LOCUS       NM_024671               2289 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 768 (ZNF768), mRNA.
ACCESSION   NM_024671
VERSION     NM_024671.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Villot,R., Poirier,A., Bakan,I., Boulay,K., Fernandez,E.,
            Devillers,R., Gama-Braga,L., Tribouillard,L., Gagne,A.,
            Duchesne,E., Caron,D., Berube,J.S., Berube,J.C., Coulombe,Y.,
            Orain,M., Gelinas,Y., Gobeil,S., Bosse,Y., Masson,J.Y., Elowe,S.,
            Bilodeau,S., Manem,V., Joubert,P., Mallette,F.A. and Laplante,M.
  TITLE     ZNF768 links oncogenic RAS to cellular senescence
  JOURNAL   Nat Commun 12 (1), 4841 (2021)
   PUBMED   34404770
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Rohrmoser,M., Kluge,M., Yahia,Y., Gruber-Eber,A., Maqbool,M.A.,
            Forne,I., Krebs,S., Blum,H., Greifenberg,A.K., Geyer,M.,
            Descostes,N., Imhof,A., Andrau,J.C., Friedel,C.C. and Eick,D.
  TITLE     MIR sequences recruit zinc finger protein ZNF768 to expressed genes
  JOURNAL   Nucleic Acids Res 47 (2), 700-715 (2019)
   PUBMED   30476274
  REMARK    GeneRIF: A report on the specific binding of zinc finger protein
            ZNF768 to the sequence motif GCTGTGTG (N20) CCTCTCTG in the core
            region of mammalian-wide interspersed repeats.
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   O'Reilly,J.A., Fitzgerald,J., Fitzgerald,S., Kenny,D., Kay,E.W.,
            O'Kennedy,R. and Kijanka,G.S.
  TITLE     Diagnostic potential of zinc finger protein-specific autoantibodies
            and associated linear B-cell epitopes in colorectal cancer
  JOURNAL   PLoS One 10 (4), e0123469 (2015)
   PUBMED   25875936
  REMARK    GeneRIF: High ZNF768 expression is associated with colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 2289)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013760.1 and BQ635980.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024671.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013760.1, SRR1163655.191567.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380412.7/ ENSP00000369777.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-695               BC013760.1         24-718
            696-942             BQ635980.1         26-272
            943-2289            BC013760.1         966-2312
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2289
                     /gene="ZNF768"
                     /note="zinc finger protein 768"
                     /db_xref="GeneID:79724"
                     /db_xref="HGNC:HGNC:26273"
                     /db_xref="MIM:618032"
     exon            1..241
                     /gene="ZNF768"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1776
                     /gene="ZNF768"
                     /codon_start=1
                     /product="zinc finger protein 768"
                     /protein_id="NP_078947.3"
                     /db_xref="CCDS:CCDS10681.2"
                     /db_xref="GeneID:79724"
                     /db_xref="HGNC:HGNC:26273"
                     /db_xref="MIM:618032"
                     /translation="MEREALPWGLEPQDVQSSDEMRSPEGYLRGNMSENEEEEISQQE
                     GSGDYEVEEIPFGLEPQSPGFEPQSPEFEPQSPRFEPESPGFESRSPGLVPPSPEFAP
                     RSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRYESQNTELKTQS
                     PEFEAQSSKFQEGAEMLLNPEEKSPLNISVGVHPLDSFTQGFGEQPTGDLPIGPPFEM
                     PTGALLSTPQFEMLQNPLGLTGALRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTL
                     IQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLR
                     HQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCTECGKCYSQNSSLRSHQ
                     RVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHART
                     HLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHS
                     GERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR"
     exon            242..2289
                     /gene="ZNF768"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2268..2273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF768"
                     /note="hexamer: AATAAA"
     polyA_site      2289
                     /gene="ZNF768"
                     /note="major polyA site"
ORIGIN      
        1 agacgtccgg cctcgggggc ccgggctggg ccgccgagtc ccctgggcgg cgctgagcgg
       61 gcgggaggcg ggggcccgcg gctcggggca accgaggccg ggtcgcggga tcggccgcca
      121 tcgccgccgc cgctgcactg ggagcccgcg gggatggagc gggaggcgtt gccgtggggc
      181 ctcgagcccc aggatgtgca gagttctgac gaaatgagga gccccgaagg gtacctcaga
      241 ggcaacatga gtgagaatga ggaagaggaa atttctcagc aagaaggcag tggggactat
      301 gaagtcgaag agataccatt tgggcttgaa ccccagagcc ctgggtttga gccacaaagc
      361 ccagagtttg aaccccaaag ccccagattt gagcctgaaa gcccggggtt tgagtcccga
      421 agccctgggc ttgtgccccc aagccctgag tttgcaccca gaagccctga atcagattct
      481 cagagccctg agtttgaatc ccagagccct aggtatgaac cccaaagccc tggctatgaa
      541 cctcggagcc ccgggtatga accccggagc cctggctatg aatctgagag ctctagatat
      601 gaatcccaga acactgagct caaaacccaa agcccagaat ttgaagctca aagttccaaa
      661 ttccaggaag gtgcggagat gcttctgaac cccgaggaaa agagtccttt gaatatctcc
      721 gtaggagttc accccctgga ctccttcact caggggtttg gggagcagcc cacaggggac
      781 ctgcccatag ggccaccttt tgagatgccc acaggggccc tgctgtctac accgcagttt
      841 gagatgcttc agaatcccct gggtctcaca ggagcccttc gaggtccagg tcggcggggt
      901 ggccgggcca ggggtgggca gggccctcgg cctaacatct gtggcatctg cgggaagagc
      961 ttcgggcggg gctccaccct gatccagcac cagcgcatcc acaccggtga gaagccctac
     1021 aaatgtgagg tctgcagcaa ggccttctcc cagagctctg acctcatcaa acaccagcgc
     1081 acccacactg gcgagcggcc ctacaaatgt ccccgttgcg gcaaggcctt cgccgacagc
     1141 tcttacctgc ttcgccacca gcgcactcac tctggccaga agccctacaa gtgcccacat
     1201 tgtggcaagg ccttcggcga cagctcctac ctcctgcgac accagcgcac ccacagccac
     1261 gagcggccct acagctgcac cgagtgcggc aagtgctata gccagaactc gtccctgcgc
     1321 agccatcaga gggtgcacac cggtcagagg cccttcagct gtggcatctg cggcaagagc
     1381 ttctcccagc ggtcggccct tatcccccat gcccgcagcc acgcccggga gaagcccttc
     1441 aagtgccctg agtgcggcaa gcgctttggc cagagctcgg tgctggccat ccacgcccgc
     1501 acccacctgc caggccgcac ctacagctgc cccgactgcg gcaagacctt caatcgctcc
     1561 tccactctca tccagcacca gcgctcccac acgggcgagc ggccctacag gtgcgccgtg
     1621 tgcggcaagg gcttctgccg ctcctccacg cttctgcagc atcaccgggt ccacagtggc
     1681 gagcggcctt acaagtgcga tgactgcgga aaggccttct cccagagctc cgacctcatc
     1741 cgccaccagc ggacccacgc ggcgggccgg cgctgacctg gggccccagc aggggtggga
     1801 ggtgtgggca gaagataagg ggccagggag ctagaggaac ctttagggag gatagtggag
     1861 aagccgcagg agaatggagg agctgaggat gctggaagaa gagaaccagg gtggaggaag
     1921 tgacatgccc tggagacttg tgggaagtgg gttggaggga ggccaggccg gcagcgggag
     1981 gccctgggag aaatggagag aggtcagcgg agggctggcc tcagccgcgg ctccttggtg
     2041 ggtgcctggc ttggcaactg ctagagcagg gaggggggag ggcaggggat tacctaatta
     2101 gagtgggtta gcttagattg gtagctgctg aaactctcgt tgagtcagga gcgggtaaaa
     2161 ggtaggtggg gtggggagtg gggccccggg gtggggcctg ggcctctgcg tgcaaacccc
     2221 agcctccctc ttcttcctca ggctttggag cccctgagtt tgagttcaat aaaaacttta
     2281 tgtggtaaa
//
