116630-116644       c
            16-1266             BC077728.1         1-1251
            1267-1269           KF573663.1         81-83
            1270-1927           AC024580.6         82725-83382         c
            1928-1940           AI037960.1         31-43               c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..1940
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /note="zinc finger protein 787"
                     /db_xref="GeneID:126208"
                     /db_xref="HGNC:HGNC:26998"
     exon            1..124
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /inference="alignment:Splign:2.1.0"
     exon            125..213
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1283
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription termination factor I interacting peptide 20;
                     TTF-I-interacting peptide 20"
                     /codon_start=1
                     /product="zinc finger protein 787 isoform 1"
                     /protein_id="NP_001002836.2"
                     /db_xref="CCDS:CCDS42634.1"
                     /db_xref="GeneID:126208"
                     /db_xref="HGNC:HGNC:26998"
                     /translation="MELREEAWSPGPLDSEDQQMASHENPVDILIMDDDDVPSWPPTK
                     LSPPQSAPPAGPPPRPRPPAPYICNECGKSFSHWSKLTRHQRTHTGERPNACADCGKT
                     FSQSSHLVQHRRIHTGEKPYACLECGKRFSWSSNLMQHQRIHTGEKPYTCPDCGRSFT
                     QSKSLAKHRRSHSGLKPFVCPRCGRGFSQPKSLARHLRLHPELSGPGVAAKVLAASVR
                     RAKGPEEAVAADGEIAIPVGDGEGIIVVGAPGEGAAAAAAMAGAGAKAAGPRSRRAPA
                     PKPYVCLECGKGFGHGAGLLAHQRAQHGDGLGAAGGEEPAHICVECGEGFVQGAALRR
                     HKKIHAVGAPSVCSSCGQSYYRAGGEEEDDDDEAAGGRCPECRGGEGR"
     exon            214..1940
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="ZNF787"
                     /gene_synonym="TIP20"
                     /note="major polyA site"
ORIGIN      
        1 acttccggcc tgggcgcccg tccccctgac cccagggtct gagtcgccgc tgccgccgct
       61 gccaccatcc gcgaggcagg agagaggagg aggagtgcgg cgcggcggcc ccgggaccaa
      121 ggagggaccc agacatggag ctgcgggaag aagcctggtc tccggggccg ctggattctg
      181 aggaccagca gatggccagt cacgagaacc cagtggacat cctcatcatg gatgatgacg
      241 acgtccccag ctggcctccc accaagctgt ccccgcccca gtctgcgccc ccagccggcc
      301 cgcctccccg gccgcggccg cccgccccct acatctgcaa cgagtgtggc aagagcttta
      361 gccactggtc caagctgacg cggcaccagc gcacgcacac cggcgagcgg cccaacgcct
      421 gcgccgactg cggcaagacc ttctcgcaga gctcgcacct ggtgcagcac cggcgcatcc
      481 acacgggcga gaagccctac gcctgcttgg agtgcggcaa gcgcttcagc tggagctcca
      541 acctcatgca gcaccagcgc atccacacgg gcgagaagcc ctacacctgc cccgactgcg
      601 gccgcagctt cactcagagc aagagcctgg ccaagcaccg gcgctcgcac agcggcctca
      661 agcccttcgt gtgcccgcgc tgcggccgcg gcttcagcca gcccaagagc ctcgcgcgtc
      721 acctgcggct gcacccggag ctgtcggggc ctggcgtggc ggccaaggtg ctggcggcta
      781 gcgtccggcg ggccaagggg cccgaagagg cggtggcggc ggacggcgag atcgccatcc
      841 ccgtgggcga tggcgagggc atcatcgtgg tgggcgcgcc gggcgagggg gccgcggccg
      901 cggcagccat ggcgggcgcg ggggcaaagg ccgcggggcc ccggtcgcgg cgcgccccgg
      961 cccccaagcc gtacgtgtgt ctggagtgcg ggaagggctt cgggcacggg gccgggctcc
     1021 tggcgcacca gcgggcccag cacggggacg ggctcggggc ggcggggggc gaggagccgg
     1081 cccacatctg cgtggagtgc ggggagggct tcgtgcaggg cgccgcgctc cggagacaca
     1141 agaagatcca cgcggtgggc gcgccctcgg tctgcagcag ctgcggacag agctactacc
     1201 gcgcgggcgg ggaggaggag gacgacgacg acgaggccgc gggcgggcgg tgccccgagt
     1261 gccgcggtgg ggagggccgg taggggaggg gcccgggggg gggggcgggc agggcccctc
     1321 gggcttggcg ggagcgacga cgtgcaagac caagagaccc agggagaagc ggacggggtg
     1381 cgatggaccc cgcggcatcc ccggctcccc gccctcctct gtccctgcgc cgtccgtggg
     1441 ggggcactgg ggcgtattag ggcccgttca cttctccgcc tcgagactct gccccctcag
     1501 cctggcccgc ccttcctaag ttatcggcct gcgagccgga gagacaatgg agagaactgc
     1561 agaggccgag tggcgaccag gccccaagcg gaaggccatt ttccctgctc ttcctcagtt
     1621 gtccggggcg ggggtggggg gtgctgcgag gaatggagaa accaggccct ttagaggatc
     1681 ccagagaggg aagagaacca ggggcccttt tctcttttag aattttcttt taatcagccc
     1741 accttttgac tccccgcccg ccccaatcca ttattttttt ctgccttccg ggtcccatcc
     1801 ttagagctcg agtcgttcct tcccctcctg gattccgggt agcagaggca gcgccgcagg
     1861 aggcgggtgc ccgtttgtcc caggcctggg cgtggtggag gaaggggtgc tggaacaata
     1921 aacggcacta tccaaatgtc
//
