LOCUS       NM_001195220            4424 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 783 (ZNF783), transcript variant
            1, mRNA.
ACCESSION   NM_001195220
VERSION     NM_001195220.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4424)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 4424)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4424)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4424)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4424)
  AUTHORS   Gauci,S., Helbig,A.O., Slijper,M., Krijgsveld,J., Heck,A.J. and
            Mohammed,S.
  TITLE     Lys-N and trypsin cover complementary parts of the phosphoproteome
            in a refined SCX-based approach
  JOURNAL   Anal Chem 81 (11), 4493-4501 (2009)
   PUBMED   19413330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004890.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001195220.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.442946.1,
                                           SRR1660805.346092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434415.6/ ENSP00000410890.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC004890.2         127630-127791
            163-558             AC004890.2         131769-132164
            559-685             AC004890.2         132253-132379
            686-811             AC004890.2         132531-132656
            812-940             AC004890.2         143833-143961
            941-4424            AC004890.2         146939-150422
FEATURES             Location/Qualifiers
     source          1..4424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4424
                     /gene="ZNF783"
                     /note="zinc finger protein 783"
                     /db_xref="GeneID:100289678"
                     /db_xref="HGNC:HGNC:27222"
     exon            1..162
                     /gene="ZNF783"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1779
                     /gene="ZNF783"
                     /note="protein ZNF783; zinc finger family member 783"
                     /codon_start=1
                     /product="zinc finger protein 783"
                     /protein_id="NP_001182149.1"
                     /db_xref="CCDS:CCDS56519.1"
                     /db_xref="GeneID:100289678"
                     /db_xref="HGNC:HGNC:27222"
                     /translation="MAEAAPARDPETDKHTEDQSPSTPLPQPAAEKNSYLYSTEITLW
                     TVVAAIQALEKKVDSCLTRLLTLEGRTGTAEKKLADCEKTAVEFGNQLEGKWAVLGTL
                     LQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVPVTFDDVAVYFSELEWGKL
                     EDWQKELYKHVMRGNYETLVSLDYAISKPDILTRIERGEEPCLDRWGQEKGNEVEVGR
                     PRMMGTGLPPYPEHLTSPLSPAQEELKEGQAPKQQQDSEARVAPAGPEAGGGVAIKTE
                     AQSEDEMTPERLFLGVSRGQTECRIPRGPRNRPGGPSRHQAQGMPRVRAGEPRPPGAS
                     GETPRVLSRRRQRAFPCPDCGQSFRLKINLTIHQRTHVEEGRQEAPGRSPTSCGDSQA
                     MLEPGEVVVPGPVIRWLPEEPEGRRSVAGGRALVGRRPAASKMYHCSECLRFFQQRKS
                     LLLHQRLHTGNGQGWPACPYCGKAFRRPSDLFRHQRIHTGERPYQCPQCGRTFNRNHH
                     LAVHMQTHARGQVGPHFPAAPARHGSLPLPWPSRKEEG"
     exon            163..558
                     /gene="ZNF783"
                     /inference="alignment:Splign:2.1.0"
     exon            559..685
                     /gene="ZNF783"
                     /inference="alignment:Splign:2.1.0"
     exon            686..811
                     /gene="ZNF783"
                     /inference="alignment:Splign:2.1.0"
     exon            812..940
                     /gene="ZNF783"
                     /inference="alignment:Splign:2.1.0"
     exon            941..4424
                     /gene="ZNF783"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4405..4410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF783"
                     /note="hexamer: AATAAA"
     polyA_site      4424
                     /gene="ZNF783"
                     /note="major polyA site"
ORIGIN      
        1 gggacgcagt tcgctgccgc ccggcagtag ctctcaggtt aggcgggtcc cgctccgctt
       61 ccgccgtcgc tgccgcgccg ccccgggccc gacaggccgg gtccagggac tgcaacccag
      121 cgagggacgc gggcagccat ggccgaagcg gcgcctgccc gggaccccga gacagacaag
      181 cacacagagg accagagtcc ttcgacaccc ttgccccagc cagctgctga gaagaactcg
      241 tacctctact ccacggaaat cacactgtgg acggtggtgg ccgccattca ggccttggag
      301 aagaaggtgg attcctgcct gacccgcttg ctgactctgg aggggcgcac ggggacagcc
      361 gagaagaagc tggccgactg cgagaagaca gctgtggagt tcgggaacca gctggagggc
      421 aagtgggccg tgctggggac cttgctgcag gagtacgggc tgctgcagag gcggctggag
      481 aatgtggaga acttgctgcg caacaggaac ttctggatct tgcggctgcc cccgggcagc
      541 aagggggagg cccccaaggt gcccgtgacc ttcgatgatg tggccgtgta tttctctgag
      601 ctggagtggg gcaagctgga ggactggcag aaggagctct acaagcacgt gatgaggggc
      661 aactacgaga cgctggtctc cctggattat gcaatctcca aaccagacat cctcacccgg
      721 atagagaggg gagaggagcc ttgtcttgac cggtggggcc aggagaaggg gaatgaagta
      781 gaggtgggac gtccaaggat gatgggcact ggcctccctc cgtatccaga gcacctcacc
      841 agcccactta gccctgccca ggaggagctg aaagaagggc aggcccccaa gcagcagcag
      901 gactcagagg cgagagtggc cccagccggg ccagaagcag gtggtggtgt ggccatcaag
      961 acagaggcac agtctgaaga cgagatgacg cctgagcggc tctttctggg ggtgtcccga
     1021 ggccagaccg agtgtagaat cccccgaggg cccaggaaca ggcctggggg ccccagccgt
     1081 catcaggccc agggcatgcc cagggtgcgg gcaggggagc cacggccacc gggggccagt
     1141 ggggagacgc cccgagtcct ctcccgcagg cggcagcggg cattcccctg ccccgactgc
     1201 gggcagagct tccgcctgaa gatcaatctg acgattcatc agcggaccca tgtggaggag
     1261 gggcggcagg aggcccccgg ccgctcgccc accagctgcg gggacagcca ggccatgctg
     1321 gagccggggg aggtggtggt acccggccct gtcatccgct ggctccccga ggagcctgag
     1381 ggtcgccgct ccgtggcagg gggccgtgcc ttggtggggc ggcggcctgc agccagcaag
     1441 atgtaccact gcagcgagtg cctgcgcttc ttccagcagc gcaagagcct gctgctgcac
     1501 cagcgcctgc acaccggcaa tggccagggc tggcccgcct gcccctactg cggcaaggcc
     1561 ttccgccggc cctcggacct cttccggcac cagcgcatcc acaccggtga gcggccctac
     1621 cagtgccccc agtgtggccg gaccttcaac cgcaaccacc acctggccgt gcacatgcag
     1681 acccacgccc gaggccaggt gggcccacac ttccctgccg cccccgcccg ccacgggagc
     1741 ctgcccctgc cctggcccag ccggaaggag gagggctgac ctggcaggag cccacagagg
     1801 acccctggcg gggtctctcc cctgtgcctg acgcaggttc ttccttttcc tgggatggag
     1861 agaggtttgt tgtttttacc cattcaaatg ggaagctagc tgcccttctg gtgacattgt
     1921 gtgtgaccgg gtgctttctg tttcctgttt gcactcttcg ctgccttttc tgcattcctg
     1981 acttctaaaa gatgccttaa ggcttaaggg atgccatatt tttgataagg cctctggtag
     2041 gtaccacagc caagaggacc agagatcatg gcccttccag tatgggggcg atagagacat
     2101 cggggacctg ggatttttgt tttgtgcaga gatctcctgc ctgctgtcac catgagaaac
     2161 agtggagtgg agtggatgga tggcctgact tgaagaaagg gccctggaaa gttttctact
     2221 ttgctatttt gaaatttttt tcccttctta tagagacttt gaaatacttt tgtaaatgtg
     2281 tgtagttgtt aatggaactt tgccttttgc aaagtcggaa agagtcggct tttccatgtg
     2341 aggctcgcag agctgaaagg ggagctacgt ccaccagcct gtgggtcttt tggttttttt
     2401 tttgttgttg ttgttgtttt tttaagatgg agtttcactc ttgttgccca ggctggagtg
     2461 caatggtaca atctccgctc actgcaacct ccgcctctcg ggttcaggtg attctcctgc
     2521 ctcagcctcc tgagtagctg ggattacagg cgcccaccac cactcccggc taatttttgt
     2581 atttttagta gagacagggt ttcatcatgt tgtccagact ggtctcgaac tcctgatgtt
     2641 aggtgacccg cacacctcgg cctcctgaag tgctgggatt acaggcgtga gccaccactc
     2701 ttggcccagc ctgtgggttt tgatggggat gtcttggctg ctgtcttgga ggcacagtgt
     2761 ctccccatgt gtgtgtttct tggcccagag tgactcccag tattcctagt ccttccccac
     2821 aggatagtca catccattat ttacttttgt tgtcagctgg gaggggaaac tgaagcctgg
     2881 acacgtctcc ccaagggctc agtgttcatg ggtgtgtaag atccattgac tggaccccag
     2941 aaagcaccct gaggggcagt gcagagagag cccaggaagc ccctccacta gaggaggccc
     3001 ttggtctggc tgaggaccac gtccaccctg ggcctccagg cctgcttttc acattaaagg
     3061 cggggcagtc tcctctcaaa ggagttctcc cttgagcact ttgggctctg gggcagagtt
     3121 gggctaggag atctgggtga atcctttagt cacagctagt ctcatgttcc tcttctgtca
     3181 aaggggtcat ggccccagtg tgtcctacct cagagttgtc agggtcaaag taacaggcac
     3241 tgggacaaat atgaagccta gctttgtgct tcctttcaaa ttcagggcct cctttctact
     3301 ccattccagc ctttttttcc tgtcagaatc cctcaggaag gacctttatc ttctggagtg
     3361 agtggcagtt ccactgggtt cagtgaaaga gtcgcccatg gggctctgtt ccccaggagt
     3421 cctttgtatt ttggtgaaca aattcttacc aaagcatgag attcggactg tagaagttca
     3481 gactgcctca gttcagactg cctcatgggg cagtctggag gtcagctggc ttctggtgtc
     3541 tctcatcaca ccactgcgga cgctgtctgt agagcagcct tggtgtgggt gactctgaag
     3601 ctggagtgat gggaccccag ctatccttgt tttttaccgc cttgtctggc actgtgacca
     3661 cgcttcaggg ctgcttctgg gggtcttggt ccctggatgt gccatttcct tgcccttctg
     3721 accctcacac ttcttccaaa gtcttgagca gagttggggg ccaatggtag cattgctgtc
     3781 atctctggga ggagagtgag tatacaagtc agtgacagtt cagccaggct cccttgggtt
     3841 tgggaagagg cactgccctt ctgtgctgtg gatcctgctt gtctgctctg gagtcccccc
     3901 acccttgcca ggagcttcac aaaccagaga cgggctgtca gcaagagctc agacaggatg
     3961 tggtgcaagt gcaggtgcac gagtttaacc ctcagctgca ggagctagtc tcaggtgttc
     4021 tggggatgcc tcaggctaag aattttgccg actttctggg cttggttggc taatgccaaa
     4081 tgcccctgct taaatatcac aaggtgctga ttctcctttt ttcttttttt cataccaatg
     4141 tgctcaaact ttgagctagg tcttgtgagt ttgcctagca ctcagacctg tttaagtaac
     4201 gttctttaca ttgaaacaag tcaaccgaag ctttgtggtg caggagctga gggtgcccca
     4261 gactcagtgg gagccctggt tgggccccaa actctcccag cagggtcctc ggtttcctca
     4321 tttgtgaaat aaatgagtgg gccacgacgt taataagccc aagagaactg tgaaggtggt
     4381 agtcccttgc cctaattggt gctcaataaa gttgttggca taaa
//
