LOCUS       NM_001201407           11192 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 778 (ZNF778), transcript variant
            1, mRNA.
ACCESSION   NM_001201407
VERSION     NM_001201407.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11192)
  AUTHORS   Villot,R., Poirier,A., Bakan,I., Boulay,K., Fernandez,E.,
            Devillers,R., Gama-Braga,L., Tribouillard,L., Gagne,A.,
            Duchesne,E., Caron,D., Berube,J.S., Berube,J.C., Coulombe,Y.,
            Orain,M., Gelinas,Y., Gobeil,S., Bosse,Y., Masson,J.Y., Elowe,S.,
            Bilodeau,S., Manem,V., Joubert,P., Mallette,F.A. and Laplante,M.
  TITLE     ZNF768 links oncogenic RAS to cellular senescence
  JOURNAL   Nat Commun 12 (1), 4841 (2021)
   PUBMED   34404770
  REMARK    GeneRIF: ZNF768 links oncogenic RAS to cellular senescence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11192)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 11192)
  AUTHORS   Willemsen,M.H., Fernandez,B.A., Bacino,C.A., Gerkes,E., de
            Brouwer,A.P., Pfundt,R., Sikkema-Raddatz,B., Scherer,S.W.,
            Marshall,C.R., Potocki,L., van Bokhoven,H. and Kleefstra,T.
  TITLE     Identification of ANKRD11 and ZNF778 as candidate genes for autism
            and variable cognitive impairment in the novel 16q24.3
            microdeletion syndrome
  JOURNAL   Eur J Hum Genet 18 (4), 429-435 (2010)
   PUBMED   19920853
  REMARK    GeneRIF: ZNF778 is a candidate gene for autism and variable
            cognitive impairment in the novel 16q24.3 microdeletion syndrome.
REFERENCE   4  (bases 1 to 11192)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009113.8.
            
            On Mar 12, 2020 this sequence version replaced NM_001201407.1.
            
            Summary: The protein encoded by this gene is a member of the
            krueppel C2H2-type zinc-finger protein family, and it contains one
            KRAB domain and eighteen C2H2-type zinc fingers. This gene is a
            candidate gene for autism and variable cognitive impairment in the
            16q24.3 microdeletion syndrome. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Jan
            2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.12116.1,
                                           SRR18074969.2739737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433976.7/ ENSP00000405289.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC009113.8         48528-48735         c
            209-364             AC009113.8         45286-45441         c
            365-456             AC009113.8         44255-44346         c
            457-583             AC009113.8         43155-43281         c
            584-667             AC009113.8         41636-41719         c
            668-744             AC009113.8         40807-40883         c
            745-11192           AC009113.8         29297-39744         c
FEATURES             Location/Qualifiers
     source          1..11192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..11192
                     /gene="ZNF778"
                     /note="zinc finger protein 778"
                     /db_xref="GeneID:197320"
                     /db_xref="HGNC:HGNC:26479"
     exon            1..208
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     exon            209..364
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2613
                     /gene="ZNF778"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 778 isoform 1"
                     /protein_id="NP_001188336.1"
                     /db_xref="CCDS:CCDS73928.1"
                     /db_xref="GeneID:197320"
                     /db_xref="HGNC:HGNC:26479"
                     /translation="MAAPDLAHGGHVSRDSVCLHEEQTQAAGMVAGWLINCYQDAVTF
                     DDVAVDFTQEEWTLLDPSQRDLYRDVMLENYENLASVGHHLFQPSVIYWLEQEEELRA
                     GRRAVLQEWRLKTKGPALRQDRSWFRASNETQTARSHNGGQLCDRTQCGEAFSEHSGL
                     STHVRTQNTGDSCVSNHYERDFFIPCQKTLFKIGEQFSVLGQCGKAFSSTPNVVSQQA
                     CTRDRSLDYSSCGEVFLNQSYLQARAGSHNGEETWKWKPCGKALTHSMGCATPVEMHA
                     VRNPHVCRECGKAFRYTAYLTGRVQVHPGEKPCELEECGKASPVSSSLTQHVRIHAAE
                     KPCECKECGKAFTGLSGLSKHVQTDPGQKPYECKDCGKACGGFYLLNEHGKTHTREKP
                     FACVVCGKYFRNSSCLNNHVRIHTGIKPYTCSYCGKAFTVRCGLTRHVRTHTGEKPYT
                     CKDCGKAFCTSSGLTEHVRTHTGEKPYECKDCGKSFTVSSSLTEHARIHTGEKPYECK
                     QCGKAFTGRSGLTKHMRTHTGEKPYECKDCGKAYNRVYLLNEHVKTHTEEKPFICTVC
                     RKSFRNSSCLNKHIQIHTGIKPYECKDCGKTFTVSSSLTEHIRTHTGEKPYECKVCGK
                     AFTTSSHLIVHIRTHTGEKPYICKECGKAFASSSHLIEHRRTHTGEKPYICNECGKAF
                     RASSHLHKHGRIHTGQKPYKCKECGKAYNRFYLLKEHLKTYTEEQVFVCKDCGKSFKN
                     SSCLNHHTQIHTDEKPF"
     exon            365..456
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     exon            457..583
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     exon            584..667
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     exon            668..744
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     exon            745..11192
                     /gene="ZNF778"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6667..6672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF778"
                     /note="hexamer: ATTAAA"
     polyA_site      6688
                     /gene="ZNF778"
                     /note="major polyA site"
     regulatory      8176..8181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF778"
                     /note="hexamer: GATAAA"
     polyA_site      8197
                     /gene="ZNF778"
     regulatory      10418..10423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF778"
                     /note="hexamer: AATAAA"
     polyA_site      10439
                     /gene="ZNF778"
     regulatory      11170..11175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF778"
                     /note="hexamer: ATTAAA"
     polyA_site      11192
                     /gene="ZNF778"
ORIGIN      
        1 ctgtcttaca gctgatccgg ttcttgcggc ggtgcgtgct ggcgccggag agttccgcgc
       61 gtgtcctcgg gctgtccgcg gggaagctgg tccgggagtg ggcgcccgcc cgcctgcctc
      121 gcgccttgcg cccccggcac cgcttccaga agggaaagtc gccgccgctc gcggtagacc
      181 cgggcagcgc ttccattccg cggagctgga aatagggatc cagccatccg tgggtcagga
      241 ggaatggaga ctgtaccttc cacatagatt cacaagctgc cctgcagtgg ccttggcttc
      301 aggaaaggag cattcagacg cttccgtcag cctcccagga tggcagcccc tgacctggcc
      361 cacggaggtc atgtttctag ggactcagtc tgccttcatg aagaacagac acaggcagca
      421 gggatggtgg ctggctggct gataaattgt taccaggacg cggtgacctt tgacgacgtg
      481 gctgtggact tcacccagga ggaatggact ttactggacc catctcagag agacctctac
      541 agagatgtga tgctggaaaa ctacgagaac ctggcctcag taggacatca cctgttccaa
      601 cccagtgtga tctattggct ggagcaggaa gaggagttga gggcagggcg gagagcagtt
      661 ctccaagaat ggcgacttaa aaccaaaggg ccagcacttc ggcaggatag atcttggttc
      721 agagcatcaa atgagacaca gacggcaaga agccacaatg gagggcagct ctgtgaccgc
      781 acgcagtgtg gagaagcttt cagtgaacac tcaggcctca gcacacacgt gagaactcaa
      841 aatacaggag acagttgtgt gtctaatcat tatgaaaggg acttttttat tccatgccag
      901 aaaaccttgt tcaaaattgg agagcagttt tccgtgttgg gtcagtgtgg aaaagccttc
      961 agctctactc caaatgttgt ttcccagcaa gcatgcactc gggacagatc tcttgactac
     1021 agcagctgtg gggaagtgtt ccttaatcag tcataccttc aggcacgtgc gggaagtcac
     1081 aacggagaag aaacatggaa atggaagccg tgtgggaaag ctctaactca ctccatgggc
     1141 tgcgccacac ctgttgaaat gcatgccgtc aggaatcccc acgtatgtag ggaatgtggg
     1201 aaggccttta ggtacactgc ctaccttact ggtcgcgtgc aagtccaccc tggggaaaag
     1261 ccctgtgaat tggaagaatg tggaaaagcc tcccctgttt cttccagcct aactcaacat
     1321 gtaagaattc atgctgcaga gaaaccctgt gaatgtaaag aatgcggaaa agccttcact
     1381 ggactctcag gtctttctaa acacgtccaa acagaccctg gacagaagcc ctatgaatgt
     1441 aaggactgtg ggaaagcctg cggtgggttt tatctactga atgagcatgg aaaaactcac
     1501 acgagggaga agccctttgc atgtgtggtt tgcggaaaat attttagaaa ttcctcatgc
     1561 cttaataatc atgttcgaat tcacactgga ataaaaccct atacatgcag ctactgtggg
     1621 aaggccttca ctgtgcgctg tggccttact agacacgtac gaacacacac gggcgagaag
     1681 ccatacacgt gtaaggactg cgggaaagcc ttctgtacat cctcgggcct tactgagcat
     1741 gtaaggactc acactggaga gaaaccatat gaatgtaaag attgtgggaa atccttcact
     1801 gtttcttcaa gcctgactga gcacgcgaga atccataccg gagagaaacc ctacgaatgt
     1861 aagcagtgtg gcaaagcctt cacagggcgc tcaggcctca ctaaacacat gcggacacac
     1921 accggggaga agccctatga atgtaaggac tgtgggaaag cctacaatag ggtttatcta
     1981 ctgaatgagc atgtgaaaac tcacacagag gagaagccct ttatatgtac ggtatgcagg
     2041 aaatccttca gaaattcctc gtgcctgaat aagcacattc agattcacac tggaataaaa
     2101 ccttatgaat gtaaggactg tgggaaaaca ttcactgttt cttcgagcct aaccgagcac
     2161 atacgaactc acactggaga gaaaccttat gaatgtaaag tatgcggaaa ggccttcacc
     2221 acatcctcac accttatcgt gcacataaga acccacaccg gtgagaaacc ctacatatgt
     2281 aaggagtgtg ggaaagcctt tgcttcctcc tcacacctta tcgaacacag aaggactcac
     2341 acaggagaga aaccttacat atgtaacgag tgtgggaaag ccttccgtgc ctcctctcac
     2401 ctgcataaac atggaagaat tcacactggg cagaaaccct ataaatgtaa ggaatgtggg
     2461 aaagcataca ataggtttta tctactaaaa gaacatttaa aaacttacac tgaagagcag
     2521 gtttttgtat gtaaggactg tggaaaatct tttaagaatt cctcatgcct taaccatcac
     2581 actcaaattc acactgatga gaaacctttc taatgtaaag aatgtgggga agctgtcagc
     2641 tacactcatt cacgttgaag acatgaaaga cctctcgttc tccagatgtc catgacttga
     2701 ggaatgtggc taggcaatca gcatctcatc acaacccggc aggcaggaac tcaccctgga
     2761 gccctatgca gcagacacag agaaagccct cagtgttctc taaggtcttg ctgaatatgg
     2821 atggtatcca gtagagagaa ctctattgat gtgtgatatg cagcagcatt gttgctgttc
     2881 tgctcagtac tttgatgatc ccttgtgatc tcacaatgaa gaaaaacctt aggagggtga
     2941 gaattgttgg gaagtcattt tttacattac atctttcctc accctttagt aaacgtggtg
     3001 attgacactt gaagtgttgt gaatgtatgg aagatagcag tcgcttccct gtgttctaaa
     3061 accttgtggg ctaacttgag acatgtcttt ctgggggttc tgtagacgta ttttgaatct
     3121 ttatgatgct gcactgatca ttcttggagt gaggactctg ttccctgtag aaatcctcca
     3181 gtctggttgc tacagtgtcc acgtcgcagc ctggctaaca gtaggccttg aggactcaga
     3241 tgtgatcctg tgtgagcagt gtaggctctg gttggttagt cttgaggatc cagatgtgat
     3301 tctttgagca gcgtaggctc tggttggtta gtcttgagga tccagatgtg attctgtgag
     3361 cagtgtaagc tctggttggt tagtcttcag gatccagatg tgatcttgtg tgagcactgt
     3421 aggctctggt tggttagtct tgaggatcca gatgtgattc tgtgagcagt gtaggctctg
     3481 gttggttagt cttgaggatg cagatgtgat tctgtgtgag cagcgtaggc tctggttggt
     3541 tagtcttgag gatccagatg tgattctgtg agcagcatag gctctggttg gttagtcttg
     3601 aggatccaga tgtgattctg tgagcagcgt aggctctggt tggttagtct tgaggatcca
     3661 gatgtgattc tgtgagcagc gtaggctctg cttggttagt cttgaggatc cagatgtgat
     3721 cctgcgtgag cagcgtaggc tctggttggt tagtcttgag gatccagatg tgatcctgtg
     3781 tgagcagcgt aggctctggt tggttagtct tgaggatcca gatgtgattc tgtgagcagt
     3841 gtaggctctg gttggttagt cttaggtatc cagatgtgat cctgtgtgag cagcgtaggc
     3901 tctggttggt tagtcttgag gatccagatg tgatcctgtg tgagcagcgt aggctctggt
     3961 tggttagtgt tgaggatcca gatgtgattc tgtgagcagt gtaggctctg gttggttagt
     4021 cttgaggatc cagatgtgat cctgtgtgag cagtgtaggc tctggttggt tagtcttaag
     4081 tatccagatg ggatcctgta tgagcagcgt aggctctggt tggttagtca tgctcttagg
     4141 catgacccac ctgtagggtc ccacactggc caatgttggg gcataacaca gctctacatt
     4201 ttatgaaaat gcccttgttc ctctcccata cctgatccct tcagataaaa caccagggtg
     4261 caaggagggg cagagtggag aggggcgagg tctgtaccct gagatgcccc cgtttcatgg
     4321 ccgtggaggg agaaccacca ccccccacgt ggggaggagg gaattcctgt accttaggca
     4381 gtgccggacg ggtgagagcc ctgagtgtcc ttgttgacct ccagatcctc ttcacagcat
     4441 gcagagcggt cctggcagct gctgcaatct ggcactcctg gggcagctgc tgcgatccgg
     4501 cactgatgag gcagctgctg tgatccggca ttcatggggc agctgctgcg acccggcact
     4561 cctggggcag ctgctgcttg tgtgtgtgct gctcctttgt gtaccatgaa aacagaccag
     4621 ggacacggct ggtcctgatg ttctgtggcg cttggccctg tcactggcgc ttcttggatg
     4681 aggcccttaa acacacacag tggcagagca agacttcatg tgagtgacac gaatgtgtgt
     4741 cctctggctg cagcaatcct gggttatgtt ttttgtggcc atcagggcag cagctgcttg
     4801 gtgactgttt ctgtggtgtt gaatccccac ggtataaagg taatctacaa cgaggtgaac
     4861 aataaatcct ggatggacag acccgtgcac cttcatatta cgtgtttgaa atcctggatg
     4921 gacagacccg tccaccttca tgtcacgtgt ttgaaattct ggatggacag acccatgcac
     4981 cttcatgtta cgtgtttaaa attctggatg gacagacccg tgcaccttcc tgtcacatgt
     5041 ttgaaatcct ggatggacag acctgtgcac cttcatgtca cgtgtttgaa attctggatg
     5101 gacagagcca tgcaccttca tgttacgtgt ttgttgtgga gaggagtggg ttgtgccatg
     5161 tttctcttgt gggattgagt gtggctattt agctcatctg ttgccacctt taattgttgg
     5221 cattgacact aaaggtcatc agattagcgg gaaccagctt gtggggttgt agcggctcct
     5281 ggactggtct caggtgacat cctgattggc tgaaataagt cctgcaggtc tctgctagaa
     5341 ctgactcaca gttgcctgag tccagaactt gtgggtcaca ggtgacgcca ggactgcatc
     5401 atcctggtgc tcggactcct agtgacagca tcctgagcag gcggtagccc agacaccacc
     5461 ctgcctgata tgcccactgt tggtggagac atcaccccag cacagacctc aattaagacg
     5521 actacccctc cgacgactcc ccctcccttc actggaggtg acttcacgca cttcttcaga
     5581 acctcctcag cagcgatgcc catggactgg ggttcctaag gcacaaattt gatatttgag
     5641 attctgtgat gagctgagct tgctgtccgc taacccgtga tcctggtgta atctcaacca
     5701 aaacccacag ccctgcaccc cttgcctgta ggaaaatctg gtaggagtta gtagtgtctg
     5761 tgaagtctca ataattgata ccaaaatgtt ttgtttcacc aggaggtgcc cgcctcctat
     5821 cagcctctgg gaaggccact gtctccccag tgccttctcc tccgctgcag ctttccatct
     5881 catctcctta ctcccttgac ttggcttcac acagagcctc ttctttacac atactaactg
     5941 tttgcttcat accctcctgc agcagaacta cagacctgcc atcctgataa ttgtcaaact
     6001 catcccttta tcacctttat aactcctcaa ggatattatc attggacccc caacatttca
     6061 aagtgatttt cttgagtaat accatatgct gtgatgtgga tgtgattggt ttgccctcat
     6121 caagtctcat gttgagcttt gaccctcagt gtggcagtgc tgggaggggg cctggtgggg
     6181 gtttgggtca tgggggcacc ctcctgaatg gttggatacc attcattctt gctgtgtcaa
     6241 gcctggattg gtttgtaggg gaatgcacta gttactggga gcatggttgt gataaagcca
     6301 agccgtccct cgggtttggc tcactgccct tgaccttctc tgccctgttt gacacagcaa
     6361 atagtcctca ccagaagcag gtcagatgcc agtgctatgc ttgcacagcc tgctgaacca
     6421 tgagccaaat aagcctcttt ctaagttacc cacagcctca gatatgtagc aacacagaca
     6481 gactaagaca ccaagcatga tggaaaactg ggttatgggc aggactgcaa gtactggtta
     6541 ggcagatacc tgtatttctc ttcctaactc tcagaacgtg ttctgtgtca cttagggcaa
     6601 cttatgccct cctgtgtgaa aatctccact cccaatgtct gagggttcct cagagtaaga
     6661 taaaatatta aaggaccaat tgtattaatt atgttttttt tttttttgtt agggtacatt
     6721 ttcatcctgg ggtcttgctg tgggggctag accgtccctc tcaggctaga tcattcctaa
     6781 agatggtaaa caacttgctg gaaacatgca ctgcatatac aaatcaactc actgcatatg
     6841 cacatcaact cactgcatat gcaactcaac tcacaccgta tatgcaactc aactcacacc
     6901 gtgtatgcaa atcaactcgc actgcgtatg caactcaact cgcactgcgt atgcaactca
     6961 actcgcactg cgtatgcgaa tccactcact gcctatgcaa ctcagctcgc tctgcgtatg
     7021 caactgagct cgctctgcgt atgcaaccca gctcgctctg cgtatgcaac tcaagtcgca
     7081 ctgcgtatgc aactcagctc gctctgcgta tgcaactcag ctcgcactgc gtatgcaact
     7141 cagctcgcac tgcgtatgca agtcagctcg ctctgcgtat gcaactcagc tcgctctgcg
     7201 tatgcaactc agctcgcact gcgtatgcaa ctcagctcgc actgcgtatg caactcagct
     7261 cgctctgcgt atgcaactca gctcgctctg cgtatgcaac tcagctcgct ctgcgtatgc
     7321 aactcagctc gcactgcgta tgcaactcag ctcgctctgc gtatgcaact cagctcgctc
     7381 tgcgtatgca actcagctcg cactgcgtat gcaactcgca ctgcgtatgc aactcaactc
     7441 gcactgcgta tgcaactcaa ctcgcactgc gtatgcaact caactcgcac tgcgtgtgca
     7501 actcaactcg cactgcgtgt gcaactcaac tcacactgcg tatgcaactc agcttgctct
     7561 gtgtatgcaa ctcaactcgc actgcgtatg caaatcaact cactgcatat gcaactcagc
     7621 tcgcactgca tatgcaacgc aactcaactc atactgcata tgcaactcaa ctcacactgt
     7681 atgcaactca gctcgctctg catatgcaat tcaactcgca ctgcgtatgc aaatcaactt
     7741 actgcatatg caactcaact cactgcgtat gcaactcaac tcgcactgca tatgcaactc
     7801 aactcgcact gcgtatgcaa ctcaactcgc actgcgtatg caactcagct cgcactgcgt
     7861 atgcaactca actgttgcaa gtacttattt ccggccactt cctttttcta actaccacac
     7921 caagccagta tttctcctcc ctgaagtcag cccaggatga ggcactagac agcaggacat
     7981 gctgtatgcc cttgggcctg ctggaagtat gcagactagc cagccccaga cttcatcctg
     8041 ccctgtcctg cctttcctgt gaaaaccctg tggcctctgc ctcccctggc tctgacttct
     8101 gcctcctgcc cagctctgca gctccccttg ggccctgcct ggagtgatgt gccgccttct
     8161 cttgacactg tgagtgataa actttccatg tcaggaacct gtgtgtgtca ctcactcacc
     8221 ttgacgagtc cgcgtctagg ccccaccagt ggtgtggttt tcctcatagt ctctctacct
     8281 aagcacatgt ctgtgacaag gtcttaccca gcccagggat tcttgaacta tctgtaggaa
     8341 ctgccatgtt gactcctggg cagttttatt ctttctctct actcgttcaa ccttcttagg
     8401 gagtgacgtt ttttccaaag tggttgtgaa acagcatctc cttggggtgt tggtttgcac
     8461 ttctcttcat tactgatagt atgaacatgg ttttgcttac gctggctatt ttcctttttg
     8521 gatgaagtac ctggtcttgt tttttcctgg tttgtttgat ctttgttctt ttttagaaat
     8581 agtgaggctg ttgtgaggtg agtcaccact tgtgacttag aagattgcag tggtttccac
     8641 ttcacctgtt tccacttttg tgatgatgcc ttaaggaaaa agattgtgcc aggtgtggtg
     8701 gctcaggcct gtaatcccaa cactttggga ggccgaggtg ggtggatcac aaggtcagga
     8761 gatcaagacc atcctggcca acatggtgaa acgccatctc tactaaaaat agaaaaattg
     8821 gctagatgtg gtggtgcacg cctgtaatcc cagctccttg ggaggctgag gcaggagaat
     8881 tgcttgaaga tgggaagcac agattgcagt gaaccgagat cgcgccactg cactccagcc
     8941 tggcaacaga gtgagactct gtctcaaaaa aaaaggaaaa atatttctta attttggcat
     9001 actcaaattt atacaacctt tcctttatct tcatcagaaa tttcttttct cctaaggcct
     9061 taaatatgct gtactatttt ggcttccaca gtttctatgt tttatcccaa gttgcttaat
     9121 ccatttggag ttgatttttg ttgaccgtat ctgtagagtg taatgtcatt tttcccacta
     9181 tggacataaa aatttttgca aggcctcttt tttttaatga agaaaagagg tttattttgt
     9241 tcacaattct gaaggcctgg agggtcccag aagcttggca ccagcaccca ctaggctcca
     9301 gatcggggcc tcatgctgac ttccgttttc acacaacgag tgggaaacag gtgtcctaac
     9361 actgtgagag aaaaaatccg aaagtttagt ttttcccatt cgcttgccct ggcctccagg
     9421 cagtcctgca gcagcaaaca catcatcagc cttaggagct ggcctgtgag gttgaccact
     9481 ctgtaggtgg acgagcctcg cccgagaaga gacatgagca gttctgcgta ggctttaaga
     9541 cagaatcaac atggaaagca cgacccacat ggtttcaata gaacttgcct cctgaacctg
     9601 actaggttac tcgcctgatg aaccagtatc tccatcaccc gtgggactga cagacccaga
     9661 gtgtcataac ctaaaattca gaagtgtaga ctataatctt aaattattca gcatatgtgc
     9721 aacagccttg gggagcagtg ttatgatacc aaatggctaa cattcatgac ctcagtatcc
     9781 tggaagaaaa ggagaaagtg tgatgtagta aaaccacttg aaaaaataat gatgaaacat
     9841 ttctcatatt tggtgtaaga taaaaactta agtttgaaga ggttccatga gccccagaca
     9901 ggataaacct aaagaaaacc aagcccaggc cgggggcggt ggctcacacc tgtaatccca
     9961 gcactttggg aggccgaggt gggcggatca caaggtcagg agatcatgac catcctggcc
    10021 aacacagtga aacctcgtct ctagtaaaaa aaaaaaaaaa aaagaaaaat acaaaaattt
    10081 agttgggcgt ggtggcgggc gactgcagtc ccagctactg gggaggctga ggcaggagaa
    10141 tggcgtgaac ccgggaggca gagcatgcag tgagctgaga ttgcaccact gcactccagc
    10201 ctgggcaaca gagcgagact ctgtctcaaa aaagaagaaa gaaaagaaaa ccaagcccct
    10261 gccaccacga agctgccgaa agctacagag tgaaagtctt ggaaggaggc tgagaaagtg
    10321 gacacagtgc ttccagaaga acaattcaat tgaccgggtt tctcgtcgga agccatagag
    10381 gccaacagga aatgtaggag catttttcaa gttctgaaat aaaaagaaat gccaacccag
    10441 attgctatat ccaacaaaat atcctttagg aatgaaacag aagtaacgat gaggcaatac
    10501 aaagaattgc ctgcagacct ggtttaaata aatggttaca gaaaactctt aaggaaacct
    10561 ggaacaaagg aaaagcaata gaagagtaaa tacctgagta aatagatcag atcattctac
    10621 tcttgagttc tttaaaatat atattattgt caaaagcaaa aattatcaca tggggtttca
    10681 actgatgtat atttaataca taagacaact acaacatgaa ggtgaggggc aacgtggctg
    10741 gacggcgtgg aggttccgtg ctccatttca gtggcaaaat accattccag aaggactgga
    10801 aaagctaagt ctgtatattt taattactaa agaagtgtac agctgggtgt ggtggctcac
    10861 gcctgtaatc ccaccacttt gggagagtga ggtgggtgga tcacttgagg tcaggagttt
    10921 gagaccagct tggccaacat ggtgaaaccc catctctact aagaaataca aaaattagct
    10981 gtgtgtggtt gggggcacct gtaatctcag cttctcagga ggctgaggca ggagaatcac
    11041 ttgaacccag gaggtggagg ttgcagtcag tcgagattgt gccacggcac tccagcctgg
    11101 gtgacagagc aagactctgt ctaaaaaaaa aaaggacaat gagatatact aaaatggtcc
    11161 aatatgttaa ttaaaacata ctactaaaaa aa
//
