LOCUS       NM_001142578            3550 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 780A (ZNF780A), transcript variant
            3, mRNA.
ACCESSION   NM_001142578
VERSION     NM_001142578.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005614.1, BC021982.1, AK091274.1, DA758840.1 and BU685481.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001142578.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is 1 aa shorter than isoform a.
            Both variants 2 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.518359.1,
                                           SRR14038195.1872938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683561.1/ ENSP00000506741.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC005614.1         42213-42217         c
            6-71                BC021982.1         5-70
            72-462              AK091274.1         129-519
            463-621             DA758840.1         389-547
            622-3148            AK091274.1         679-3205
            3149-3550           BU685481.1         68-469              c
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3550
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /note="zinc finger protein 780A"
                     /db_xref="GeneID:284323"
                     /db_xref="HGNC:HGNC:27603"
     exon            1..38
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /inference="alignment:Splign:2.1.0"
     exon            39..108
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /inference="alignment:Splign:2.1.0"
     exon            109..162
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2079
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /note="isoform b is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 780A isoform b"
                     /protein_id="NP_001136050.1"
                     /db_xref="CCDS:CCDS33026.2"
                     /db_xref="GeneID:284323"
                     /db_xref="HGNC:HGNC:27603"
                     /translation="MVHGSVTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLIS
                     LGSSISKPDVITLLEQEKEPWMVVRKETSRRYPDLELKYGPEKVSPENDTSEVNLPKQ
                     VIKQISTTLGIEAFYFRNDSEYRQFEGLQGYQEGNINQKMISYEKLPTHTPHASLICN
                     THKPYECKECGKYFSRSANLIQHQSIHTGEKPFECKECGKAFRLHIQFTRHQKFHTGE
                     KPFECNECGKAFSLLTLLNRHKNIHTGEKLFECKECGKSFNRSSNLVQHQSIHSGVKP
                     YECKECGKGFNRGAHLIQHQKIHSNEKPFVCKECGMAFRYHYQLIEHCQIHTGEKPFE
                     CKECGKAFTLLTKLVRHQKIHTGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECK
                     ECGKSFNRSSNLVQHQSIHAGIKPYECKECGKGFNRGAHLIQHQKIHSNEKPFVCREC
                     EMAFRYHCQLIEHSRIHTGDKPFECQDCGKAFNRGSSLVQHQSIHTGEKPYECKECGK
                     AFRLYLQLSQHQKTHTGEKPFECKECGKFFRRGSNLNQHRSIHTGKKPFECKECGKAF
                     RLHMHLIRHQKLHTGEKPFECKECGKAFRLHMQLIRHQKLHTGEKPFECKECGKVFSL
                     PTQLNRHKNIHTGEKAS"
     exon            163..289
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /inference="alignment:Splign:2.1.0"
     exon            290..385
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /inference="alignment:Splign:2.1.0"
     exon            386..3550
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3321..3326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /note="hexamer: CATAAA"
     polyA_site      3340
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /note="major polyA site"
     regulatory      3376..3381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /note="hexamer: AATATA"
     polyA_site      3401
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
                     /note="hexamer: AATATA"
     polyA_site      3550
                     /gene="ZNF780A"
                     /gene_synonym="ZNF780"
ORIGIN      
        1 agtccacttc cggtctccgg ggtcgacgac atagcgggtc gtatttttat ccaaaagaag
       61 gacctggagg aggatgagag cgttactgct gcacacctaa agtcaagggg gagaagcccg
      121 aggaagattg accagttttg taattctagc aacatggtcc atggatcagt gacattcagg
      181 gatgtggcca ttgacttctc tcaggaggag tgggagtgcc tgcagcctga tcagaggacc
      241 ttgtacaggg atgtgatgtt ggagaactac agccacctga tctcactggg aagttccatt
      301 tctaaaccag atgtaattac gttactagag caagagaaag agccctggat ggttgtaagg
      361 aaagaaacaa gcagacggta tccagatttg gagttaaaat atggacctga gaaagtatct
      421 ccagaaaatg atacctctga agtaaattta cccaaacagg ttataaagca aataagtaca
      481 actcttggca ttgaggcctt ttattttaga aatgactcag aatatagaca atttgaggga
      541 ctacagggat atcaagaagg aaatatcaat caaaagatga tcagctatga aaaactgcct
      601 actcatactc ctcatgcttc tcttatttgc aatacacata aaccgtatga atgtaaggaa
      661 tgtgggaaat actttagtcg tagtgcaaat cttattcagc atcagagtat tcatactgga
      721 gagaaaccct ttgaatgtaa ggagtgtggg aaagcctttc gacttcacat acaatttact
      781 cgacatcaga aatttcatac tggtgagaaa ccttttgaat gtaacgaatg tggaaaggcc
      841 tttagtcttc ttaccctgct taatcgccat aagaacattc acacaggtga gaaactgttt
      901 gaatgtaagg aatgtgggaa gtcctttaat cgtagctcaa accttgttca acatcagagt
      961 attcattctg gtgtaaaacc atatgaatgt aaggagtgtg ggaaaggctt taatcgtggt
     1021 gcacacctta ttcagcatca gaaaattcat tccaatgaga aaccctttgt atgtaaggaa
     1081 tgtgggatgg cctttcgata tcattaccaa cttattgaac attgccaaat tcatactggt
     1141 gagaaaccct ttgaatgtaa agaatgtgga aaggcgttta ctcttctgac aaagcttgtt
     1201 cgacatcaga agattcatac tggtgagaaa ccctttgaat gcagggaatg tgggaaggcc
     1261 tttagtcttc tcaaccagct taatcgccat aagaacattc acacaggtga aaaaccgttt
     1321 gaatgtaagg aatgtgggaa gtcctttaat cgtagctcaa accttgttca acatcagagt
     1381 attcatgctg gtataaaacc atatgaatgt aaggagtgtg ggaaaggctt taatcgtggt
     1441 gcacacctta ttcagcatca gaaaattcat tccaatgaga aaccttttgt atgtagggaa
     1501 tgtgagatgg cctttagata tcattgccaa cttattgaac attctcgaat tcatactggt
     1561 gacaagccat ttgaatgtca agactgtggg aaggccttca atcgtggctc aagccttgtt
     1621 caacatcaga gtattcacac tggtgagaag ccctatgaat gtaaggagtg tgggaaggct
     1681 tttagacttt acctacaact ttcccaacat cagaaaactc acacaggtga aaaaccattt
     1741 gaatgtaagg aatgtgggaa attctttcgt cgtggttcaa atcttaatca acatcgaagt
     1801 attcatactg gaaagaaacc ctttgaatgt aaggaatgtg ggaaagcctt tcgacttcat
     1861 atgcacctta ttcgacatca gaaattgcat actggtgaga aaccctttga atgtaaggag
     1921 tgtgggaaag cctttcgact tcatatgcaa cttattcgac atcagaaatt gcatactggt
     1981 gagaaaccct ttgaatgtaa ggaatgtgga aaggttttta gtcttcccac ccagcttaat
     2041 cgccataaga acattcacac aggtgagaag gcatcttgaa tgtaaggaat gtggaaagtc
     2101 ctttaatcgt gtctcaaacc atgttcaaca tcagagtatt cgtgctggtg taaaaccatg
     2161 tgaatgtaag gggtgtggga aaggcttcat ttgtggttca aacgttattc agcatcagaa
     2221 aattcattcc agtgagaaac tctttgtatg caaggagtgg aggacgacct ttagatatca
     2281 ttaccactta tttaacatta ccaaattcac actggtaaaa aaccctttga atgtaaagaa
     2341 tgtggaaagg ccttcagttt tctgacacag cttgctggac ttcaggtcat tcatactggc
     2401 gagaagccat ttgaatttga gaaatgtggg aaggccttca atagtggctc aaaccttgtt
     2461 caacatcaga gtattcatac tggtgagaaa ctctatgaat gtaaggagtg tgggaaaact
     2521 ttcagattta gtttggtcct gactgcacat caaagaattc atactggtat gaaaccctgt
     2581 gaatgtacag aatgtgggaa gacctttagt tgtagctcaa acattgttca acatgttaaa
     2641 attcatactg gtgagaaacg ctataatgta aggaatatgg gaaagcattt gctgtggatg
     2701 atcagctgtc tcaacatcag aaaattcaga atagttagaa attttgtgac aataaggagt
     2761 gtggacaagc cttcactgtg tacgaaaaat ttactcaaca ccagagagct catattgatg
     2821 agaaatcttg tgaacataaa agaatgtgtg aagaactttc atcatggcct gggatttgct
     2881 caacttctga gtattcatac ttctgagaaa tctttgagtg taaggaatgt ggggcgtttt
     2941 atagccacac taaatacctt agagttcgga gaagataatt cttgtgagaa agtctttgaa
     3001 tgaggaatat agggtagttg tcatgttcac aatgtactcc ctatgaaata atttaccaga
     3061 tacaggcata cctcgctgaa ttgtgcattg cagttattgt gttttataca aactgaaggt
     3121 ttgtggcaac cctgtggtga gcaagacgat caggtccatt ttcccaacgt caggtgtgca
     3181 tttcatgtct ttatgtcaca ttttggtaat tctcagaata tttcaaacta tttcattgtt
     3241 atatatctat catggtgatc aatgaccagt gatttttgat gttgctattg taattgcttt
     3301 gggataccac aaattctgcc cataaaagat ggtaaaccta gttgatactt gttgtgggtt
     3361 ttgaaagaat agtcaaatat acaatcatat accccaacct agattcaaaa ttgttaacaa
     3421 tttgcacgtt tattttttgt atatttgttg taccattgag aataagtttt agacatcatg
     3481 acactttacc ctttatttaa tcaacgtgtg tatcaaccaa acatgaagac aatatagaca
     3541 atatcatata
//
