LOCUS       NM_001004309            3163 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 774 (ZNF774), mRNA.
ACCESSION   NM_001004309 XM_292384
VERSION     NM_001004309.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3163)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3163)
  AUTHORS   Guan,C., He,L., Chang,Z., Gu,X., Liang,J. and Liu,R.
  TITLE     ZNF774 is a potent suppressor of hepatocarcinogenesis through
            dampening the NOTCH2 signaling
  JOURNAL   Oncogene 39 (8), 1665-1680 (2020)
   PUBMED   31659254
  REMARK    GeneRIF: ZNF774 is a potent suppressor of hepatocarcinogenesis
            through dampening the NOTCH2 signaling.
            Erratum:[Oncogene. 2020 Mar;39(13):2844. doi:
            10.1038/s41388-020-1180-0.. PMID: 32015484]
REFERENCE   4  (bases 1 to 3163)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3163)
  AUTHORS   Okada,Y., Terao,C., Ikari,K., Kochi,Y., Ohmura,K., Suzuki,A.,
            Kawaguchi,T., Stahl,E.A., Kurreeman,F.A., Nishida,N., Ohmiya,H.,
            Myouzen,K., Takahashi,M., Sawada,T., Nishioka,Y., Yukioka,M.,
            Matsubara,T., Wakitani,S., Teshima,R., Tohma,S., Takasugi,K.,
            Shimada,K., Murasawa,A., Honjo,S., Matsuo,K., Tanaka,H., Tajima,K.,
            Suzuki,T., Iwamoto,T., Kawamura,Y., Tanii,H., Okazaki,Y.,
            Sasaki,T., Gregersen,P.K., Padyukov,L., Worthington,J.,
            Siminovitch,K.A., Lathrop,M., Taniguchi,A., Takahashi,A.,
            Tokunaga,K., Kubo,M., Nakamura,Y., Kamatani,N., Mimori,T.,
            Plenge,R.M., Yamanaka,H., Momohara,S., Yamada,R., Matsuda,F. and
            Yamamoto,K.
  TITLE     Meta-analysis identifies nine new loci associated with rheumatoid
            arthritis in the Japanese population
  JOURNAL   Nat Genet 44 (5), 511-516 (2012)
   PUBMED   22446963
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA017564.1, BC067279.1 and AC018946.12.
            
            On May 17, 2019 this sequence version replaced NM_001004309.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.139194.1,
                                           SRR3476690.634412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354377.8/ ENSP00000346348.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                DA017564.1         40-88
            50-394              BC067279.1         24-368
            395-395             DA017564.1         435-435
            396-1799            BC067279.1         370-1773
            1800-3163           AC018946.12        134093-135456       c
FEATURES             Location/Qualifiers
     source          1..3163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..3163
                     /gene="ZNF774"
                     /note="zinc finger protein 774"
                     /db_xref="GeneID:342132"
                     /db_xref="HGNC:HGNC:33108"
     exon            1..128
                     /gene="ZNF774"
                     /inference="alignment:Splign:2.1.0"
     exon            129..251
                     /gene="ZNF774"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1599
                     /gene="ZNF774"
                     /codon_start=1
                     /product="zinc finger protein 774"
                     /protein_id="NP_001004309.2"
                     /db_xref="CCDS:CCDS32330.1"
                     /db_xref="GeneID:342132"
                     /db_xref="HGNC:HGNC:33108"
                     /translation="MWLGTSGKSGLPGHCLENPLQECHPAQLEEWALKGISRPSVISQ
                     PEQKEEPWVLPLQNFEARKIPRESHTDCEHQVAKLNQDNSETAEQCGTSSERTNKDLS
                     HTLSWGGNWEQGLELEGQHGTLPGEGQLESFSQERDLNKLLDGYVGEKPMCAECGKSF
                     NQSSYLIRHLRTHTGERPYTCIECGKGFKQSSDLVTHRRTHTGEKPYQCKGCEKKFSD
                     SSTLIKHQRTHTGERPYECPECGKTFGRKPHLIMHQRTHTGEKPYACLECHKSFSRSS
                     NFITHQRTHTGVKPYRCNDCGESFSQSSDLIKHQRTHTGERPFKCPECGKGFRDSSHF
                     VAHMSTHSGERPFSCPDCHKSFSQSSHLVTHQRTHTGERPFKCENCGKGFADSSALIK
                     HQRIHTGERPYKCGECGKSFNQSSHFITHQRIHLGDRPYRCPECGKTFNQRSHFLTHQ
                     RTHTGEKPFHCSKCNKSFRQKAHLLCHQNTHLI"
     exon            252..358
                     /gene="ZNF774"
                     /inference="alignment:Splign:2.1.0"
     exon            359..3163
                     /gene="ZNF774"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF774"
                     /note="hexamer: GATAAA"
     polyA_site      1787
                     /gene="ZNF774"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF774"
                     /note="hexamer: TATAAA"
     polyA_site      3142
                     /gene="ZNF774"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccccac agccctgtca cgaatcccgg tcgggttctg ggaggcacag cctcggggtt
       61 gcgggccggg tgcggctcgg cggtggagga ctcacttcct gctccatccc cggctgggcc
      121 ctggggcgga actgatgacg cttgataatg tggctgggga cttcagggaa gagtgggtta
      181 cctggacact gcttagagaa tcctctccag gaatgccacc cagcacagtt agaagaatgg
      241 gctctcaaag gaatttccag gcctagtgta atctcccagc cggagcagaa agaagagcca
      301 tgggtcctac cactccaaaa ctttgaggcg aggaagatcc cgagggaaag ccacacagac
      361 tgtgagcatc aggtggcaaa gctcaatcag gacaattctg aaacagcaga acaatgtgga
      421 acatcctcag aaaggaccaa taaagatctt tctcatactc ttagttgggg aggaaactgg
      481 gagcaaggcc tagaattaga agggcaacat ggaacccttc caggagaggg ccagctggag
      541 tccttttcac aggagaggga tttaaacaag ctcctggatg gatatgtagg agagaagcct
      601 atgtgtgcag aatgcgggaa aagctttaac cagagttcct atctcataag acacctaaga
      661 acccacactg gcgagaggcc ctatacgtgc attgagtgtg ggaaaggctt caaacagagc
      721 tcagaccttg tcacccatcg cagaacacac acaggagaga agccctacca atgcaagggg
      781 tgtgagaaga aattcagcga cagctcaaca ctcatcaaac atcagagaac ccacacaggg
      841 gagagaccct atgagtgccc agagtgtgga aagacttttg ggcggaagcc acacctcata
      901 atgcaccaaa gaacccacac aggcgagaag ccctacgcgt gcctggaatg tcacaaaagc
      961 ttcagtcgaa gctcaaattt catcactcac cagaggaccc acacaggggt gaagccttac
     1021 aggtgtaatg actgtgggga gagttttagc cagagctcgg atttgattaa gcaccaacga
     1081 acccacacgg gagaacggcc cttcaaatgc ccggagtgcg ggaagggctt cagagatagt
     1141 tctcattttg tagctcacat gagcactcat tcaggagaga ggcctttcag ttgtcctgac
     1201 tgccacaaaa gcttcagtca gagctcacat ttggtcacgc accaaagaac acacacaggt
     1261 gagagacctt ttaagtgcga aaactgtggg aaaggattcg ccgacagctc cgccctcatt
     1321 aagcaccaac gaatccacac cggagaaaga ccctacaaat gtggagagtg tgggaagagc
     1381 ttcaatcaga gctcccactt tattacccat cagcgaatcc acttaggaga caggccctat
     1441 cgatgtcctg agtgtggcaa gaccttcaat cagcgttccc atttcctcac acaccagaga
     1501 acgcatacag gagaaaaacc tttccactgt agtaaatgta acaagagctt ccgtcagaaa
     1561 gcgcatcttt tatgccatca aaacacccat ttgatttagg aagtagtctt tggtgttcag
     1621 ctgctccctt gcacattttc attgctactg tcttcaagca ccccaaatag agaaaacctg
     1681 ggcgtcagtg gctcaatttg ggccctgatc tattctccct ctttcttgtc tatgttataa
     1741 cagagaggat aaacttaaag ggtccaaata acggtccgaa tacaaaaggc attccttcag
     1801 tgtgtgactg actcttaggg aaatgtgagt ttaatagttg atgcccgcca ggcgtggtgg
     1861 ctcacccctg taatcccagc acttttggga ggccaaggtg ggtggatcac ttgaggtcag
     1921 gagttgagac cagcctggtg agcatggtga aacctcatct ctactaaaaa tgcaaaaatt
     1981 agctgggcat ggtggcacgt gcctgtagtc ccagctactc gggaggccga ggcagaagaa
     2041 tcatttgaac tcagaaggtg caggttgcag tgagttgaga tcatgccact gcactccagc
     2101 ctgggcaaca gagagagact ctgtctccaa aaaaattaaa aagttgatgc ctagttacta
     2161 aatgagaagt gagaaaaatg tggcctagag atcacatgtt caccacctag tacagtgcct
     2221 ggcacaacat agatgctcaa taactaaatg gtcccatcat tattaatgat taatagttga
     2281 ggtcttatat aaaggcttta atgcagtacc tggcccttaa aagacactca gtacaagatt
     2341 ggtggctttt atcagtctta ttactcaatt agaaatttat tagtgtagtc cccccgcccc
     2401 aaactcagaa cgtgaaagaa attagattgg aactagaagg tttggggttg gaatacacaa
     2461 attgaataaa atggaaatgc actgccagtt cagtgctgtg caggcattag tcaccagagg
     2521 tctcactgcc atgacaaggc caaattatcg tagaggatgt ttgcggtctt gtgacttgga
     2581 ggctgaaaga atttcagaag ctcttttaaa tggcagtgta tggcagtgta tctaccagag
     2641 gtttgctgtc atctgacaca gagaaaatat cctacaatga acaagccaga gggacctggt
     2701 agaggactat aaaattgtgg aagcaaaatt gctgagaatg tcaaatgata ttacagggat
     2761 cctccctggc atttagctga aggaagcaac tcttgttttc taatttgctg ggtcattggc
     2821 catttagttt taggttaata taattctctg atccttttag ggccatccag gttatgcact
     2881 agtacattcc tacattcaat tgaaataaat tgagggacgg caagtgtgtt ggaaagaaca
     2941 ccgacttcat tgagaaggta aagtatttga gtcctggccc tgacgcttaa tttggccaga
     3001 ctttcatctt ctcccagcct caagttttac ctacctcaca aggttgttgt gaggatctaa
     3061 aaatacacac acacacacac acacacacac acacacacac actttgttgg ttaactataa
     3121 atgtaatatc tctatgttat aattctgttg ctaatgtctt ttt
//
