LOCUS       NM_001172679            2846 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 764 (ZNF764), transcript variant
            2, mRNA.
ACCESSION   NM_001172679
VERSION     NM_001172679.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2846)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2846)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2846)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 2846)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2846)
  AUTHORS   Fadda,A., Syed,N., Mackeh,R., Papadopoulou,A., Suzuki,S.,
            Jithesh,P.V. and Kino,T.
  TITLE     Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein
            ZNF764 on the Glucocorticoid Receptor
  JOURNAL   Sci Rep 7, 41598 (2017)
   PUBMED   28139699
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2846)
  AUTHORS   Kino,T., Pavlatou,M.G., Moraitis,A.G., Nemery,R.L., Raygada,M. and
            Stratakis,C.A.
  TITLE     ZNF764 haploinsufficiency may explain partial glucocorticoid,
            androgen, and thyroid hormone resistance associated with 16p11.2
            microdeletion
  JOURNAL   J Clin Endocrinol Metab 97 (8), E1557-E1566 (2012)
   PUBMED   22577170
  REMARK    GeneRIF: effect of ZNF764 on the glucocorticoid receptor
            transcriptional activity was mediated through cooperation with a
            general nuclear hormone receptor coactivator, transcriptional
            intermediary factor 1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002310.1, BF725095.1, AK093992.1 and BC008821.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001172679.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            resulting isoform (2) lacks one internal amino acid, compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.262734.1, AK093992.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267766, SAMN03267783
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395091.3/ ENSP00000378526.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC002310.1         29373-29425
            54-88               BF725095.1         1-35
            89-1303             AK093992.1         1-1215
            1304-2846           BC008821.2         1196-2738
FEATURES             Location/Qualifiers
     source          1..2846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2846
                     /gene="ZNF764"
                     /note="zinc finger protein 764"
                     /db_xref="GeneID:92595"
                     /db_xref="HGNC:HGNC:28200"
                     /db_xref="MIM:619524"
     exon            1..388
                     /gene="ZNF764"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1416
                     /gene="ZNF764"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 764 isoform 2"
                     /protein_id="NP_001166150.1"
                     /db_xref="CCDS:CCDS54001.1"
                     /db_xref="GeneID:92595"
                     /db_xref="HGNC:HGNC:28200"
                     /db_xref="MIM:619524"
                     /translation="MAPPLAPLPPRDPNGAGPEWREPGAVSFADVAVYFCREEWGCLR
                     PAQRALYRDVMRETYGHLSALGIGGNKPALISWVEEEAELWGPAAQDPEVAKCQTQTD
                     PDSRNKKKERQREGTGALEKPDPVAAGSPGLKSPQAPSAGPPYGWEQLSKAPHRGRPS
                     LCAHPPVPRADQRHGCYVCGKSFAWRSTLVEHVYSHTGEKPFHCTDCGKGFGHASSLS
                     KHRAIHRGERPHRCLECGRAFTQRSALTSHLRVHTGEKPYGCADCGRRFSQSSALYQH
                     RRVHSGETPFPCPDCGRAFAYPSDLRRHVRTHTGEKPYPCPDCGRCFRQSSEMAAHRR
                     THSGEKPYPCPQCGRRFGQKSAVAKHQWVHRPGAGGHRGRVAGRLSVTLTPGHGDLDP
                     PVGFQLYPEIFQECG"
     exon            389..502
                     /gene="ZNF764"
                     /inference="alignment:Splign:2.1.0"
     exon            503..2846
                     /gene="ZNF764"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2427
                     /gene="ZNF764"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF764"
                     /note="hexamer: AGTAAA"
     polyA_site      2846
                     /gene="ZNF764"
                     /note="major polyA site"
ORIGIN      
        1 atttctgatt atacacccgc tgccatcggc accgttagtt tccacgccct ctagtgcgcc
       61 ctcgggggcc ctagtaacct ccctccttcc cttgggcccg ggccggggag gctttctcgg
      121 gcgcaggagg ttccgcaggc ccaggccagg ccaggggagg cagccgatcc gtcgtcgggg
      181 ttgacagtta ccatggcgcc gcctctggcc ccgctccctc cccgggaccc aaacggggcc
      241 ggacccgagt ggagggagcc gggggctgtg agcttcgcgg acgtggccgt gtacttctgc
      301 cgggaggagt ggggctgctt gcggccagcg cagagggccc tgtaccggga cgtgatgcgg
      361 gagacctacg gccacctgag cgctctcgga atcggaggca acaagccagc tctcatctcc
      421 tgggtggagg aggaggccga actgtggggt ccggctgccc aggatccgga ggtggcgaaa
      481 tgtcagacac aaacggaccc agattccaga aacaagaaaa aggaaagaca aagggaaggg
      541 acgggagccc tggagaagcc cgaccctgtg gccgccgggt ctcctgggct gaagtctccc
      601 caagccccct cggccgggcc cccttatggt tgggagcagc tgtccaaggc accgcaccgg
      661 ggacgcccct ccctctgtgc ccacccccct gtcccccgag ctgaccagcg tcatggctgc
      721 tacgtgtgcg ggaagagctt tgcctggcgc tccacactgg tggagcacgt ctacagtcac
      781 actggcgaga agcccttcca ctgcactgac tgcggcaagg gcttcggcca cgcttcctcc
      841 ctgagcaaac accgggccat ccatcgtggg gagcggcccc accgctgtct ggagtgtggc
      901 cgggccttca cgcagcgctc ggcgctgact tcgcacctgc gcgtccacac cggcgagaaa
      961 ccctatggct gcgccgactg tggccgccgc ttcagccaga gctctgccct ctaccagcac
     1021 cggcgcgtgc acagcggcga gacccccttc ccctgcccgg actgtggccg cgccttcgcc
     1081 tacccctcgg acctgcggcg ccacgtgcgc acccacaccg gcgagaagcc ctacccgtgc
     1141 ccggactgcg ggcgctgctt ccgccagagc tcggagatgg cagcccacag gcgcacccac
     1201 agcggcgaga agccctaccc ctgcccgcag tgcggccgcc gctttggcca gaagtcagcc
     1261 gtggccaaac accagtgggt tcatcggccc ggggccgggg gccacagggg ccgggtcgcc
     1321 gggcgtctgt ctgtgaccct gacccctggc cacggagacc tggacccgcc cgtgggcttc
     1381 cagctgtacc cggagatatt ccaggagtgt gggtgacggc cttaaaagtg actatctaga
     1441 cattacggga ggcccgagat gggctcaggg gcccgaacct ctgcggcggc ctgcagggag
     1501 gtcccagaat ctagggcaag agctggccct ggggtgcgga cagtctgatc ttgggccctt
     1561 agcagcctcc tctgccagca ccttgctccc cactgcccag ggctctccaa ggccccctct
     1621 actgaggcag ggctgagttg agaaccccca gacctacata aggggaacca aaagctgttt
     1681 ctcagcccag aggtgctaag aggactgagg tagaggagaa ccttgtttta cccattgtct
     1741 ttttaaattt tttatcatta tttttattct tgtgaccctc ccagaacaca atactcattg
     1801 tctttttatt tatttattta tttatttctg agacagcttc ctgctctgtc acccaggctg
     1861 gagtgcagtg gtgtgaacag ggctaactgc agcctcaacc tgcagtgctc aaggaatcct
     1921 ctcccatcag ccttccaaat atctgagact acaggcgggc aacactacgg ccagctaatt
     1981 tttaaatttt acatagagat gaggttctca ctgttgtcca ggctggtctc aaactccttg
     2041 gctgaagtga tcctgtcgtc tcggcttccg caagtgctgg gattacaggc gtgagctacc
     2101 accatgcctg gcttccattg tctttgtgtg tgtgtgtgtg tgatggggtt ttgctcttgt
     2161 tgcccaggct ggagtgcaat agcgcaatct cagctcactg caacctctgc ctccagagtt
     2221 caagcaattc tccttcctca gcctcccaag tagctgggac tacaggcacc caccacctcc
     2281 attgtctttt tactgcccaa gttaaaatcc tgtgactgtg tactggatct ggcctgcggt
     2341 tgtcatattt attgatctga gtccaggcag tgtttttaag tgatatgagt tagtagtgaa
     2401 aattgaaaag gatattttac aaccaaatac aggttttctg gtgtcttttg aaaaatccaa
     2461 agatttggca actcgaccta ggctccgaca aaaccacagt tgttgggagc tgagccggag
     2521 ccagaactca caattcaccg tggcccggcc acccatcccc accactcccg tgggctcctg
     2581 accaagcacc acgtgccatt catcatggct tgcttttagt gtttttggtg tttatcttaa
     2641 agtacagcga agaagaaagg gaagtatttc ttagacccat gtctctgtcc aaataggcct
     2701 ttccatctgg catttcccgc tcatttatat gacttgctga gttcctatgg tcatttgagt
     2761 ttgcaaacag tggtctgtag cactcaggtt ttctggagtt ggagagaaag ggtggcaaga
     2821 gagaagtaaa agttggtttt atttta
//
