LOCUS       NM_001040185            4572 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 765 (ZNF765), transcript variant
            1, mRNA.
ACCESSION   NM_001040185
VERSION     NM_001040185.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Liu,X., Wu,P., Su,R., Xue,Y., Yang,C., Wang,D., Ruan,X., Zheng,J.,
            Yang,Y., Li,Z. and Liu,Y.
  TITLE     IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier
            permeability by negatively regulating ZNF765 by STAU1-mediated mRNA
            decay
  JOURNAL   RNA Biol 17 (12), 1777-1788 (2020)
   PUBMED   32713259
  REMARK    GeneRIF: IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour
            barrier permeability by negatively regulating ZNF765 by
            STAU1-mediated mRNA decay.
REFERENCE   3  (bases 1 to 4572)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4572)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD656338.1 and AC022137.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001040185.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM834105.1, BX647981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396408.8/ ENSP00000379689.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               CD656338.1         27-581
            556-4572            AC022137.6         108965-112981       c
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..4572
                     /gene="ZNF765"
                     /note="zinc finger protein 765"
                     /db_xref="GeneID:91661"
                     /db_xref="HGNC:HGNC:25092"
     exon            1..45
                     /gene="ZNF765"
                     /inference="alignment:Splign:2.1.0"
     exon            46..133
                     /gene="ZNF765"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1690
                     /gene="ZNF765"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 765 isoform 1"
                     /protein_id="NP_001035275.1"
                     /db_xref="CCDS:CCDS46171.1"
                     /db_xref="GeneID:91661"
                     /db_xref="HGNC:HGNC:25092"
                     /translation="MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLDISSKCMMKEFSSTAQGNREVFHAGTSQRHESHHNGDFCFQDIDKDIHDIEFQWQ
                     EDERNGHEALMTKIKKLTGSTERYDQNYAGNKPVKYQLGFSFHSHLPELHIFHTEEKI
                     DNQVVKSIHDASLVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQEVHMREKSFQCN
                     DSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNEC
                     GKTFSQTYYLTCHRRLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGK
                     TFSQKSYLTCHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTF
                     SHKSSLTYHRRLHTEEKPYKCNECGKTFNQQLTLNICRLHSGEKPYKCEECDKAYSFK
                     SNLEIHQKIHTEENPYKCNECGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSN
                     LERHRRIYTGEKLHV"
     exon            134..260
                     /gene="ZNF765"
                     /inference="alignment:Splign:2.1.0"
     exon            261..4572
                     /gene="ZNF765"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4546..4551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF765"
                     /note="hexamer: AATATA"
     polyA_site      4572
                     /gene="ZNF765"
                     /note="major polyA site"
ORIGIN      
        1 agacccggaa gcggacggcg tggagtgact atcccaccgc cgcgggattg acttctaaag
       61 actcttggta tgtgaggaag aaacctggaa gaggaagagg aaagcaaagg agtcagggat
      121 ggctcttcct cagggtctat tgacattcag ggatgtggcc atagaattct ctcaggagga
      181 gtggaaatgc ctggaccctg ctcagaggac tctatacagg gacgtgatgc tggagaatta
      241 taggaacctg gtctccctgg atatctcttc caaatgcatg atgaaggagt tctcgtcaac
      301 agcacaaggc aatagagaag tgttccatgc agggacatct caaagacatg aaagtcatca
      361 caatggagat ttttgtttcc aggatattga taaagatatt catgacattg agtttcagtg
      421 gcaagaagat gaaagaaatg gccatgaagc actcatgaca aaaatcaaaa agttgacagg
      481 tagtacagag cgatatgatc aaaattatgc tggaaacaag cctgttaaat atcagcttgg
      541 attcagcttt cattcgcatc tgcctgaact gcacatattt cacactgaag agaaaattga
      601 taatcaagtt gtgaagtcta tccacgatgc ttccttggtt tcaacagccc aaagaatttc
      661 ttgtaggcct gaaacccata tttctaatga ctatgggaat aatttcctga attcttcatt
      721 attcacacaa aaacaggaag tacatatgag ggaaaaatct ttccaatgca atgacagtgg
      781 caaagcctat aattgtagct cactcttaag gaaacatcag ttaatccatt taggagagaa
      841 acaatataaa tgcgatatat gtggcaaggt ctttaattcg aagcgatacg ttgcacgcca
      901 tcgtagatgt cacactggtg agaaacctta caagtgtaat gagtgtggca agaccttcag
      961 tcagacatat tacctaacat gccatcgtag acttcatact ggagagaaac cttacaaatg
     1021 tgaagaatgt gacaaagctt tccatttcaa atcaaagctt caaatacata ggagaattca
     1081 tactggagag aaaccgtaca agtgtaatga gtgtggcaag acctttagtc agaagtcgta
     1141 ccttacatgc catcgtaggc ttcatactgg agagaaacct tacaagtgta atgagtgtgg
     1201 caagaccttt agtcggaagt cacattttac atgccatcat agagttcata ctggagagaa
     1261 accttacaag tgtaatgagt gtagcaagac ctttagtcac aagtcatctc ttacatacca
     1321 tcgtagactt catactgaag agaaacctta caagtgtaat gagtgtggca agaccttcaa
     1381 tcagcagtta acccttaaca tttgtagact tcatagtgga gagaaacctt acaaatgtga
     1441 agaatgtgac aaagcctaca gtttcaaatc aaaccttgaa atacatcaga aaattcatac
     1501 tgaagagaat ccttacaagt gtaatgagtg tggcaagacc ttcagccgga cgtcatccct
     1561 tacataccat catagacttc atactggaca gaaaccttac aaatgtgaag attgtgatga
     1621 agctttcagt ttcaaatcaa accttgaaag acataggaga atttatactg gagagaaact
     1681 acacgtgtaa tgagtgtggt aagaccttca atcaggagtt aacccttaca tgccatcgta
     1741 ggcttcatag tggagagaaa ccttacaaat atgaagaact tgacaaagct tacaatttca
     1801 aatcaaacct tgaaatacat cagaaaattc gtactgaaga gaatcttaca agtgtaatga
     1861 gtgtggcaag accttgagtc atacgtcatc ttttgtgtac catcataaac ttcatagtgg
     1921 agagacctta caaatgtgaa gaatgtgaag aagctttctg tttcaaatcc aaccttgaaa
     1981 gacataggag aattcacact ggtgagaaac cttacaggtg taatgagtgt ggcaagacct
     2041 tcagccagac ctcatccctt acatgccatt gtagacttcg tactggagag aaaccttaca
     2101 aatgtgaaga atttgagttt tccatttcaa atcaaacctt gaaagacaaa ggagaattca
     2161 tactggagag aaaccataca agtgtaatga gtgtggcaag acctttagtc agaactcata
     2221 ccttacacgc catcgtagac ttcatactgg aggatacctt acaaatgtaa tgagtgtggc
     2281 aagaccttta gtcagaactc ataccttaca tgccatcata gacttcatac tggagagata
     2341 ccttaaaagt gtagtgagtg tggcaagacc tttagtctga agtcatacct tacgcaccat
     2401 cgtagacttc atactggaga ggtaccttac aaggataatg agtgtagaaa aacctttcat
     2461 gggcagtcag cattttacaa atgtaatgat tgtcaccaag tcttgagtaa tgctacaact
     2521 attgcaaatc attggagaat ccataatgaa gagagatcct acaagtgtga taaatgcaga
     2581 ataaatgcag aaaatttttc agacatcctt catacctttg cagttcatgg gtgaagtcgt
     2641 attagaaacc ttacaaatgt gaagaatgtg atgaagcttt cagattcaaa tcaaaccttg
     2701 atagtcatag aattcatact agagagaaac cttagcagtg taatgaacgt ggcaaggttt
     2761 taaatcaaaa agcaaagctt gcacatcatc atagaattca tactggagat aaacgttaca
     2821 aatgtgaagc atgtgacaaa gtttacagtc gcaaatcaag cctccaaaga caggagaatt
     2881 catactggag agaaagctta catatgtgaa gaatgtcacc aagttttcag tcacactcaa
     2941 accttgaaag acacaggaga attcctactg gagagatagc ataaaaatgt aagagtttgt
     3001 gacaaggctt tcaggcataa ttcgcacctg gcacaacatc ctagaattca cattggagag
     3061 aaagcttaca agtataatga atgtgacagg tctttagtgg gcagtcaaca cttgtttacc
     3121 atcaggcaat ccatggtgta gggaaacttt acttatgtaa tgattgtcac aaagtcttca
     3181 gttacactac aaccattgcg aatcattgga gaatccataa tgaagagaga tcatactagt
     3241 ttaataaatt tggcaaattt ttcagacatt gttcataact tgcagttcat cggcgaactc
     3301 gtactggaga gaaaccttac aaatgtcatg attgtgacaa ggtctcagtc aagcttcatt
     3361 ctatgcaaaa cataggagaa ttcatacagg agagaaacct cacaagtgtg atgattgcgg
     3421 caaagccttt aattcacatt cacacctcac tagacatcag agaatgcata ctggacagaa
     3481 atcttataaa tgtcatcagt gtgccaaagt cttcagtctg agctcactcc ttgcaggata
     3541 tcagaaaatt cattttggag atagttgttc caaatacaat gtgtatagca aaccatcaag
     3601 cattaattga cactagagtc agttcagcat tgacttgagt ttgacttaac attgagttga
     3661 agccttaatt gacattaaag tgtttatgtt aagaggactg ggccaggcac agtggctcac
     3721 acctgtaatc tgagcgcttt gggaggccag caccggtaga tcacttgagt tcaggagttt
     3781 gaggtcagcc tggccaacag acgtgagcca ttttcccagc ctgttttttg tttctttaac
     3841 aaaaactgat agggattttt tttttttttt ttgagatgga gtttcactct tgttgcccag
     3901 gctggactgc aatggagcga tcccagctca ctacaacctc cgcctcccag gttcaagcaa
     3961 ttctcctgcc tcagcctcca gagtagctag gattacaggc atgagccacc acgcccagct
     4021 aattttgtat ttttagtaga gatggggttt ctccatgttg gttaggctgg tcttgaactc
     4081 ccagcctcag atgatccacc cacctcggcc tcccaaagtg ctgggattac aggcgtgagc
     4141 cactgcgccc agccccagtg ataaggattt ttatgggtac cgtgttgaat ctaaatcaca
     4201 ttgggttata taatcattta acaatattaa tttttccaaa ccataagtat gggttgtagc
     4261 tctatgtttc taatcatttt gatcaatgtt tgtagatttc aaggtaaaaa cctctgacct
     4321 ttttacgttt atttctaagt atttcttact ttaagttctc cagccaatgg aagtgtttta
     4381 aaattttctt ttaaagttgt ttgttgttaa aagtatggaa attcaactaa tttttggtgc
     4441 tgatactgta ttgtgcaaat ccactgaata tgttacttag ttccagtagt attttggttg
     4501 actctttgtg attttctgca cagaagatca tgtcgtctac aaacaaatat aattttactt
     4561 ctttctttct ga
//
