LOCUS       NM_021217               2040 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 77 (ZNF77), transcript variant 1,
            mRNA.
ACCESSION   NM_021217
VERSION     NM_021217.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2040)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2040)
  AUTHORS   Gago,S., Overton,N.L.D., Ben-Ghazzi,N., Novak-Frazer,L., Read,N.D.,
            Denning,D.W. and Bowyer,P.
  TITLE     Lung colonization by Aspergillus fumigatus is controlled by ZNF77
  JOURNAL   Nat Commun 9 (1), 3835 (2018)
   PUBMED   30237437
  REMARK    GeneRIF: ZNF77 as a key controller of Aspergillus colonization and
            suggest its utility as a risk-marker for patient stratification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2040)
  AUTHORS   Huebner,K., Druck,T., LaForgia,S., Lasota,J., Croce,C.M.,
            Lanfrancone,L., Donti,E., Pengue,G., La Mantia,G., Pelicci,P.G. et
            al.
  TITLE     Chromosomal localization of four human zinc finger cDNAs
  JOURNAL   Hum Genet 91 (3), 217-222 (1993)
   PUBMED   8478004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006277.1 and AC011559.4.
            
            On Nov 23, 2018 this sequence version replaced NM_021217.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062561.1, SRR1660805.202410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314531.5/ ENSP00000319053.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC006277.1         8287-8420           c
            135-261             AC006277.1         2730-2856           c
            262-442             AC011559.4         400-580
            443-2040            AC011559.4         2289-3886
FEATURES             Location/Qualifiers
     source          1..2040
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2040
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /note="zinc finger protein 77"
                     /db_xref="GeneID:58492"
                     /db_xref="HGNC:HGNC:13150"
                     /db_xref="MIM:194551"
     exon            1..134
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1769
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ZNFpT1"
                     /codon_start=1
                     /product="zinc finger protein 77 isoform 1"
                     /protein_id="NP_067040.1"
                     /db_xref="CCDS:CCDS12099.1"
                     /db_xref="GeneID:58492"
                     /db_xref="HGNC:HGNC:13150"
                     /db_xref="MIM:194551"
                     /translation="MDCVIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLD
                     CYIYVRTSGSSSQRDVFGNGISNDEEIVKFTGSDSWSIFGENWRFDNTGDQHQIPQRH
                     LRSQLGRLCESNEGHQCGETLSQTANLLVHKSYPTEAKPSECTKCGKAFENRQRSHTG
                     QRPCKECGQACSCLSCQSPPMKTQTVEKPCNCQDSRTASVTYVKSLSSKKSYECQKCG
                     KAFICPSSFRGHVNSHHGQKTHACKVCGKTFMYYSYLTRHVRTHTGEKPYECKECGKA
                     FSCPSYFREHVRTHTGEKPYECKHCGKSFSCYSSFRDHVRTHTGEKPCQCKHCGKAFT
                     CYSSLREHGRTHSGEKPYECKECGKAFRYPSSLRAHMRMHTGEKPYVCKQCGKAFGCP
                     TYFRRHVKTHSGVKPYQCKECGKAYSFSSSLRIHVRTHTGEKPFECKHCGKAFSCHSS
                     LREHVRTHSGEKPYECNQCGKAFSHAQYFQKHVRSHSGVKPYECTECGKAYSCSSSLR
                     VHVRTHTGERPYECKQCGKTFRYLASLQAHVRTHAGA"
     exon            135..261
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..442
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..2040
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /note="hexamer: AATAAA"
     polyA_site      2040
                     /gene="ZNF77"
                     /gene_synonym="pT1"
                     /note="major polyA site"
ORIGIN      
        1 aagccgagtt cccctctgcc ttgcgcgctt ccccgcctac cccgagcggc tcaggtgtcc
       61 tgtcgtgctc acctgcgccg gtcgctggac cgcggggcgc taaccctgga gagcccagga
      121 gcgggcggga catggactgc gtgatctttg aggaagtggc tgtgaacttc accccagaag
      181 agtgggcatt gctggatcat gctcagagga gcctctacag agatgtgatg ctggagacct
      241 gcaggaacct tgcctccttg gattgttaca tttatgttag aaccagtgga tcaagttctc
      301 agagggacgt ttttgggaat ggaatatcca atgatgaaga gattgtaaag ttcacaggaa
      361 gtgattcctg gtctattttt ggagaaaatt ggagatttga taacactgga gatcagcacc
      421 aaatcccaca gaggcatctg agaagtcagc tggggagact ctgtgaaagt aatgaaggtc
      481 atcaatgcgg agagaccttg agccagactg cgaaccttct tgtgcacaag agttacccta
      541 ccgaagctaa accctctgag tgcactaagt gtggcaaagc cttcgagaat cggcagagat
      601 ctcacactgg acagagaccg tgtaaggaat gtgggcaagc ctgcagctgc ctctcctgcc
      661 aaagccctcc tatgaaaacg cagactgtag agaaaccctg taattgccag gactcaagga
      721 cagcatctgt gacatacgtg aaaagtctca gcagtaaaaa gtcttatgaa tgtcagaaat
      781 gtggaaaagc tttcatttgt ccctcatctt tcaggggaca tgtgaatagt catcatgggc
      841 agaaaaccca tgcatgtaaa gtatgtggga agacctttat gtattactcc taccttacac
      901 ggcacgtaag aactcacaca ggagagaaac cctatgagtg taaggagtgt gggaaagcct
      961 tcagctgtcc ctcatacttt cgagaacatg tcagaacaca cactggagag aaaccgtatg
     1021 aatgtaagca ttgtggaaaa tcattcagct gttactcctc ctttagagat cacgtgagga
     1081 cgcacactgg agagaaaccc tgtcagtgta aacattgcgg aaaagcgttc acttgttact
     1141 cgtctcttcg agaacatggg agaacgcaca gtggagagaa accctatgaa tgtaaggaat
     1201 gcggcaaagc cttcaggtac ccctcctctc tgcgagcaca catgagaatg cacaccggag
     1261 agaagcccta tgtgtgcaag cagtgtggga aggccttcgg atgtcccact tactttagaa
     1321 gacatgtgaa aacacacagc ggggtgaagc cctatcaatg taaagagtgt gggaaagcct
     1381 acagtttttc ctcctccctt cgaatccacg tgaggacgca tactggagag aagccctttg
     1441 agtgtaagca ttgtgggaaa gccttcagct gtcactcctc ccttcgagag catgtgcgaa
     1501 cccacagcgg agagaaaccg tacgaatgta atcaatgtgg gaaagccttc agccacgctc
     1561 agtactttca aaagcatgtg agatcacaca gtggggtcaa accctacgaa tgtactgaat
     1621 gtgggaaagc ctacagttgt tcctcgtccc ttcgtgtgca cgtgagaacg cacactggag
     1681 agagaccgta tgaatgcaag cagtgtggga aaaccttcag gtatctcgca tcgcttcaag
     1741 cacatgtgag aacacatgct ggagcgtgaa tctacgaata cagtggacct gggagagtgt
     1801 tcaaccgtaa aaccttgttg taaatgtgag aaacgttatt tatgtagagc atgtaggaaa
     1861 acctggtata gcacttattt tgtacctaaa aattcagagt aggagagaaa tctcttaatt
     1921 atgattaata tggtattgcc tttacatgcc tcagccttaa tagtgattcc ttttgtatta
     1981 atttctagtg tatgtttgtg atataaacat ttaataaata tcctgttttg tacgctttca
//
